Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1VEDLV)

DOT Name Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
Synonyms EC 2.7.11.17; CaM kinase I gamma; CaM kinase IG; CaM-KI gamma; CaMKI gamma; CaMKIG; CaMK-like CREB kinase III; CLICK III
Gene Name CAMK1G
Related Disease
Amyotrophic lateral sclerosis-parkinsonism-dementia complex ( )
Acute myelogenous leukaemia ( )
Amyotrophic lateral sclerosis ( )
UniProt ID
KCC1G_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2JAM
EC Number
2.7.11.17
Pfam ID
PF00069
Sequence
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF
RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA
SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC
GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES
PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA
KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV
LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS
SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1.
Tissue Specificity Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system.
KEGG Pathway
Calcium sig.ling pathway (hsa04020 )
Oxytocin sig.ling pathway (hsa04921 )
Aldosterone synthesis and secretion (hsa04925 )
Glioma (hsa05214 )

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Amyotrophic lateral sclerosis-parkinsonism-dementia complex DISTHQI1 Strong Biomarker [1]
Acute myelogenous leukaemia DISCSPTN Limited Genetic Variation [2]
Amyotrophic lateral sclerosis DISF7HVM Limited Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G). [3]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G). [4]
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References

1 Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.Nat Genet. 2013 Jun;45(6):697-700. doi: 10.1038/ng.2627. Epub 2013 Apr 28.
2 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.Oncotarget. 2017 Jan 31;8(5):7891-7899. doi: 10.18632/oncotarget.13631.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.