Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0FTJKK)

DOT Name Transmembrane protein with metallophosphoesterase domain (TMPPE)
Synonyms EC 3.1.-.-
Gene Name TMPPE
Related Disease
GM1 gangliosidosis type 1 ( )
Major depressive disorder ( )
GM1 gangliosidosis ( )
Mucopolysaccharidosis type 4B ( )
UniProt ID
TMPPE_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
3.1.-.-
Pfam ID
PF00149
Sequence
MAIFRQLSLGAKATLAAVTVFVSMIASRSYLAESLELRAWRWLLRLQLALFVNSLLLIGS
LYIWRSTVSNLCHSPAAESTCFQLWKVVVLAFLALAHSSFFTMFFLVAEEPYLFSLAAYS
CLGAYIIMLFFLFILSGMEQAYQLLAWRSGRVVGSLEKTRKLVLRPALAVGVTAVLSVAG
ILNAAQPPAVKTVEVPIHQLPASMNNLKIVLLSDIHLGPTVGRTKMEMFVRMVNVLEPDI
TVIVGDLSDSEASVLRTAVAPLGQLHSHLGAYFVTGNHEYYTSDVSNWFALLESLHVQPL
HNENVKISATRAQRGGGGSGSGSEDEDWICLAGVDDIEADILHYSGHGMDLDKALEGCSP
DHTIILLAHQPLAAKRALQARPDINLILSGHTHAGQIFPLNVAAYLLNPFFAGLYQVAQA
TFVYVSPGTAYYGIPMRLGSRAEITELILQRSP

Molecular Interaction Atlas (MIA) of This DOT

4 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
GM1 gangliosidosis type 1 DISE7GM9 Strong CausalMutation [1]
Major depressive disorder DIS4CL3X Strong Genetic Variation [2]
GM1 gangliosidosis DISN3L2M Limited CausalMutation [3]
Mucopolysaccharidosis type 4B DISPCAUH Limited CausalMutation [3]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Transmembrane protein with metallophosphoesterase domain (TMPPE). [4]
Estradiol DMUNTE3 Approved Estradiol increases the expression of Transmembrane protein with metallophosphoesterase domain (TMPPE). [5]
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References

1 Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis.Am J Hum Genet. 1994 Jun;54(6):1004-13.
2 Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.Transl Psychiatry. 2018 Jan 10;8(1):9. doi: 10.1038/s41398-017-0034-1.
3 Mosaic uniparental disomy results in GM1 gangliosidosis with normal enzyme assay.Am J Med Genet A. 2018 Jan;176(1):230-234. doi: 10.1002/ajmg.a.38549. Epub 2017 Nov 21.
4 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
5 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.