Details of Disease

General Information of Disease (ID: DIS4CL3X)

Disease Name Major depressive disorder
Synonyms
major depressive disorder 2; major depressive disorder 1; unipolar depression, susceptibility to; unipolar depression; single major depressive episode; recurrent major depression; major depressive disorder, response to citalopram therapy in; major depressive disorder and accelerated response to antidepressant drug treatment; major depressive disorder; major depression
Disease Class 6A70-6A7Z: Depression
Definition An episode of depression lasting two or more weeks without an intervening episode of mania.
Disease Hierarchy
DIS3XJ69: Depression
DIS4CL3X: Major depressive disorder
ICD Code
ICD-11
ICD-11: 6A70.3
ICD-10
ICD-10: F32.2
ICD-9
ICD-9: 296.2, 296.3
Expand ICD-11
'6A70.3
Expand ICD-10
'F32.2
Expand ICD-9
296.2,296.3
Disease Identifiers
MONDO ID
MONDO_0002009
MESH ID
D003865
UMLS CUI
C1269683
OMIM ID
608516
MedGen ID
266123
SNOMED CT ID
370143000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 31 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Amoxapine DMKITQE Approved Small molecular drug [1]
Aripiprazole DM3NUMH Approved Small molecular drug [2]
Bupropion DM5PCS7 Approved Small molecular drug [3]
Citalopram DM2G9AE Approved Small molecular drug [4]
Clovoxamine DMT2K5L Approved Small molecular drug [5]
Desvenlafaxine DMHD4PE Approved Small molecular drug [6]
Dothiepin DM3EP8N Approved Small molecular drug [7]
Duloxetine DM9BI7M Approved Small molecular drug [8]
Escitalopram DMFK9HG Approved Small molecular drug [5]
Fluoxetine DM3PD2C Approved Small molecular drug [9]
Gepirone DMGX5Q0 Approved Small molecular drug [10]
Levomilnacipran DMV26S8 Approved Small molecular drug [11]
Lofepramine DMH4PEY Approved Small molecular drug [12]
Maprotiline DMPWB7T Approved Small molecular drug [5]
Melitracen DM8AES7 Approved Small molecular drug [5]
Nefazodone DM4ZS8M Approved Small molecular drug [5]
Olanzapine DMPFN6Y Approved Small molecular drug [13]
OPC-34712 DMHG57U Approved Small molecular drug [14]
Paroxetine DM5PVQE Approved Small molecular drug [15]
Quetiapine DM1N62C Approved Small molecular drug [16]
Reboxetine DM26PRD Approved Small molecular drug [17]
Scopolamine DMOM8AL Approved Small molecular drug [18]
Selegiline DM6034S Approved Small molecular drug [19]
Tianeptine DMYN8MA Approved Small molecular drug [20]
Tranylcypromine DMGB5RE Approved Small molecular drug [5]
Trimipramine DM1SC8M Approved Small molecular drug [5]
Venlafaxine DMR6QH0 Approved Small molecular drug [21]
Vilazodone DM4LECQ Approved Small molecular drug [22]
Viloxazine DMPUIWD Approved Small molecular drug [5]
Vortioxetine DM6F1PU Approved Small molecular drug [23]
Zuranolone DMGR98T Approved NA [24]
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⏷ Show the Full List of 31 Drug(s)
This Disease is Treated as An Indication in 57 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
DOV-216419 DMKGEBB Phase 3 NA [25]
Edivoxetine DMFTTMK Phase 3 Small molecular drug [26]
GLYX-13 DMOHUR2 Phase 3 Small molecular drug [24]
ITI-007 DMUQ1DO Phase 3 Small molecular drug [24]
JNJ 67953964 DMJ8Y5N Phase 3 Small molecule [27]
REL-1017 DM34GOF Phase 3 Small molecular drug [28]
SEP-363856 DMG2QP4 Phase 3 NA [29]
Sirukumab DMK8AQP Phase 3 Monoclonal antibody [24]
TGFK07AD DM43LBB Phase 3 NA [30]
AGN-241751 DM4KOAC Phase 2 Small molecular drug [31]
Apimostinel DM7IGO9 Phase 2 NA [32]
AV-101 DMN7VK1 Phase 2 NA [24]
BCI-952 DMVJMNB Phase 2 NA [33]
BLI-1005 DMYK1DR Phase 2 NA [24]
BMS-820836 DMVTKJZ Phase 2 Small molecular drug [34]
BTRX-246040 DMA9238 Phase 2 NA [24]
BTRX-335140 DMWPDUZ Phase 2 Small molecular drug [35]
CERC-301 DMSABRI Phase 2 NA [36]
CGP-28014 DMYNTQV Phase 2 Small molecular drug [37]
CLR-3001 DM3Z6IQ Phase 2 NA [38]
CP-122721 DMSWLM5 Phase 2 Small molecular drug [39]
ETS-6103 DM19M05 Phase 2 NA [40]
GSK561679 DMEVARK Phase 2 Small molecular drug [41]
GW 597599 DMY53PL Phase 2 Small molecular drug [42]
Igmesine DMH97XA Phase 2 Small molecular drug [43]
JNJ-18038683 DMV1T59 Phase 2 Small molecular drug [44]
JNJ-61393215 DME2S4D Phase 2 Small molecular drug [45]
Lithium DMZ3OU6 Phase 2 Small molecular drug [46]
LY-2456302 DMLTSDC Phase 2 Small molecular drug [24]
LY-2940094 DMB5L6Q Phase 2 NA [47]
MIJ821 DMN45RI Phase 2 NA [48]
MIN-117 DMSLIW6 Phase 2 NA [49]
MIN-202 DMZFW8V Phase 2 NA [50]
NSI-189 DMRD8B8 Phase 2 Small molecular drug [24]
OnabotulinumtoxinA DMD1L8H Phase 2 NA [24]
ORG-13011 DMAWXJT Phase 2 Small molecular drug [24]
PF-06290510 DMUAOFM Phase 2 Vaccine [51]
PH10 nasal spray DM9JGTQ Phase 2 NA [24]
RO-4995819 DMNTC7O Phase 2 NA [52]
RP5063 DMKUE8O Phase 2 NA [24]
SAGE-217b DMRFK0B Phase 2 NA [53]
SSR149415 DMCMD93 Phase 2 Small molecular drug [54]
SSR411298 DMGTB2Q Phase 2 NA [55]
Strada DM0BH3X Phase 2 NA [24]
TS-121 DM5PGJV Phase 2 NA [24]
BCI-632 DMZYCWT Phase 1 Small molecular drug [56]
BCI-838 DMRXDN3 Phase 1 NA [57]
DSP-1053 DMJDP0E Phase 1 NA [58]
EVT100 DMAKWQD Phase 1 NA [24]
GSK-1360707 DMZC9XU Phase 1 NA [59]
JNJ-54175446 DMQ5ZVK Phase 1 NA [24]
NV-5138 DMLKS7W Phase 1 Small molecular drug [60]
RG-7351 DMFGR98 Phase 1 NA [61]
SKL-10406 DMW64UZ Phase 1 NA [62]
SUVN 911 DMZP671 Phase 1 Small molecular drug [63]
SUVN-911 DMLPBVF Phase 1 NA [24]
Tedatioxetine DMV5LGJ Phase 1 Small molecular drug [64]
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⏷ Show the Full List of 57 Drug(s)
This Disease is Treated as An Indication in 37 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Agomelatine DMXYA5K Withdrawn from market Small molecular drug [65]
Amineptine DMGVNJ7 Withdrawn from market Small molecular drug [5]
ZIMELIDINE DMNI3U2 Withdrawn from market Small molecular drug [5]
Amibegron DMPS14M Discontinued in Phase 3 Small molecular drug [66]
Befloxatone DMZIV6D Discontinued in Phase 3 Small molecular drug [67]
Femoxetine DMLL7T3 Discontinued in Phase 3 Small molecular drug [68]
AZD2066 DMHP6OY Discontinued in Phase 2 Small molecular drug [69]
AZD6765 DMHZ3DE Discontinued in Phase 2 Small molecular drug [70]
Ceronapril DMFBNI6 Discontinued in Phase 2 Small molecular drug [71]
CP-316,311 DMZ76EM Discontinued in Phase 2 Small molecular drug [72]
Esuprone DM1DHOT Discontinued in Phase 2 Small molecular drug [73]
GSK 679769 DMSV6KP Discontinued in Phase 2 NA [74]
GSK163090 DMX7DVH Discontinued in Phase 2 Small molecular drug [75]
Manifaxine DMRN7GC Discontinued in Phase 2 Small molecular drug [76]
Napitane mesilate DMF9Y57 Discontinued in Phase 2 Small molecular drug [77]
Nemifitide DM6VP9U Discontinued in Phase 2 Small molecular drug [78]
NS-2389 DMVRJ8D Discontinued in Phase 2 NA [79]
Radafaxine DMARQE0 Discontinued in Phase 2 Small molecular drug [80]
RG1578 DM3TU7D Discontinued in Phase 2 NA [81]
RS-8359 DMERM0K Discontinued in Phase 2 Small molecular drug [82]
SEP-227162 DM54MWK Discontinued in Phase 2 NA [83]
SR-57227 DMV4FT2 Discontinued in Phase 2 Small molecular drug [84]
Suritozole DMDZ7AY Discontinued in Phase 2 Small molecular drug [85]
BW-1370U87 DM296HE Discontinued in Phase 1 Small molecular drug [86]
EVT-103 DM9450Z Discontinued in Phase 1 NA [87]
Farampator DM76GRQ Discontinued in Phase 1 Small molecular drug [88]
NEBO-174 DMJ5SA2 Discontinued in Phase 1 NA [89]
RG-7166 DMKLPMW Discontinued in Phase 1 NA [90]
SDZ-NVI-085 DMTOH03 Discontinued in Phase 1 Small molecular drug [91]
403U76 DM3FSZC Terminated NA [95]
AEP-924 DMGAUZH Terminated NA [96]
CGP-25454A DM5ESZU Terminated NA [97]
F-12682 DM23OHW Terminated NA [98]
FCE-25876 DMR3ZWA Terminated NA [99]
GR-127935 DM01HLX Terminated Small molecular drug [100]
NS-1546 DM75DZ1 Terminated NA [101]
PPRT-152 DMOYMDP Terminated NA [102]
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⏷ Show the Full List of 37 Drug(s)
This Disease is Treated as An Indication in 3 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Cutamesine DMB1ET0 Preclinical Small molecular drug [92]
F-16242 DMBFHSB Preclinical NA [93]
S32504 DM4V8ZD Preclinical Small molecular drug [94]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 25 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
11C-R-129144 DMFJAWQ Investigative NA [25]
AA-29504 DMI59T7 Investigative NA [103]
BC-22 DMLEBN3 Investigative NA [25]
CLR-300 DMH8H8G Investigative NA [25]
DT-2228 DMCKQF7 Investigative NA [104]
E-1413 DMXU6GE Investigative NA [25]
EDG-005 DMB9M55 Investigative NA [25]
EDG-006 DMWA9OQ Investigative NA [25]
EDP-18 DMTVRKG Investigative NA [105]
F-98214 DMBUOCX Investigative NA [25]
FA-70 DMDBO89 Investigative NA [106]
Flufenoxina DM3N3MO Investigative NA [25]
GRN-529 DMJ47DM Investigative Small molecular drug [107]
GW-3965 DMG60ET Investigative Small molecular drug [108]
INDUS-860 DMPYSTO Investigative NA [25]
LU-AA33810 DM34AYV Investigative NA [109]
MCP-203 DM0GLYB Investigative NA [110]
NCT-400 DM09UFT Investigative NA [111]
NNI-351 DMMUHCV Investigative NA [25]
NPT-500 DMMUY73 Investigative NA [112]
PF-454583 DMMNEJB Investigative Small molecular drug [113]
RP-6000 DMHX22E Investigative NA [25]
S-41744 DMFC430 Investigative NA [114]
Sazetidine-A DM68JI5 Investigative Small molecular drug [115]
SNP-002 DM3YQY4 Investigative NA [25]
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⏷ Show the Full List of 25 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 262 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CACNA1C TTZIFHC Limited Genetic Variation [117]
CCL11 TTCF05Y Limited Biomarker [118]
DLG4 TT9PB26 Limited Posttranslational Modification [119]
ESR2 TTOM3J0 Limited Genetic Variation [120]
GAL TTXZAJ5 Limited Altered Expression [121]
MAPKAP1 TTWDKCL Limited Altered Expression [122]
PDE8A TTIS4OW Limited Altered Expression [123]
PDE9A TTZOEBC Limited Genetic Variation [124]
SPDEF TT2ZUPY Limited Biomarker [125]
ACHE TT1RS9F moderate Biomarker [126]
BMP1 TT0L58T moderate Biomarker [127]
CHRNA7 TTLA931 moderate Biomarker [128]
CRHR2 TTIY658 moderate Biomarker [129]
CRY1 TT5MLZR moderate Genetic Variation [130]
ESRRG TT9ZRHB moderate Genetic Variation [131]
GRIN2A TTKJEMQ moderate Biomarker [132]
GRIN2B TTN9D8E moderate Biomarker [133]
MAG TT9XFON moderate Altered Expression [134]
SIGMAR1 TT5TPI6 moderate Altered Expression [135]
SLC1A3 TT8WRDA moderate Biomarker [136]
TNFAIP3 TT5W0IO moderate Biomarker [137]
ADCY5 TTN64VU Strong Biomarker [138]
ADCYAP1 TTW4LYC Strong Biomarker [139]
ADCYAP1R1 TT5OREU Strong Genetic Variation [140]
ADRA1A TTNGILX Strong Biomarker [141]
ADRA2A TTWG9A4 Strong Genetic Variation [142]
ADRA2C TT2NUT5 Strong Genetic Variation [143]
ADRB1 TTR6W5O Strong Biomarker [144]
ALKBH5 TTOHB1M Strong Genetic Variation [145]
AMACR TTLN1AP Strong Biomarker [146]
ANPEP TTPHMWB Strong Biomarker [147]
APOE TTKS9CB Strong Biomarker [148]
ARHGEF3 TT1R5DZ Strong Biomarker [149]
ARRB1 TTMVD4A Strong Biomarker [150]
ARSA TTYQANR Strong Biomarker [151]
ASIC2 TTVMWLP Strong Genetic Variation [152]
ASPA TT6TLZP Strong Biomarker [153]
ATG7 TTLVB9Z Strong Genetic Variation [154]
ATP7B TTOPO51 Strong Genetic Variation [155]
AVP TTJ8EWH Strong Biomarker [156]
AVPR1B TTL9MHW Strong Genetic Variation [157]
BDKRB1 TTG5QIA Strong Genetic Variation [158]
BDKRB2 TTGY8IW Strong Biomarker [158]
BMP7 TTKOBRA Strong Biomarker [159]
BRPF1 TTT46BN Strong Biomarker [160]
CACNA1E TTYRP0M Strong Genetic Variation [120]
CACNA2D1 TTFK1JQ Strong Genetic Variation [161]
CAPN2 TTG5QB7 Strong Biomarker [162]
CAT TTPS279 Strong Biomarker [163]
CCKAR TTCG0AL Strong Genetic Variation [164]
CCL2 TTNAY0P Strong Genetic Variation [165]
CCND1 TTFCJ7S Strong Genetic Variation [166]
CD160 TTOFEAS Strong Biomarker [167]
CD34 TTZAVYN Strong Biomarker [168]
CDKN2A TTFTWQ8 Strong Biomarker [169]
CFB TTA0P7K Strong Genetic Variation [152]
CFP TTLA0VS Strong Genetic Variation [170]
CHRM2 TTYEG6Q Strong Biomarker [171]
CHRNA4 TT4H1MQ Strong Biomarker [172]
CIT TT3BKTU Strong Biomarker [173]
CNP TT71P0H Strong Altered Expression [174]
CNR1 TT6OEDT Strong Genetic Variation [175]
CNTF TTGEM5Q Strong Altered Expression [176]
CPS1 TT42M75 Strong Biomarker [177]
CRH TTA7YIZ Strong Altered Expression [178]
CRY2 TTAO58M Strong Genetic Variation [179]
CSE1L TTTRULD Strong Genetic Variation [180]
CSF2RB TTPYS82 Strong Biomarker [181]
CSNK1E TTA8PLI Strong Genetic Variation [182]
CSNK1G1 TTQR5YD Strong Genetic Variation [154]
CXCL10 TTQOVYA Strong Altered Expression [183]
CYP1A2 TTS1DTU Strong Genetic Variation [184]
CYP21A2 TTP4GLG Strong Genetic Variation [117]
CYP2D6 TTVG215 Strong Genetic Variation [185]
DAG1 TT4X7PG Strong Genetic Variation [154]
DAGLA TTRQ6UD Strong Genetic Variation [120]
DBH TTYIP79 Strong Biomarker [186]
DCLK2 TTHK3MO Strong Genetic Variation [180]
DDC TTN451K Strong Biomarker [187]
DDIT4 TTVEOY6 Strong Biomarker [188]
DFFA TTYVQ9C Strong Genetic Variation [189]
DPP10 TTOVUPC Strong Genetic Variation [180]
DRD1 TTZFYLI Strong Genetic Variation [190]
DRD3 TT4C8EA Strong Biomarker [191]
DRD5 TTS2PH3 Strong Biomarker [192]
EGF TTED8JB Strong Altered Expression [193]
EIF4EBP1 TTKGEBL Strong Altered Expression [194]
ENPEP TT9PBIL Strong Biomarker [195]
EPHX2 TT7WVHI Strong Altered Expression [196]
ERBB3 TTSINU2 Strong Biomarker [197]
ERBB4 TTWALCO Strong Biomarker [198]
ESRRB TTKF0XS Strong Genetic Variation [199]
FADS2 TTT2VDU Strong Genetic Variation [200]
FAT1 TTGUJYV Strong Genetic Variation [161]
FHIT TTMS54D Strong Genetic Variation [120]
FUT3 TTUPAD7 Strong Biomarker [201]
GAD1 TTKGEP3 Strong Altered Expression [136]
GAD2 TT7UY6K Strong Genetic Variation [202]
GALC TT5IZRB Strong Altered Expression [203]
GALR1 TTX3HNZ Strong Biomarker [121]
GALR2 TTBPW3J Strong Biomarker [121]
GDNF TTF23ML Strong Altered Expression [204]
GFAP TTI6FFX Strong Altered Expression [205]
GJA1 TT4F7SL Strong Biomarker [206]
GLUL TTURQ2G Strong Biomarker [177]
GNAI3 TT8QF3W Strong Genetic Variation [207]
GRIA1 TTVPQTF Strong Genetic Variation [208]
GRIA3 TT82EZV Strong Biomarker [209]
GRIK3 TTNP6O2 Strong Genetic Variation [210]
GRIK4 TTQV6BO Strong Genetic Variation [208]
GRK2 TTAZ3MN Strong Biomarker [141]
GRM2 TTXJ47W Strong Biomarker [211]
GRM3 TT8A9EF Strong Altered Expression [211]
GRM4 TTICZ1O Strong Genetic Variation [212]
GRM8 TT0IFKL Strong Biomarker [213]
HCN1 TTNB6UQ Strong Altered Expression [214]
HCRT TTU5HJP Strong Biomarker [215]
HCRTR1 TT60Q8D Strong Genetic Variation [216]
HDAC5 TTUELN5 Strong Altered Expression [217]
HIF1A TTSN6QU Strong Altered Expression [218]
HLA-A TTHONFT Strong Genetic Variation [152]
HP TTLC8E1 Strong Altered Expression [219]
HPSE TTR7GJO Strong Biomarker [220]
HRC TTR4FKD Strong Biomarker [221]
HSD11B1 TTN7BL9 Strong Altered Expression [222]
HSP90AA1 TT78R5H Strong Biomarker [223]
HTR1F TT0MI3F Strong Biomarker [224]
HTR2C TTWJBZ5 Strong Biomarker [225]
HTR3B TTR6K75 Strong Biomarker [226]
HTR4 TT07C3Y Strong Biomarker [227]
HTT TTIWZ0O Strong Genetic Variation [120]
IGFBP2 TTU4QSN Strong Biomarker [228]
IL11 TTGUYTR Strong Biomarker [229]
IL1R1 TTWOTEA Strong Altered Expression [230]
IL1R2 TT51DEV Strong Altered Expression [231]
IL2 TTF89GD Strong Biomarker [232]
IL20 TTNZMY2 Strong Biomarker [233]
IL24 TT1EPXZ Strong Genetic Variation [233]
IL2RA TT10Y9E Strong Biomarker [234]
IL2RB TT9721Y Strong Biomarker [235]
IRAK3 TTBPJOK Strong Altered Expression [137]
ISG15 TTVOH3T Strong Biomarker [236]
ITGA11 TTANXZ7 Strong Genetic Variation [237]
KCNB1 TT5OEKU Strong Genetic Variation [154]
KCNK9 TTL4FMB Strong Biomarker [238]
KCNQ5 TTWVL5Q Strong Genetic Variation [152]
KDM4A TTZHPB8 Strong Altered Expression [239]
KDR TTUTJGQ Strong Altered Expression [240]
KMO TTIY56R Strong Biomarker [241]
KMT2A TT1GNDM Strong Genetic Variation [242]
LBP TTVQJLY Strong Genetic Variation [243]
LDHA TTW76JE Strong Altered Expression [218]
LINGO1 TTZYQ80 Strong Genetic Variation [154]
LRP1 TTF2V7I Strong Altered Expression [244]
M6PR TT95ICL Strong Biomarker [245]
MAD1L1 TTNE9U7 Strong Genetic Variation [120]
MAOB TTGP7BY Strong Biomarker [246]
MAP2K1 TTIDAPM Strong Genetic Variation [247]
MAPT TTS87KH Strong Genetic Variation [154]
MC1R TT0MV2T Strong Genetic Variation [248]
MDM4 TT9OUDQ Strong Genetic Variation [249]
MGAM TTXWASR Strong Biomarker [250]
MMP8 TTGA1IV Strong Biomarker [147]
MOG TTQAFX5 Strong Altered Expression [134]
MPO TTVCZPI Strong Biomarker [251]
MTHFR TTQWOU1 Strong Genetic Variation [252]
MTNR1B TT32JK8 Strong Biomarker [253]
MTOR TTCJG29 Strong Biomarker [254]
MUSK TT6SA0X Strong Genetic Variation [255]
NCAM1 TTVXPHT Strong Genetic Variation [154]
NELL1 TT7H4BF Strong Biomarker [256]
NGFR TTEDJN4 Strong Altered Expression [257]
NISCH TT789FN Strong Biomarker [258]
NPPC TTRK0B9 Strong Biomarker [162]
NPY TT64REZ Strong Genetic Variation [259]
NPY2R TTJ6WK9 Strong Genetic Variation [260]
NR1H3 TTECBXN Strong Genetic Variation [154]
NR4A1 TTMXE2Q Strong Biomarker [236]
NR4A2 TT9HKN3 Strong Biomarker [261]
NTF3 TTZHKV9 Strong Altered Expression [262]
NTRK2 TTKN7QR Strong Genetic Variation [263]
NTRK3 TTXABCW Strong Biomarker [264]
OLFM4 TTK1CX7 Strong Genetic Variation [265]
OPA1 TTTU49Q Strong Genetic Variation [266]
OPRK1 TTQW87Y Strong Biomarker [267]
OPRM1 TTKWM86 Strong Biomarker [268]
ORAI1 TTE76YK Strong Genetic Variation [269]
OXTR TTSCIUP Strong Altered Expression [270]
P2RX1 TTJW7B3 Strong Biomarker [271]
P2RX3 TT2THBD Strong Biomarker [271]
P2RX4 TT1NLOA Strong Biomarker [271]
P2RY1 TTA93TL Strong Biomarker [271]
P2RY2 TTOZHQC Strong Biomarker [271]
PAM TTF4ZPC Strong Biomarker [272]
PAX5 TTA4REJ Strong Genetic Variation [120]
PBRM1 TTH8ZRL Strong Genetic Variation [273]
PDE11A TTTWC79 Strong Biomarker [274]
PDE1A TT73TEJ Strong Genetic Variation [275]
PDE4A TTZ97H5 Strong Biomarker [276]
PDE4B TTVIAT9 Strong Biomarker [277]
PDGFC TTOABM9 Strong Altered Expression [217]
PFKFB3 TTTHMQJ Strong Biomarker [218]
PGC TT7K6AD Strong Genetic Variation [278]
PKLR TT31N4S Strong Genetic Variation [161]
PLCB1 TTLPGU7 Strong Genetic Variation [279]
PLCG1 TT6T4JI Strong Genetic Variation [266]
PLG TTP86E2 Strong Biomarker [280]
PRCP TTTJZ4M Strong Biomarker [127]
PRKCB TTYPXQF Strong Altered Expression [281]
PRKCG TTRFOXJ Strong Biomarker [282]
PROKR2 TTM67AX Strong Genetic Variation [283]
PROM1 TTXMZ81 Strong Genetic Variation [284]
PSIP1 TTH9LDP Strong Biomarker [235]
PTGER3 TTPNGDE Strong Altered Expression [285]
RORA TT1TYN7 Strong Genetic Variation [286]
RTN4 TT7GXMU Strong Genetic Variation [152]
RXFP3 TT64ZVP Strong Biomarker [287]
SEMA3A TTVKD3S Strong Genetic Variation [131]
SERPINE1 TTTO43N Strong Biomarker [288]
SGK1 TTTV8EJ Strong Biomarker [289]
SGSH TTPJ2SH Strong Biomarker [206]
SLC12A5 TTH6UZY Strong Genetic Variation [120]
SLC18A2 TTNZRI3 Strong Genetic Variation [290]
SLC1A1 TTG2A6F Strong Altered Expression [291]
SLC1A2 TT2F078 Strong Biomarker [292]
SLC1A6 TT6KMPN Strong Biomarker [291]
SLC1A7 TTK41DM Strong Biomarker [292]
SLC22A16 TTITAVR Strong Biomarker [293]
SLC25A4 TTU5A6Q Strong Genetic Variation [294]
SLC38A7 TTEARWC Strong Biomarker [295]
SLC5A7 TTRV7W3 Strong Biomarker [296]
SLC6A15 TT4LRUE Strong Biomarker [285]
SLC6A3 TTVBI8W Strong Genetic Variation [297]
SMPD1 TTJTM88 Strong Biomarker [298]
SNAP25 TTYQWA0 Strong Biomarker [299]
SORT1 TTRX9AV Strong Altered Expression [257]
SOX5 TTXHSZK Strong Genetic Variation [120]
SRD5A1 TTTU72V Strong Biomarker [300]
SST TTWF7UG Strong Altered Expression [301]
SSTR5 TT2BC4G Strong Biomarker [302]
STAR TTEI40H Strong Biomarker [303]
SV2A TTT3P91 Strong Genetic Variation [304]
TBX21 TTNF9PH Strong Biomarker [305]
TCF3 TTULOD8 Strong Biomarker [235]
TERT TTQY2EJ Strong Altered Expression [163]
TH TTUHP71 Strong Biomarker [198]
TLR7 TTRJ1K4 Strong Biomarker [306]
TMPRSS6 TTL9KE7 Strong Biomarker [253]
TNC TTUCPMY Strong Genetic Variation [180]
TNFRSF1B TT63WSF Strong Biomarker [235]
TNFSF12 TTBTDM1 Strong Biomarker [138]
TNKS TTVUSO7 Strong Genetic Variation [307]
TNKS2 TTFQI4H Strong Genetic Variation [308]
TRH TT2Z39D Strong Biomarker [309]
TRPC7 TT06GRA Strong Altered Expression [310]
TSPO TTPTXIN Strong Biomarker [311]
TYK2 TTBYWP2 Strong Genetic Variation [312]
TYR TTULVH8 Strong Genetic Variation [152]
UTRN TTNO1VA Strong Genetic Variation [313]
VEGFA TT3LJ9K Strong Genetic Variation [314]
VIPR2 TT4O5P0 Strong Biomarker [315]
XDH TT7RJY8 Strong Biomarker [251]
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⏷ Show the Full List of 262 DTT(s)
This Disease Is Related to 10 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
CACNB2 DTBZWL4 Strong Biomarker [316]
KCNK2 DTENHUP Strong Biomarker [317]
SLC17A6 DT5LHCR Strong Altered Expression [318]
SLC17A7 DTNK0FR Strong Biomarker [319]
SLC18A1 DTM953D Strong Genetic Variation [290]
SLC25A6 DTLMGFJ Strong Genetic Variation [294]
SLC30A9 DT2I79L Strong Genetic Variation [320]
SLC44A5 DTU8NCX Strong Genetic Variation [154]
SLC6A13 DTX8KP0 Strong Biomarker [302]
SLC9A9 DT8LP62 Strong Genetic Variation [321]
------------------------------------------------------------------------------------
⏷ Show the Full List of 10 DTP(s)
This Disease Is Related to 16 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
APRT DE2MV1R Strong Biomarker [322]
AS3MT DE9KJP3 Strong Genetic Variation [323]
CYP7B1 DE36TMY Strong Genetic Variation [120]
DDO DE8PQ7T Strong Genetic Variation [152]
FADS1 DE05S8C Strong Genetic Variation [200]
GLS DE3E0VT Strong Biomarker [324]
GPX6 DEOS3FD Strong Genetic Variation [152]
HSD3B2 DEN0GVQ Strong Genetic Variation [300]
MARS1 DE0K52I Strong Biomarker [325]
MSRA DEU2ZBY Strong Genetic Variation [313]
NT5C2 DE1DOKJ Strong Genetic Variation [323]
PGPEP1 DEVDR46 Strong Biomarker [127]
SAT1 DEMWO83 Strong Biomarker [326]
SI DE5EO4Y Strong Biomarker [250]
THOP1 DE95LJC Strong Biomarker [327]
UPP2 DEBQ2WU Strong Genetic Variation [328]
------------------------------------------------------------------------------------
⏷ Show the Full List of 16 DME(s)
This Disease Is Related to 464 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CPOX OTIAY121 Limited Biomarker [329]
FLOT1 OT0JPPJZ Limited Altered Expression [330]
LHPP OT9AGAIJ Limited Genetic Variation [331]
AMPD3 OT5SP1KJ moderate Genetic Variation [332]
BICC1 OTYRKIJ1 moderate Altered Expression [333]
CACYBP OTJMZD2T moderate Genetic Variation [334]
IGSF9B OTNOMYYQ moderate Genetic Variation [131]
KANK2 OT3SZIWM moderate Genetic Variation [334]
KLF12 OTVH4KD4 moderate Genetic Variation [131]
NCALD OTJZ8UEL moderate Genetic Variation [131]
NUCB2 OTHO6JWN moderate Biomarker [335]
PDLIM7 OTAZVODU moderate Biomarker [336]
RBM14 OTO9GMBD moderate Genetic Variation [334]
RHBDL2 OTJPJ8N6 moderate Genetic Variation [131]
STAG3 OTEV0AOD moderate Genetic Variation [131]
TP53INP1 OT2363Z9 moderate Genetic Variation [334]
TSACC OT3QW6PH moderate Genetic Variation [334]
TSNAX OTZ9SGWB moderate Genetic Variation [337]
A1CF OTJBKFA1 Strong Biomarker [153]
AANAT OTUBJ7SX Strong Genetic Variation [338]
ABCA13 OTTHTUQN Strong Biomarker [339]
ABI3BP OTW8DN50 Strong Biomarker [340]
ABT1 OT9YGIDB Strong Genetic Variation [152]
ACACA OT5CQPZY Strong Biomarker [341]
ACP1 OTJ9CKLU Strong Biomarker [342]
ACSM1 OT1TS9M9 Strong Biomarker [343]
ADAMTS10 OTNJ9VSU Strong Genetic Variation [344]
ADAMTS16 OTTKUH99 Strong Genetic Variation [345]
ADAMTS6 OTSZE6L4 Strong Genetic Variation [180]
ADARB1 OTGKSZEV Strong Altered Expression [346]
ADCY3 OTGOQM6B Strong Genetic Variation [347]
ADCY7 OTAWMGP3 Strong Biomarker [348]
ADGRE2 OTUYJVYG Strong Genetic Variation [269]
ADSL OTSNJALL Strong Biomarker [349]
AGBL4 OTOX2H61 Strong Genetic Variation [117]
AK9 OTWYT1VS Strong Genetic Variation [189]
AKAP8 OTK3EQAI Strong Biomarker [350]
ALDH7A1 OTV57BZD Strong Genetic Variation [274]
ALX4 OTNS9A29 Strong Genetic Variation [351]
AMBP OTLU8GU8 Strong Biomarker [221]
AMY1A OT6G4B8O Strong Biomarker [352]
ANK3 OTJ3IRBP Strong Biomarker [316]
ANKK1 OT0OM1O0 Strong Genetic Variation [353]
ANKRD27 OT5DCXIG Strong Genetic Variation [237]
ANO8 OT07SRRX Strong Genetic Variation [269]
APAF1 OTJWIVY0 Strong Biomarker [354]
APBB2 OT1VD51B Strong Genetic Variation [180]
AREL1 OTSYV9R3 Strong Genetic Variation [120]
ARFGAP2 OTIP5ZJ7 Strong Genetic Variation [154]
ARHGAP15 OT9CKHDC Strong Genetic Variation [154]
ARHGAP8 OT19H5Q9 Strong Genetic Variation [269]
ARHGEF5 OTUVGFT9 Strong Biomarker [355]
ARL5B OTYYBIDG Strong Genetic Variation [356]
ARPP21 OTWXZN5I Strong Genetic Variation [154]
ARTN OTWIWGL6 Strong Biomarker [357]
ASPM OTKXQMNA Strong Biomarker [153]
ASTN1 OT23FQIB Strong Genetic Variation [152]
ASTN2 OTF0W2FJ Strong Genetic Variation [120]
ATAD2B OTQMSTTC Strong Genetic Variation [154]
ATF7IP OTU6ZA7F Strong Biomarker [358]
ATP5MG OTD569IJ Strong Genetic Variation [152]
ATP6V1B2 OTNX2V4Z Strong Genetic Variation [359]
AUTS2 OTAEXHSC Strong Genetic Variation [360]
B3GLCT OTXH6KOQ Strong Genetic Variation [152]
BAIAP2 OT1KKMYZ Strong Genetic Variation [154]
BAZ1A OTWHOVZS Strong Genetic Variation [180]
BBX OTNQ3QUC Strong Genetic Variation [154]
BCAR3 OTPJ17M8 Strong Genetic Variation [269]
BCL9 OTRBIPR4 Strong Biomarker [361]
BCR OTCN76C1 Strong Biomarker [362]
BCS1L OT5PY5CY Strong Biomarker [363]
BEND4 OT7Z1422 Strong Genetic Variation [265]
BHLHE40 OTITX14U Strong Genetic Variation [182]
BHLHE41 OTY9GJ1Y Strong Genetic Variation [180]
BICRA OTDTPGW0 Strong Genetic Variation [180]
BMP5 OTC0Y6E0 Strong Genetic Variation [364]
BMS1 OTEGQ8ZO Strong Biomarker [341]
BTN2A1 OTUYPMZJ Strong Genetic Variation [154]
BTN3A1 OTGZADIX Strong Genetic Variation [152]
BTN3A2 OT3DIBU3 Strong Genetic Variation [154]
BTNL8 OTRQT8CK Strong Altered Expression [365]
C1QL1 OTNQ0G3E Strong Biomarker [366]
C4orf33 OT3O3FC3 Strong Genetic Variation [313]
CALB2 OTSNMCG9 Strong Altered Expression [367]
CAMK2A OTJGX19T Strong Biomarker [368]
CAMTA1 OTAN1S5B Strong Genetic Variation [152]
CAPN15 OT0WE161 Strong Genetic Variation [356]
CARF OTWE0T6Q Strong Genetic Variation [356]
CARTPT OTTE4V9S Strong Altered Expression [369]
CAVIN3 OTOLBK79 Strong Genetic Variation [179]
CBLIF OTNE20WU Strong Biomarker [370]
CBX5 OT8VYY84 Strong Biomarker [371]
CCDC170 OTNQOJ6S Strong Genetic Variation [356]
CCL24 OT9LGHV0 Strong Biomarker [372]
CCS OTXHT3QO Strong Genetic Variation [152]
CD5L OTPY4WQR Strong Altered Expression [373]
CD81 OTQFXNAZ Strong Altered Expression [374]
CDC42BPB OTO6NT7Q Strong Genetic Variation [152]
CDH7 OTQEXCKU Strong Biomarker [375]
CDH8 OTS3SRZ6 Strong Genetic Variation [180]
CDH9 OTV9N5XK Strong Genetic Variation [154]
CDYL OTCUK5KZ Strong Biomarker [376]
CEBPZ OT11BATG Strong Biomarker [377]
CELF4 OT4FS4F5 Strong Genetic Variation [120]
CHD7 OTHNIZWZ Strong Genetic Variation [378]
CHST9 OT1DEZRM Strong Genetic Variation [379]
CMYA5 OTYV0RME Strong Genetic Variation [380]
CNNM2 OTZHO8WU Strong Genetic Variation [323]
CNTN3 OTC1274J Strong Genetic Variation [363]
CNTN5 OTWU5FLZ Strong Genetic Variation [381]
CNTNAP1 OT5Y03EU Strong Genetic Variation [269]
CNTNAP2 OT48T2ZP Strong Biomarker [382]
CNTNAP5 OTF0AAJD Strong Genetic Variation [152]
COL22A1 OTSWGZRD Strong Genetic Variation [383]
COMMD3 OT1UTJH4 Strong Biomarker [384]
CORT OTX3GUHB Strong Biomarker [385]
CRB1 OTXYUNG0 Strong Genetic Variation [152]
CREB3L1 OT2JHIHM Strong Genetic Variation [154]
CRTAP OT53H5U6 Strong Genetic Variation [161]
CRYBA1 OT8617WJ Strong Genetic Variation [320]
CSMD1 OTIVDSC4 Strong Genetic Variation [323]
CSMD2 OT541Z3W Strong Genetic Variation [328]
CSTF3 OT1Y7B5U Strong Genetic Variation [180]
CTNNA3 OT9Z0P1E Strong Genetic Variation [152]
CTNND2 OTYKE30Y Strong Biomarker [386]
CTTNBP2 OT4CL1EW Strong Genetic Variation [120]
DCC OT2C1SHW Strong Genetic Variation [120]
DCDC1 OTQEHINP Strong Genetic Variation [120]
DCDC2 OTSUFH1H Strong Genetic Variation [152]
DDB2 OTO8HVVB Strong Genetic Variation [154]
DDT OTF5HTYL Strong Biomarker [387]
DEAF1 OTCLX3ZW Strong Biomarker [388]
DEFA1 OT5N1B9B Strong Biomarker [371]
DEFB1 OT5SV0E4 Strong Genetic Variation [349]
DENND1A OTONDAA0 Strong Genetic Variation [120]
DENND1B OT3VCNPE Strong Genetic Variation [120]
DGKG OTBL32T3 Strong Genetic Variation [180]
DLG2 OTQ3BD8U Strong Biomarker [389]
DLG3 OTH591WK Strong Biomarker [390]
DLX4 OTLWVCN4 Strong Altered Expression [194]
DMTF1 OTDKO9OO Strong Genetic Variation [391]
DOCK4 OTH3XY8B Strong Genetic Variation [392]
DPY19L3 OTM2DHUR Strong Genetic Variation [154]
DSCAM OTL7PRMK Strong Genetic Variation [393]
DST OTHZBM4X Strong Biomarker [309]
DTNBP1 OT9UQT2S Strong Biomarker [139]
DVL3 OTPRROHJ Strong Genetic Variation [394]
EARS2 OTNCJKY7 Strong Altered Expression [395]
EBPL OT59J1GY Strong Biomarker [396]
ECD OT3L3PCU Strong Biomarker [397]
EDEM1 OTWHN69S Strong Biomarker [398]
EGFLAM OTACZZJ0 Strong Genetic Variation [180]
EHD3 OTOKC2G5 Strong Genetic Variation [399]
EIF4B OTE8TXA8 Strong Biomarker [400]
EIF5B OTZTT22W Strong Genetic Variation [273]
ELAVL2 OT6EJ8MQ Strong Genetic Variation [120]
ELAVL4 OT3YH6J6 Strong Genetic Variation [120]
ELOVL5 OT375W1Z Strong Altered Expression [401]
EMCN OTS03CZC Strong Genetic Variation [154]
EML1 OTOP2E01 Strong Genetic Variation [189]
EMP1 OTSZHUHQ Strong Biomarker [402]
ENOX1 OT4WOLA8 Strong Genetic Variation [320]
ERC2 OTFEDI56 Strong Genetic Variation [152]
ERCC6L2 OTWFECWG Strong Genetic Variation [393]
ERICH3 OT5O76FJ Strong Genetic Variation [349]
EXD2 OTEM0BTG Strong Genetic Variation [154]
EYS OT0NBPL5 Strong Genetic Variation [403]
FAM120A OTLAG3VN Strong Genetic Variation [154]
FAM13A OTZ6GN0Q Strong Genetic Variation [356]
FAM222A OTRD9AUH Strong Genetic Variation [189]
FAM228B OT26MFMA Strong Genetic Variation [154]
FBXL4 OTZECCIQ Strong Biomarker [378]
FER1L6 OTII95GE Strong Genetic Variation [356]
FEZ1 OTWCXPRE Strong Genetic Variation [323]
FGF9 OT2SKDGM Strong Biomarker [404]
FLAD1 OTY8R02L Strong Genetic Variation [255]
FOXD3 OTXYV6GO Strong Biomarker [405]
FOXP2 OTVX6A59 Strong Genetic Variation [406]
FREM3 OTXF7MOZ Strong Biomarker [407]
FSTL4 OTTNB9ZP Strong Genetic Variation [180]
FYB1 OT6345CH Strong Genetic Variation [180]
GABBR1 OTU5A52J Strong Genetic Variation [152]
GABBR2 OT67RIFY Strong Biomarker [408]
GABRA6 OTX4UC3O Strong Genetic Variation [409]
GALR3 OTXU6PKO Strong Biomarker [121]
GCHFR OTEOT8GI Strong Genetic Variation [410]
GDE1 OTU6FSBF Strong Biomarker [411]
GFER OTVK43OK Strong Biomarker [206]
GLRA3 OTC8C2NC Strong Biomarker [412]
GLT8D1 OTG14TPO Strong Biomarker [413]
GMIP OTRFXK76 Strong Biomarker [414]
GMPR OTERWHYM Strong Genetic Variation [237]
GNL1 OTWTVIVM Strong Genetic Variation [266]
GNL3 OTILGYO4 Strong Genetic Variation [273]
GPHN OTAKK1SV Strong Genetic Variation [356]
GPM6A OT8G13EG Strong Genetic Variation [154]
GPR158 OTYOC1RQ Strong Altered Expression [415]
GPR50 OT0EJBM4 Strong Biomarker [416]
GRHL3 OT1V4ZEH Strong Biomarker [417]
GRIP1 OT958HK1 Strong Genetic Variation [284]
GRTP1 OT8HORRZ Strong Genetic Variation [356]
GSDME OT1ZWY32 Strong Genetic Variation [154]
H2AC11 OTN9P0BO Strong Biomarker [418]
H2BC15 OTU39CFZ Strong Genetic Variation [154]
HACD3 OTISMCAF Strong Biomarker [419]
HAT1 OT307KEN Strong Biomarker [420]
HCLS1 OTX7WGYN Strong Biomarker [235]
HLA-DMB OT17HGXJ Strong Genetic Variation [323]
HLA-DQB1 OTVVI3UI Strong Genetic Variation [421]
HLF OTTRK9XN Strong Altered Expression [422]
HOMER1 OTWFD3SI Strong Biomarker [423]
HSPA1L OTC2V1K6 Strong Biomarker [424]
IFI44L OTXKORJP Strong Biomarker [236]
IFI6 OTWOOAM4 Strong Biomarker [236]
IFIT3 OTPGHZB9 Strong Biomarker [355]
IFNA1 OTPMKY0L Strong Altered Expression [425]
IGFBPL1 OTY4HVN8 Strong Biomarker [426]
IKBKE OT5VYOSM Strong Biomarker [427]
IL34 OTZ15VVK Strong Altered Expression [374]
IRF7 OTC1A2PQ Strong Biomarker [428]
ITGB5 OT21MF51 Strong Genetic Variation [429]
ITIH1 OTSXJGQF Strong Biomarker [430]
ITIH3 OT4SLMLY Strong Genetic Variation [117]
KALRN OT8WRCBH Strong Genetic Variation [431]
KANSL1 OTYNSNNZ Strong Genetic Variation [154]
KAZN OTPM7BYM Strong Genetic Variation [356]
KCNK10 OT93GC7V Strong Biomarker [317]
KCNMB2 OTBXUQGK Strong Genetic Variation [161]
KHSRP OTDHZARB Strong Biomarker [235]
KIDINS220 OTLBH2MA Strong Genetic Variation [432]
KL OTD4VWU6 Strong Altered Expression [230]
KLC1 OTSTTTW7 Strong Genetic Variation [152]
KLF11 OTKVQDJD Strong Biomarker [433]
KLHDC8B OTKP6LCR Strong Genetic Variation [154]
KLHL23 OT2UVSD2 Strong Genetic Variation [356]
KLHL29 OTS5Z1QN Strong Genetic Variation [154]
KPNA3 OTLI3TM2 Strong Biomarker [434]
KRBA1 OTXZPPXD Strong Genetic Variation [269]
KSR2 OTSMUL59 Strong Genetic Variation [242]
KYAT3 OTO4U2QK Strong Biomarker [435]
L3MBTL2 OTKX1XIX Strong Genetic Variation [320]
LARGE1 OTUH7H9F Strong Genetic Variation [266]
LILRA1 OTZ4NA7Q Strong Genetic Variation [269]
LIN28B OTVWP0FN Strong Biomarker [285]
LMOD1 OTZ2MEMG Strong Genetic Variation [154]
LMX1B OTM8145D Strong Biomarker [436]
LPGAT1 OTN4HEJ4 Strong Genetic Variation [437]
LRFN5 OTK7QZ3B Strong Biomarker [438]
LRP8 OTZ71YV2 Strong Altered Expression [244]
LSAMP OTYXVQX2 Strong Biomarker [439]
LTBP3 OTME98V7 Strong Genetic Variation [120]
MAB21L4 OT4FRKXR Strong Genetic Variation [269]
MAP2 OT6UYT3X Strong Biomarker [440]
MCF2L OTEURA8N Strong Biomarker [441]
MCM9 OTALGFW8 Strong Genetic Variation [189]
MCTP2 OTFMZ8I2 Strong Biomarker [264]
MED12 OTQZ4D2X Strong Biomarker [442]
METTL3 OTSXP1M3 Strong Genetic Variation [145]
METTL9 OT3YR9B2 Strong Genetic Variation [120]
MGAT4B OTEHCPLY Strong Genetic Variation [266]
MICAL1 OTJEDVWA Strong Genetic Variation [189]
MICB OTS2DVDW Strong Genetic Variation [421]
MIXL1 OT584VOQ Strong Biomarker [443]
MOCOS OT0TL3Q5 Strong Genetic Variation [363]
MORC1 OTCCJKFN Strong Biomarker [444]
MRPL48 OTVAELNS Strong Genetic Variation [161]
MTERF4 OT50CTOJ Strong Genetic Variation [392]
MTMR12 OTH3V9L1 Strong Genetic Variation [328]
MUC21 OTQ8GP5L Strong Biomarker [117]
MUC5B OTPW6K5C Strong Genetic Variation [269]
MUCL3 OTGAD3I0 Strong Genetic Variation [323]
MYO10 OTHB78ZQ Strong Genetic Variation [237]
MYT1L OTV45MAS Strong Genetic Variation [445]
NANOS3 OTGX9IQU Strong Biomarker [446]
NAT8L OTA96AVN Strong Biomarker [447]
NAV3 OT97M1TR Strong Genetic Variation [180]
NBAS OTW9IBRI Strong Genetic Variation [152]
NCAN OT8OO6ZE Strong Biomarker [448]
NCOA5 OTOGWTWB Strong Genetic Variation [154]
ND4 OT4RQVAA Strong Genetic Variation [449]
NDUFV1 OTEVK4WW Strong Biomarker [450]
NEFL OTQESJV4 Strong Altered Expression [451]
NEGR1 OT57ECW9 Strong Genetic Variation [265]
NEK4 OTOB8366 Strong Genetic Variation [273]
NLGN2 OTHDYL3H Strong Altered Expression [452]
NLK OT2LETFS Strong Genetic Variation [180]
NOP53 OTA2YKO6 Strong Biomarker [355]
NOX1 OTZPJQCC Strong Biomarker [453]
NPAS2 OTMRT2TS Strong Biomarker [315]
NPAS3 OT8D1ILB Strong Biomarker [332]
NRDC OTWBBCXO Strong Genetic Variation [120]
NRG3 OTIFZ5CT Strong Biomarker [454]
NRGN OTVGE10W Strong Biomarker [455]
NTM OTHF0UQU Strong Biomarker [456]
NUP160 OTUKVV3I Strong Genetic Variation [154]
NVL OTWTGVTI Strong Genetic Variation [457]
OAS2 OT64CCTM Strong Biomarker [458]
OGN OTKP5S4L Strong Genetic Variation [459]
OLIG1 OTIMFI31 Strong Altered Expression [174]
OPCML OT93PQ6Y Strong Genetic Variation [403]
OPN4 OT1LZ7TS Strong Biomarker [460]
OR12D3 OTQ9XNBB Strong Genetic Variation [152]
OR2T12 OTOHY3TU Strong Genetic Variation [269]
OSTM1 OTKNJDH7 Strong Genetic Variation [461]
OTUD7A OT3GCY98 Strong Genetic Variation [356]
OXT OT48M72Z Strong Biomarker [462]
P2RX2 OT0LF34A Strong Biomarker [271]
P2RX5 OTLBR20R Strong Biomarker [271]
P2RX6 OT1FNTXA Strong Biomarker [271]
PAEP OTQA0NV4 Strong Biomarker [463]
PAFAH1B1 OT9T2TCJ Strong Genetic Variation [154]
PANK2 OTFBW889 Strong Biomarker [206]
PARP14 OTFXJAKK Strong Genetic Variation [464]
PARP15 OTYO1C46 Strong Genetic Variation [465]
PATZ1 OT0X9WGR Strong Genetic Variation [422]
PCDH15 OTU9C2EH Strong Genetic Variation [356]
PCDH9 OTX3BFV4 Strong Genetic Variation [120]
PCDHA1 OT65E2NU Strong Genetic Variation [154]
PCDHA2 OTAV93M9 Strong Genetic Variation [154]
PCDHA3 OT7UREAI Strong Genetic Variation [154]
PCDHA4 OTJH4515 Strong Genetic Variation [154]
PCDHA5 OTHZT1GR Strong Genetic Variation [154]
PCDHA6 OTMAD36Z Strong Genetic Variation [154]
PCLO OTXJZZ98 Strong Genetic Variation [120]
PCMTD1 OT5TS6P7 Strong Genetic Variation [266]
PCNT OTW4Z65J Strong Biomarker [466]
PDIA3 OTHPQ0Q3 Strong Biomarker [467]
PDYN OTEJ6430 Strong Biomarker [468]
PDZD2 OTPPVRGY Strong Genetic Variation [469]
PEA15 OTKCKTSX Strong Altered Expression [470]
PER3 OTVKYVJA Strong Biomarker [471]
PEX5L OTLR4HSR Strong Biomarker [472]
PGBD4 OT95HCMO Strong Genetic Variation [356]
PHACTR1 OTAMPX9V Strong Genetic Variation [328]
PHF2 OTJCIQR2 Strong Genetic Variation [154]
PHF21B OTU5GLCQ Strong Biomarker [269]
PHF3 OTNOYLG9 Strong Genetic Variation [403]
PINK1 OT50NR57 Strong Biomarker [473]
PIPOX OTWTCOTN Strong Genetic Variation [120]
PLCB4 OTPA0QHW Strong Biomarker [467]
PLCL2 OTK5FDF6 Strong Genetic Variation [154]
PLEK2 OTUBWUUK Strong Genetic Variation [117]
PLEKHM1 OT1SLPGD Strong Genetic Variation [313]
PLP1 OT8CM9CX Strong Altered Expression [174]
PLPP5 OTHT51D6 Strong Altered Expression [418]
PLXNA3 OTMZIBVG Strong Biomarker [474]
POM121L2 OTQI36MZ Strong Genetic Variation [421]
POU5F2 OTMC1I7R Strong Genetic Variation [120]
PPP1R9B OTDCTHTT Strong Biomarker [475]
PPP4R3A OTXTCULM Strong Genetic Variation [180]
PRIMA1 OT9ITT3P Strong Biomarker [476]
PROK2 OT70IFEZ Strong Biomarker [477]
PRR16 OTG4TEGR Strong Genetic Variation [154]
PRRC2A OTBX6FM5 Strong Genetic Variation [152]
PSMA2 OTJRT2ZL Strong Altered Expression [478]
PSMA7 OTPHI6ST Strong Altered Expression [479]
PSMB4 OTOJ9OHA Strong Biomarker [305]
PSMD13 OTNQ351N Strong Genetic Variation [479]
PSORS1C1 OT9HK436 Strong Genetic Variation [117]
PSORS1C2 OTK43GE4 Strong Genetic Variation [117]
PTPRD OTZPJ3GX Strong Genetic Variation [180]
PTPRR OT790UA2 Strong Biomarker [480]
PTX3 OTPXHRKU Strong Biomarker [481]
PVALB OTZW1WVQ Strong Posttranslational Modification [482]
QKI OTTAUGLB Strong Altered Expression [483]
RAB27B OTPF9D0K Strong Genetic Variation [120]
RAB3D OTGKRR3C Strong Biomarker [484]
RABGAP1L OT7QO47I Strong Genetic Variation [154]
RAPGEF5 OT53VS75 Strong Genetic Variation [189]
RAPH1 OTMQXW7S Strong Genetic Variation [306]
RAPSN OTGMSWDQ Strong Genetic Variation [255]
RARRES2 OT1BJE8K Strong Genetic Variation [284]
RASGRF2 OT67DAGF Strong Genetic Variation [485]
RBFOX1 OTFPKEL7 Strong Genetic Variation [120]
REEP5 OTZU4TJI Strong Genetic Variation [486]
RELN OTLKMW1O Strong Biomarker [487]
REM1 OTUXL0HC Strong Altered Expression [488]
RERE OT3G4GBZ Strong Genetic Variation [120]
REST OTLL92LQ Strong Genetic Variation [489]
REV1 OTHIKICX Strong Genetic Variation [273]
RFESD OTLYAJIB Strong Genetic Variation [392]
RLN3 OTQSQMUQ Strong Biomarker [287]
RNF41 OTN1DQOY Strong Altered Expression [490]
ROBO2 OTFJ9FQW Strong Genetic Variation [154]
ROPN1L OTRWZJ68 Strong Biomarker [153]
RPL29 OTUFIBJL Strong Biomarker [491]
RPL34 OT0U9VMQ Strong Altered Expression [492]
RPRD2 OTPPH601 Strong Genetic Variation [117]
RSRC1 OTFCJ4S0 Strong Genetic Variation [120]
RTN1 OTCX1SMK Strong Genetic Variation [120]
SAGE1 OT4H6FFA Strong Biomarker [493]
SAMD5 OT95NRVS Strong Genetic Variation [120]
SCPEP1 OT43LYEZ Strong Genetic Variation [494]
SDS OT5WTJ2M Strong Biomarker [404]
SEC11A OT06L834 Strong Genetic Variation [485]
SEC24C OTMTJBQ1 Strong Biomarker [495]
SEMA6D OTU0UAZS Strong Genetic Variation [120]
SERPINF2 OTZGAF8B Strong Genetic Variation [496]
SFTA2 OTVRIUIV Strong Genetic Variation [323]
SGIP1 OTQW6R3Z Strong Genetic Variation [120]
SHANK2 OTSQTPFQ Strong Genetic Variation [120]
SHBG OTPWU5IW Strong Altered Expression [373]
SHISA9 OTZI2V0J Strong Genetic Variation [120]
SIAE OTDQUESH Strong Biomarker [497]
SIGLEC7 OTNDLURR Strong Biomarker [235]
SKA2 OTVYF4XT Strong Biomarker [498]
SLA2 OTNVE666 Strong Biomarker [325]
SLIT3 OTU8MKEU Strong Biomarker [499]
SMCP OTXKY794 Strong Genetic Variation [363]
SNED1 OTBQVXY5 Strong Genetic Variation [392]
SNX29 OTYMXH13 Strong Genetic Variation [152]
SORCS3 OT4VOMBC Strong Genetic Variation [265]
SOSTDC1 OTAKDNSM Strong Biomarker [500]
SOX6 OTT0W0LE Strong Genetic Variation [154]
SOX9 OTVDJFGN Strong Biomarker [422]
SP4 OTWB30IZ Strong Genetic Variation [501]
SPAG9 OT45AHMB Strong Biomarker [206]
SPCS1 OTUHQ4UC Strong Genetic Variation [273]
SPPL3 OT2HLJF6 Strong Genetic Variation [120]
SPSB4 OTG9MLO4 Strong Genetic Variation [180]
SRRM4 OTALUISN Strong Altered Expression [502]
SRRT OTMYPSWV Strong Biomarker [495]
SSPN OTYG2SL7 Strong Genetic Variation [180]
ST13 OTNML6UP Strong Biomarker [491]
ST6GALNAC2 OT9PBQVT Strong Altered Expression [503]
STAU1 OTTR5311 Strong Genetic Variation [154]
STIP1 OT7TXLOX Strong Biomarker [355]
STK19 OTYM6437 Strong Genetic Variation [117]
STK24 OTGUHOIL Strong Genetic Variation [120]
STMN2 OT0FUHLH Strong Genetic Variation [328]
STT3A OTDPS6AV Strong Genetic Variation [323]
SUDS3 OTZ1AARI Strong Genetic Variation [152]
SYN2 OTK0DEGH Strong Biomarker [504]
SYNE1 OTSBSLUH Strong Biomarker [316]
SYNE2 OTBUXGQ0 Strong Genetic Variation [320]
SYNM OTOI8TRJ Strong Biomarker [505]
SYP OTFJKMO4 Strong Biomarker [374]
TAAR6 OTUBUJ2N Strong Biomarker [506]
TAC1 OTM842YW Strong Biomarker [507]
TCF4 OTB9ASTK Strong Genetic Variation [120]
TEF OTY3LAD9 Strong Biomarker [423]
TENM2 OTPLUYEF Strong Genetic Variation [152]
TENM4 OT91K3FC Strong Genetic Variation [323]
TESC OTI8C76M Strong Genetic Variation [508]
TFAP2D OT71O6YN Strong Genetic Variation [180]
TFCP2 OTA246TE Strong Biomarker [243]
TIMELESS OTD8DCBJ Strong Genetic Variation [182]
TIMM8A OTDX9687 Strong Biomarker [509]
TLN2 OT10QQBC Strong Biomarker [510]
TMEM106B OTUWA6NW Strong Genetic Variation [120]
TMEM132D OTV6I4Z0 Strong Genetic Variation [409]
TMEM150B OTFTD4WV Strong Genetic Variation [269]
TMPPE OT0FTJKK Strong Genetic Variation [161]
TNIP3 OTSAE5UE Strong Altered Expression [511]
TOLLIP OTYEO4NR Strong Biomarker [512]
TOMM40 OTZDQ29F Strong Biomarker [513]
TOX2 OT7RZRVK Strong Altered Expression [514]
TRIM26 OTS0DJIP Strong Genetic Variation [323]
TRIM31 OT7VW6RP Strong Genetic Variation [152]
TRIO OT71X1AK Strong Genetic Variation [269]
TSNARE1 OTTJHX9A Strong Genetic Variation [117]
TSPAN5 OTHCCHHV Strong Genetic Variation [349]
TSPYL1 OTVVPELG Strong Genetic Variation [515]
TTC12 OTDB24YV Strong Genetic Variation [154]
------------------------------------------------------------------------------------
⏷ Show the Full List of 464 DOT(s)

References

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45 ClinicalTrials.gov (NCT04080752) A Study of JNJ-61393215 in the Treatment of Depression. U.S. National Institutes of Health.
46 Lithium FDA Label
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49 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037483)
50 ClinicalTrials.gov (NCT02464046) Study to Evaluate Efficacy, Safety and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder Without Psychiatric Comorbidity.
51 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035724)
52 ClinicalTrials.gov (NCT01457677) ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatment in Hoffmann-La Roche.
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68 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000721)
69 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027605)
70 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7681).
71 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000355)
72 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009248)
73 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005281)
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83 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020412)
84 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4316).
85 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001322)
86 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002739)
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93 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023432)
94 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012906)
95 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006150)
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97 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004095)
98 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010898)
99 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001389)
100 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 14).
101 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006187)
102 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010221)
103 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
104 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).
105 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 509).
106 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2489).
107 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6428).
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109 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 308).
110 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).
111 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319).
112 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1).
113 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).
114 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360).
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118 Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis.Mol Psychiatry. 2020 Feb;25(2):339-350. doi: 10.1038/s41380-019-0474-5. Epub 2019 Aug 19.
119 DNA methylation of DLG4 and GJA-1 of human hippocampus and prefrontal cortex in major depression is unchanged in comparison to healthy individuals.J Clin Neurosci. 2017 Sep;43:261-263. doi: 10.1016/j.jocn.2017.05.030. Epub 2017 Jun 20.
120 Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.Nat Neurosci. 2019 Mar;22(3):343-352. doi: 10.1038/s41593-018-0326-7. Epub 2019 Feb 4.
121 Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide.Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8472-E8481. doi: 10.1073/pnas.1617824113. Epub 2016 Dec 9.
122 Whole Exome Sequencing Identifies a Novel Predisposing Gene, MAPKAP1, for Familial Mixed Mood Disorder.Front Genet. 2019 Feb 15;10:74. doi: 10.3389/fgene.2019.00074. eCollection 2019.
123 Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.Transl Psychiatry. 2019 Feb 15;9(1):91. doi: 10.1038/s41398-018-0331-3.
124 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.Mol Psychiatry. 2014 Feb;19(2):228-34. doi: 10.1038/mp.2012.183. Epub 2013 Jan 15.
125 Biological and psychological components of depression in patients receiving IFN-alpha therapy for hepatitis C.Adv Clin Exp Med. 2019 Sep;28(9):1217-1222. doi: 10.17219/acem/104617.
126 Nutraceutical Potential of Phenolics from 'Brava' and 'Mansa' Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of 'Picual' and 'Cornicabra'.Molecules. 2018 Mar 21;23(4):722. doi: 10.3390/molecules23040722.
127 Racial/ethnic differences in the treatment of adolescent major depressive disorders (MDD) across healthcare providers participating in the medicaid program.J Affect Disord. 2018 Aug 1;235:155-161. doi: 10.1016/j.jad.2018.04.045. Epub 2018 Apr 6.
128 Chromosome 15q13.3 microduplications are associated with treatment refractory major depressive disorder.Genes Brain Behav. 2020 Jun;19(5):e12628. doi: 10.1111/gbb.12628. Epub 2019 Dec 15.
129 DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.Transl Psychiatry. 2019 Oct 3;9(1):245. doi: 10.1038/s41398-019-0582-7.
130 The role of clock genes in the etiology of Major Depressive Disorder: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.J Affect Disord. 2018 Jul;234:351-357. doi: 10.1016/j.jad.2017.11.015. Epub 2017 Nov 7.
131 Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275.
132 Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression.Eur Arch Psychiatry Clin Neurosci. 2015 Jun;265(4):331-41. doi: 10.1007/s00406-014-0572-y. Epub 2015 Jan 9.
133 BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.ACS Med Chem Lett. 2018 Apr 13;9(5):472-477. doi: 10.1021/acsmedchemlett.8b00080. eCollection 2018 May 10.
134 Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-nave patients with major depressive disorder.J Affect Disord. 2018 May;232:61-68. doi: 10.1016/j.jad.2018.02.044. Epub 2018 Feb 16.
135 Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression.Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1521-H1531. doi: 10.1152/ajpheart.00607.2017. Epub 2018 Sep 14.
136 An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway.J Neural Transm (Vienna). 2014 Jul;121(7):783-92. doi: 10.1007/s00702-014-1189-z. Epub 2014 Mar 22.
137 Antidepressants Improve Negative Regulation of Toll-Like Receptor Signaling in Monocytes from Patients with Major Depression.Neuroimmunomodulation. 2018;25(1):42-48. doi: 10.1159/000489562. Epub 2018 Jun 13.
138 Aberrant REST-mediated transcriptional regulation in major depressive disorder.J Psychiatr Res. 2010 Apr;44(6):378-84. doi: 10.1016/j.jpsychires.2009.09.009. Epub 2009 Oct 20.
139 Molecular basis of major psychiatric diseases such as schizophrenia and depression.Anat Sci Int. 2015 Jun;90(3):137-43. doi: 10.1007/s12565-014-0269-3. Epub 2015 Jan 17.
140 Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women.J Affect Disord. 2015 Nov 15;187:147-50. doi: 10.1016/j.jad.2015.08.002. Epub 2015 Aug 28.
141 Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients.Eur Neuropsychopharmacol. 2010 Oct;20(10):721-30. doi: 10.1016/j.euroneuro.2010.04.008. Epub 2010 May 21.
142 Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder.Brain Res. 2009 Mar 25;1262:1-6. doi: 10.1016/j.brainres.2009.01.013. Epub 2009 Jan 20.
143 Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression.Neuropsychopharmacology. 2006 Aug;31(8):1750-6. doi: 10.1038/sj.npp.1301010. Epub 2006 Jan 11.
144 Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response.Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):85-9. doi: 10.1002/ajmg.b.20017.
145 An association study of the m6A genes with major depressive disorder in Chinese Han population.J Affect Disord. 2015 Sep 1;183:279-86. doi: 10.1016/j.jad.2015.05.025. Epub 2015 May 21.
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206 The Influence of Depression on the Psychometric Properties of the Maslach Burnout Inventory-Human Services Survey: A Cross-Sectional Study With Nursing Assistants.Front Psychiatry. 2018 Dec 18;9:695. doi: 10.3389/fpsyt.2018.00695. eCollection 2018.
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210 Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):20-6. doi: 10.1002/ajmg.b.30374.
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214 Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress.Mol Psychiatry. 2018 Apr;23(4):892-903. doi: 10.1038/mp.2017.28. Epub 2017 Apr 18.
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216 Orexin/hypocretin receptor, Orx(1), gene variants are associated with major depressive disorder.Int J Psychiatry Clin Pract. 2019 Jun;23(2):114-121. doi: 10.1080/13651501.2018.1551549. Epub 2018 Dec 31.
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230 Differences in the immune-inflammatory profiles of unipolar and bipolar depression.J Affect Disord. 2020 Feb 1;262:8-15. doi: 10.1016/j.jad.2019.10.037. Epub 2019 Oct 30.
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233 Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.BMC Med Genet. 2008 Dec 16;9:111. doi: 10.1186/1471-2350-9-111.
234 Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder.J Affect Disord. 2010 Jul;124(1-2):68-75. doi: 10.1016/j.jad.2009.10.018. Epub 2009 Nov 8.
235 Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders.Sci Rep. 2017 Jul 31;7(1):6871. doi: 10.1038/s41598-017-06832-6.
236 Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:177-186. doi: 10.1016/j.pnpbp.2017.11.017. Epub 2017 Nov 22.
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238 Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression.Mol Neurobiol. 2019 Apr;56(4):3038-3052. doi: 10.1007/s12035-018-1288-1. Epub 2018 Aug 7.
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250 Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays.Food Res Int. 2018 Apr;106:558-567. doi: 10.1016/j.foodres.2018.01.026. Epub 2018 Jan 31.
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285 Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.Cell Rep. 2018 May 22;23(8):2225-2235. doi: 10.1016/j.celrep.2018.04.054.
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287 Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats.Br J Pharmacol. 2019 Oct;176(20):3899-3923. doi: 10.1111/bph.14774. Epub 2019 Sep 11.
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289 Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.Biomed Res Int. 2015;2015:492367. doi: 10.1155/2015/492367. Epub 2015 Feb 1.
290 Vesicular monoamine transporter 1 gene polymorphism and white matter integrity in major depressive disorder.Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:138-145. doi: 10.1016/j.pnpbp.2017.02.028. Epub 2017 Apr 10.
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292 Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.Transl Psychiatry. 2019 May 23;9(1):149. doi: 10.1038/s41398-019-0483-9.
293 Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression.BMC Psychiatry. 2005 Oct 24;5:38. doi: 10.1186/1471-244X-5-38.
294 Aberrant executive attention in unaffected youth at familial risk for mood disorders.J Affect Disord. 2013 May;147(1-3):397-400. doi: 10.1016/j.jad.2012.08.020. Epub 2012 Sep 11.
295 Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder.PLoS One. 2016 Oct 10;11(10):e0164301. doi: 10.1371/journal.pone.0164301. eCollection 2016.
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298 Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.Int J Mol Sci. 2019 Dec 11;20(24):6253. doi: 10.3390/ijms20246253.
299 SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population.J Clin Psychiatry. 2015 Jan;76(1):e76-82. doi: 10.4088/JCP.13m08962.
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305 Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.Mol Psychiatry. 2008 Aug;13(8):800-12. doi: 10.1038/mp.2008.59. Epub 2008 May 27.
306 Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy.Transl Psychiatry. 2014 Sep 16;4(9):e442. doi: 10.1038/tp.2014.66.
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311 Replicating predictive serum correlates of greater translocator protein distribution volume in brain.Neuropsychopharmacology. 2020 May;45(6):925-931. doi: 10.1038/s41386-019-0561-y. Epub 2019 Nov 4.
312 Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.Arch Gen Psychiatry. 2010 Apr;67(4):348-59. doi: 10.1001/archgenpsychiatry.2009.201. Epub 2010 Feb 1.
313 Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.Front Psychiatry. 2018 Mar 6;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018.
314 Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-nave patients with first-episode major depressive disorder.Eur Arch Psychiatry Clin Neurosci. 2019 Oct;269(7):785-794. doi: 10.1007/s00406-018-0953-8. Epub 2018 Nov 7.
315 Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.Neuropsychopharmacology. 2010 May;35(6):1279-89. doi: 10.1038/npp.2009.230. Epub 2010 Jan 13.
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317 Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers.Int J Mol Sci. 2017 Nov 19;18(11):2460. doi: 10.3390/ijms18112460.
318 Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia.Bipolar Disord. 2009 Nov;11(7):711-25. doi: 10.1111/j.1399-5618.2009.00752.x.
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320 Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.Nat Genet. 2018 May;50(5):668-681. doi: 10.1038/s41588-018-0090-3. Epub 2018 Apr 26.
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325 Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models.Transl Psychiatry. 2019 Aug 5;9(1):187. doi: 10.1038/s41398-019-0524-4.
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329 Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease.Neuropsychopharmacology. 2019 Apr;44(5):837-849. doi: 10.1038/s41386-018-0090-0. Epub 2018 May 16.
330 Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.Neuropsychopharmacology. 2019 Aug;44(9):1542-1551. doi: 10.1038/s41386-019-0345-4. Epub 2019 Feb 16.
331 Association of LHPP genetic variation (rs35936514) with structural and functional connectivity of hippocampal-corticolimbic neural circuitry.Brain Imaging Behav. 2020 Aug;14(4):1025-1033. doi: 10.1007/s11682-019-00140-5.
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334 Is the effect of work-related psychosocial exposure on depressive and anxiety disorders short-term, lagged or cumulative?.Int Arch Occup Environ Health. 2020 Jan;93(1):87-104. doi: 10.1007/s00420-019-01466-9. Epub 2019 Aug 3.
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336 No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis.Am J Psychiatry. 2019 Dec 1;176(12):1039-1049. doi: 10.1176/appi.ajp.2019.18101144. Epub 2019 Jul 29.
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342 Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome.Neurosci Lett. 2002 Sep 20;330(2):198-200. doi: 10.1016/s0304-3940(02)00750-4.
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344 Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.Int J Geriatr Psychiatry. 2018 Dec;33(12):1604-1612. doi: 10.1002/gps.4955. Epub 2018 Jul 23.
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351 Association of Novel ALX4 Gene Polymorphisms with Antidepressant Treatment Response: Findings from the CO-MED Trial.Mol Neuropsychiatry. 2018 Jun;4(1):7-19. doi: 10.1159/000487321. Epub 2018 May 3.
352 Elevated salivary alpha-amylase levels at awakening in patients with depression.Psychoneuroendocrinology. 2018 Nov;97:69-77. doi: 10.1016/j.psyneuen.2018.07.001. Epub 2018 Jul 6.
353 DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder.Int J Neuropsychopharmacol. 2013 Oct;16(9):2095-101. doi: 10.1017/S146114571300045X. Epub 2013 May 20.
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361 Common variants in the BCL9 gene conferring risk of schizophrenia.Arch Gen Psychiatry. 2011 Mar;68(3):232-40. doi: 10.1001/archgenpsychiatry.2011.1.
362 The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder.Biol Psychiatry. 2005 May 15;57(10):1097-102. doi: 10.1016/j.biopsych.2005.02.019.
363 Impact of pre-diagnosis depressive symptoms and health-related quality of life on treatment choice for ductal carcinoma in situ and stage I breast cancer in older women.Breast Cancer Res Treat. 2019 Feb;173(3):709-717. doi: 10.1007/s10549-018-5006-5. Epub 2018 Nov 8.
364 Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression.J Psychopharmacol. 2013 Oct;27(10):915-20. doi: 10.1177/0269881113499829. Epub 2013 Aug 7.
365 Differentially expressed genes related to major depressive disorder and antidepressant response: genome-wide gene expression analysis.Exp Mol Med. 2018 Aug 3;50(8):1-11. doi: 10.1038/s12276-018-0123-0.
366 Evidence for the role of corticotropin-releasing factor in major depressive disorder.Neurosci Biobehav Rev. 2015 Nov;58:63-78. doi: 10.1016/j.neubiorev.2015.07.011. Epub 2015 Aug 10.
367 GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders.Int J Neuropsychopharmacol. 2011 Jul;14(6):721-34. doi: 10.1017/S1461145710001616.
368 Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains.Neurosci Res. 2008 Feb;60(2):184-91. doi: 10.1016/j.neures.2007.10.010. Epub 2007 Nov 6.
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370 Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.Biol Psychiatry. 2010 Mar 15;67(6):550-7. doi: 10.1016/j.biopsych.2009.11.005. Epub 2009 Dec 24.
371 Haptoglobin phenotypes and gene frequencies in unipolar major depression.Am J Psychiatry. 1994 Jan;151(1):112-6. doi: 10.1176/ajp.151.1.112.
372 Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients.PLoS One. 2014 Mar 11;9(3):e91076. doi: 10.1371/journal.pone.0091076. eCollection 2014.
373 Increased serum levels of leptin and insulin in both schizophrenia and major depressive disorder: A cross-disorder proteomics analysis.Eur Neuropsychopharmacol. 2019 Jul;29(7):835-846. doi: 10.1016/j.euroneuro.2019.05.010. Epub 2019 Jun 21.
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375 Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population.Behav Genet. 2014 Mar;44(2):97-101. doi: 10.1007/s10519-014-9645-y. Epub 2014 Feb 20.
376 Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors.Biol Psychiatry. 2019 Apr 15;85(8):635-649. doi: 10.1016/j.biopsych.2018.11.025. Epub 2018 Dec 5.
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378 Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.Neuropsychopharmacology. 2018 Sep;43(10):2146-2153. doi: 10.1038/s41386-018-0078-9. Epub 2018 Apr 27.
379 Association of Genetic Variation at AQP4 Locus with Vascular Depression.Biomolecules. 2018 Dec 5;8(4):164. doi: 10.3390/biom8040164.
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402 Gene expression and association analysis of the epithelial membrane protein 1 gene in major depressive disorder in the Japanese population.Neurosci Lett. 2011 Feb 4;489(2):126-30. doi: 10.1016/j.neulet.2010.12.001. Epub 2010 Dec 10.
403 Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder.PLoS One. 2018 Dec 20;13(12):e0209160. doi: 10.1371/journal.pone.0209160. eCollection 2018.
404 The screen for cognitive impairment in psychiatry (SCIP) is associated with disease severity and cognitive complaints in major depression.Int J Psychiatry Clin Pract. 2019 Mar;23(1):49-56. doi: 10.1080/13651501.2018.1450512. Epub 2018 Mar 19.
405 Gene expression profiling in postmortem prefrontal cortex of major depressive disorder.J Neurosci. 2007 Nov 28;27(48):13329-40. doi: 10.1523/JNEUROSCI.4083-07.2007.
406 FoxP2 is significantly associated with schizophrenia and major depression in the Chinese Han population.World J Biol Psychiatry. 2013 Mar;14(2):146-50. doi: 10.3109/15622975.2011.615860. Epub 2012 Mar 9.
407 FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk.Front Psychol. 2015 Sep 16;6:1377. doi: 10.3389/fpsyg.2015.01377. eCollection 2015.
408 Expression of GABAA 2-, 1- and -receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.Transl Psychiatry. 2013 Sep 10;3(9):e303. doi: 10.1038/tp.2013.64.
409 Association of TMEM132D, COMT, and GABRA6 genotypes with cingulate, frontal cortex and hippocampal emotional processing in panic and major depressive disorder.Int J Psychiatry Clin Pract. 2015;19(3):192-200. doi: 10.3109/13651501.2015.1043133. Epub 2015 May 14.
410 A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants.Pharmacogenomics J. 2011 Jun;11(3):207-13. doi: 10.1038/tpj.2010.23. Epub 2010 Mar 30.
411 Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202.J Res Med Sci. 2018 Aug 23;23:69. doi: 10.4103/jrms.JRMS_879_17. eCollection 2018.
412 P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.Hum Mol Genet. 2006 Aug 15;15(16):2438-45. doi: 10.1093/hmg/ddl166. Epub 2006 Jul 5.
413 ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1.J Psychiatr Res. 2014 Mar;50:79-83. doi: 10.1016/j.jpsychires.2013.12.002. Epub 2013 Dec 15.
414 The Gem interacting protein (GMIP) gene is associated with major depressive disorder.Neurogenetics. 2005 Sep;6(3):127-33. doi: 10.1007/s10048-005-0003-3. Epub 2005 Sep 28.
415 Orphan receptor GPR158 controls stress-induced depression.Elife. 2018 Feb 8;7:e33273. doi: 10.7554/eLife.33273.
416 GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families.Psychiatr Genet. 2007 Dec;17(6):347-50. doi: 10.1097/YPG.0b013e3281ac232f.
417 Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3 Signaling Pathway.Front Behav Neurosci. 2019 Jun 18;13:131. doi: 10.3389/fnbeh.2019.00131. eCollection 2019.
418 Identification of commonly altered genes between in major depressive disorder and a mouse model of depression.Sci Rep. 2017 Jun 8;7(1):3044. doi: 10.1038/s41598-017-03291-x.
419 Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: a CAN-BIND report.Neuropsychopharmacology. 2020 Jan;45(2):283-291. doi: 10.1038/s41386-019-0542-1. Epub 2019 Oct 14.
420 Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation.Brain Behav Immun. 2012 Aug;26(6):979-87. doi: 10.1016/j.bbi.2012.05.010. Epub 2012 Jun 6.
421 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.Eur Respir J. 2019 Dec 19;54(6):1901507. doi: 10.1183/13993003.01507-2019. Print 2019 Dec.
422 Differential co-expression and regulation analyses reveal different mechanisms underlying major depressive disorder and subsyndromal symptomatic depression.BMC Bioinformatics. 2015 Apr 3;16:112. doi: 10.1186/s12859-015-0543-y.
423 Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.Gene. 2017 Mar 1;603:34-41. doi: 10.1016/j.gene.2016.12.006. Epub 2016 Dec 10.
424 Heat-shock protein-70 genes and response to antidepressants in major depression.Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. doi: 10.1016/j.pnpbp.2007.02.011. Epub 2007 Feb 27.
425 Anhedonic-like behavior correlates with IFN serum levels in a two-hit model of depression.Behav Brain Res. 2019 Nov 5;373:112076. doi: 10.1016/j.bbr.2019.112076. Epub 2019 Jul 5.
426 IGF-I in major depression and antidepressant treatment response.Eur Neuropsychopharmacol. 2015 Jun;25(6):864-72. doi: 10.1016/j.euroneuro.2014.12.013. Epub 2015 Jan 5.
427 Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder.Brain Behav. 2015 Apr;5(4):e00314. doi: 10.1002/brb3.314. Epub 2015 Feb 13.
428 Gene expression biomarkers of response to citalopram treatment in major depressive disorder.Transl Psychiatry. 2011 Jun 21;1(6):e13. doi: 10.1038/tp.2011.12.
429 Dissecting the genetic heterogeneity of depression through age at onset.Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):859-68. doi: 10.1002/ajmg.b.32093. Epub 2012 Aug 22.
430 ITIH family genes confer risk to schizophrenia and major depressive disorder in the Han Chinese population.Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:34-8. doi: 10.1016/j.pnpbp.2013.12.004. Epub 2014 Jan 2.
431 A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness.Nat Commun. 2014 Sep 16;5:4858. doi: 10.1038/ncomms5858.
432 Amplification refractory mutation system polymerase chain reaction versus optimized polymerase chain reaction restriction-fragment length polymorphism for apolipoprotein E genotyping of majorly depressed patients.Mol Med Rep. 2015 Nov;12(5):6829-34. doi: 10.3892/mmr.2015.4251. Epub 2015 Aug 25.
433 Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders.Neuropsychopharmacology. 2015 May;40(6):1373-82. doi: 10.1038/npp.2014.321. Epub 2014 Dec 15.
434 KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. Dis Markers. 2012;33(4):163-70. doi: 10.3233/DMA-2012-0921.
435 The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes.Psychiatry Res. 2011 Aug 15;188(3):355-60. doi: 10.1016/j.psychres.2011.03.012. Epub 2011 Apr 13.
436 Increased symptoms of attention deficit hyperactivity disorder and major depressive disorder symptoms in Nail-patella syndrome: potential association with LMX1B loss-of-function.Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):59-66. doi: 10.1002/ajmg.b.31138. Epub 2010 Nov 2.
437 Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.Am J Psychiatry. 2018 Jun 1;175(6):545-554. doi: 10.1176/appi.ajp.2017.17060621. Epub 2018 Mar 2.
438 Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.Transl Psychiatry. 2019 Nov 20;9(1):310. doi: 10.1038/s41398-019-0613-4.
439 Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder.Transl Psychiatry. 2012 Aug 14;2(8):e152. doi: 10.1038/tp.2012.74.
440 Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines.Am J Psychiatry. 2004 Oct;161(10):1848-55. doi: 10.1176/ajp.161.10.1848.
441 Long-Term Outcomes of Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression.Am J Psychiatry. 2019 Nov 1;176(11):949-956. doi: 10.1176/appi.ajp.2019.18121427. Epub 2019 Oct 4.
442 The association of a HOPA polymorphism with major depression and phobia.Compr Psychiatry. 2002 Sep-Oct;43(5):404-10. doi: 10.1053/comp.2002.33489.
443 Antidepressant-induced hypomania/mania in patients with major depression: Evidence from the BRIDGE-II-MIX study.J Affect Disord. 2017 Sep;219:187-192. doi: 10.1016/j.jad.2017.05.035. Epub 2017 May 24.
444 Methylation of MORC1: A possible biomarker for depression?.J Psychiatr Res. 2018 Aug;103:208-211. doi: 10.1016/j.jpsychires.2018.05.026. Epub 2018 May 30.
445 Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population.Genes Brain Behav. 2012 Feb;11(1):87-93. doi: 10.1111/j.1601-183X.2011.00734.x. Epub 2011 Oct 19.
446 A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder.Int J Neuropsychopharmacol. 2006 Feb;9(1):13-20. doi: 10.1017/S1461145705005560. Epub 2005 Jun 21.
447 Vulnerability to depressive behavior induced by overexpression of striatal Shati/Nat8l via the serotonergic neuronal pathway in mice.Behav Brain Res. 2019 Dec 30;376:112227. doi: 10.1016/j.bbr.2019.112227. Epub 2019 Sep 11.
448 NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression.Neuropsychopharmacology. 2015 Oct;40(11):2510-6. doi: 10.1038/npp.2015.86. Epub 2015 Mar 24.
449 Mitochondrial DNA (mtDNA) in brain samples from patients with major psychiatric disorders: gene expression profiles, mtDNA content and presence of the mtDNA common deletion.Am J Med Genet B Neuropsychiatr Genet. 2013 Mar;162B(2):213-23. doi: 10.1002/ajmg.b.32134. Epub 2013 Jan 25.
450 Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression.PLoS One. 2008;3(11):e3676. doi: 10.1371/journal.pone.0003676. Epub 2008 Nov 7.
451 Treatment resistance in major depression is correlated with increased plasma levels of neurofilament light protein reflecting axonal damage.Med Hypotheses. 2019 Jun;127:159-161. doi: 10.1016/j.mehy.2019.03.022. Epub 2019 Mar 23.
452 Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1111-1116. doi: 10.1073/pnas.1719014115. Epub 2018 Jan 16.
453 Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1.J Neurosci. 2017 Apr 12;37(15):4200-4212. doi: 10.1523/JNEUROSCI.2988-16.2017. Epub 2017 Mar 17.
454 Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.Am J Psychiatry. 2017 Mar 1;174(3):256-265. doi: 10.1176/appi.ajp.2016.16060721. Epub 2016 Oct 24.
455 Electroconvulsive therapy does not alter the synaptic protein neurogranin in the cerebrospinal fluid of patients with major depression.J Neural Transm (Vienna). 2017 Dec;124(12):1641-1645. doi: 10.1007/s00702-017-1802-z. Epub 2017 Oct 23.
456 NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies.Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):154-60. doi: 10.1016/j.pnpbp.2010.10.016. Epub 2010 Oct 29.
457 The NVL gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population.Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:7-13. doi: 10.1016/j.pnpbp.2015.04.001. Epub 2015 Apr 17.
458 Molecular signatures of peripheral blood mononuclear cells during chronic interferon- treatment: relationship with depression and fatigue.Psychol Med. 2012 Aug;42(8):1591-603. doi: 10.1017/S0033291711002868. Epub 2011 Dec 9.
459 Characterization and Comparison of Physical and Mental Health Profiles and Department of Veterans Affairs Health Care Utilization Patterns among Operation Iraqi Freedom/Operation Enduring Freedom Women Veterans in Puerto Rico versus the United States.Womens Health Issues. 2020 Jan-Feb;30(1):49-56. doi: 10.1016/j.whi.2019.10.004. Epub 2019 Nov 30.
460 Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder.Front Neurol. 2018 Sep 13;9:764. doi: 10.3389/fneur.2018.00764. eCollection 2018.
461 Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank.Transl Psychiatry. 2017 Nov 30;7(11):1263. doi: 10.1038/s41398-017-0010-9.
462 Variant in oxytocin receptor gene is associated with amygdala volume.Psychoneuroendocrinology. 2011 Jul;36(6):891-7. doi: 10.1016/j.psyneuen.2010.12.004. Epub 2011 Jan 3.
463 Usefulness of the 15-item geriatric depression scale (GDS-15) for classifying minor and major depressive disorders among community-dwelling elders.J Affect Disord. 2019 Dec 1;259:370-375. doi: 10.1016/j.jad.2019.08.053. Epub 2019 Aug 20.
464 A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen.Mol Neurobiol. 2017 Oct;54(8):5868-5882. doi: 10.1007/s12035-016-0102-1. Epub 2016 Sep 22.
465 A novel relationship for schizophrenia, bipolar and major depressive disorder Part 7: A hint from chromosome 7 high density association screen.Behav Brain Res. 2015 Oct 15;293:241-51. doi: 10.1016/j.bbr.2015.06.043. Epub 2015 Jul 17.
466 Association study between the pericentrin (PCNT) gene and schizophrenia.Neuromolecular Med. 2010 Sep;12(3):243-7. doi: 10.1007/s12017-009-8106-x. Epub 2009 Nov 24.
467 Molecular cytogenetic interphase analysis of Phosphoinositide-specific Phospholipase C 1 gene in paraffin-embedded brain samples of major depression patients.J Affect Disord. 2012 Jan;136(1-2):177-180. doi: 10.1016/j.jad.2011.07.023. Epub 2011 Aug 31.
468 Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression.J Clin Invest. 2013 Dec;123(12):5334-41. doi: 10.1172/JCI70395. Epub 2013 Nov 15.
469 Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.Br J Clin Pharmacol. 2014 Aug;78(2):373-83. doi: 10.1111/bcp.12348.
470 FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments.Neuroscience. 2014 Sep 26;277:541-51. doi: 10.1016/j.neuroscience.2014.07.027. Epub 2014 Jul 27.
471 Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks.Transl Psychiatry. 2016 Mar 1;6(3):e748. doi: 10.1038/tp.2016.9.
472 HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects.Mol Psychiatry. 2017 Mar;22(3):458-465. doi: 10.1038/mp.2016.99. Epub 2016 Jul 12.
473 Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers.Biol Psychiatry. 2008 Aug 1;64(3):241-7. doi: 10.1016/j.biopsych.2007.12.010. Epub 2008 Feb 7.
474 White matter architecture in major depression with anxious distress symptoms.Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109664. doi: 10.1016/j.pnpbp.2019.109664. Epub 2019 May 31.
475 CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model.Cereb Cortex. 2019 Aug 14;29(9):3752-3765. doi: 10.1093/cercor/bhy254.
476 Genome-wide DNA methylation scan in major depressive disorder.PLoS One. 2012;7(4):e34451. doi: 10.1371/journal.pone.0034451. Epub 2012 Apr 12.
477 Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population.Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1618-22. doi: 10.1016/j.pnpbp.2011.06.001. Epub 2011 Jun 13.
478 Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems.Transl Psychiatry. 2017 Apr 4;7(4):e1078. doi: 10.1038/tp.2017.39.
479 Proteasome system dysregulation and treatment resistance mechanisms in major depressive disorder.Transl Psychiatry. 2015 Dec 1;5(12):e687. doi: 10.1038/tp.2015.180.
480 Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function.Dev Neuropsychol. 2017;42(3):231-240. doi: 10.1080/87565641.2017.1306527. Epub 2017 May 3.
481 Differential expression of pentraxin 3 in fibroblasts from patients with major depression.Neuropsychopharmacology. 2004 Jan;29(1):126-32. doi: 10.1038/sj.npp.1300307.
482 Parvalbumin Promoter Methylation Altered in Major Depressive Disorder.Int J Med Sci. 2019 Aug 14;16(9):1207-1214. doi: 10.7150/ijms.36131. eCollection 2019.
483 Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.Biol Psychiatry. 2009 Nov 1;66(9):824-31. doi: 10.1016/j.biopsych.2009.05.010. Epub 2009 Jul 9.
484 Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial.J Psychiatr Res. 2018 Feb;97:65-69. doi: 10.1016/j.jpsychires.2017.11.001. Epub 2017 Nov 16.
485 Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.Transl Psychiatry. 2018 Dec 14;8(1):280. doi: 10.1038/s41398-018-0311-7.
486 Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population.Gen Hosp Psychiatry. 2012 Sep-Oct;34(5):571-7. doi: 10.1016/j.genhosppsych.2012.05.015. Epub 2012 Jul 12.
487 The involvement of Reelin in neurodevelopmental disorders.Neuropharmacology. 2013 May;68:122-35. doi: 10.1016/j.neuropharm.2012.08.015. Epub 2012 Sep 7.
488 The 'affect tagging and consolidation' (ATaC) model of depression vulnerability.Neurobiol Learn Mem. 2017 Apr;140:43-51. doi: 10.1016/j.nlm.2017.02.003. Epub 2017 Feb 15.
489 Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9078-9083. doi: 10.1073/pnas.1900390116. Epub 2019 Apr 12.
490 An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.Biol Psychiatry. 2009 Mar 1;65(5):425-31. doi: 10.1016/j.biopsych.2008.09.015. Epub 2008 Nov 4.
491 Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder.Neuroimage Clin. 2018 Jul 6;20:42-50. doi: 10.1016/j.nicl.2018.07.002. eCollection 2018.
492 Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.J Psychiatr Res. 2018 Sep;104:202-210. doi: 10.1016/j.jpsychires.2018.08.010. Epub 2018 Aug 6.
493 SAGE-217, A Novel GABA(A) Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.Clin Pharmacokinet. 2020 Jan;59(1):111-120. doi: 10.1007/s40262-019-00801-0.
494 Psychometric properties of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10) in Chinese undergraduates and depressive patients.J Affect Disord. 2020 Jan 15;261:211-220. doi: 10.1016/j.jad.2019.10.018. Epub 2019 Oct 12.
495 Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression.BMC Bioinformatics. 2011;12 Suppl 13(Suppl 13):S20. doi: 10.1186/1471-2105-12-S13-S20. Epub 2011 Nov 30.
496 Medication Adherence, Health Care Utilization, and Costs in Patients With Major Depressive Disorder Initiating Adjunctive Atypical Antipsychotic Treatment.Clin Ther. 2019 Feb;41(2):221-232. doi: 10.1016/j.clinthera.2018.12.005. Epub 2019 Jan 5.
497 Comparative Effectiveness of a Technology-Facilitated Depression Care Management Model in Safety-Net Primary Care Patients With Type 2 Diabetes: 6-Month Outcomes of a Large Clinical Trial.J Med Internet Res. 2018 Apr 23;20(4):e147. doi: 10.2196/jmir.7692.
498 GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER.Depress Anxiety. 2016 Jun;33(6):531-540. doi: 10.1002/da.22499. Epub 2016 Mar 31.
499 Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder.PLoS One. 2010 Dec 1;5(12):e15463. doi: 10.1371/journal.pone.0015463.
500 Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent (11)C-raclopride positron emission tomography and functional magnetic resonance imaging investigation.Transl Psychiatry. 2018 Nov 30;8(1):264. doi: 10.1038/s41398-018-0316-2.
501 Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population.Br J Psychiatry. 2016 May;208(5):441-5. doi: 10.1192/bjp.bp.114.151688. Epub 2015 Oct 8.
502 A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression.J Neurosci. 2018 Sep 19;38(38):8200-8210. doi: 10.1523/JNEUROSCI.0902-18.2018. Epub 2018 Aug 7.
503 Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression.J Affect Disord. 2018 Jun;233:79-85. doi: 10.1016/j.jad.2017.08.057. Epub 2017 Aug 19.
504 DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.BMC Psychiatry. 2016 Aug 11;16(1):286. doi: 10.1186/s12888-016-0989-0.
505 Personality traits are related with dynamic functional connectivity in major depression disorder: A resting-state analysis.J Affect Disord. 2019 Feb 15;245:1032-1042. doi: 10.1016/j.jad.2018.11.002. Epub 2018 Nov 2.
506 Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample.J Psychiatr Res. 2008 Jan;42(1):35-40. doi: 10.1016/j.jpsychires.2006.09.011. Epub 2006 Nov 9.
507 The association between substance P and white matter integrity in medication-naive patients with major depressive disorder.Sci Rep. 2017 Aug 29;7(1):9707. doi: 10.1038/s41598-017-10100-y.
508 TESC gene-regulating genetic variant (rs7294919) affects hippocampal subfield volumes and parahippocampal cingulum white matter integrity in major depressive disorder.J Psychiatr Res. 2017 Oct;93:20-29. doi: 10.1016/j.jpsychires.2017.05.010. Epub 2017 May 25.
509 Clinical and sociodemographic variables associated with interictal dysphoric disorder and interictal personality in patients with drug-resistant temporal lobe epilepsy: A controlled study.Epilepsy Behav. 2017 Apr;69:100-103. doi: 10.1016/j.yebeh.2017.01.021. Epub 2017 Feb 23.
510 Serum agrin and talin are increased in major depression while agrin and creatine phosphokinase are associated with chronic fatigue and fibromyalgia symptoms in depression.Metab Brain Dis. 2020 Jan;35(1):225-235. doi: 10.1007/s11011-019-00506-0. Epub 2019 Nov 16.
511 Elevated TNIP3 mRNA Expression in TNF--Secreting Cells from Patients with Major Depressive Disorder.Neuroimmunomodulation. 2019;26(3):153-158. doi: 10.1159/000501083. Epub 2019 Jul 15.
512 Differential Peripheral Proteomic Biosignature of Fluoxetine Response in a Mouse Model of Anxiety/Depression.Front Cell Neurosci. 2017 Aug 16;11:237. doi: 10.3389/fncel.2017.00237. eCollection 2017.
513 TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder.Neuropsychopharmacology. 2014 Jun;39(7):1743-53. doi: 10.1038/npp.2014.22. Epub 2014 Jan 29.
514 Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder.Biol Psychiatry. 2017 Sep 1;82(5):312-321. doi: 10.1016/j.biopsych.2016.12.012. Epub 2016 Dec 16.
515 Dual Roles for the TSPYL Family in Mediating Serotonin Transport and the Metabolism of Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.Clin Pharmacol Ther. 2020 Mar;107(3):662-670. doi: 10.1002/cpt.1692. Epub 2019 Nov 30.