Details of Disease

General Information of Disease (ID: DISWASB4)

Disease Name	Female hypogonadism
Synonyms	hypergonadotrophic ovarian failure; hypergonadotropic hypogonadism; premature ovarian failure; primary female hypogonadism; premature ovarian insufficiency; hypergonadotropic hypogonadism (female); female hypergonadotropic hypogonadism; premature menopause; primary ovarian insufficiency; primary ovarian failure
Disease Class	GA30: Menopausal disorder
Definition	Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Disease Hierarchy	DIST09IB: Ovarian dysfunction DISWASB4: Female hypogonadism
ICD Code	ICD-11 ICD-11: GA30.6 ICD-10 ICD-10: E28.3 Expand ICD-9 253256
Disease Identifiers	MONDO ID MONDO_0005387 MESH ID D016649 UMLS CUI C0085215 MedGen ID 38820 HPO ID HP:0000134 Orphanet ID 619 SNOMED CT ID 237788002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ethinyl Estradiol	DMODJ40	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 22 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CYP2C19	TTZ58XG	Limited	Genetic Variation	[2]
ESRRG	TT9ZRHB	Limited	Biomarker	[3]
HTR4	TT07C3Y	Limited	Biomarker	[4]
ACVR2B	TTLFRKS	moderate	Genetic Variation	[5]
AGTR2	TTQVOEI	moderate	Genetic Variation	[6]
BMPR2	TTGKF90	moderate	Genetic Variation	[7]
FANCA	TTV5HJS	moderate	Genetic Variation	[8]
FSHB	TT13GFV	moderate	Genetic Variation	[9]
GADD45B	TTMDW9L	moderate	Altered Expression	[10]
GJA4	TTQO1VY	moderate	Genetic Variation	[11]
GPR3	TTHZVSK	moderate	Genetic Variation	[12]
HAX1	TT21BYA	moderate	Genetic Variation	[13]
HSD17B4	TTL1WGS	moderate	Genetic Variation	[14]
ID2	TTW8A5N	moderate	Genetic Variation	[15]
SENP1	TTW9HY5	moderate	Genetic Variation	[16]
TRIM37	TTAMCSL	moderate	Biomarker	[17]
CYP19A1	TTSZLWK	Strong	Biomarker	[18]
FANCF	TTNZKFJ	Strong	Biomarker	[19]
NFE2L2	TTA6ZN2	Strong	Biomarker	[20]
PGRMC1	TTY3LAZ	Strong	Biomarker	[21]
WT1	TTZ8UT4	Strong	Biomarker	[22]
XPNPEP2	TTI9MBZ	Strong	Biomarker	[23]
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⏷ Show the Full List of 22 DTT(s)

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYB5A	DE9A2LB	moderate	Genetic Variation	[24]
CYP7A1	DEDZRQ1	moderate	Genetic Variation	[24]
PMM2	DEBRX3L	moderate	Genetic Variation	[25]
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This Disease Is Related to 94 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABRAXAS1	OT1K4J80	Limited	Genetic Variation	[26]
AFM	OTPOR8IO	Limited	Altered Expression	[27]
ATG9A	OTAZWZH7	Limited	Genetic Variation	[28]
BMPR1B	OTGFN0OD	Limited	Biomarker	[29]
CBX2	OTOQ5WS4	Limited	Biomarker	[30]
DDT	OTF5HTYL	Limited	Biomarker	[31]
DKKL1	OTWS7DED	Limited	Altered Expression	[27]
HARS2	OTC8X3H9	Limited	Genetic Variation	[32]
MAP3K15	OT1E21HI	Limited	Biomarker	[30]
MEIOB	OTTX5TF0	Limited	Genetic Variation	[33]
NPAS4	OTA3HH6W	Limited	Genetic Variation	[34]
RPA1	OT76POLP	Limited	Genetic Variation	[33]
RPL10	OTBHOZGC	Limited	Biomarker	[35]
SPATA22	OTBU7CWP	Limited	Genetic Variation	[33]
SSB	OTCCTPBR	Limited	Biomarker	[33]
TGFBR3	OTQOOUC4	Limited	Genetic Variation	[36]
TLK1	OTICTXI8	Limited	Biomarker	[37]
TMEM150B	OTFTD4WV	Limited	Genetic Variation	[38]
AARS2	OTOB0KSG	moderate	Genetic Variation	[39]
ACSL6	OT0TT8P8	moderate	Genetic Variation	[40]
ACTA1	OTOVGLPG	moderate	Genetic Variation	[12]
ADAMTS16	OTTKUH99	moderate	Genetic Variation	[41]
AFF2	OTMF1PZW	moderate	Biomarker	[42]
ATP6	OTPHOGLX	moderate	Genetic Variation	[43]
BBS9	OT23V9YF	moderate	Biomarker	[44]
BCKDHB	OT8OSVYU	moderate	Genetic Variation	[45]
CITED2	OT812TV7	moderate	Genetic Variation	[46]
CLDN2	OTRF3D6Y	moderate	Altered Expression	[47]
CPEB1	OTLCXC6H	moderate	Biomarker	[48]
DAZL	OTZMTD4R	moderate	Altered Expression	[49]
DLX5	OTEEFBEU	moderate	Biomarker	[50]
DLX6	OT0FIJHY	moderate	Biomarker	[50]
DMC1	OT1FHMW4	moderate	Genetic Variation	[51]
DNAH6	OTUZNWKV	moderate	Genetic Variation	[52]
DROSHA	OTCE68KZ	moderate	Genetic Variation	[12]
EIF2B1	OT4NCVY1	moderate	Biomarker	[53]
EIF2B2	OTQQMHM1	moderate	Biomarker	[53]
EIF2B4	OTTM5SX1	moderate	Biomarker	[53]
EIF2S2	OTXF0B09	moderate	Biomarker	[53]
EIF4ENIF1	OTZWDB2X	moderate	Genetic Variation	[54]
FANCM	OTNJG99Z	moderate	Genetic Variation	[55]
FIGLA	OTARXZN8	moderate	Biomarker	[56]
FOXE1	OT5IR5IT	moderate	Genetic Variation	[57]
FOXO4	OT90X9LN	moderate	Genetic Variation	[58]
HACD1	OTEC7EP7	moderate	Altered Expression	[59]
HDX	OTXD5MU6	moderate	Posttranslational Modification	[60]
INSL3	OT7KUNTE	moderate	Biomarker	[61]
LAMC1	OTIG527N	moderate	Biomarker	[62]
LHB	OT5GBOVJ	moderate	Genetic Variation	[63]
LHX8	OT0DFL7C	moderate	Genetic Variation	[64]
MCM9	OTALGFW8	moderate	Genetic Variation	[65]
MSH5	OTDARQT3	moderate	Genetic Variation	[66]
NOG	OTGRHHPG	moderate	Altered Expression	[67]
OXA1L	OTS0BFRD	moderate	Genetic Variation	[68]
PACC1	OTKBS8CC	moderate	Biomarker	[69]
PCDH11X	OTLICG18	moderate	Genetic Variation	[70]
PCMT1	OTGYVSGU	moderate	Genetic Variation	[71]
POU5F1	OTDHHN7O	moderate	Altered Expression	[72]
PRIM1	OTWWP8Y6	moderate	Genetic Variation	[73]
PSMC3IP	OT9UB5UO	moderate	Genetic Variation	[74]
RPS26	OTBYTA6A	moderate	Biomarker	[75]
RSPO2	OT3HHXU0	moderate	Altered Expression	[76]
SALL4	OTC08PR5	moderate	Genetic Variation	[77]
SEMA6C	OT1N59T5	moderate	Biomarker	[78]
SETX	OTG3JNOQ	moderate	Biomarker	[79]
SH2B2	OTEDHHDH	moderate	Genetic Variation	[80]
SOHLH2	OTB9EM6C	moderate	Biomarker	[81]
SPO11	OTP49B2R	moderate	Genetic Variation	[82]
SYCE1	OTTOIXW8	moderate	Biomarker	[83]
TBPL2	OTDEC1KO	moderate	Biomarker	[84]
TCFL5	OTJL4348	moderate	Genetic Variation	[85]
TGIF2LX	OTLBWKZA	moderate	Biomarker	[70]
TSHB	OTFDI39D	moderate	Genetic Variation	[41]
ADAMTS19	OTEG5Q2G	Strong	Biomarker	[86]
AIRE	OTA7G1Y1	Strong	Genetic Variation	[87]
BMP15	OT2G3YR1	Strong	Biomarker	[21]
BNC1	OTGJ5WUF	Strong	Genetic Variation	[88]
DIAPH2	OTBEYFEZ	Strong	Biomarker	[89]
HFM1	OTHV3EFE	Strong	Genetic Variation	[90]
INHBB	OT2QLD11	Strong	Biomarker	[91]
MCM8	OTC93H3S	Strong	Genetic Variation	[89]
MEGF8	OT5G38CH	Strong	Biomarker	[92]
MSC	OTBRPZL5	Strong	Biomarker	[93]
MSH4	OTJZMG1Z	Strong	Genetic Variation	[94]
NLRP5	OTLU1YML	Strong	Biomarker	[87]
NOBOX	OT0YFYPZ	Strong	Genetic Variation	[95]
NR5A1	OTOULYR4	Strong	Biomarker	[96]
NUDT11	OTFDXJA1	Strong	Genetic Variation	[87]
POLR3H	OT7GM7MX	Strong	Genetic Variation	[97]
STAG3	OTEV0AOD	Strong	Biomarker	[98]
AGFG2	OTXQZHCR	Definitive	Biomarker	[99]
NUP107	OTG4RDYS	Definitive	Biomarker	[99]
OSR2	OTYG371T	Definitive	Genetic Variation	[100]
RGPD2	OTMUZ0HX	Definitive	Biomarker	[99]
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⏷ Show the Full List of 94 DOT(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7071).
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6	Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome.Mol Cell Endocrinol. 1997 Mar 28;127(2):221-8. doi: 10.1016/s0303-7207(97)04011-2.
7	A potential functional association between mutant BMPR2 and primary ovarian insufficiency.Syst Biol Reprod Med. 2017 Jun;63(3):145-149. doi: 10.1080/19396368.2017.1291767. Epub 2017 Mar 17.
8	Rare variants in FANCA induce premature ovarian insufficiency.Hum Genet. 2019 Dec;138(11-12):1227-1236. doi: 10.1007/s00439-019-02059-9. Epub 2019 Sep 18.
9	Follicle-stimulating hormone beta gene structure in premature ovarian failure.Fertil Steril. 1993 Nov;60(5):852-7. doi: 10.1016/s0015-0282(16)56286-4.
10	Menstrual blood derived mesenchymal stem cells combined with Bushen Tiaochong recipe improved chemotherapy-induced premature ovarian failure in mice by inhibiting GADD45b expression in the cell cycle pathway.Reprod Biol Endocrinol. 2019 Jul 16;17(1):56. doi: 10.1186/s12958-019-0499-2.
11	A common African variant of human connexin37 is associated with Caucasian primary ovarian insufficiency and has a deleterious effect invitro.Int J Mol Med. 2018 Feb;41(2):640-648. doi: 10.3892/ijmm.2017.3257. Epub 2017 Nov 16.
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14	Epistasis between the HSD17B4 and TG polymorphisms is associated with premature ovarian failure.Fertil Steril. 2012 Apr;97(4):968-73. doi: 10.1016/j.fertnstert.2011.12.044. Epub 2012 Jan 20.
15	Association between polymorphisms in renin-angiotensin system genes and primary ovarian insufficiency in Korean women.Menopause. 2013 May;20(5):561-7. doi: 10.1097/GME.0b013e3182733921.
16	Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression.Cell Biosci. 2017 Jul 25;7:36. doi: 10.1186/s13578-017-0163-5. eCollection 2017.
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18	Cytotoxicity and DNA Damage Caused from Diazinon Exposure by Inhibiting the PI3K-AKT Pathway in Porcine Ovarian Granulosa Cells.J Agric Food Chem. 2019 Jan 9;67(1):19-31. doi: 10.1021/acs.jafc.8b05194. Epub 2018 Dec 21.
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20	Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice.Reprod Toxicol. 2015 Dec;58:24-32. doi: 10.1016/j.reprotox.2015.07.080. Epub 2015 Aug 3.
21	The role of BMP15 and GDF9 in the pathogenesis of primary ovarian insufficiency.Hum Fertil (Camb). 2021 Dec;24(5):325-332. doi: 10.1080/14647273.2019.1672107. Epub 2019 Oct 14.
22	Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.Sci Rep. 2015 Sep 11;5:13983. doi: 10.1038/srep13983.
23	Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats.Biol Reprod. 2015 Mar;92(3):67. doi: 10.1095/biolreprod.114.125708. Epub 2015 Jan 7.
24	Alterations in the expression, structure and function of progesterone receptor membrane component-1 (PGRMC1) in premature ovarian failure.Hum Mol Genet. 2008 Dec 1;17(23):3776-83. doi: 10.1093/hmg/ddn274. Epub 2008 Sep 9.
25	Genetic disorders in premature ovarian failure.Hum Reprod Update. 2002 Sep-Oct;8(5):483-91. doi: 10.1093/humupd/8.5.483.
26	Mutational analysis of theFAM175A gene in patients with premature ovarian insufficiency.Reprod Biomed Online. 2019 Jun;38(6):943-950. doi: 10.1016/j.rbmo.2019.02.006. Epub 2019 Feb 28.
27	Serum biomarker analysis in patients with premature ovarian insufficiency.Cytokine. 2020 Feb;126:154876. doi: 10.1016/j.cyto.2019.154876. Epub 2019 Oct 16.
28	ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.Genet Med. 2019 Apr;21(4):930-938. doi: 10.1038/s41436-018-0287-y. Epub 2018 Sep 19.
29	BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz226. doi: 10.1210/clinem/dgz226.
30	The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach.Sci Rep. 2019 Nov 19;9(1):17033. doi: 10.1038/s41598-019-53370-4.
31	Selected persistent organic pollutants associated with the risk of primary ovarian insufficiency in women.Environ Int. 2019 Aug;129:51-58. doi: 10.1016/j.envint.2019.05.023. Epub 2019 May 17.
32	A recurrent missense variant in HARS2 results in variable sensorineural hearing loss in three unrelated families.J Hum Genet. 2020 Mar;65(3):305-311. doi: 10.1038/s10038-019-0706-1. Epub 2019 Dec 12.
33	A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks.EBioMedicine. 2019 Apr;42:524-531. doi: 10.1016/j.ebiom.2019.03.075. Epub 2019 Apr 15.
34	De novo duplication of Xq22.1q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure.Taiwan J Obstet Gynecol. 2011 Sep;50(3):339-44. doi: 10.1016/j.tjog.2011.01.018.
35	Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer.J Cancer. 2018 Feb 6;9(4):745-756. doi: 10.7150/jca.21614. eCollection 2018.
36	Haplotype and mutation analysis of the TGFBR3 gene in Chinese women with idiopathic premature ovarian failure.Gynecol Endocrinol. 2012 Jan;28(1):63-7. doi: 10.3109/09513590.2011.583954. Epub 2011 Jul 14.
37	Variation analysis of tousled like kinase 1 gene in patients with sporadic premature ovarian insufficiency.Gynecol Endocrinol. 2020 Jan;36(1):33-35. doi: 10.1080/09513590.2019.1630606. Epub 2019 Jul 31.
38	Variation analysis of theTMEM150B gene in Chinese women with premature ovarian insufficiency.Reprod Biomed Online. 2019 Mar;38(3):407-412. doi: 10.1016/j.rbmo.2018.12.009. Epub 2018 Dec 21.
39	Novel alanyl-tRNA synthetase 2 (AARS2) homozygous mutation in a consanguineous Chinese family with premature ovarian insufficiency.Fertil Steril. 2019 Sep;112(3):569-576.e2. doi: 10.1016/j.fertnstert.2019.05.005. Epub 2019 Jul 4.
40	Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.Fertil Steril. 2009 Apr;91(4 Suppl):1339-43. doi: 10.1016/j.fertnstert.2008.03.035. Epub 2008 Jun 13.
41	Epistasis between polymorphisms in TSHB and ADAMTS16 is associated with premature ovarian failure.Menopause. 2014 Aug;21(8):890-5. doi: 10.1097/GME.0000000000000172.
42	Distribution of FMR1 and FMR2 Repeats in Argentinean Patients with Primary Ovarian Insufficiency.Genes (Basel). 2017 Aug 16;8(8):194. doi: 10.3390/genes8080194.
43	Oxidative stress and ATPase6 mutation is associated with primary ovarian insufficiency.Arch Gynecol Obstet. 2010 Sep;282(3):313-8. doi: 10.1007/s00404-010-1444-y. Epub 2010 Apr 2.
44	Parathyroid hormone-responsive B1 gene is associated with premature ovarian failure.Hum Reprod. 2008 Jun;23(6):1457-65. doi: 10.1093/humrep/den086. Epub 2008 Mar 18.
45	Branched chain alpha-keto acid dehydrogenase, E1-beta subunit gene is associated with premature ovarian failure.Fertil Steril. 2008 Mar;89(3):728-31. doi: 10.1016/j.fertnstert.2007.03.063. Epub 2007 May 24.
46	CITED2 mutations potentially cause idiopathic premature ovarian failure.Transl Res. 2012 Nov;160(5):384-8. doi: 10.1016/j.trsl.2012.05.006. Epub 2012 Jun 16.
47	Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus.J Neurogastroenterol Motil. 2018 Jan 30;24(1):147-158. doi: 10.5056/jnm17012.
48	Deletion of CPEB1 Gene: A Rare but Recurrent Cause of Premature Ovarian Insufficiency.J Clin Endocrinol Metab. 2016 May;101(5):2099-104. doi: 10.1210/jc.2016-1291. Epub 2016 Mar 22.
49	Premature ovarian failure (POF) syndrome: towards the molecular clinical analysis of its genetic complexity.Curr Med Chem. 2006;13(12):1397-410. doi: 10.2174/092986706776872943.
50	Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency.Hum Mol Genet. 2011 Jul 1;20(13):2642-50. doi: 10.1093/hmg/ddr166. Epub 2011 Apr 19.
51	DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing.J Med Genet. 2018 Mar;55(3):198-204. doi: 10.1136/jmedgenet-2017-104992. Epub 2018 Jan 13.
52	Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency (POI) by a customized high-resolution array comparative genomic hybridization platform.Hum Reprod. 2014 Aug;29(8):1818-27. doi: 10.1093/humrep/deu149. Epub 2014 Jun 17.
53	The latest on leukodystrophies.Curr Opin Neurol. 2004 Apr;17(2):187-92. doi: 10.1097/00019052-200404000-00017.
54	A novel EIF4ENIF1 mutation associated with a diminished ovarian reserve and premature ovarian insufficiency identified by whole-exome sequencing.J Ovarian Res. 2019 Dec 6;12(1):119. doi: 10.1186/s13048-019-0595-0.
55	A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.Elife. 2017 Dec 12;6:e30490. doi: 10.7554/eLife.30490.
56	Bi-allelic recessive loss-of-function mutations in FIGLA cause premature ovarian insufficiency with short stature.Clin Genet. 2019 Mar;95(3):409-414. doi: 10.1111/cge.13486. Epub 2018 Dec 18.
57	FOXE1 polyalanine tract length screening by MLPA in idiopathic premature ovarian failure.Reprod Biol Endocrinol. 2011 Dec 16;9:158. doi: 10.1186/1477-7827-9-158.
58	Screening for mutations of the FOXO4 gene in premature ovarian failure patients.Reprod Biomed Online. 2012 Mar;24(3):339-41. doi: 10.1016/j.rbmo.2011.11.017. Epub 2011 Dec 2.
59	Oxytalan-positive peripheral ossifying fibromas express runt-related transcription factor 2, bone morphogenetic protein-2, and cementum attachment protein. An immunohistochemical study.J Oral Pathol Med. 2015 Sep;44(8):628-33. doi: 10.1111/jop.12275. Epub 2014 Oct 30.
60	Disruption of HDX gene in premature ovarian failure.Syst Biol Reprod Med. 2013 Aug;59(4):218-22. doi: 10.3109/19396368.2013.769028. Epub 2013 Feb 26.
61	Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology.Hum Reprod Update. 2018 Nov 1;24(6):639-651. doi: 10.1093/humupd/dmy029.
62	LAMC1 gene is associated with premature ovarian failure.Maturitas. 2012 Apr;71(4):402-6. doi: 10.1016/j.maturitas.2012.01.011. Epub 2012 Feb 10.
63	Increased prevalence of luteinizing hormone beta-subunit variant in patients with premature ovarian failure.Fertil Steril. 1999 Jan;71(1):96-101. doi: 10.1016/s0015-0282(98)00409-9.
64	Analysis of LHX8 mutation in premature ovarian failure.Fertil Steril. 2008 Apr;89(4):1012-4. doi: 10.1016/j.fertnstert.2007.04.017. Epub 2007 Jul 10.
65	MCM8 and MCM9 Nucleotide Variants in Women With Primary Ovarian Insufficiency.J Clin Endocrinol Metab. 2017 Feb 1;102(2):576-582. doi: 10.1210/jc.2016-2565.
66	Mutations in MSH5 in primary ovarian insufficiency.Hum Mol Genet. 2017 Apr 15;26(8):1452-1457. doi: 10.1093/hmg/ddx044.
67	Premature ovarian failure in a female with proximal symphalangism and Noggin mutation.Fertil Steril. 2004 Apr;81(4):1137-9. doi: 10.1016/j.fertnstert.2003.08.054.
68	Contribution of domestic animals to the identification of new genes involved in sex determination.J Exp Zool. 2001 Dec 1;290(7):700-8. doi: 10.1002/jez.1120.
69	Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene.Cytogenet Cell Genet. 2000;89(1-2):44-50. doi: 10.1159/000015560.
70	Copy number variants on the X chromosome in women with primary ovarian insufficiency.Fertil Steril. 2011 Apr;95(5):1584-8.e1. doi: 10.1016/j.fertnstert.2011.01.018. Epub 2011 Feb 12.
71	Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure.Fertil Steril. 2009 Apr;91(4 Suppl):1362-5. doi: 10.1016/j.fertnstert.2008.03.078. Epub 2008 Jun 25.
72	Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness.Stem Cell Res Ther. 2019 Jul 5;10(1):198. doi: 10.1186/s13287-019-1299-5.
73	Variation analysis of PRIM1 gene in Chinese patients with primary ovarian insufficiency.Reprod Biomed Online. 2016 Nov;33(5):587-591. doi: 10.1016/j.rbmo.2016.08.017. Epub 2016 Aug 24.
74	Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation.J Clin Endocrinol Metab. 2018 Feb 1;103(2):555-563. doi: 10.1210/jc.2017-01966.
75	Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure.Cell Death Dis. 2018 Nov 19;9(12):1144. doi: 10.1038/s41419-018-1196-3.
76	R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.J Ovarian Res. 2017 Jul 25;10(1):51. doi: 10.1186/s13048-017-0345-0.
77	Whole-exome sequencing reveals SALL4 variants in premature ovarian insufficiency: an update on genotype-phenotype correlations.Hum Genet. 2019 Jan;138(1):83-92. doi: 10.1007/s00439-018-1962-4. Epub 2019 Jan 2.
78	Suppression of SEMA6C promotes preantral follicles atresia with decreased cell junctions in mice ovaries.J Cell Physiol. 2019 Apr;234(4):4934-4943. doi: 10.1002/jcp.27294. Epub 2018 Sep 6.
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