Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0YFYPZ)

DOT Name Homeobox protein NOBOX (NOBOX)
Gene Name NOBOX
Related Disease
Autism ( )
Female hypogonadism ( )
Familial male-limited precocious puberty ( )
Premature ovarian failure 5 ( )
UniProt ID
NOBOX_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00046
Sequence
MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRC
SLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSA
PHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQT
QGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRG
PCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSD
KRREIAQTVGVTPQRIMVKGAGSLVAGWSGGGPTIETLELQSERSAVAWVWFQNRRAKWR
KMEKLNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEPPMLLT
SDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHK
DGPCGSWGTSITLPPPCSYLEELEPQDYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPT
FPFSMPSSLTLPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNIGTASWSDPC
LPELPFPGPFCPQALGHPPGGDGYFPDLFPTPCPQALGRQPSSALSWMPEGARPGTGPLL
SKAKEEPPAASLDQPSALEEARGDDKNSHVP
Function Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
Tissue Specificity Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female germline, from primordial follicles through to MII oocytes.

Molecular Interaction Atlas (MIA) of This DOT

4 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Autism DISV4V1Z Strong Genetic Variation [1]
Female hypogonadism DISWASB4 Strong Genetic Variation [2]
Familial male-limited precocious puberty DISNNKVB Limited Biomarker [3]
Premature ovarian failure 5 DISCIA0C Limited Autosomal dominant [4]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Homeobox protein NOBOX (NOBOX). [5]
Arsenic DMTL2Y1 Approved Arsenic affects the methylation of Homeobox protein NOBOX (NOBOX). [6]
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References

1 A 12Mb deletion at 7q33-q35 associated with autism spectrum disorders and primary amenorrhea.Eur J Med Genet. 2008 Nov-Dec;51(6):631-8. doi: 10.1016/j.ejmg.2008.06.010. Epub 2008 Jul 16.
2 A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency.Hum Reprod. 2017 Jan;32(1):248-255. doi: 10.1093/humrep/dew271. Epub 2016 Nov 11.
3 Clinical, biological and genetic analysis of prepubertal isolated ovarian cyst in 11 girls.PLoS One. 2010 Jun 25;5(6):e11282. doi: 10.1371/journal.pone.0011282.
4 NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9. doi: 10.1126/science.1099755.
5 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
6 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.