Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT79E7DW)

• DOT Name: Epididymal sperm-binding protein 1 (ELSPBP1)
• Synonyms: Epididymal secretory protein 12; hE12
• Gene Name: ELSPBP1
• Related Disease:
  Neoplasm
  Acute lymphocytic leukaemia
  Chondrosarcoma
  Advanced cancer
• UniProt ID: ESPB1_HUMAN
• Pfam ID: PF00040
• Sequence:
  MTRWSSYLLGWTTFLLYSYESSGGMHEECVFPFTYKGSVYFTCTHIHSLSPWCATRAVYN
  GQWKYCQSEDYPRCIFPFIYRGKAYNSCISQGSFLGSLWCSVTSVFDEKQQWKFCETNEY
  GGNSLRKPCIFPSIYRNNVVSDCMEDESNKLWCPTTENMDKDGKWSFCADTRISALVPGF
  PCHFPFNYKNKNYFNCTNEGSKENLVWCATSYNYDQDHTWVYC
• Function: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity.
• Tissue Specificity: Detected in cauda epididymidal fluid and on sperm membrane (at protein level).

Molecular Interaction Atlas (MIA) of This DOT

4 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Neoplasm	DISZKGEW	Definitive	Altered Expression	[1]
Acute lymphocytic leukaemia	DISPX75S	Strong	Genetic Variation	[2]
Chondrosarcoma	DIS4I7JB	Strong	Biomarker	[3]
Advanced cancer	DISAT1Z9	Limited	Genetic Variation	[4]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Epididymal sperm-binding protein 1 (ELSPBP1).	[5]

References

• [1] CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia.Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16852-7. doi: 10.1073/pnas.1007896107. Epub 2010 Sep 14.
• [2] CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.Br J Haematol. 2012 Jan;156(1):89-98. doi: 10.1111/j.1365-2141.2011.08901.x. Epub 2011 Oct 21.
• [3] The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes.FEBS Lett. 1998 Oct 30;438(1-2):85-90. doi: 10.1016/s0014-5793(98)01268-x.
• [4] CD22E12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule.Integr Biol (Camb). 2015 Feb;7(2):237-49. doi: 10.1039/c4ib00221k.
• [5] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.