Details of Disease

General Information of Disease (ID: DIS4I7JB)

Disease Name	Chondrosarcoma
Synonyms	primary chondrosarcoma of the bone; chondrosarcoma of bone; chondrosarcoma, malignant; chondrosarcoma, somatic mutation; chondrosarcoma; chondrosarcoma (disease)
Disease Class	2B50: Chondrosarcoma
Definition	A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.
Disease Hierarchy	DISZDG3U: Sarcoma DIS5D0E2: Connective tissue neoplasm DIS8I9FS: Hereditary disorder of connective tissue DIS4I7JB: Chondrosarcoma
ICD Code	ICD-11 ICD-11: 2B50 ICD-9 ICD-9: 170.9 Expand ICD-11 'XH8J23 Expand ICD-9 170.9
Disease Identifiers	MONDO ID MONDO_0008977 MESH ID D002813 UMLS CUI C0008479 OMIM ID 215300 MedGen ID 3054 HPO ID HP:0006765 Orphanet ID 55880 SNOMED CT ID 1163016002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Patidegib	DM2NJYC	Phase 2	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 35 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IDH1	TTV2A1R	Limited	Biomarker	[2]
NR4A3	TTJQB49	Limited	Biomarker	[3]
TEC	TT1ZV49	moderate	Biomarker	[4]
ADAM8	TTQWYMD	Strong	Biomarker	[5]
ADAMTS4	TTYG6BU	Strong	Biomarker	[6]
AHCY	TTE2KUJ	Strong	Biomarker	[7]
AREG	TT76B3W	Strong	Altered Expression	[8]
CCNA2	TTAMQ62	Strong	Altered Expression	[9]
CLCN3	TT8XNZ7	Strong	Altered Expression	[10]
CSPG4	TT7MYXI	Strong	Biomarker	[6]
CTSK	TTDZN01	Strong	Biomarker	[11]
DCPS	TTLSW9V	Strong	Biomarker	[12]
DRD3	TT4C8EA	Strong	Altered Expression	[13]
FGFR3	TTST7KB	Strong	Genetic Variation	[14]
HDAC7	TTMUEK1	Strong	Altered Expression	[15]
HDC	TTV9GOF	Strong	Altered Expression	[16]
INHBA	TTVB30D	Strong	Biomarker	[17]
MAGEA4	TT9EQUY	Strong	Biomarker	[18]
MMP1	TTMX39J	Strong	Biomarker	[19]
MMP13	TTHY57M	Strong	Altered Expression	[19]
MMP3	TTUZ2L5	Strong	Altered Expression	[19]
MTOR	TTCJG29	Strong	Biomarker	[20]
NAPRT	TTVR1FW	Strong	Altered Expression	[21]
PRNP	TTY5F9C	Strong	Biomarker	[22]
PTGER1	TTG1QMU	Strong	Altered Expression	[23]
PTH1R	TTFPD47	Strong	Biomarker	[24]
RARG	TT1Q3IE	Strong	Altered Expression	[25]
RUNX2	TTD6SZ8	Strong	Altered Expression	[26]
TLR6	TTWRI8V	Strong	Biomarker	[27]
TNC	TTUCPMY	Strong	Biomarker	[28]
UCP3	TT12RJK	Strong	Altered Expression	[29]
ACVR2A	TTX2DRI	Definitive	Genetic Variation	[30]
ITGAV	TTT1R2L	Definitive	Altered Expression	[31]
MMP12	TTXZ0KQ	Definitive	Biomarker	[32]
TNFRSF11A	TT3K9S2	Definitive	Biomarker	[33]
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⏷ Show the Full List of 35 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCB6	DTF9Y2V	Strong	Biomarker	[22]
SLC25A16	DTNU9EW	Strong	Biomarker	[34]
SLC2A10	DT3BI6S	Strong	Altered Expression	[35]
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This Disease Is Related to 65 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FERMT2	OTZNPWWX	Limited	Altered Expression	[36]
IDH2	OTTQA4PB	Limited	Genetic Variation	[37]
ITM2B	OTMXEPXB	Limited	Genetic Variation	[38]
CCN6	OTRFHQ2Z	moderate	Biomarker	[39]
EXT2	OT8IR5QN	moderate	Genetic Variation	[40]
HBP1	OTDPGGDV	moderate	Genetic Variation	[41]
PDCD5	OT6T2DDL	moderate	Altered Expression	[42]
ACAN	OTUOCW8K	Strong	Biomarker	[43]
ADAM15	OTZ7VLTP	Strong	Altered Expression	[44]
ADAMTS2	OTTK22NO	Strong	Biomarker	[45]
ADAMTS3	OT2U6VF5	Strong	Biomarker	[45]
ADAMTSL1	OTBNYF3F	Strong	Altered Expression	[46]
ALX1	OTZVARA5	Strong	Biomarker	[47]
ATG12	OTJRO09Y	Strong	Biomarker	[48]
C4BPA	OTHNH6Y8	Strong	Biomarker	[22]
CA11	OT8RX3AJ	Strong	Genetic Variation	[49]
CARD14	OTADQHOV	Strong	Biomarker	[22]
CDS1	OT2F591M	Strong	Biomarker	[50]
COL2A1	OT5E59C8	Strong	Biomarker	[51]
COL4A5	OTHG60RE	Strong	Altered Expression	[35]
CREBRF	OT2GK1HI	Strong	Biomarker	[52]
CSAG1	OT7LTW6K	Strong	Altered Expression	[53]
CYCS	OTBFALJD	Strong	Biomarker	[54]
DISC1	OT43AW4H	Strong	Altered Expression	[13]
EDIL3	OTDVVNS0	Strong	Genetic Variation	[55]
EFNA5	OTOH4DRR	Strong	Altered Expression	[56]
ELSPBP1	OT79E7DW	Strong	Biomarker	[57]
EWSR1	OT7SRHV3	Strong	Biomarker	[58]
EXT1	OTRPALJK	Strong	Autosomal dominant	[59]
GFM1	OTUN4V3N	Strong	Altered Expression	[60]
HLCS	OTPDUX30	Strong	Biomarker	[54]
HS3ST1	OT5DVN9P	Strong	Posttranslational Modification	[61]
IFI16	OT4SPU0U	Strong	Biomarker	[62]
IFT88	OTDR3VBD	Strong	Biomarker	[63]
IHH	OT1DWGXC	Strong	Altered Expression	[64]
INSM1	OTG8RV8E	Strong	Biomarker	[65]
LBH	OT87AT1X	Strong	Biomarker	[66]
LRCH1	OT0RCL85	Strong	Altered Expression	[67]
MATN3	OTH9H74J	Strong	Biomarker	[68]
MID1	OTWN1PGU	Strong	Biomarker	[69]
MMP28	OTHQZXM1	Strong	Altered Expression	[70]
MYOG	OTPLJKFA	Strong	Biomarker	[71]
NCOA2	OTMQFPBB	Strong	Biomarker	[72]
PLAGL1	OTZAO900	Strong	Altered Expression	[73]
PPFIBP1	OTRA2S7B	Strong	Biomarker	[74]
PPP1R11	OTSHYPPW	Strong	Altered Expression	[7]
PRDX2	OTLWCY9T	Strong	Biomarker	[22]
PTHLH	OTI1JF13	Strong	Altered Expression	[75]
RAB11FIP3	OTDFFCZA	Strong	Biomarker	[47]
SFTPC	OTIZJD09	Strong	Genetic Variation	[38]
SH2B2	OTEDHHDH	Strong	Altered Expression	[35]
SOX9	OTVDJFGN	Strong	Altered Expression	[76]
SRGAP2	OTUWFMCQ	Strong	Altered Expression	[77]
TAF15	OTNE038N	Strong	Biomarker	[3]
TOB1	OTNW949D	Strong	Altered Expression	[78]
TRAF4	OTJLRVMC	Strong	Biomarker	[47]
ADAMTS16	OTTKUH99	Definitive	Altered Expression	[79]
CHN1	OTM196M3	Definitive	Genetic Variation	[80]
COMP	OTS2FPMI	Definitive	Altered Expression	[81]
ETV5	OTE2OBM4	Definitive	Biomarker	[82]
OSCP1	OTZ4IFGJ	Definitive	Biomarker	[83]
PEG10	OTWD2278	Definitive	Biomarker	[84]
RRAD	OTW2O4GD	Definitive	Altered Expression	[85]
SIX3	OTP5E3VU	Definitive	Biomarker	[83]
TFG	OT2KJENI	Definitive	Biomarker	[4]
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⏷ Show the Full List of 65 DOT(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8198).
2	Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.Clin Cancer Res. 2020 Jan 15;26(2):419-427. doi: 10.1158/1078-0432.CCR-18-4212. Epub 2019 Oct 15.
3	NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas.J Pathol. 2019 Sep;249(1):90-101. doi: 10.1002/path.5284. Epub 2019 May 14.
4	The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.Carcinogenesis. 2012 Aug;33(8):1450-8. doi: 10.1093/carcin/bgs164. Epub 2012 May 11.
5	ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-B/MMP-13 signaling axis.Anticancer Drugs. 2019 Aug;30(7):e0790. doi: 10.1097/CAD.0000000000000790.
6	Functional roles of CSPG4/NG2 in chondrosarcoma.Int J Exp Pathol. 2016 Apr;97(2):178-86. doi: 10.1111/iep.12189. Epub 2016 Jun 12.
7	The Antitumoral Effect of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaneplanocin A, is Independent of EZH2 but is Correlated with EGFR Downregulation in Chondrosarcomas.Cell Physiol Biochem. 2019;53(4):731-745. doi: 10.33594/000000168.
8	Amphiregulin Promotes Vascular Endothelial Growth Factor-C Expression and Lymphangiogenesis through STAT3 Activation in Human Chondrosarcoma Cells.Cell Physiol Biochem. 2019;52(1):1-15. doi: 10.33594/000000001. Epub 2019 Feb 18.
9	The cyclin D1 and cyclin A genes are targets of activated PTH/PTHrP receptors in Jansen's metaphyseal chondrodysplasia.Mol Endocrinol. 2002 Sep;16(9):2163-73. doi: 10.1210/me.2001-0103.
10	Overexpression of ClC-3 Chloride Channel in Chondrosarcoma: An In Vivo Immunohistochemical Study with Tissue Microarray.Med Sci Monit. 2019 Jul 8;25:5044-5053. doi: 10.12659/MSM.917382.
11	Cysteine proteinases in chondrosarcomas.Matrix Biol. 2001 Jan;19(8):717-25. doi: 10.1016/s0945-053x(00)00124-4.
12	Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, NCC-dCS1-C1.Hum Cell. 2019 Apr;32(2):202-213. doi: 10.1007/s13577-018-00232-2. Epub 2019 Feb 8.
13	Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma.Front Mol Biosci. 2019 Nov 26;6:134. doi: 10.3389/fmolb.2019.00134. eCollection 2019.
14	Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia.PLoS One. 2013 Dec 4;8(12):e81569. doi: 10.1371/journal.pone.0081569. eCollection 2013.
15	Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.Mod Rheumatol. 2010 Feb;20(1):11-7. doi: 10.1007/s10165-009-0224-7. Epub 2009 Sep 26.
16	Usefulness of cytofluorometric DNA ploidy analysis in distinguishing benign cartilaginous tumors from chondrosarcomas.Mod Pathol. 1999 Sep;12(9):863-72.
17	Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.Rheumatol Int. 2007 Sep;27(11):1049-55. doi: 10.1007/s00296-007-0350-5. Epub 2007 Apr 14.
18	MAGEA4 expression in bone and soft tissue tumors: its utility as a target for immunotherapy and diagnostic marker combined with NY-ESO-1.Virchows Arch. 2017 Sep;471(3):383-392. doi: 10.1007/s00428-017-2206-z. Epub 2017 Jul 26.
19	Expression of MMP-9 decreases metastatic potential of Chondrosarcoma: an immunohistochemical study.BMC Musculoskelet Disord. 2018 Jan 9;19(1):9. doi: 10.1186/s12891-017-1920-7.
20	Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27.Acta Histochem. 2018 Feb;120(2):142-150. doi: 10.1016/j.acthis.2018.01.002. Epub 2018 Feb 3.
21	NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.Mol Cancer Res. 2017 Dec;15(12):1714-1721. doi: 10.1158/1541-7786.MCR-17-0293. Epub 2017 Aug 31.
22	PRP? significantly decreases the ALDHhigh cancer stem cell population and regulates the aberrant Wnt/catenin pathway in human chondrosarcoma JJ012cells.Oncol Rep. 2019 Jul;42(1):103-114. doi: 10.3892/or.2019.7172. Epub 2019 May 24.
23	Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells.Mol Cancer. 2010 Feb 23;9:43. doi: 10.1186/1476-4598-9-43.
24	Enchondromatosis (Ollier disease, Maffucci syndrome) is not caused by the PTHR1 mutation p.R150C.Hum Mutat. 2004 Dec;24(6):466-73. doi: 10.1002/humu.20095.
25	Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS-2/8 Chondrosarcoma Cells.J Orthop Res. 2020 May;38(5):1045-1051. doi: 10.1002/jor.24555. Epub 2019 Dec 19.
26	BAG3 promotes chondrosarcoma progression by upregulating the expression of -catenin.Mol Med Rep. 2018 Apr;17(4):5754-5763. doi: 10.3892/mmr.2018.8611. Epub 2018 Feb 15.
27	Toll like receptors TLR1/2, TLR6 and MUC5B as binding interaction partners with cytostatic proline rich polypeptide 1 in human chondrosarcoma.Int J Oncol. 2018 Jan;52(1):139-154. doi: 10.3892/ijo.2017.4199. Epub 2017 Nov 9.
28	Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell.Cancer Lett. 2005 Nov 8;229(1):101-5. doi: 10.1016/j.canlet.2004.12.012. Epub 2005 Jan 18.
29	GH directly stimulates UCP3 expression.Growth Horm IGF Res. 2018 Jun;40:44-54. doi: 10.1016/j.ghir.2018.01.002. Epub 2018 Jan 31.
30	Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement.Mod Pathol. 2019 Dec;32(12):1762-1771. doi: 10.1038/s41379-019-0315-8. Epub 2019 Jul 4.
31	Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells.J Cell Physiol. 2009 Feb;218(2):334-42. doi: 10.1002/jcp.21601.
32	Herpes simplex virus: discovering the link between heparan sulphate and hereditary bone tumours.Rev Med Virol. 2000 Nov-Dec;10(6):373-84. doi: 10.1002/1099-1654(200011/12)10:6<373::aid-rmv291>3.0.co;2-n.
33	Effects of icariin on the regulation of the OPG-RANKL-RANK system are mediated through the MAPK pathways in IL-1-stimulated human SW1353 chondrosarcoma cells.Int J Mol Med. 2014 Dec;34(6):1720-6. doi: 10.3892/ijmm.2014.1952. Epub 2014 Sep 30.
34	GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study.Ann Oncol. 2013 Nov;24(11):2922-6. doi: 10.1093/annonc/mdt391.
35	Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.Osteoarthritis Cartilage. 2003 Jul;11(7):524-37. doi: 10.1016/s1063-4584(03)00079-7.
36	Prognostic value of Kindlin-2 expression in patients with solid tumors: a meta-analysis.Cancer Cell Int. 2018 Oct 22;18:166. doi: 10.1186/s12935-018-0651-7. eCollection 2018.
37	IDH mutation status in a series of 88 head and neck chondrosarcomas: different profile between tumors of the skull base and tumors involving the facial skeleton and the laryngotracheal tract.Hum Pathol. 2019 Feb;84:183-191. doi: 10.1016/j.humpath.2018.09.015. Epub 2018 Oct 5.
38	BRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?.FEBS J. 2011 Oct;278(20):3893-904. doi: 10.1111/j.1742-4658.2011.08209.x. Epub 2011 Jul 5.
39	CCN6-mediated MMP-9 activation enhances metastatic potential of human chondrosarcoma.Cell Death Dis. 2018 Sep 20;9(10):955. doi: 10.1038/s41419-018-1008-9.
40	Familial solitary chondrosarcoma resulting from germline EXT2 mutation. Genes Chromosomes Cancer. 2017 Feb;56(2):128-134. doi: 10.1002/gcc.22419. Epub 2016 Oct 25.
41	Functional testing of thousands of osteoarthritis-associated variants for regulatory activity.Nat Commun. 2019 Jun 4;10(1):2434. doi: 10.1038/s41467-019-10439-y.
42	Diagnostic investigations of DKK-1 and PDCD5 expression levels as independent prognostic markers of human chondrosarcoma.IUBMB Life. 2016 Jul;68(7):597-601. doi: 10.1002/iub.1519. Epub 2016 Jun 3.
43	Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma.Eur J Med Chem. 2018 Oct 5;158:51-67. doi: 10.1016/j.ejmech.2018.08.060. Epub 2018 Aug 23.
44	Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage.Arthritis Rheum. 1999 Sep;42(9):1946-50. doi: 10.1002/1529-0131(199909)42:9<1946::AID-ANR21>3.0.CO;2-E.
45	Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis.J Biol Chem. 2001 Aug 24;276(34):31502-9. doi: 10.1074/jbc.M103466200. Epub 2001 Jun 14.
46	Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.Mol Cancer Ther. 2014 May;13(5):1259-69. doi: 10.1158/1535-7163.MCT-13-0731. Epub 2014 Mar 14.
47	Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA.DNA Cell Biol. 1996 Jul;15(7):531-41. doi: 10.1089/dna.1996.15.531.
48	Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth.Cell Death Dis. 2017 Feb 9;8(2):e2605. doi: 10.1038/cddis.2017.31.
49	BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer.Trends Biochem Sci. 2002 Jul;27(7):329-32. doi: 10.1016/s0968-0004(02)02134-5.
50	New Chondrosarcoma Cell Lines with Preserved Stem Cell Properties to Study the Genomic Drift During In Vitro/In Vivo Growth.J Clin Med. 2019 Apr 4;8(4):455. doi: 10.3390/jcm8040455.
51	Association between Kniest dysplasia and chondrosarcoma in a child.Am J Med Genet A. 2015 Dec;167A(12):3204-8. doi: 10.1002/ajmg.a.37361. Epub 2015 Sep 8.
52	The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance.Carcinogenesis. 2012 Nov;33(11):2076-83. doi: 10.1093/carcin/bgs254. Epub 2012 Jul 30.
53	Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma.Gene. 2002 Feb 20;285(1-2):269-78. doi: 10.1016/s0378-1119(02)00395-5.
54	Effects of long-term low oxygen tension in human chondrosarcoma cells.J Cell Biochem. 2018 Feb;119(2):2320-2332. doi: 10.1002/jcb.26394. Epub 2017 Oct 18.
55	Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease.Cancer Genet Cytogenet. 1998 Sep;105(2):128-33. doi: 10.1016/s0165-4608(98)00027-2.
56	Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma.Hum Pathol. 2009 Dec;40(12):1679-85. doi: 10.1016/j.humpath.2009.03.024. Epub 2009 Aug 19.
57	The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes.FEBS Lett. 1998 Oct 30;438(1-2):85-90. doi: 10.1016/s0014-5793(98)01268-x.
58	Correlation of Classic and Molecular Cytogenetic Alterations in Soft-Tissue Sarcomas: Analysis of 46 Tumors With Emphasis on Adipocytic Tumors and Synovial Sarcoma.Appl Immunohistochem Mol Morphol. 2017 Mar;25(3):168-177. doi: 10.1097/PAI.0000000000000294.
59	Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma. Nat Genet. 2013 Aug;45(8):923-6. doi: 10.1038/ng.2668. Epub 2013 Jun 16.
60	Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells.Anticancer Res. 2002 Nov-Dec;22(6C):4169-72.
61	Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.FASEB J. 2010 Feb;24(2):436-50. doi: 10.1096/fj.09-136291. Epub 2009 Oct 7.
62	IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells.Front Biosci. 2007 Sep 1;12:4855-63. doi: 10.2741/2433.
63	HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia.Oncol Rep. 2017 Jul;38(1):229-236. doi: 10.3892/or.2017.5694. Epub 2017 Jun 2.
64	Differential expression of runx2 and Indian hedgehog in cartilaginous tumors.Pathol Oncol Res. 2007;13(1):32-7. doi: 10.1007/BF02893438. Epub 2007 Mar 27.
65	INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma.Mod Pathol. 2018 May;31(5):744-752. doi: 10.1038/modpathol.2017.189. Epub 2018 Jan 12.
66	Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines.Oncotarget. 2017 Aug 24;8(44):77254-77267. doi: 10.18632/oncotarget.20460. eCollection 2017 Sep 29.
67	Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling.Arthritis Rheum. 2006 Feb;54(2):524-32. doi: 10.1002/art.21624.
68	Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.Arthritis Rheum. 2008 Sep;58(9):2798-808. doi: 10.1002/art.23761.
69	Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies.Am J Pathol. 2019 Jan;189(1):132-146. doi: 10.1016/j.ajpath.2018.09.008.
70	Expression and function of matrix metalloproteinase (MMP)-28.Matrix Biol. 2009 Jun;28(5):263-72. doi: 10.1016/j.matbio.2009.04.006. Epub 2009 Apr 16.
71	Mutational and Immunophenotypic Profiling of a Series of 8 Tubo-ovarian Carcinosarcomas Revealed a Monoclonal Origin of the Disease.Int J Gynecol Pathol. 2020 Jul;39(4):305-312. doi: 10.1097/PGP.0000000000000645.
72	Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.Genes Chromosomes Cancer. 2012 Feb;51(2):127-39. doi: 10.1002/gcc.20937. Epub 2011 Oct 27.
73	The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors.Cancer Lett. 2005 Sep 28;227(2):185-91. doi: 10.1016/j.canlet.2004.12.007. Epub 2005 Jan 8.
74	Array-comparative genomic hybridization of central chondrosarcoma: identification of ribosomal protein S6 and cyclin-dependent kinase 4 as candidate target genes for genomic aberrations.Cancer. 2006 Jul 15;107(2):380-8. doi: 10.1002/cncr.22001.
75	Evaluating the role of PTH in promotion of chondrosarcoma cell proliferation and invasion by inhibiting primary cilia expression.Int J Mol Sci. 2014 Oct 31;15(11):19816-31. doi: 10.3390/ijms151119816.
76	Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma.Oncogene. 2019 Oct;38(42):6835-6849. doi: 10.1038/s41388-019-0929-9. Epub 2019 Aug 12.
77	FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.Int J Mol Med. 2003 Jun;11(6):791-7.
78	Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.Arthritis Res Ther. 2005;7(2):R274-84. doi: 10.1186/ar1479. Epub 2005 Jan 11.
79	The Investigation of ADAMTS16 in Insulin-Induced Human Chondrosarcoma Cells.Cancer Biother Radiopharm. 2015 Aug;30(6):255-60. doi: 10.1089/cbr.2015.1840.
80	Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma.Mod Pathol. 2008 Nov;21(11):1303-10. doi: 10.1038/modpathol.2008.114. Epub 2008 Jun 27.
81	COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.J Cell Biochem. 2008 Feb 15;103(3):778-87. doi: 10.1002/jcb.21445.
82	The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma.J Cell Biochem. 2015 Jan;116(1):37-44. doi: 10.1002/jcb.24940.
83	Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes.Cancer Genet Cytogenet. 2004 Jul 15;152(2):101-7. doi: 10.1016/j.cancergencyto.2003.11.011.
84	PEG10 counteracts signaling pathways of TGF- and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells.J Bone Miner Metab. 2019 May;37(3):441-454. doi: 10.1007/s00774-018-0946-8. Epub 2018 Aug 9.
85	CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.J Cell Biochem. 2009 May 15;107(2):345-56. doi: 10.1002/jcb.22132.