Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0F6IE4)

• DOT Name: Protein CC2D2B (CC2D2B)
• Gene Name: CC2D2B
• UniProt ID: C2D2B_HUMAN
• Pfam ID: PF15625 ; PF17661
• Sequence:
  MKKSQREDIFKKMSEEMDNITAEEIIDKHLQKDLDAEENQNVAKTLRGKVREKLKISKIN
  KGEKSSTEQLIDSEIHQRSKLSPQTEVSLDESLSFFILSGEEGSALGKSSEQRPVNRSYP
  KCFSLGVNLQNVAESEEEEFMKEFILTDILKVKAADYEDDQEQIKKQKANIFVPSSSPVV
  NQRKLPKDMMPRILEDEGFYIQRKPEIYKKTCNKMENRLLKLEEGKCWFGESGEIMSLPT
  PIKQSWNFRLNVRKEPLNPLLKTIYRKAVKYDLGSSFMNKMEGSREIYQLDLNIVGLQFS
  HHHLFNQEQVLCARLLQLYECFQDRQQQNVSQLLYEKLKALTDATKLSNENSEINQLTRK
  SLQDYYWQISNTKQMYDLERGKDLSLLHSILRTWKQIKSLRHGQGFTSTPIKLQVQRIKM
  NKCDEQEQISEMSETEKKNEGKELKNGKKLESLSYLASDETEIERIKPITLRPQLSFTAE
  LTSLSKCSLHEQKRRAKIQKLKYFIKIFYNNKQVSCTSVSPLQFDFKVMFQQIFNIQLMY
  WPEVICLEVYEKSKRTSLLAKLYIPLPNYTELKGKTALQYVEFSSDKLVMPADGEVGSNV
  PFLLEGNGTEELCLLTSGKLSYSLSWSLDENGLPLIPMPQSLRSSYCSMLRNVDARSVPG
  IPWLMNEQKLFEWANEVRIDPNNPEYSDLMESVTYMRLKGQDIPKYFRLEQLQDEFNFVS
  EEEMAKSKRFQLLQLRNAGQLDNFLLQQMPLHDTEIPDLVFQEYESQKEKEVSVSDVNSI
  TAQRINSANFLKKVRRLIMKRIVKISKCNLSDIVNDYEEIVSTSQLTDAVCKFVEPRRKL
  KPQRKERKKVTAQAISDGDIKILVRIVRAYNIPTRKTTINGSLDMPTCLKSSISCLRHRE
  TIKSVASDETLHEDTVHPFVEVSFQHTVYKTNTASGSHPCWNEEIKVDFVSPGHDYSFSS
  LSKIKDNIYINIFDEMMTEKHEDHCLKSCSGHSYIRKNWLGCIVFPFSALLQQSEISGTF
  QVTIPPVLLGYTWSNTYVFPKEDSNEQNLKECTFLNIFATIEPQISYVTCNPTLDKFLDQ
  TEVLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKALNPPQQLLDIFLHNSNA
  TFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHAILLCNFFLYFGKKA
  LVLLGTSVLEGHVAYVVTQETNEYLLWNPSTGQCYKQFDPFCPLKSVDCLFDDRNVWFNI
  QQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQPEEIIYFETDKSMVEDLRNRIERT
  LKSKVMEWRPKHPTHWNRQCTFILRQILPKLEFGIGSFVSSEGDNEFERILQFYWVTGFP
  IQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYLASLVQHQ

Molecular Interaction Atlas (MIA) of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Protein CC2D2B (CC2D2B).	[1]
Marinol	DM70IK5	Approved	Marinol increases the expression of Protein CC2D2B (CC2D2B).	[2]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Protein CC2D2B (CC2D2B).	[3]

References

• [1] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [2] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [3] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.