General Information of Disease (ID: DISPX75S)

Disease Name Acute lymphocytic leukaemia
Synonyms
lymphoblastic leukaemia; lymphoblastic leukemia; ALL - acute lymphocytic leukemia; acute lymphoid leukemia; acute lymphogenous leukaemia; precursor Lymphoblasic leukaemia; acute lymphoblastic leukaemia (ALL); acute lymphoblastic leukaemia (disease); precursor cell lymphoblastic leukemia; lymphoblastic leukemia, acute; precursor cell lymphoblastic leukaemia; acute lymphocytic leukemia; leukemia, lymphoblastic, malignant; precursor lymphoblastic leukaemia; acute lymphocytic leukemias; ALL - acute lymphocytic leukaemia; acute lymphoid leukaemia; acute lymphoblastic leukemia/lymphoma; acute lymphocytic leukaemia; acute lymphoblastic leukemia (disease); precursor lymphoblastic leukemia; acute lymphogenous leukemia; ALL; acute lymphoblastic leukemia (ALL); precursor Lymphoblasic leukemia; acute lymphoblastic leukemia
Disease Class 2B33: Malignant haematopoietic neoplasm
Definition
Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.
Disease Hierarchy
DISS2Y8A: Non-hodgkin lymphoma
DIS65TYQ: Lymphoid leukemia
DIS2BEJ2: Neoplasm of immature B and T cells
DIS1X51P: Precursor lymphoblastic lymphoma/leukemia
DISDQFDI: Acute leukaemia
DISPX75S: Acute lymphocytic leukaemia
ICD Code
ICD-11
ICD-11: 2B33.3
ICD-10
ICD-10: C91, C91.9
Expand ICD-11
'XH5J37
Disease Identifiers
MONDO ID
MONDO_0004967
UMLS CUI
C0023449
MedGen ID
7317
HPO ID
HP:0006721
Orphanet ID
513
SNOMED CT ID
91857003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Calaspargase pegol DMQZBXI Approved Antibody [1]
Inotuzumab ozogamicin DMAC130 Approved Antibody [2]
Mercaptopurine DMTM2IK Approved Small molecular drug [3]
Thioguanine DM7NKEV Approved Small molecular drug [3]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 9 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CART-19 cells DMZUV7T Phase 2 CAR T Cell Therapy [4]
Anti-CD19 CAR transduced T cells DMHSLVJ Phase 1/2 CAR T Cell Therapy [5]
Anti-CD19 CAR-T cells DMDRYZK Phase 1/2 CAR T Cell Therapy [6]
CARCIK-CD19 DMOI5PB Phase 1/2 CAR T Cell Therapy [7]
EPZ-5676 DMN2FS3 Phase 1/2 Small molecular drug [8]
PCAR-019 DM9DR13 Phase 1/2 CAR T Cell Therapy [9]
CD19 CAR T Cells DMCUBFR Phase 1 CAR T Cell Therapy [10]
CD19/CD22 CAR T-Cells DMKA2FL Phase 1 CAR T Cell Therapy [11]
CTL119 DM4JRE4 Phase 1 NA [8]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 232 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ANPEP TTPHMWB Limited Altered Expression [12]
BTK TTGM6VW Limited Biomarker [13]
BUB1 TT78309 Limited Biomarker [14]
CASP2 TT12VNG Limited Biomarker [15]
CD33 TTJVYO3 Limited Biomarker [12]
CD58 TT5KSBY Limited Altered Expression [16]
CDKN1C TTBSUAR Limited Biomarker [17]
CDKN2C TTBRUGA Limited Altered Expression [18]
CEACAM1 TTA9CK4 Limited Altered Expression [19]
CSF3R TTC70AJ Limited Biomarker [20]
DCK TTJOCE4 Limited Biomarker [21]
EIF2AK4 TT9U4EP Limited Biomarker [22]
FBXW7 TT29KY7 Limited Genetic Variation [23]
FCGRT TTKLPHO Limited Genetic Variation [24]
HDAC1 TT6R7JZ Limited Biomarker [25]
IGFBP7 TTUQ01B Limited Biomarker [26]
ITPR1 TT5HWAT Limited Biomarker [27]
LCK TT860QF Limited Biomarker [28]
LYN TT1RWNJ Limited Biomarker [29]
MAP3K10 TT9FN4J Limited Genetic Variation [30]
MAP3K20 TTTUZ3O Limited Altered Expression [31]
MPL TTIHYA4 Limited Genetic Variation [32]
MPO TTVCZPI Limited Altered Expression [33]
MSLN TT4RXME Limited Biomarker [34]
NKX3-1 TT1E0JK Limited Altered Expression [35]
NOTCH1 TTB1STW Limited Biomarker [36]
OPRK1 TTQW87Y Limited Altered Expression [37]
RBPJ TT72D4Z Limited Biomarker [38]
SYK TT2HUPM Limited Biomarker [39]
TERF1 TT1Y6J2 Limited Altered Expression [40]
XRCC5 TTCB9KW Limited Altered Expression [41]
ZFP36L1 TT8QVJO Limited Genetic Variation [42]
CASP10 TTX5HEK Disputed Altered Expression [43]
CBL TT7QT13 Disputed Genetic Variation [44]
EPHA3 TTHS2LR Disputed Biomarker [45]
FAT1 TTGUJYV Disputed Biomarker [46]
FOLH1 TT9G4N0 Disputed Genetic Variation [47]
PMEL TT8MK59 Disputed Genetic Variation [48]
PRAME TTPH7T0 Disputed Altered Expression [49]
S100A6 TT716MY Disputed Biomarker [50]
SELPLG TTS5K8U Disputed Biomarker [51]
CD37 TTFCW29 moderate Altered Expression [52]
CES1 TTMF541 moderate Biomarker [53]
CRYZ TTP6UO8 moderate Genetic Variation [54]
GGH TTZJRL0 moderate Genetic Variation [55]
IL7R TTAWI51 moderate Biomarker [56]
JAK3 TTT7PJU moderate Biomarker [57]
LMO2 TTFX379 moderate Biomarker [58]
MSI2 TTTXQF6 moderate Genetic Variation [59]
NPM1 TTHBS98 moderate Altered Expression [60]
NRP1 TTIPJCB moderate Altered Expression [61]
PML TTLH9NY moderate Genetic Variation [62]
SH2B3 TT36N7Z moderate Biomarker [63]
STEAP1 TT9E64S moderate Altered Expression [64]
ABCC1 TTOI92F Strong Altered Expression [65]
ABCG2 TTIMJ02 Strong Altered Expression [66]
AICDA TTKRTP6 Strong Genetic Variation [67]
AKR1C3 TT5ZWB6 Strong Biomarker [68]
ALPI TTHYMUV Strong Altered Expression [69]
ATIC TT9NVXQ Strong Posttranslational Modification [70]
ATRAID TTFLIKM Strong Genetic Variation [71]
BAK1 TTFM7V0 Strong Genetic Variation [72]
BCL11A TTR61MW Strong Altered Expression [73]
BCL6 TTC9YX5 Strong Biomarker [74]
BTG1 TTL7N2W Strong Genetic Variation [75]
CALCA TTVSFJW Strong Biomarker [76]
CASR TTBUYHA Strong Biomarker [77]
CBLB TTHRAIJ Strong Biomarker [78]
CCN2 TTIL516 Strong Altered Expression [79]
CCR7 TT2GIDQ Strong Biomarker [80]
CCR9 TTIPS8B Strong Altered Expression [81]
CD160 TTOFEAS Strong Biomarker [82]
CD200 TT0BE68 Strong Biomarker [83]
CD22 TTM6QSK Strong Biomarker [84]
CD27 TTDO1MV Strong Genetic Variation [85]
CD38 TTPURFN Strong Biomarker [86]
CD5 TTEGYK1 Strong Biomarker [87]
CD52 TTQT5S9 Strong Biomarker [88]
CD55 TT5Z9WY Strong Biomarker [89]
CD70 TTNCIE0 Strong Biomarker [90]
CD79B TTBN5I7 Strong Altered Expression [91]
CD83 TTT9MRQ Strong Altered Expression [92]
CD86 TT53XHB Strong Altered Expression [61]
CDK6 TTO0FDJ Strong Altered Expression [93]
CEACAM6 TTIGH2W Strong Altered Expression [94]
CEL TTTRNQW Strong Genetic Variation [95]
CFB TTA0P7K Strong Biomarker [96]
CLCF1 TTI6V13 Strong Altered Expression [97]
CLEC12A TT70N8V Strong Altered Expression [98]
CNTFR TTT2F9E Strong Biomarker [99]
CR1 TTEA8OW Strong Biomarker [89]
CREBBP TTFRCTK Strong Biomarker [100]
CRHR1 TT7EFHR Strong Genetic Variation [101]
CRLF2 TTRMZ0N Strong Altered Expression [102]
CTCFL TTY0RZT Strong Altered Expression [103]
CXCR4 TTBID49 Strong Altered Expression [104]
CYP2E1 TTWVHQ5 Strong Genetic Variation [105]
CYP3A4 TTWP7HQ Strong Genetic Variation [106]
DDC TTN451K Strong Genetic Variation [107]
DHFR TTYZVDJ Strong Genetic Variation [108]
DKK2 TTST5KX Strong Biomarker [109]
DLL1 TT9CFQD Strong Genetic Variation [110]
EBI3 TTJF68X Strong Genetic Variation [111]
EIF2AK2 TTXEZJ4 Strong Genetic Variation [112]
EIF4E TTZGCP6 Strong Biomarker [113]
EIF5A TTIVCNR Strong Biomarker [114]
EP300 TTGH73N Strong Altered Expression [115]
EPHA1 TTLFZVU Strong Posttranslational Modification [116]
EPOR TTAUX24 Strong Altered Expression [117]
EZH2 TT9MZCQ Strong Biomarker [118]
F8 TT1290U Strong Genetic Variation [119]
FABP3 TT3TGLR Strong Biomarker [120]
FCGR2B TT5RWKQ Strong Genetic Variation [121]
FDXR TT3W4IX Strong Biomarker [122]
FER TTRA9G0 Strong Biomarker [123]
FHIT TTMS54D Strong Altered Expression [124]
FUT4 TTNV1KZ Strong Biomarker [125]
GART TTEXB9Z Strong Altered Expression [126]
GATA3 TT45KOB Strong Altered Expression [102]
GEM TTAZF9M Strong Biomarker [127]
GPR132 TTNBW4F Strong Altered Expression [128]
GRIK2 TT0K5RG Strong Biomarker [129]
HAL TTXQOZW Strong Biomarker [130]
HDAC5 TTUELN5 Strong Altered Expression [131]
HDAC7 TTMUEK1 Strong Altered Expression [131]
HDC TTV9GOF Strong Biomarker [132]
HPGDS TTCYE56 Strong Genetic Variation [133]
IL1RL1 TT4GZA4 Strong Biomarker [134]
IL3RA TTENHJ0 Strong Biomarker [135]
IL7 TT8FRMO Strong Biomarker [136]
ITGA4 TTJMF9P Strong Altered Expression [137]
JAK1 TT6DM01 Strong Genetic Variation [138]
JMJD1C TTBISK4 Strong Biomarker [139]
LILRB2 TTHC6XU Strong Biomarker [140]
LIPA TTS8T1M Strong Genetic Variation [141]
LRP1 TTF2V7I Strong Altered Expression [142]
LSS TT7O8ZA Strong Biomarker [143]
LTB TTHQ6US Strong Altered Expression [144]
LY96 TT8S9AV Strong Genetic Variation [145]
MAP2K2 TT8H9GB Strong Genetic Variation [146]
MARCKS TTHRM39 Strong Biomarker [147]
MCL1 TTL53M6 Strong Altered Expression [148]
MDM4 TT9OUDQ Strong Biomarker [149]
MERTK TTO7LKR Strong Biomarker [150]
MSH2 TTCAWRT Strong Biomarker [151]
MSR1 TT2TDH9 Strong Genetic Variation [152]
MTAP TTDBX7N Strong Biomarker [153]
MTR TTUTO39 Strong Genetic Variation [154]
MYB TT8V13P Strong Biomarker [155]
NAAA TTMN4HY Strong Biomarker [156]
NCAM1 TTVXPHT Strong Altered Expression [157]
NEDD8 TTNDC4K Strong Biomarker [158]
NELL1 TT7H4BF Strong Altered Expression [159]
NME1 TTDY8JH Strong Altered Expression [160]
NOTCH3 TTVX7IA Strong Biomarker [161]
NR0B2 TT25A9Q Strong Posttranslational Modification [162]
NR1I3 TTRANFM Strong Biomarker [77]
OTC TT5KIO9 Strong Biomarker [163]
P2RY14 TT72OKI Strong Altered Expression [164]
P2RY8 TT84EWY Strong Biomarker [165]
PAM TTF4ZPC Strong Genetic Variation [166]
PDE1A TT73TEJ Strong Altered Expression [167]
PDGFRB TTI7421 Strong Biomarker [168]
PIGL TTQA8DT Strong Genetic Variation [169]
PIK3CB TT9H4P3 Strong Biomarker [170]
PIM2 TT69J2Z Strong Altered Expression [171]
PKD2L1 TTAHD89 Strong Biomarker [172]
PLK4 TTGPNZQ Strong Biomarker [173]
PNP TTMCF1Y Strong Altered Expression [174]
PNPLA3 TTEUAEH Strong Biomarker [175]
PRDX4 TTPBL9I Strong Genetic Variation [176]
PRKAR1A TTNAHEX Strong Biomarker [77]
PRMT1 TTVOJAI Strong Posttranslational Modification [177]
PRSS1 TT2WR1T Strong Genetic Variation [178]
PSMB6 TT8EPLT Strong Genetic Variation [110]
PTK7 TTXH2ZN Strong Biomarker [179]
PTPN6 TT369M5 Strong Biomarker [17]
PTPRC TTUS45N Strong Biomarker [180]
RARA TTW38KT Strong Biomarker [181]
ROR1 TTDEJAU Strong Biomarker [182]
RPSA TTLUW5B Strong Biomarker [183]
S100A4 TTPR5SX Strong Biomarker [184]
SCT TTOBVIN Strong Biomarker [185]
SEPTIN6 TTAGE7U Strong Biomarker [186]
SLC19A1 TT09I7D Strong Altered Expression [187]
SLC25A1 TTTD730 Strong Biomarker [188]
SLC27A4 TT20AYF Strong Biomarker [189]
SLCO1A2 TTUGD21 Strong Genetic Variation [190]
SMYD2 TT7YJFO Strong Altered Expression [191]
SNAP25 TTYQWA0 Strong Biomarker [192]
SPHK2 TTCN0M9 Strong Biomarker [193]
SPRY1 TT0PSN6 Strong Biomarker [194]
TBL1XR1 TTYXT16 Strong Biomarker [195]
TCF3 TTULOD8 Strong Genetic Variation [196]
TCL1A TTUKRDV Strong Genetic Variation [197]
THPO TTCG5PE Strong Altered Expression [198]
TNFRSF13C TT7NJSE Strong Biomarker [199]
TNFRSF4 TTL31H0 Strong Biomarker [200]
TNFRSF9 TTPW9LJ Strong Biomarker [201]
TNFSF4 TTBW580 Strong Biomarker [200]
TRB TT84HCW Strong Genetic Variation [202]
TRBC1 TT1DHW2 Strong Genetic Variation [202]
TRIM24 TT9Q7AE Strong Biomarker [26]
TSLP TTHMW3T Strong Genetic Variation [203]
TYRO3 TTIEMFN Strong Altered Expression [204]
USP33 TT4E85Q Strong Altered Expression [205]
USP7 TTXU3EQ Strong Genetic Variation [206]
WEE1 TTJFOAL Strong Biomarker [207]
WNT5A TTKG7F8 Strong Biomarker [182]
WNT7A TT8NARC Strong Altered Expression [208]
WWP1 TTBWMKT Strong Biomarker [209]
ZAP70 TTUMHT8 Strong Biomarker [210]
ABCB4 TTJUXV6 Definitive Biomarker [211]
ABCC3 TTVLG21 Definitive Altered Expression [212]
ABCC4 TTUEAFL Definitive Genetic Variation [213]
ADA TTLP57V Definitive Biomarker [214]
BMP6 TT07RIB Definitive Posttranslational Modification [215]
BTLA TTER58P Definitive Biomarker [216]
CAMP TTULOB6 Definitive Genetic Variation [217]
CEACAM3 TTPX7I5 Definitive Biomarker [218]
CTSG TTQAJF1 Definitive Biomarker [219]
DDR1 TTI1FPZ Definitive Altered Expression [220]
DNM2 TTVRA5G Definitive Genetic Variation [221]
DPYD TTZPS91 Definitive Genetic Variation [222]
HOXA5 TTXSVQP Definitive Altered Expression [223]
INPP5D TTTP2Z1 Definitive Biomarker [224]
IRS1 TTAJSQ0 Definitive Biomarker [225]
KIR2DL1 TT4UXPE Definitive Genetic Variation [226]
MAP3K7 TTJQT60 Definitive Biomarker [227]
PTP4A3 TT7YM8D Definitive Biomarker [228]
SERPINC1 TT4QPUL Definitive Altered Expression [229]
XPO1 TTCJUR4 Definitive Biomarker [230]
------------------------------------------------------------------------------------
⏷ Show the Full List of 232 DTT(s)
This Disease Is Related to 8 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC11 DTWN7FC Limited Biomarker [231]
ABCC5 DTYVM24 Limited Biomarker [34]
ABCA3 DT2T6VQ Strong Altered Expression [232]
ABCB5 DTKVEXO Strong Altered Expression [233]
SLC27A5 DT0TQS3 Strong Genetic Variation [95]
SLC28A3 DT4YL5R Strong Genetic Variation [234]
SLC29A2 DTW78DQ Strong Genetic Variation [235]
SLCO6A1 DTIFXNS Strong Genetic Variation [236]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DTP(s)
This Disease Is Related to 11 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
EPHX1 DELB4KP Disputed Genetic Variation [237]
NNMT DECVGJ3 Disputed Biomarker [238]
SCLY DEH4TD6 Disputed Genetic Variation [239]
MTRR DE6NIY9 moderate Altered Expression [240]
CYP4F3 DEFCMPI Strong Biomarker [241]
FADS1 DE05S8C Strong Genetic Variation [242]
FPGS DECWT2V Strong Genetic Variation [243]
GLS DE3E0VT Strong Biomarker [244]
HPRT1 DEVXTP5 Strong Biomarker [245]
UBASH3B DE10BJ5 Strong Altered Expression [194]
UCK2 DETN1O0 Strong Altered Expression [246]
------------------------------------------------------------------------------------
⏷ Show the Full List of 11 DME(s)
This Disease Is Related to 367 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
A2ML1 OTWNUXIS Limited Altered Expression [247]
AFF3 OTR0705Z Limited Biomarker [248]
ATP11A OT7M9ZDK Limited Altered Expression [249]
AUTS2 OTAEXHSC Limited Altered Expression [250]
B3GAT1 OTXFP98E Limited Biomarker [82]
BCL9 OTRBIPR4 Limited Altered Expression [251]
CALM2 OTNYA92F Limited Biomarker [252]
CD79A OTOJC8DV Limited Biomarker [253]
CILK1 OTWOYEYP Limited Altered Expression [31]
CKS1B OTNUPLUJ Limited Biomarker [254]
CKS2 OTPTMHIV Limited Altered Expression [254]
CMPK2 OTOG90R0 Limited Altered Expression [255]
COBL OTTB4VFQ Limited Genetic Variation [256]
CORO1A OTVAZOHC Limited Posttranslational Modification [257]
COX8A OTU0NR39 Limited Genetic Variation [119]
CSN2 OT22C0PD Limited Biomarker [258]
CTCF OT8ZB70U Limited Posttranslational Modification [259]
DDX41 OT6KEIHP Limited Altered Expression [260]
DHX32 OTDYB66V Limited Biomarker [260]
EFS OT06O7XL Limited Biomarker [261]
ELF3 OTUTLEQO Limited Altered Expression [262]
ELP2 OTBXG37N Limited Biomarker [263]
FANCL OTJC7QPQ Limited Genetic Variation [264]
GATA1 OTX1R7O1 Limited Biomarker [265]
GCSAM OTZNOPYK Limited Altered Expression [266]
GML OTHKIB62 Limited Biomarker [267]
HFE OTDD93KB Limited Genetic Variation [268]
IGF2BP1 OT9G360P Limited Genetic Variation [72]
ISG20 OTCWRJJW Limited Biomarker [269]
KLHL1 OTAX6SAD Limited Altered Expression [34]
LBR OT1HG3HG Limited Biomarker [270]
LEF1 OTWS5I5H Limited Biomarker [271]
LRPPRC OTXSK5LP Limited Altered Expression [272]
MEIS1 OTH9DKAD Limited Altered Expression [273]
MPST OTCDPH5D Limited Genetic Variation [30]
MSTO1 OT37XCNP Limited Genetic Variation [30]
NAT9 OT4ZKCRS Limited Biomarker [274]
NFIL3 OTQH9HM3 Limited Altered Expression [275]
NLRP2 OTJA81JU Limited Genetic Variation [276]
NMU OTW9X7BQ Limited Altered Expression [277]
NUDC OT073JKX Limited Biomarker [278]
PACSIN2 OTC2R00C Limited Genetic Variation [279]
PNN OT0HXICH Limited Biomarker [280]
QRSL1 OTJDU2UG Limited Altered Expression [281]
RALGAPB OTY8CGA3 Limited Altered Expression [247]
RBBP4 OTG3BT3M Limited Biomarker [29]
RCSD1 OTOICQFW Limited Genetic Variation [282]
RTEL1 OTI3PJCT Limited Biomarker [283]
SIX6 OTD1RD9D Limited Biomarker [35]
SNAP91 OTE3EXWZ Limited Biomarker [252]
SRL OT7IEBWZ Limited Genetic Variation [284]
SYCE1L OTXU44F3 Limited Altered Expression [34]
TFIP11 OT7NVSWU Limited Altered Expression [263]
TFR2 OTMYCCEO Limited Genetic Variation [285]
TRIM33 OT0KS4J7 Limited Biomarker [286]
AFF4 OTTL5Y8R Disputed Altered Expression [287]
CASP8AP2 OTTWT68S Disputed Genetic Variation [288]
CBFB OTIAC6W4 Disputed Genetic Variation [289]
CCNA1 OTX4HD45 Disputed Genetic Variation [290]
CEACAM8 OTLL9WWO Disputed Altered Expression [94]
CHST9 OT1DEZRM Disputed Biomarker [291]
CIB1 OT4BVCRU Disputed Genetic Variation [292]
DAZAP1 OTWLY0UE Disputed Biomarker [293]
DCC OT2C1SHW Disputed Genetic Variation [294]
DOCK8 OTNQLL21 Disputed Genetic Variation [295]
EIF3A OTFABY9G Disputed Biomarker [296]
GFI1 OT9HB9H8 Disputed Biomarker [297]
GNG11 OTHIXBGW Disputed Altered Expression [298]
KRT7 OTLT3JFN Disputed Genetic Variation [239]
LYL1 OTCNOV1M Disputed Genetic Variation [299]
NOL3 OT1K0L0D Disputed Biomarker [300]
PDIK1L OTISF4KG Disputed Posttranslational Modification [301]
PPP1R13B OTC88VQO Disputed Biomarker [302]
PRDM9 OTWAHLUR Disputed Genetic Variation [303]
PTPRG OT9N2WOF Disputed Posttranslational Modification [304]
RMDN1 OTE1NB6U Disputed Altered Expression [305]
RMDN3 OTKO7AUM Disputed Altered Expression [305]
SNX2 OT889MQA Disputed Biomarker [306]
STIL OT9799VN Disputed Genetic Variation [48]
SYBU OT3FQV7N Disputed Altered Expression [305]
TES OTL8PP6V Disputed Altered Expression [307]
TOM1 OT30QA56 Disputed Biomarker [308]
EBF1 OTZ61YYH moderate Biomarker [309]
GIPC2 OT68YFO1 moderate Altered Expression [310]
HOXA9 OTKNK5H0 moderate Biomarker [311]
IKZF1 OTCW1FKL moderate Genetic Variation [312]
MARCKSL1 OT13J2FM moderate Altered Expression [313]
MLLT1 OT41UZU5 moderate Biomarker [314]
MRPL28 OT4LUTZU moderate Posttranslational Modification [315]
MTX1 OTLSDNZO moderate Biomarker [316]
MVP OTJGHJRB moderate Biomarker [183]
NXT1 OT0VO6AY moderate Posttranslational Modification [315]
PLCG2 OTGVC9MY moderate Biomarker [317]
RAG1 OTV131E4 moderate Altered Expression [318]
RFC1 OT3L5PK3 moderate Genetic Variation [319]
SUB1 OTK71JYU moderate Posttranslational Modification [315]
ACCS OTHIHI9D Strong Genetic Variation [320]
ADAMTSL4 OTBILJMW Strong Biomarker [194]
ADAMTSL5 OTQAGNQP Strong Biomarker [321]
AFF1 OTT2C78E Strong Genetic Variation [322]
AFF2 OTMF1PZW Strong Biomarker [323]
AFM OTPOR8IO Strong Biomarker [324]
AIF1L OTDEOB80 Strong Biomarker [325]
AMN OTS1TJXG Strong Biomarker [326]
ANP32B OT3SQMLU Strong Biomarker [327]
APAF1 OTJWIVY0 Strong Altered Expression [328]
ARHGAP24 OTCQCEZS Strong Biomarker [167]
ARHGEF1 OTXU4HBW Strong Biomarker [329]
ARHGEF12 OTM2D3LT Strong Biomarker [330]
ARID5B OTUQ4CQY Strong Genetic Variation [331]
ARPP21 OTWXZN5I Strong Genetic Variation [85]
ARR3 OTRZ00CH Strong Biomarker [77]
ATAD1 OTJ02XFL Strong Genetic Variation [332]
ATF7IP OTU6ZA7F Strong Biomarker [333]
ATN1 OTNZFLKY Strong Biomarker [334]
BAALC OTUZSRVF Strong Altered Expression [335]
BAG4 OTUPX3M2 Strong Biomarker [43]
BCL11B OT8KKCVJ Strong Altered Expression [336]
BCL2L11 OTNQQWFJ Strong Biomarker [337]
BIRC6 OTCQJAB0 Strong Altered Expression [338]
BLID OT479VJV Strong Genetic Variation [339]
BLM OTEJOAJX Strong Biomarker [340]
BLNK OTSSPF6F Strong Biomarker [341]
BLVRB OTHCFN2C Strong Altered Expression [26]
BRINP1 OTEUVSCP Strong Altered Expression [342]
CAPG OTJ86KI6 Strong Genetic Variation [343]
CARD8 OTXXZYWU Strong Genetic Variation [344]
CASC3 OTLK3K4U Strong Biomarker [345]
CAV3 OTWSFDB4 Strong Altered Expression [346]
CBFA2T3 OTOJ10S1 Strong Altered Expression [347]
CCAR2 OTLUDG5T Strong Altered Expression [342]
CCNC OTMVK4K4 Strong Genetic Variation [348]
CD1D OT3ROU4J Strong Altered Expression [349]
CD48 OT83ZNPP Strong Altered Expression [253]
CD72 OTPOJID2 Strong Genetic Variation [350]
CDKN2D OT2TTZPZ Strong Genetic Variation [351]
CEACAM4 OT0C7YUD Strong Altered Expression [352]
CEBPE OTKZA25M Strong Genetic Variation [353]
CEP72 OTVYNPNL Strong Genetic Variation [354]
CERS6 OTOP4GV1 Strong Biomarker [355]
CFL1 OTT6D5MH Strong Genetic Variation [71]
CIB2 OT9ZJX1I Strong Biomarker [356]
CLEC4D OTT7X1UC Strong Biomarker [357]
CNDP2 OTJR9436 Strong Genetic Variation [358]
CNTNAP1 OT5Y03EU Strong Biomarker [359]
COIL OTP4I4DL Strong Biomarker [360]
COLEC10 OTMBADGZ Strong Altered Expression [98]
CREBRF OT2GK1HI Strong Biomarker [361]
CRKL OTOYSD1R Strong Posttranslational Modification [362]
CXADR OT9ZP02A Strong Biomarker [77]
CYFIP1 OTOBEH24 Strong Biomarker [363]
DACT1 OT19Z704 Strong Altered Expression [364]
DAP OT5YLL7E Strong Posttranslational Modification [365]
DDX51 OTLMA7AH Strong Posttranslational Modification [366]
DEFB1 OT5SV0E4 Strong Genetic Variation [367]
DHX15 OT4F98TK Strong Altered Expression [368]
DLEU7 OTVKX1YP Strong Altered Expression [369]
DLX3 OTARP5SQ Strong Biomarker [370]
DNTT OTFSEF12 Strong Biomarker [371]
DUSP7 OT6Z5AHP Strong Altered Expression [372]
EEF1E1 OTRA6XOB Strong Genetic Variation [71]
EFNB1 OT7JJW8P Strong Biomarker [116]
ELSPBP1 OT79E7DW Strong Genetic Variation [373]
EMCN OTS03CZC Strong Altered Expression [205]
ENDOU OTB7OF7Y Strong Altered Expression [374]
ENO2 OTRODL0T Strong Biomarker [375]
ERCC2 OT1C8HQ4 Strong Genetic Variation [376]
EXOSC6 OTAC10N6 Strong Altered Expression [374]
FADD OTV7GFHH Strong Biomarker [377]
FANCB OTMZTXB5 Strong Biomarker [378]
FANCC OTTIDM3P Strong Posttranslational Modification [379]
FBLIM1 OTFHXMON Strong Biomarker [380]
FBRS OTUVH446 Strong Biomarker [381]
FBXL2 OT5EZ7PD Strong Altered Expression [382]
FBXL5 OT93D50X Strong Biomarker [383]
FBXO8 OTZNGJGW Strong Biomarker [381]
FCRL1 OTXOYT29 Strong Biomarker [384]
FLII OT7G9JG6 Strong Altered Expression [385]
FMN2 OTUY7BSV Strong Altered Expression [386]
FOXO3 OTHXQG4P Strong Genetic Variation [387]
GDF10 OTEVXGJ7 Strong Altered Expression [388]
GFI1B OTRDW8YO Strong Altered Expression [389]
GNA15 OTFYRZGV Strong Altered Expression [390]
GOPC OTRBGH71 Strong Biomarker [380]
GSTK1 OTDNGWAF Strong Genetic Variation [236]
GSTM2 OTG4WT05 Strong Genetic Variation [391]
GSTM3 OTLA2WJT Strong Altered Expression [392]
GYPA OTABU4YV Strong Genetic Variation [393]
GYPB OTESHUIX Strong Genetic Variation [393]
GYPE OTBHAG6A Strong Genetic Variation [393]
GZMA OT43R33L Strong Biomarker [394]
H2AZ1 OT3KJJNQ Strong Altered Expression [395]
H4C1 OTB71W46 Strong Biomarker [261]
HCST OTILCB4K Strong Biomarker [396]
HERPUD1 OT9EROL6 Strong Biomarker [192]
HLA-DPB1 OTW8JHU2 Strong Genetic Variation [397]
HLX OT7DTH46 Strong Altered Expression [398]
HMMR OT4M0JTZ Strong Altered Expression [399]
HOXB1 OTGC0EKI Strong Biomarker [400]
HOXB2 OTTD6HMV Strong Biomarker [400]
HOXB3 OT9UC5PE Strong Biomarker [400]
HOXB4 OTH1HRW5 Strong Biomarker [400]
HOXB5 OTU74TB8 Strong Biomarker [400]
HOXB6 OT3TFQ0U Strong Biomarker [400]
HOXB8 OTKHOD17 Strong Biomarker [400]
HOXB9 OTMVHQOU Strong Biomarker [400]
HOXD4 OTQR4WCG Strong Genetic Variation [401]
HPR OTXSC9UB Strong Biomarker [402]
HPSE2 OTGEPP8V Strong Genetic Variation [332]
IFNA1 OTPMKY0L Strong Biomarker [403]
IGF2BP2 OT4ZSEEE Strong Altered Expression [404]
IGF2BP3 OTB97VIK Strong Biomarker [404]
IKZF5 OTJN51OC Strong Biomarker [405]
IL18R1 OT83XMPQ Strong Genetic Variation [111]
IL3 OT0CQ35N Strong Altered Expression [406]
IMPACT OTQ923OB Strong Biomarker [407]
ING2 OT6H0EWF Strong Biomarker [408]
IRS4 OTTOL40K Strong Altered Expression [409]
ITPA OTQ47WVR Strong Genetic Variation [343]
KAT2A OTN0W2SW Strong Biomarker [410]
KDM3B OTZU5J5S Strong Altered Expression [411]
KIR3DL1 OTPOSXFX Strong Biomarker [127]
KMT2B OTMMAZQX Strong Biomarker [412]
KMT2C OTC59BCO Strong Biomarker [413]
KNL1 OT4Q3LHV Strong Biomarker [414]
LAMTOR1 OTIBJBW9 Strong Genetic Variation [71]
LAT2 OTWJDKIH Strong Altered Expression [415]
LBH OT87AT1X Strong Altered Expression [416]
LHX4 OTVX3J6S Strong Genetic Variation [417]
LIG4 OT40DNXU Strong Biomarker [340]
MAFK OTZJUE4P Strong Genetic Variation [71]
MAGT1 OTQSAV5C Strong Altered Expression [69]
MAML2 OT1TSVAR Strong Genetic Variation [418]
MAP3K12 OT5HODDD Strong Biomarker [26]
MAPRE1 OTCVQD60 Strong Genetic Variation [419]
MCM2 OTGGORIQ Strong Altered Expression [173]
MECOM OTP983W8 Strong Biomarker [420]
MEF2C OTZGF1Y5 Strong Genetic Variation [421]
MEF2D OT7CEIG0 Strong Genetic Variation [422]
METTL14 OT6TPQMH Strong Biomarker [423]
METTL3 OTSXP1M3 Strong Altered Expression [423]
MLC1 OTCNZLSP Strong Biomarker [424]
MLLT10 OTURMDV7 Strong Biomarker [425]
MLLT3 OTXH4DDG Strong Biomarker [426]
MOCOS OT0TL3Q5 Strong Biomarker [427]
MOGS OT99MBGB Strong Genetic Variation [428]
MOS OTNMQPFJ Strong Biomarker [429]
MPP1 OTA2ENZQ Strong Altered Expression [430]
MPRIP OT5FV5NS Strong Altered Expression [431]
MTHFD1 OTMKHVWC Strong Genetic Variation [432]
MXD3 OT4U88UP Strong Biomarker [433]
MYH11 OTVNVWY3 Strong Genetic Variation [289]
NBN OT73B5MD Strong Genetic Variation [434]
NCOR1 OT04XNOU Strong Altered Expression [435]
NET1 OTZHNMJV Strong Altered Expression [436]
NEU3 OTQ5PQOW Strong Biomarker [437]
NR2C2 OTDZWVOJ Strong Biomarker [227]
NRXN1 OTJN1JQA Strong Biomarker [438]
NSD2 OTQ6SW4R Strong Genetic Variation [439]
NUDT15 OTX8SZOT Strong Biomarker [440]
NUP214 OTWEA19O Strong Biomarker [441]
NUP88 OT647WOR Strong Biomarker [442]
OPN1LW OTFNUZ7O Strong Biomarker [100]
PACRG OT1NYNNW Strong Biomarker [443]
PAG1 OTFOJUIQ Strong Biomarker [100]
PARN OTTG4PE3 Strong Posttranslational Modification [444]
PARP9 OT7K4494 Strong Genetic Variation [95]
PBX4 OTUWEWSW Strong Altered Expression [273]
PCBP4 OTDLL4NB Strong Biomarker [100]
PCDH10 OT2GIT0E Strong Posttranslational Modification [445]
PCDH17 OTRK0M05 Strong Biomarker [446]
PER3 OTVKYVJA Strong Altered Expression [447]
PGP OT6QQ7OR Strong Biomarker [448]
PHC1 OT1JMX8U Strong Altered Expression [449]
PIAS2 OTJLSC3V Strong Biomarker [450]
PICALM OTQVRPMQ Strong Biomarker [425]
PIK3R3 OTXGJ8N1 Strong Altered Expression [430]
PIP4K2A OTO9JO9U Strong Genetic Variation [451]
PLA2G15 OT6VJTPA Strong Genetic Variation [320]
PLEKHG2 OTMGR6I6 Strong Biomarker [452]
PMAIP1 OTXEE550 Strong Altered Expression [142]
POLG2 OTDBMZJB Strong Altered Expression [430]
PPP1R13L OTNCPLWE Strong Genetic Variation [152]
PRDM16 OT0BGA27 Strong Biomarker [453]
PRF1 OTFVXD7H Strong Genetic Variation [454]
PRPS1 OTN3A6CN Strong Biomarker [455]
PRRC1 OT3YMI6Z Strong Biomarker [456]
PSMD12 OTWICA51 Strong Altered Expression [430]
PTPRA OTZA82J1 Strong Biomarker [183]
PTPRO OTFLKWOY Strong Biomarker [304]
RAB40B OTCA9ZF5 Strong Biomarker [457]
RAG2 OTG9UYTW Strong Altered Expression [318]
RANBP17 OTQEVTYH Strong Genetic Variation [458]
RAP1GDS1 OTH70UHD Strong Genetic Variation [459]
RASGRP1 OTX9WN2E Strong Genetic Variation [460]
RASSF6 OT25GVWY Strong Biomarker [461]
RB1 OT9VMY7B Strong Biomarker [309]
RIN2 OTCY73U9 Strong Biomarker [147]
RMDN2 OTK5WSFI Strong Altered Expression [305]
RNF20 OT9NK6ZT Strong Altered Expression [462]
RPL22 OTVCN8K0 Strong Biomarker [463]
RUNX1T1 OT30DED5 Strong Altered Expression [347]
SACM1L OT6ORKTD Strong Biomarker [464]
SCYL1 OTQ0IN7P Strong Biomarker [465]
SEPTIN11 OTX2O0ZX Strong Altered Expression [466]
SEPTIN4 OTD16B30 Strong Biomarker [455]
SEPTIN5 OT6JTJBO Strong Altered Expression [467]
SETDB2 OTBVVP9Q Strong Biomarker [18]
SHMT1 OTIINA3J Strong Genetic Variation [468]
SLX4IP OTRZQJV9 Strong Genetic Variation [469]
SMCP OTXKY794 Strong Biomarker [427]
SMR3B OTL5HNM8 Strong Biomarker [228]
SOAT1 OTB4Y5RJ Strong Altered Expression [470]
SPAG9 OT45AHMB Strong Genetic Variation [471]
SPG7 OT8OY9ST Strong Biomarker [77]
SPI1 OTVCA1D0 Strong Biomarker [435]
SPIDR OTO1OII0 Strong Genetic Variation [472]
SRSF2 OTVDHO6U Strong Genetic Variation [473]
SSBP2 OTYG1G80 Strong Genetic Variation [474]
STAP1 OTUTZH0W Strong Altered Expression [475]
STAT5A OTBSJGN3 Strong Posttranslational Modification [359]
STAT5B OTZVPEBT Strong Posttranslational Modification [359]
TADA1 OTV9RKSL Strong Biomarker [476]
TAF15 OTNE038N Strong Genetic Variation [477]
TAL1 OTX4K6QZ Strong Genetic Variation [206]
TCF12 OTZVONNU Strong Biomarker [478]
TCF7L1 OTTUTF0O Strong Genetic Variation [151]
TCFL5 OTJL4348 Strong Biomarker [26]
TCIM OTARUXQF Strong Genetic Variation [479]
TCL1B OT4CSO39 Strong Genetic Variation [197]
TCOF1 OT4BOYTM Strong Altered Expression [480]
TIMM8A OTDX9687 Strong Biomarker [147]
TLE1 OT50MRZ1 Strong Altered Expression [481]
TLX1 OTVN0MNW Strong Genetic Variation [62]
TLX3 OTBUHHK3 Strong Genetic Variation [482]
TMEM132D OTV6I4Z0 Strong Biomarker [483]
TNFSF8 OTDYGDJ3 Strong Altered Expression [484]
TNMD OTHLVA9G Strong Biomarker [485]
TP73 OT0LUO47 Strong Biomarker [167]
TPPP2 OTI3WA6X Strong Genetic Variation [71]
TRABD OTCFGFJH Strong Biomarker [486]
TRIM13 OTQIUACB Strong Biomarker [77]
TSGA10 OTIF1O1T Strong Altered Expression [487]
TSPAN16 OTIWCL05 Strong Biomarker [194]
TTC4 OTAPMYXU Strong Biomarker [488]
AVEN OTGIN5YK Definitive Altered Expression [489]
CD99 OTPUZ5DE Definitive Altered Expression [490]
CEACAM7 OTKFDTZY Definitive Biomarker [218]
DERL1 OTJUS74N Definitive Genetic Variation [491]
EXT1 OTRPALJK Definitive Altered Expression [492]
FLT3LG OTU0YGC4 Definitive Biomarker [493]
GATA2 OTBP2QQ2 Definitive Genetic Variation [494]
GFER OTVK43OK Definitive Altered Expression [495]
GLS2 OT08MSHL Definitive Biomarker [496]
HAP1 OT6SG0JQ Definitive Biomarker [497]
HLA-DRA OT7KZMP2 Definitive Genetic Variation [498]
HOXB7 OTC7WYU8 Definitive Biomarker [499]
LMO1 OTB59SKB Definitive Genetic Variation [107]
PHF2 OTJCIQR2 Definitive Altered Expression [500]
PSG2 OT2EIXAI Definitive Biomarker [218]
RASSF10 OTGB7EBG Definitive Biomarker [461]
RBM45 OTWTHD77 Definitive Genetic Variation [501]
SET OTGYYQJO Definitive Altered Expression [441]
SIAH2 OTKED2XN Definitive Biomarker [502]
SORL1 OTQ8FFNS Definitive Altered Expression [503]
SYNE1 OTSBSLUH Definitive Genetic Variation [504]
TCF7 OT1ID822 Definitive Altered Expression [505]
------------------------------------------------------------------------------------
⏷ Show the Full List of 367 DOT(s)

References

1 Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of patients with acute lymphoblastic leukemia: results from Children's Oncology Group Study AALL07P4. J Clin Oncol. 2014 Dec 1;32(34):3874-82.
2 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 ClinicalTrials.gov (NCT01551043) Allo CART-19 Protocol
5 ClinicalTrials.gov (NCT03191773) A Study of Anti-CD19 CAR-T Cell Immunotherapy for Refractory /Relapsed B Cell Malignancies
6 ClinicalTrials.gov (NCT02851589) Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
7 ClinicalTrials.gov (NCT03389035) Transposon-manipulated Allogeneic CARCIK-CD19 Cells in Pediatric and Adult Patients With r/r ALL Post HSCT
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 ClinicalTrials.gov (NCT02819583) CAR-T Cell Immunotherapy in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
10 ClinicalTrials.gov (NCT01853631) Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN)
11 ClinicalTrials.gov (NCT03448393) CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies
12 Spectrum and Immunophenotypic Profile of Acute Leukemia: A Tertiary Center Flow Cytometry Experience.Mediterr J Hematol Infect Dis. 2019 Mar 1;11(1):e2019017. doi: 10.4084/MJHID.2019.017. eCollection 2019.
13 Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines.Bioorg Med Chem. 2017 Jan 15;25(2):765-772. doi: 10.1016/j.bmc.2016.11.054. Epub 2016 Nov 29.
14 hBUB1 defects in leukemia and lymphoma cells.Oncogene. 2002 Jul 11;21(30):4673-9. doi: 10.1038/sj.onc.1205585.
15 Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.Clin Cancer Res. 1999 Dec;5(12):4041-7.
16 Role of CD81 and CD58 in minimal residual disease detection in pediatric B lymphoblastic leukemia.Int J Lab Hematol. 2018 Jun;40(3):343-351. doi: 10.1111/ijlh.12795. Epub 2018 Mar 2.
17 Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia.Biomed Pharmacother. 2018 Jan;97:1493-1500. doi: 10.1016/j.biopha.2017.11.033. Epub 2017 Nov 20.
18 SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.Cell Rep. 2018 Apr 24;23(4):1166-1177. doi: 10.1016/j.celrep.2018.03.124.
19 Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro.Leuk Lymphoma. 2015 Jan;56(1):202-10. doi: 10.3109/10428194.2014.913287. Epub 2014 Jun 6.
20 Expression and role of granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) and granulocyte colony-stimulating factor receptor (G-CSFR) on Ph-positive acute B lymphoblastic leukemia.Hematology. 2018 Sep;23(8):439-447. doi: 10.1080/10245332.2018.1426540. Epub 2018 Jan 17.
21 Clofarabine exerts antileukemic activity against cytarabine-resistant B-cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression.Cancer Med. 2018 Apr;7(4):1297-1316. doi: 10.1002/cam4.1323. Epub 2018 Feb 23.
22 Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503. doi: 10.1021/acsmedchemlett.9b00400. eCollection 2019 Oct 10.
23 Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.BMC Cancer. 2016 May 26;16:335. doi: 10.1186/s12885-016-2374-2.
24 T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.J Clin Invest. 1987 Dec;80(6):1770-7. doi: 10.1172/JCI113270.
25 HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.Leukemia. 2018 Jan;32(1):49-60. doi: 10.1038/leu.2017.174. Epub 2017 Jun 5.
26 Gene expression pattern contributing to prognostic factors in childhood acute lymphoblastic leukemia.Leuk Lymphoma. 2013 Feb;54(2):310-4. doi: 10.3109/10428194.2012.710330. Epub 2012 Sep 8.
27 RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):261-9. doi: 10.1016/0165-4608(86)90055-5.
28 Pre T-cell receptor alpha (pTalpha) expression patterns and functional analysis in human T-cell lymphoblastic leukemia.Cell Oncol. 2010;32(1-2):101-8. doi: 10.3233/CLO-2009-0500.
29 Routine expression profiling of microarray gene signatures in acute leukaemia by real-time PCR of human bone marrow.Br J Haematol. 2005 Jul;130(2):233-48. doi: 10.1111/j.1365-2141.2005.05594.x.
30 Frequent deletions at 12q14.3 chromosomal locus in adult acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2005 Jan;42(1):87-94. doi: 10.1002/gcc.20116.
31 Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia.Haematologica. 2000 Jul;85(7):711-21.
32 Concurrence of B-lymphoblastic leukemia and myeloproliferative neoplasm with copy neutral loss of heterozygosity at chromosome 1p harboring a MPL W515S mutation.Cancer Genet. 2014 Oct-Dec;207(10-12):489-94. doi: 10.1016/j.cancergen.2014.10.001. Epub 2014 Oct 13.
33 Flow cytometric false myeloperoxidase-positive childhood B-lineage acute lymphoblastic leukemia.Cytometry B Clin Cytom. 2018 May;94(3):477-483. doi: 10.1002/cyto.b.21613. Epub 2018 Jan 17.
34 The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype.Blood. 2003 Dec 15;102(13):4493-8. doi: 10.1182/blood-2002-11-3461. Epub 2003 Jun 19.
35 Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).PLoS One. 2012;7(7):e40747. doi: 10.1371/journal.pone.0040747. Epub 2012 Jul 27.
36 GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia.Cancer Discov. 2019 Dec;9(12):1774-1791. doi: 10.1158/2159-8290.CD-19-0471. Epub 2019 Sep 13.
37 The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells.Leukemia. 1999 May;13(5):779-85. doi: 10.1038/sj.leu.2401408.
38 Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14908-13. doi: 10.1073/pnas.1109023108. Epub 2011 Jul 7.
39 SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric ETV6-RUNX1 B-Acute Lymphoblastic Leukemia Patients.Int J Mol Sci. 2019 Dec 7;20(24):6175. doi: 10.3390/ijms20246175.
40 Impaired telomere regulation mechanism by TRF1 (telomere-binding protein), but not TRF2 expression, in acute leukemia cells.Int J Oncol. 2001 Mar;18(3):593-8. doi: 10.3892/ijo.18.3.593.
41 Expression of DNA repair gene Ku80 in lymphoid neoplasm.Eur J Haematol. 2005 Jun;74(6):481-8. doi: 10.1111/j.1600-0609.2005.00428.x.
42 Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.Nat Immunol. 2010 Aug;11(8):717-24. doi: 10.1038/ni.1901. Epub 2010 Jul 11.
43 Silencer of death domains controls cell death through tumour necrosis factor-receptor 1 and caspase-10 in acute lymphoblastic leukemia.PLoS One. 2014 Jul 25;9(7):e103383. doi: 10.1371/journal.pone.0103383. eCollection 2014.
44 Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia.Leuk Res. 2012 Aug;36(8):1009-15. doi: 10.1016/j.leukres.2012.04.018. Epub 2012 May 14.
45 EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia.Leukemia. 2017 Aug;31(8):1779-1787. doi: 10.1038/leu.2016.371. Epub 2016 Dec 6.
46 Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia.Hematology. 2013 Nov;18(6):315-22. doi: 10.1179/1607845413Y.0000000080. Epub 2013 Feb 20.
47 Imaging CAR T cell therapy with PSMA-targeted positron emission tomography.Sci Adv. 2019 Jul 3;5(7):eaaw5096. doi: 10.1126/sciadv.aaw5096. eCollection 2019 Jul.
48 Prevalence of common fusion transcripts in acute lymphoblastic leukemia: A report of 304 cases.Asia Pac J Clin Oncol. 2015 Dec;11(4):293-8. doi: 10.1111/ajco.12400. Epub 2015 Aug 12.
49 Real-time RT-PCR quantification of PRAME gene expression for monitoring minimal residual disease in acute myeloblastic leukaemia.Clin Chem Lab Med. 2006;44(5):548-55. doi: 10.1515/CCLM.2006.106.
50 Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNF Treatment.Cancer Res. 2017 Aug 15;77(16):4426-4433. doi: 10.1158/0008-5472.CAN-16-2974. Epub 2017 Jun 23.
51 Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43.Cancers (Basel). 2019 Aug 27;11(9):1253. doi: 10.3390/cancers11091253.
52 Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies.MAbs. 2013 Sep-Oct;5(5):723-35. doi: 10.4161/mabs.25282. Epub 2013 Jun 7.
53 Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.Bioorg Med Chem Lett. 2018 Jun 1;28(10):1937-1942. doi: 10.1016/j.bmcl.2018.03.061. Epub 2018 Mar 23.
54 Association between NQO1 C609T polymorphism and acute lymphoblastic leukemia risk: evidence from an updated meta-analysis based on 17 case-control studies.J Cancer Res Clin Oncol. 2014 Jun;140(6):873-81. doi: 10.1007/s00432-014-1595-5. Epub 2014 Feb 2.
55 The role of transcription factor Sp1 in the regulation of gamma-glutamyl hydrolase gene expression by the rs3758149 polymorphism in CEM/C1 cells.Pharmazie. 2019 Nov 1;74(11):671-674. doi: 10.1691/ph.2019.9689.
56 Y-box-binding protein 1 contributes to IL-7-mediated survival signaling in B-cell precursor acute lymphoblastic leukemia.Oncol Lett. 2017 Jan;13(1):497-505. doi: 10.3892/ol.2016.5437. Epub 2016 Nov 28.
57 Identification of mutant alleles of JAK3 in pediatric patients with acute lymphoblastic leukemia.Leuk Lymphoma. 2015 May;56(5):1502-6. doi: 10.3109/10428194.2014.957204. Epub 2015 Jan 21.
58 ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms.Haematologica. 2019 Aug;104(8):1608-1616. doi: 10.3324/haematol.2018.207837. Epub 2019 Jan 24.
59 Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.J Biol Chem. 2018 Oct 5;293(40):15359-15369. doi: 10.1074/jbc.RA118.002243. Epub 2018 Aug 20.
60 NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome.J Transl Med. 2018 Aug 20;16(1):232. doi: 10.1186/s12967-018-1608-2.
61 Differential expression of CD73, CD86 and CD304 in normal vs. leukemic B-cell precursors and their utility as stable minimal residual disease markers in childhood B-cell precursor acute lymphoblastic leukemia.J Immunol Methods. 2019 Dec;475:112429. doi: 10.1016/j.jim.2018.03.005. Epub 2018 Mar 9.
62 Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding.J Hematol Oncol. 2014 Jun 2;7:43. doi: 10.1186/1756-8722-7-43.
63 SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia.Cancer Genet. 2018 Oct;226-227:30-35. doi: 10.1016/j.cancergen.2018.05.004. Epub 2018 Jun 8.
64 STEAP, a prostate tumor antigen, is a target of human CD8+ T cells.Cancer Immunol Immunother. 2006 Dec;55(12):1515-23. doi: 10.1007/s00262-006-0165-3. Epub 2006 Apr 19.
65 Characterizing Iranian Pediatric Patients With Relapsed Acute Lymphoblastic Leukemia Through Gene Expression Profiling of Common ATP Binding Cassette Transporters Subfamily C.J Pediatr Hematol Oncol. 2020 Jan;42(1):41-45. doi: 10.1097/MPH.0000000000001613.
66 Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia.Hematology. 2017 Jun;22(5):286-291. doi: 10.1080/10245332.2016.1265780. Epub 2016 Dec 14.
67 A causal mechanism for childhood acute lymphoblastic leukaemia.Nat Rev Cancer. 2018 Aug;18(8):471-484. doi: 10.1038/s41568-018-0015-6.
68 OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL. Clin Cancer Res. 2019 Jul 15;25(14):4493-4503.
69 Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells.Cancer Lett. 2016 May 28;375(1):127-132. doi: 10.1016/j.canlet.2016.02.040. Epub 2016 Mar 2.
70 AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.Mol Cancer Ther. 2011 Mar;10(3):437-47. doi: 10.1158/1535-7163.MCT-10-0777. Epub 2011 Jan 24.
71 Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias.Leukemia. 1996 Feb;10(2):255-60.
72 Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.Nat Commun. 2019 Nov 25;10(1):5348. doi: 10.1038/s41467-019-13069-6.
73 14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a.Am J Hematol. 2010 Aug;85(8):575-8. doi: 10.1002/ajh.21758.
74 Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.Genes Dev. 2019 Sep 1;33(17-18):1265-1279. doi: 10.1101/gad.327593.119. Epub 2019 Aug 8.
75 Chromosomal microarray analysis is superior in identifying cryptic aberrations in patients with acute lymphoblastic leukemia at diagnosis/relapse as a single assay.Int J Lab Hematol. 2019 Aug;41(4):561-571. doi: 10.1111/ijlh.13052. Epub 2019 May 21.
76 Methylation pattern of calcitonin (CALCA) gene in pediatric acute leukemia.J Pediatr Hematol Oncol. 2011 Oct;33(7):534-42. doi: 10.1097/MPH.0b013e3181f46bc4.
77 Cancer immune therapy for lymphoid malignancies: recent advances.Semin Immunopathol. 2019 Jan;41(1):111-124. doi: 10.1007/s00281-018-0696-7. Epub 2018 Jul 13.
78 Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2012 Mar;51(3):250-6. doi: 10.1002/gcc.20949. Epub 2011 Nov 10.
79 Novel CT domain-encoding splice forms of CTGF/CCN2 are expressed in B-lineage acute lymphoblastic leukaemia.Leuk Res. 2015 Aug;39(8):913-20. doi: 10.1016/j.leukres.2015.05.008. Epub 2015 May 22.
80 Molecular Players in Hematologic Tumor Cell Trafficking.Front Immunol. 2019 Feb 6;10:156. doi: 10.3389/fimmu.2019.00156. eCollection 2019.
81 Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia.Cancer Res. 2003 Oct 1;63(19):6469-77.
82 The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines.Invest New Drugs. 2012 Apr;30(2):529-40. doi: 10.1007/s10637-010-9594-0. Epub 2010 Dec 1.
83 Immunophenotypic Characterization of Cytogenetic Subgroups in Egyptian Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia.Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S19-S24.e1. doi: 10.1016/j.clml.2016.02.032.
84 Targeted therapy paves the way for the cure of acute lymphoblastic leukaemia.Br J Haematol. 2020 Jan;188(2):207-223. doi: 10.1111/bjh.16207. Epub 2019 Sep 30.
85 ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.Genes Chromosomes Cancer. 2017 Aug;56(8):608-616. doi: 10.1002/gcc.22464. Epub 2017 May 5.
86 CD38 antibodies in multiple myeloma: back to the future.Blood. 2018 Jan 4;131(1):13-29. doi: 10.1182/blood-2017-06-740944. Epub 2017 Nov 8.
87 Acute lymphocytic leukemia: correlation of clinical features with immunocytochemical classification.Am J Hematol. 1987 May;25(1):13-27. doi: 10.1002/ajh.2830250103.
88 Loss of the GPI-anchor in B-lymphoblastic leukemia by epigenetic downregulation of PIGH expression.Am J Hematol. 2019 Jan;94(1):93-102. doi: 10.1002/ajh.25337. Epub 2018 Nov 25.
89 Expression of complement regulatory proteins CR1, DAF, MCP and CD59 in haematological malignancies.Eur J Haematol. 2000 Jan;64(1):3-9. doi: 10.1034/j.1600-0609.2000.80097.x.
90 The CD70/CD27 pathway is critical for stimulation of an effective cytotoxic T cell response against B cell precursor acute lymphoblastic leukemia.J Immunol. 2009 Jan 1;182(1):718-25. doi: 10.4049/jimmunol.182.1.718.
91 Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia.Leukemia. 1996 May;10(5):769-73.
92 Preparation and identification of a novel immunomodulator composed of muramyl dipeptide and anti-CD10 monoclonal antibody for treatment of minimal residual disease in acute leukemia children.Int Immunopharmacol. 2011 Sep;11(9):1211-9. doi: 10.1016/j.intimp.2011.03.022. Epub 2011 Apr 12.
93 Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family.Br J Haematol. 2011 Oct;155(1):73-83. doi: 10.1111/j.1365-2141.2011.08812.x. Epub 2011 Aug 2.
94 High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias.Ann Hematol. 2008 Mar;87(3):205-11. doi: 10.1007/s00277-007-0388-1. Epub 2007 Oct 2.
95 Clinical and laboratory features of adult biphenotypic acute leukemia.Asia Pac J Clin Oncol. 2013 Jun;9(2):146-54. doi: 10.1111/j.1743-7563.2012.01571.x. Epub 2012 Jul 9.
96 Properdin factor B and acute lymphocytic leukemia (ALL).Cancer. 1982 Dec 1;50(11):2369-71. doi: 10.1002/1097-0142(19821201)50:11<2369::aid-cncr2820501123>3.0.co;2-s.
97 Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.Genome Res. 2017 Feb;27(2):185-195. doi: 10.1101/gr.209163.116. Epub 2016 Nov 30.
98 C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia.Cancer Res. 2004 Nov 15;64(22):8443-50. doi: 10.1158/0008-5472.CAN-04-1659.
99 microRNA-146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling.Yonsei Med J. 2019 Oct;60(10):924-934. doi: 10.3349/ymj.2019.60.10.924.
100 CBP Modulates Sensitivity to Dasatinib in Pre-BCR(+) Acute Lymphoblastic Leukemia.Cancer Res. 2018 Nov 15;78(22):6497-6508. doi: 10.1158/0008-5472.CAN-18-1703. Epub 2018 Sep 27.
101 CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia.J Clin Oncol. 2008 Jun 20;26(18):3031-7. doi: 10.1200/JCO.2007.14.6399.
102 GATA3 germline variant is associated with CRLF2 expression and predicts outcome in pediatric B-cell precursor acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2019 Sep;58(9):619-626. doi: 10.1002/gcc.22748. Epub 2019 Apr 3.
103 NF-kappa B mediated up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia.Mol Cancer. 2014 Jan 7;13:5. doi: 10.1186/1476-4598-13-5.
104 Ghrelin induces autophagy and CXCR4 expression via the SIRT1/AMPK axis in lymphoblastic leukemia cell lines.Cell Signal. 2020 Feb;66:109492. doi: 10.1016/j.cellsig.2019.109492. Epub 2019 Dec 3.
105 The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.Haematologica. 2007 Mar;92(3):308-14. doi: 10.3324/haematol.10752.
106 The effect of race on the CYP3A-mediated metabolism of vincristine in pediatric patients with acute lymphoblastic leukemia.J Oncol Pharm Pract. 2016 Feb;22(1):76-81. doi: 10.1177/1078155214553143. Epub 2014 Oct 10.
107 Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.Genet Test Mol Biomarkers. 2017 Oct;21(10):592-599. doi: 10.1089/gtmb.2017.0084. Epub 2017 Aug 2.
108 Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia.Cancer Chemother Pharmacol. 2019 Apr;83(4):755-762. doi: 10.1007/s00280-019-03776-8. Epub 2019 Jan 25.
109 miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2.Oncol Res. 2016;24(2):89-97. doi: 10.3727/096504016X14597766487753.
110 PCR-heteroduplex analysis of TCR gamma, delta and TAL-1 deletions in T-acute lymphoblastic leukemias: implications in the detection of minimal residual disease.Leuk Res. 2002 Apr;26(4):335-43. doi: 10.1016/s0145-2126(01)00130-8.
111 Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL.Pediatr Blood Cancer. 2016 Jul;63(7):1283-6. doi: 10.1002/pbc.25975. Epub 2016 Mar 23.
112 A point mutation in the RNA-binding domain I results in decrease of PKR activation in acute lymphoblastic leukemia.Blood Cells Mol Dis. 2005 Jan-Feb;34(1):1-5. doi: 10.1016/j.bcmd.2004.08.025.
113 A blood pact: the significance and implications of eIF4E on lymphocytic leukemia.Physiol Res. 2018 Jul 17;67(3):363-382. doi: 10.33549/physiolres.933696. Epub 2018 Mar 12.
114 N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of acute lymphoblastic leukemia cells to vincristine through inhibition of eif5a-2 activation.Anticancer Drugs. 2017 Nov;28(10):1097-1105. doi: 10.1097/CAD.0000000000000550.
115 EP300-ZNF384 fusion gene product up-regulates GATA3 gene expression and induces hematopoietic stem cell gene expression signature in B-cell precursor acute lymphoblastic leukemia cells.Int J Hematol. 2017 Aug;106(2):269-281. doi: 10.1007/s12185-017-2220-6. Epub 2017 Apr 4.
116 Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia.Blood. 2010 Mar 25;115(12):2412-9. doi: 10.1182/blood-2009-05-222208. Epub 2010 Jan 8.
117 GATA2 regulates the erythropoietin receptor in t(12;21) ALL.Oncotarget. 2017 Aug 2;8(39):66061-66074. doi: 10.18632/oncotarget.19792. eCollection 2017 Sep 12.
118 Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.Cell Rep. 2016 Mar 1;14(8):1953-65. doi: 10.1016/j.celrep.2016.01.064. Epub 2016 Feb 18.
119 Impact of baseline clinical and laboratory features on the risk of thrombosis in children with acute lymphoblastic leukemia: A prospective evaluation.Pediatr Blood Cancer. 2018 May;65(5):e26938. doi: 10.1002/pbc.26938. Epub 2018 Jan 15.
120 Cardiotoxicity evaluation in pediatric patients with acute lymphoblastic leukemia - results of prospective study.Med Ultrason. 2019 Nov 24;21(4):449-455. doi: 10.11152/mu-2012.
121 Case of acute lymphoblastic leukemia presenting with t(14;18)/BCL2, t(8;14)/cMYC, and t(1;2)/FCGR2B.Am J Hematol. 2003 Oct;74(2):112-8. doi: 10.1002/ajh.10393.
122 Altered conjugate formation and altered apoptosis of multidrug-resistant human leukemia cell line affects susceptibility to killing by activated natural killer (NK) cells.Int J Cancer. 2004 Jan 1;108(1):78-85. doi: 10.1002/ijc.11555.
123 Histone deacetylase inhibition improves differentiation of dendritic cells from leukemic blasts of patients with TEL/AML1-positive acute lymphoblastic leukemia.J Leukoc Biol. 2009 Mar;85(3):563-73. doi: 10.1189/jlb.0808469. Epub 2009 Jan 16.
124 FHIT Gene Expression in Acute Lymphoblastic Leukemia and its Clinical Significance.Asian Pac J Cancer Prev. 2015;16(18):8197-201. doi: 10.7314/apjcp.2015.16.18.8197.
125 Alternative splicing of Ikaros regulates the FUT4/Le(X)-51 integrin-FAK axis in acute lymphoblastic leukemia.Biochem Biophys Res Commun. 2019 Feb 26;510(1):128-134. doi: 10.1016/j.bbrc.2019.01.064. Epub 2019 Jan 22.
126 Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis.Blood. 2004 Sep 1;104(5):1435-41. doi: 10.1182/blood-2003-12-4306. Epub 2004 May 13.
127 Killer cell immunoglobulin-like receptor ligand mismatching and outcome after haploidentical transplantation with post-transplant cyclophosphamide.Leukemia. 2019 Jan;33(1):230-239. doi: 10.1038/s41375-018-0170-5. Epub 2018 Jun 15.
128 Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.Oncotarget. 2016 Oct 4;7(40):65923-65936. doi: 10.18632/oncotarget.11688.
129 A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene.Cancer Res. 2004 Jun 15;64(12):4089-98. doi: 10.1158/0008-5472.CAN-03-1871.
130 Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3.Leukemia. 1991 Apr;5(4):322-31.
131 Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia.Br J Haematol. 2010 Sep;150(6):665-73. doi: 10.1111/j.1365-2141.2010.08301.x.
132 Persistent rubella infection after erroneous vaccination in an immunocompromised patient with acute lymphoblastic leukemia in remission.J Med Virol. 1995 Dec;47(4):442-4. doi: 10.1002/jmv.1890470425.
133 Glutathione-S-transferase polymorphism and acute lymphoblastic leukemia (ALL) in north Indian children: a case-control study and meta-analysis.J Hum Genet. 2014 Sep;59(9):529-35. doi: 10.1038/jhg.2014.66. Epub 2014 Aug 7.
134 Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpoints.Mol Diagn. 1999 Dec;4(4):269-83. doi: 10.1016/s1084-8592(99)80002-2.
135 CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia.Haematologica. 2019 Apr;104(4):749-755. doi: 10.3324/haematol.2018.205252. Epub 2018 Oct 25.
136 Deleterious and Oncogenic Mutations in the IL7RA.Cancers (Basel). 2019 Dec 5;11(12):1952. doi: 10.3390/cancers11121952.
137 G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells.Cancers (Basel). 2018 Sep 12;10(9):325. doi: 10.3390/cancers10090325.
138 Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia.J Hematol Oncol. 2017 Feb 28;10(1):61. doi: 10.1186/s13045-017-0431-1.
139 shRNA screening identifies JMJD1C as being required for leukemia maintenance.Blood. 2014 Mar 20;123(12):1870-82. doi: 10.1182/blood-2013-08-522094. Epub 2014 Feb 5.
140 Low Expression of miR-18a as a Characteristic of Pediatric Acute Lymphoblastic Leukemia.J Pediatr Hematol Oncol. 2017 Nov;39(8):585-588. doi: 10.1097/MPH.0000000000000921.
141 Lack of association of the CEP72 rs924607 TT genotype with vincristine-related peripheral neuropathy during the early phase of pediatric acute lymphoblastic leukemia treatment in a Spanish population.Pharmacogenet Genomics. 2016 Feb;26(2):100-2. doi: 10.1097/FPC.0000000000000191.
142 Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia.Haematologica. 2020 Jan;105(1):170-181. doi: 10.3324/haematol.2018.199364. Epub 2019 May 9.
143 Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral cancer.Kaohsiung J Med Sci. 2012 Mar;28(3):138-44. doi: 10.1016/j.kjms.2011.10.023. Epub 2012 Jan 20.
144 Lymphotoxin beta expression is high in chronic lymphocytic leukemia but low in small lymphocytic lymphoma: a quantitative real-time reverse transcriptase polymerase chain reaction analysis.Haematologica. 2003 Jun;88(6):654-8.
145 Polymorphisms in innate immunity genes and risk of childhood leukemia.Hum Immunol. 2010 Jul;71(7):727-30. doi: 10.1016/j.humimm.2010.04.004. Epub 2010 May 16.
146 Acute lymphoblastic leukemia in the context of RASopathies.Eur J Med Genet. 2016 Mar;59(3):173-8. doi: 10.1016/j.ejmg.2016.01.003. Epub 2016 Feb 5.
147 Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells.BMC Cancer. 2015 Apr 7;15:226. doi: 10.1186/s12885-015-1282-1.
148 Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy.Pharmacol Ther. 2019 Mar;195:13-20. doi: 10.1016/j.pharmthera.2018.10.009. Epub 2018 Oct 19.
149 Wnt/catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia.Oncol Rep. 2019 Feb;41(2):1387-1394. doi: 10.3892/or.2018.6902. Epub 2018 Dec 4.
150 MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.JCI Insight. 2018 Nov 2;3(21):e97941. doi: 10.1172/jci.insight.97941.
151 PKC and PKM are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity.Leukemia. 2015 Feb;29(2):304-11. doi: 10.1038/leu.2014.210. Epub 2014 Jul 3.
152 Focused screening of a panel of cancer-related genetic polymorphisms reveals new susceptibility loci for pediatric acute lymphoblastic leukemia.Pediatr Blood Cancer. 2014 Aug;61(8):1411-5. doi: 10.1002/pbc.25011. Epub 2014 Mar 6.
153 Lack of expression of MTAP in uncommon T-cell lymphomas.Clin Lymphoma Myeloma Leuk. 2012 Oct;12(5):306-9. doi: 10.1016/j.clml.2012.07.001.
154 Thymidylate synthase and methionine synthase polymorphisms are not associated with susceptibility to childhood acute lymphoblastic leukemia in Kurdish population from Western Iran.Mol Biol Rep. 2012 Mar;39(3):2195-200. doi: 10.1007/s11033-011-0968-y. Epub 2011 Jun 5.
155 Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph(+) Acute Lymphoblastic Leukemia.Cancer Res. 2018 Feb 15;78(4):1097-1109. doi: 10.1158/0008-5472.CAN-17-2644. Epub 2017 Dec 12.
156 Clinical significance of BCR-ABL fusion gene subtypes in chronic myelogenous and acute lymphoblastic leukemias.Asian Pac J Cancer Prev. 2014;15(22):9961-6. doi: 10.7314/apjcp.2014.15.22.9961.
157 Expression of CD56 is a risk factor for acute lymphocytic leukemia with central nervous system involvement in adults.Hematology. 2017 Mar;22(2):81-87. doi: 10.1080/10245332.2016.1238183. Epub 2016 Oct 13.
158 Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.Oncotarget. 2017 Dec 31;9(5):5529-5544. doi: 10.18632/oncotarget.23797. eCollection 2018 Jan 19.
159 Role of neuropilin-1 and its expression in Egyptian acute myeloid and acute lymphoid leukemia patients.Leuk Res. 2012 Feb;36(2):169-73. doi: 10.1016/j.leukres.2011.08.017. Epub 2011 Oct 5.
160 Serum nm23-H1 protein as a prognostic factor in hematological malignancies.Leuk Lymphoma. 2002 Apr;43(4):859-67. doi: 10.1080/10428190290017006.
161 Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression.J Immunol Res. 2019 Jun 27;2019:5601396. doi: 10.1155/2019/5601396. eCollection 2019.
162 Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias.Ann Hematol. 2004 Aug;83(8):527-32. doi: 10.1007/s00277-004-0843-1. Epub 2004 Feb 5.
163 The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.Int J Cancer. 2018 Apr 1;142(7):1490-1502. doi: 10.1002/ijc.31170. Epub 2017 Dec 26.
164 Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression.Clin Epigenetics. 2018 Jun 19;10:83. doi: 10.1186/s13148-018-0516-x. eCollection 2018.
165 Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.Leukemia. 2017 Jul;31(7):1491-1501. doi: 10.1038/leu.2016.365. Epub 2016 Nov 30.
166 Pneumatosis cystoides intestinalis with abdominal free air in a 2-year-old girl after allogeneic bone marrow transplantation.Pediatr Hematol Oncol. 1998 Jan-Feb;15(1):81-4. doi: 10.3109/08880019809009512.
167 Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.Cell Signal. 2011 Jan;23(1):152-60. doi: 10.1016/j.cellsig.2010.08.015. Epub 2010 Aug 31.
168 Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL.Blood Adv. 2018 Oct 9;2(19):2554-2567. doi: 10.1182/bloodadvances.2018020693.
169 Acute lymphoblastic leukemia in a child with the CHIME neuroectodermal dysplasia syndrome.Am J Med Genet. 1997 Oct 3;72(1):24-9.
170 KMT2A rearranged acute lymphoblastic leukaemia: Unravelling the genomic complexity and heterogeneity of this high-risk disease.Cancer Lett. 2020 Jan 28;469:410-418. doi: 10.1016/j.canlet.2019.11.005. Epub 2019 Nov 6.
171 Expression of PIM-2 and NF-B genes is increased in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and is associated with complete remission rate and overall survival.Postepy Hig Med Dosw (Online). 2013 Jun 7;67:553-9. doi: 10.5604/17322693.1052449.
172 Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia.Nanoscale. 2019 Dec 21;11(47):23000-23012. doi: 10.1039/c9nr07391d. Epub 2019 Nov 26.
173 Abnormally high expression of POLD1, MCM2, and PLK4 promotes relapse of acute lymphoblastic leukemia.Medicine (Baltimore). 2018 May;97(20):e10734. doi: 10.1097/MD.0000000000010734.
174 Enzyme analysis of lymphoproliferative diseases: a useful addition to cell surface phenotyping.Blood. 1983 Sep;62(3):669-76.
175 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.Clin Pharmacol Ther. 2017 Jul;102(1):131-140. doi: 10.1002/cpt.629. Epub 2017 Apr 4.
176 Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale.Cancer Genet Cytogenet. 2007 Jul 15;176(2):131-6. doi: 10.1016/j.cancergencyto.2007.03.010.
177 Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.Blood. 2019 Oct 10;134(15):1257-1268. doi: 10.1182/blood.2019002457.
178 Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report.Haematologica. 2019 Mar;104(3):556-563. doi: 10.3324/haematol.2018.199356. Epub 2018 Nov 22.
179 Aptamer-facilitated mass cytometry.Anal Bioanal Chem. 2018 May;410(13):3047-3051. doi: 10.1007/s00216-018-1011-0. Epub 2018 Mar 20.
180 Side scatter versus CD45 flow cytometric plot can distinguish acute leukaemia subtypes.Indian J Med Res. 2016 May;143(Supplement):S17-S22. doi: 10.4103/0971-5916.191743.
181 Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor alpha.Mol Carcinog. 2005 Dec;44(4):252-61. doi: 10.1002/mc.20144.
182 Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting.Oncogene. 2019 Apr;38(17):3288-3300. doi: 10.1038/s41388-018-0670-9. Epub 2019 Jan 10.
183 Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy.Exp Mol Pathol. 2012 Feb;92(1):44-9. doi: 10.1016/j.yexmp.2011.09.004. Epub 2011 Oct 19.
184 Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood.Leukemia. 1996 Jul;10(7):1104-10.
185 Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL.Bone Marrow Transplant. 2019 Nov;54(11):1847-1858. doi: 10.1038/s41409-019-0543-z. Epub 2019 May 14.
186 SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24.Cancer Res. 2002 Jan 15;62(2):333-7.
187 MiR-595 Suppresses the Cellular Uptake and Cytotoxic Effects of Methotrexate by Targeting SLC19A1 in CEM/C1 Cells.Basic Clin Pharmacol Toxicol. 2018 Jul;123(1):8-13. doi: 10.1111/bcpt.12966. Epub 2018 Feb 22.
188 Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia.Cancer Chemother Pharmacol. 1989;24(4):203-10. doi: 10.1007/BF00257619.
189 A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to BAcute Lymphoblastic Leukemia-Associated ETV6-RUNX1.Dev Cell. 2018 Feb 5;44(3):362-377.e7. doi: 10.1016/j.devcel.2017.12.005. Epub 2017 Dec 28.
190 Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia.Leuk Res. 2018 Feb;65:61-66. doi: 10.1016/j.leukres.2018.01.004. Epub 2018 Jan 2.
191 Overexpression of SET and MYND domain-containing protein 2 (SMYD2) is associated with poor prognosis in pediatric B lineage acute lymphoblastic leukemia.Leuk Lymphoma. 2020 Feb;61(2):437-444. doi: 10.1080/10428194.2019.1675875. Epub 2019 Oct 15.
192 Long non-coding RNA SNHG16 has Tumor suppressing effect in acute lymphoblastic leukemia by inverse interaction on hsa-miR-124-3p.IUBMB Life. 2019 Jan;71(1):134-142. doi: 10.1002/iub.1947. Epub 2018 Oct 31.
193 Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.Cancer Res. 2014 May 15;74(10):2803-15. doi: 10.1158/0008-5472.CAN-13-2732. Epub 2014 Mar 31.
194 Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.J Clin Oncol. 2007 Apr 10;25(11):1341-9. doi: 10.1200/JCO.2006.09.3534. Epub 2007 Feb 20.
195 Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.J Biol Chem. 2014 Jul 25;289(30):20502-15. doi: 10.1074/jbc.M114.569889.
196 Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics.Blood. 2019 Feb 14;133(7):724-729. doi: 10.1182/blood-2018-07-862946. Epub 2018 Dec 3.
197 IGH gene involvement in two cases of acute lymphoblastic leukemia with t(14;14)(q11;q32) identified by sequential R-banding and fluorescence in situ hybridization.Cancer Genet Cytogenet. 2004 Jul 15;152(2):141-5. doi: 10.1016/j.cancergencyto.2003.11.008.
198 Expression of thrombopoietin receptor and its functional role in human B-precursor leukemia cells with 11q23 translocation or Philadelphia chromosome.Leukemia. 2000 Sep;14(9):1598-605. doi: 10.1038/sj.leu.2401893.
199 CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies.Sci Transl Med. 2019 Sep 25;11(511):eaaw9414. doi: 10.1126/scitranslmed.aaw9414.
200 Expression of the Immune Checkpoint Modulator OX40 in Acute Lymphoblastic Leukemia Is Associated with BCR-ABL Positivity.Neoplasia. 2018 Nov;20(11):1150-1160. doi: 10.1016/j.neo.2018.09.005. Epub 2018 Oct 6.
201 Treatment of acute lymphoblastic leukaemia with the second generation of CD19 CAR-T containing either CD28 or 4-1BB.Br J Haematol. 2018 May;181(3):360-371. doi: 10.1111/bjh.15195. Epub 2018 Apr 10.
202 Novel cryptic chromosomal rearrangements in childhood acute lymphoblastic leukemia detected by multiple color fluorescent in situ hybridization.Haematologica. 2005 Sep;90(9):1179-85.
203 Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways.Blood Adv. 2017 Sep 8;1(20):1749-1759. doi: 10.1182/bloodadvances.2017009837. eCollection 2017 Sep 12.
204 Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS).Blood. 2015 Jan 29;125(5):820-30. doi: 10.1182/blood-2014-06-583062. Epub 2014 Nov 26.
205 A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia.Haematologica. 2005 Jul;90(7):890-8.
206 Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children.J Natl Cancer Inst. 2019 Dec 1;111(12):1350-1357. doi: 10.1093/jnci/djz043.
207 Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia.Cancers (Basel). 2019 Oct 25;11(11):1654. doi: 10.3390/cancers11111654.
208 Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation.BMC Cancer. 2012 Feb 7;12:60. doi: 10.1186/1471-2407-12-60.
209 Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia.Integr Biol (Camb). 2016 Jul 11;8(7):761-74. doi: 10.1039/c6ib00040a. Epub 2016 Jun 17.
210 The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system.Haematologica. 2017 Feb;102(2):346-355. doi: 10.3324/haematol.2016.147744. Epub 2016 Sep 29.
211 Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias.Leuk Res. 1997 Apr;21(4):313-9. doi: 10.1016/s0145-2126(96)00130-0.
212 mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2.Cancer Biol Ther. 2014 Jan;15(1):35-41. doi: 10.4161/cbt.26603. Epub 2013 Oct 21.
213 ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia.Cancer Chemother Pharmacol. 2017 Jul;80(1):109-117. doi: 10.1007/s00280-017-3340-7. Epub 2017 May 26.
214 The rapidly evolving state of gene therapy.FASEB J. 2018 Apr;32(4):1733-1740. doi: 10.1096/fj.201700982R.
215 Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T-cell leukemia.Int J Cancer. 2008 Oct 15;123(8):1824-31. doi: 10.1002/ijc.23749.
216 Expression of Immune Checkpoint Receptors on T-Cells and Their Ligands on Leukemia Blasts in Childhood Acute Leukemia.Anticancer Res. 2019 Oct;39(10):5531-5539. doi: 10.21873/anticanres.13746.
217 A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment.Pharmacogenomics J. 2017 Mar;17(2):180-185. doi: 10.1038/tpj.2015.92. Epub 2016 Feb 9.
218 A distinguished cancer-screening package containing a DNA sensor and an aptasensor for early and certain detection of acute lymphoblastic leukemia.Clin Chim Acta. 2019 Oct;497:41-47. doi: 10.1016/j.cca.2019.07.009. Epub 2019 Jul 8.
219 Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.Front Immunol. 2018 Jan 25;8:1975. doi: 10.3389/fimmu.2017.01975. eCollection 2017.
220 3D culture enhances chemoresistance of ALL Jurkat cell line by increasing DDR1 expression.Exp Ther Med. 2019 Mar;17(3):1593-1600. doi: 10.3892/etm.2019.7153. Epub 2019 Jan 4.
221 Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.Sci Rep. 2016 Nov 25;6:38004. doi: 10.1038/srep38004.
222 Letter regarding Zhao et al. entitled " DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia".Tumour Biol. 2017 Jun;39(6):1010428317701629. doi: 10.1177/1010428317701629.
223 Physcion blocks cell cycle and induces apoptosis in human B cell precursor acute lymphoblastic leukemia cells by downregulating HOXA5.Biomed Pharmacother. 2017 Oct;94:850-857. doi: 10.1016/j.biopha.2017.07.149. Epub 2017 Aug 10.
224 Acute Lymphoblastic Leukemia With INPP5D-ABL1 Fusion Responds to Imatinib Treatment.J Pediatr Hematol Oncol. 2019 Oct;41(7):e481-e483. doi: 10.1097/MPH.0000000000001267.
225 IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells.Cancer Lett. 2019 Aug 1;456:59-68. doi: 10.1016/j.canlet.2019.04.030. Epub 2019 Apr 28.
226 Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem-cell transplantation.J Clin Oncol. 2013 Oct 20;31(30):3782-90. doi: 10.1200/JCO.2012.47.4007. Epub 2013 Sep 16.
227 Suppression of HSP70 inhibits the development of acute lymphoblastic leukemia via TAK1/Egr-1.Biomed Pharmacother. 2019 Nov;119:109399. doi: 10.1016/j.biopha.2019.109399. Epub 2019 Sep 12.
228 Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance.Oncotarget. 2017 Dec 13;9(3):3549-3561. doi: 10.18632/oncotarget.23186. eCollection 2018 Jan 9.
229 Antithrombin III as the Indicator of L-Asparaginase Activity in Children Treated for Acute Lymphoblastic Leukemia.J Pediatr Hematol Oncol. 2017 Mar;39(2):114-120. doi: 10.1097/MPH.0000000000000739.
230 The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.Clin Cancer Res. 2017 May 15;23(10):2528-2541. doi: 10.1158/1078-0432.CCR-16-1580. Epub 2016 Oct 25.
231 AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10398-403. doi: 10.1073/pnas.171321298.
232 Dysregulation of miR-335-3p, targeted by NEAT1 and MALAT1 long non-coding RNAs, is associated with poor prognosis in childhood acute lymphoblastic leukemia.Gene. 2019 Apr 15;692:35-43. doi: 10.1016/j.gene.2019.01.003. Epub 2019 Jan 11.
233 Expression of ABCB5 gene in hematological malignances and its significance.Leuk Lymphoma. 2012 Jun;53(6):1211-5. doi: 10.3109/10428194.2011.637214. Epub 2011 Dec 7.
234 Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma.BMC Cancer. 2018 Jul 3;18(1):704. doi: 10.1186/s12885-018-4629-6.
235 Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2013 Feb;52(2):202-13. doi: 10.1002/gcc.22021. Epub 2012 Oct 18.
236 Improving risk stratification of patients with childhood acute lymphoblastic leukemia: Glutathione-S-Transferases polymorphisms are associated with increased risk of relapse.Oncotarget. 2017 Jan 3;8(1):110-117. doi: 10.18632/oncotarget.8606.
237 High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia.Environ Mol Mutagen. 2012 Oct;53(8):619-30. doi: 10.1002/em.21723. Epub 2012 Aug 29.
238 Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia.Br J Haematol. 2010 Jan;148(1):3-14. doi: 10.1111/j.1365-2141.2009.07898.x. Epub 2009 Sep 22.
239 Absence of SCL mutations in myeloid malignancies.Br J Haematol. 2003 Feb;120(3):482-3. doi: 10.1046/j.1365-2141.2003.04122.x.
240 Methylation of the promoter region of the MTRR gene in childhood acute lymphoblastic leukemia.Oncol Rep. 2019 Jun;41(6):3488-3498. doi: 10.3892/or.2019.7114. Epub 2019 Apr 12.
241 Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome.Rev Environ Health. 2001 Jul-Sep;16(4):263-79. doi: 10.1515/reveh.2001.16.4.263.
242 Analysis of genomic breakpoints in p190 and p210 BCR-ABL indicate distinct mechanisms of formation.Leukemia. 2010 Oct;24(10):1742-50. doi: 10.1038/leu.2010.174. Epub 2010 Aug 12.
243 Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.Cancer Chemother Pharmacol. 2014 Aug;74(2):283-9. doi: 10.1007/s00280-014-2507-8. Epub 2014 Jun 8.
244 Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.Mol Cancer Ther. 2019 Sep;18(9):1587-1592. doi: 10.1158/1535-7163.MCT-18-1329. Epub 2019 Jun 17.
245 Genotoxicity of therapeutic intervention in children with acute lymphocytic leukemia.Cancer Res. 2004 Jul 1;64(13):4464-71. doi: 10.1158/0008-5472.CAN-03-3940.
246 Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3.Hum Mol Genet. 2007 Sep 15;16(18):2215-25. doi: 10.1093/hmg/ddm173. Epub 2007 Jul 5.
247 Multidrug resistance in acute leukemia: a comparison of different diagnostic methods.Leukemia. 1997 Jul;11(7):1067-72. doi: 10.1038/sj.leu.2400691.
248 LAF-4 is aberrantly expressed in human breast cancer.Int J Cancer. 2005 Jul 1;115(4):568-74. doi: 10.1002/ijc.20881.
249 Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.Blood. 2005 Aug 15;106(4):1355-61. doi: 10.1182/blood-2004-09-3655. Epub 2005 Apr 28.
250 Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia.Oncotarget. 2016 Jul 19;7(29):45398-45413. doi: 10.18632/oncotarget.9982.
251 MEF2D-BCL9 Fusion Gene Is Associated With High-Risk Acute B-Cell Precursor Lymphoblastic Leukemia in Adolescents.J Clin Oncol. 2016 Oct 1;34(28):3451-9. doi: 10.1200/JCO.2016.66.5547. Epub 2016 Aug 9.
252 The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.Haematologica. 2013 Nov;98(11):1711-7. doi: 10.3324/haematol.2013.086082. Epub 2013 Jul 5.
253 Biphenotypic acute leukemia with coexpression of CD79a and markers of myeloid lineage.Arch Pathol Lab Med. 2003 Mar;127(3):356-9. doi: 10.5858/2003-127-0356-BALWCO.
254 ckshs expression is linked to cell proliferation in normal and malignant human lymphoid cells.Int J Cancer. 1999 Jul 2;82(1):98-104. doi: 10.1002/(sici)1097-0215(19990702)82:1<98::aid-ijc17>3.0.co;2-a.
255 Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.J Biol Chem. 2008 Jan 18;283(3):1563-1571. doi: 10.1074/jbc.M707997200. Epub 2007 Nov 13.
256 IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia.Transl Oncol. 2019 May;12(5):726-732. doi: 10.1016/j.tranon.2019.02.002. Epub 2019 Mar 13.
257 Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias.Am J Hematol. 2005 Dec;80(4):282-7. doi: 10.1002/ajh.20503.
258 STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.Blood. 1996 Mar 1;87(5):1692-7.
259 Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia.Cancer Cell. 2018 Dec 10;34(6):906-921.e8. doi: 10.1016/j.ccell.2018.11.002.
260 Expression of DHX32 in lymphoid tissues.Exp Mol Pathol. 2005 Dec;79(3):219-23. doi: 10.1016/j.yexmp.2005.07.002. Epub 2005 Sep 21.
261 Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia.Leuk Res. 2015 Dec;39(12):1455-61. doi: 10.1016/j.leukres.2015.10.006. Epub 2015 Oct 20.
262 Disturbed expression of the anti-apoptosis gene, survivin, and EPR-1 in hematological malignancies.Leuk Res. 2000 Nov;24(11):965-70. doi: 10.1016/s0145-2126(00)00065-5.
263 STIP Regulates ERK1/2 Signaling Pathway Involved in Interaction with PP1 in Lymphoblastic Leukemia.Curr Mol Med. 2016;16(8):767-775. doi: 10.2174/1566524016666161018154401.
264 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.Blood. 2015 Jul 2;126(1):69-75. doi: 10.1182/blood-2015-02-628800. Epub 2015 May 18.
265 GATA1 Is a Sensitive and Specific Nuclear Marker for Erythroid and Megakaryocytic Lineages.Am J Clin Pathol. 2017 Apr 1;147(4):420-426. doi: 10.1093/ajcp/aqx018.
266 BCL6 expression correlates with the t(1;19) translocation in B-lymphoblastic leukemia.Am J Clin Pathol. 2015 Apr;143(4):547-57. doi: 10.1309/AJCPO4U4VYAAOTEL.
267 Philadelphia chromosome positive chronic myelogenous leukemia developing in a patient with acute lymphoblastic leukemia.Cancer. 1979 May;43(5):1782-7. doi: 10.1002/1097-0142(197905)43:5<1782::aid-cncr2820430531>3.0.co;2-j.
268 Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.Cancer. 2013 Oct 1;119(19):3555-62. doi: 10.1002/cncr.28256. Epub 2013 Jul 16.
269 Detection of balanced translocations in acute lymphoblastic leukemia by a novel multiplex reverse transcriptase reverse transcription-polymerase chain reaction.J Cancer Res Ther. 2017 Oct-Dec;13(6):1042-1046. doi: 10.4103/0973-1482.172128.
270 Sister chromatid exchanges in leukemic patients.Cancer Genet Cytogenet. 1985 Feb 1;15(1-2):169-75. doi: 10.1016/0165-4608(85)90145-1.
271 Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.Am J Cancer Res. 2017 Jun 1;7(6):1389-1406. eCollection 2017.
272 The expression of IL-6 and its related genes in acute leukemia.Leuk Lymphoma. 1996 Mar;21(1-2):49-52. doi: 10.3109/10428199609067579.
273 MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.J Exp Clin Cancer Res. 2011 Dec 20;30(1):112. doi: 10.1186/1756-9966-30-112.
274 Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids.Br J Haematol. 1990 Aug;75(4):489-95. doi: 10.1111/j.1365-2141.1990.tb07787.x.
275 Correlation of glucocorticoid-mediated E4BP4 upregulation with altered expression of pro- and anti-apoptotic genes in CEM human lymphoblastic leukemia cells.Biochem Biophys Res Commun. 2014 Aug 29;451(3):382-8. doi: 10.1016/j.bbrc.2014.07.103. Epub 2014 Aug 4.
276 Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population.Eur J Haematol. 2011 Mar;86(3):199-205. doi: 10.1111/j.1600-0609.2010.01562.x. Epub 2011 Jan 25.
277 Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias.Blood. 2004 Sep 15;104(6):1833-40. doi: 10.1182/blood-2003-10-3577. Epub 2004 Jun 8.
278 The nuclear migration gene NudC and human hematopoiesis.Leuk Lymphoma. 2000 Nov;39(5-6):447-54. doi: 10.3109/10428190009113375.
279 PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients.Pharmacogenomics J. 2020 Jun;20(3):415-425. doi: 10.1038/s41397-019-0130-0. Epub 2019 Dec 3.
280 cDNA cloning of human myeloperoxidase: decrease in myeloperoxidase mRNA upon induction of HL-60 cells.Proc Natl Acad Sci U S A. 1987 Apr;84(7):2057-61. doi: 10.1073/pnas.84.7.2057.
281 Expression of GATA transcription factors in myelogenous and lymphoblastic leukemia cells.Int J Hematol. 1997 Apr;65(3):239-49. doi: 10.1016/s0925-5710(96)00553-1.
282 RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinase inhibitors and rapidly evolves clonally by chromosomal translocations.Int J Hematol. 2011 Sep;94(3):255-260. doi: 10.1007/s12185-011-0910-z. Epub 2011 Aug 24.
283 Chimeric Antigen Receptor T-Cell Therapy: Reach to Solid Tumor Experience.Oncology. 2019;97(2):59-74. doi: 10.1159/000500488. Epub 2019 Jul 1.
284 Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells.BMC Med Genomics. 2019 Jan 15;12(1):9. doi: 10.1186/s12920-018-0465-4.
285 Analysis of HFE and TFR2 gene mutations in patients with acute leukemia.Leuk Res. 2005 Jun;29(6):661-4. doi: 10.1016/j.leukres.2005.01.001. Epub 2005 Feb 12.
286 The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer.Elife. 2015 Apr 28;4:e06377. doi: 10.7554/eLife.06377.
287 MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.J Biomed Sci. 2002 May-Jun;9(3):234-45. doi: 10.1007/BF02256070.
288 Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia.Oncol Lett. 2017 Dec;14(6):8072-8077. doi: 10.3892/ol.2017.7229. Epub 2017 Oct 20.
289 The incidence of submicroscopic deletions in reciprocal translocations is similar in acute myeloid leukemia, BCR-ABL positive acute lymphoblastic leukemia, and chronic myeloid leukemia.Haematologica. 2005 Apr;90(4):558-9.
290 IgH and TCRgamma gene rearrangements, cyclin A1 and HOXA9 gene expression in biphenotypic acute leukemias.Leuk Res. 2006 Feb;30(2):211-21. doi: 10.1016/j.leukres.2005.07.001. Epub 2005 Aug 15.
291 Examination of copy number variations of CHST9 in multiple types of hematologic malignancies.Cancer Genet Cytogenet. 2010 Dec;203(2):176-9. doi: 10.1016/j.cancergencyto.2010.07.132.
292 Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1.Blood. 1996 Apr 15;87(8):3368-74.
293 Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia.Leukemia. 2007 Dec;21(12):2470-5. doi: 10.1038/sj.leu.2404962. Epub 2007 Sep 27.
294 Expression of the DCC gene in human hematological malignancies.Leuk Lymphoma. 1994 Dec;16(1-2):13-8. doi: 10.3109/10428199409114135.
295 Compound Heterozygous DOCK8 Mutations in a Patient with B Lymphoblastic Leukemia and EBV-Associated Diffuse Large B Cell Lymphoma.J Clin Immunol. 2019 Aug;39(6):592-595. doi: 10.1007/s10875-019-00663-y. Epub 2019 Jul 2.
296 Electrochemical detection of leukemia oncogenes using enzyme-loaded carbon nanotube labels.Analyst. 2014 Sep 7;139(17):4223-30. doi: 10.1039/c3an01156a.
297 Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.Cancer Cell. 2013 Feb 11;23(2):200-14. doi: 10.1016/j.ccr.2013.01.011.
298 Identification of new markers discriminating between myeloid and lymphoid acute leukemia.Hematology. 2010 Aug;15(4):193-203. doi: 10.1179/102453310X12647083620769.
299 Shared roles for Scl and Lyl1 in murine platelet production and function.Blood. 2019 Sep 5;134(10):826-835. doi: 10.1182/blood.2019896175. Epub 2019 Jul 12.
300 A QA Program for MRD Testing Demonstrates That Systematic Education Can Reduce Discordance Among Experienced Interpreters.Cytometry B Clin Cytom. 2018 Mar;94(2):239-249. doi: 10.1002/cyto.b.21528. Epub 2017 May 5.
301 Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.BMC Cancer. 2019 Mar 6;19(1):202. doi: 10.1186/s12885-019-5411-0.
302 Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis.Cell J. 2017 Spring;19(Suppl 1):9-26. doi: 10.22074/cellj.2017.4908. Epub 2017 May 17.
303 Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes.BMC Cancer. 2015 Jul 23;15:539. doi: 10.1186/s12885-015-1549-6.
304 DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia.Leukemia. 2014 Apr;28(4):787-93. doi: 10.1038/leu.2013.270. Epub 2013 Sep 18.
305 Beclin-1 and hypoxia-inducible factor-1 genes expression: Potential biomarkers in acute leukemia patients.Cancer Biomark. 2016 Mar 18;16(4):619-26. doi: 10.3233/CBM-160603.
306 Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript.Eur J Haematol. 2014 Mar;92(3):263-7. doi: 10.1111/ejh.12234. Epub 2013 Nov 28.
307 TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells.PLoS One. 2016 Mar 17;11(3):e0151341. doi: 10.1371/journal.pone.0151341. eCollection 2016.
308 Effect of Aplidin in acute lymphoblastic leukaemia cells.Br J Cancer. 2003 Aug 18;89(4):763-73. doi: 10.1038/sj.bjc.6601130.
309 Prognostic significance of copy number alterations detected by multi-link probe amplification of multiple genes in adult acute lymphoblastic leukemia.Oncol Lett. 2018 Apr;15(4):5359-5367. doi: 10.3892/ol.2018.7985. Epub 2018 Feb 7.
310 Functional proteomics, human genetics and cancer biology of GIPC family members.Exp Mol Med. 2013 Jun 7;45(6):e26. doi: 10.1038/emm.2013.49.
311 AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice.Blood. 2012 Jan 5;119(1):64-71. doi: 10.1182/blood-2011-05-354050. Epub 2011 Oct 24.
312 The Genetic Variants of IKZF1 Gene Linked with the Growing Risk of Childhood Acute Lymphoblastic Leukaemia.Curr Mol Med. 2019;19(1):32-39. doi: 10.2174/1566524019666190219123900.
313 Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia.Sao Paulo Med J. 2004 Jul 1;122(4):166-71. doi: 10.1590/s1516-31802004000400007. Epub 2004 Nov 9.
314 Preclinical Efficacy and Safety of CD19CAR Cytokine-Induced Killer Cells Transfected with Sleeping Beauty Transposon for the Treatment of Acute Lymphoblastic Leukemia.Hum Gene Ther. 2018 May;29(5):602-613. doi: 10.1089/hum.2017.207. Epub 2018 Apr 16.
315 Prognostic impact of p15 gene aberrations in acute leukemia.Leuk Lymphoma. 2017 Feb;58(2):257-265. doi: 10.1080/10428194.2016.1201574. Epub 2016 Jul 12.
316 Identification of Risk Factors in High-Dose Methotrexate-Induced Acute Kidney Injury in Childhood Acute Lymphoblastic Leukemia.Chemotherapy. 2018 Apr 19;63(2):101-107. doi: 10.1159/000486823. Online ahead of print.
317 E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia.Cancer Res. 2016 Dec 1;76(23):6937-6949. doi: 10.1158/0008-5472.CAN-16-1899. Epub 2016 Oct 7.
318 Illegitimate RAG-mediated recombination events are involved in IKZF1 3-6 deletion in BCR-ABL1 lymphoblastic leukaemia.Clin Exp Immunol. 2016 Sep;185(3):320-31. doi: 10.1111/cei.12812. Epub 2016 Jul 28.
319 Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.Arch Med Res. 2019 May;50(4):175-180. doi: 10.1016/j.arcmed.2019.07.010. Epub 2019 Sep 6.
320 Development of Escherichia coli Asparaginase II for Immunosensing: A Trade-Off between Receptor Density and Sensing Efficiency.ACS Omega. 2017 May 31;2(5):2114-2125. doi: 10.1021/acsomega.7b00110. Epub 2017 May 17.
321 ADAMTSL5 and CDH11: putative epigenetic markers for therapeutic resistance in acute lymphoblastic leukemia.Hematology. 2017 Aug;22(7):386-391. doi: 10.1080/10245332.2017.1299417. Epub 2017 Mar 15.
322 Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report.Medicine (Baltimore). 2018 May;97(21):e10874. doi: 10.1097/MD.0000000000010874.
323 Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.Hum Mol Genet. 2011 May 15;20(10):1873-85. doi: 10.1093/hmg/ddr069. Epub 2011 Feb 17.
324 Characterization of the specific interaction between the DNA aptamer sgc8c and protein tyrosine kinase-7 receptors at the surface of T-cells by biosensing AFM.Anal Bioanal Chem. 2017 Apr;409(11):2767-2776. doi: 10.1007/s00216-017-0238-5. Epub 2017 Feb 22.
325 Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin.Genes Chromosomes Cancer. 2018 Sep;57(9):471-477. doi: 10.1002/gcc.6. Epub 2018 Jul 30.
326 Is AMN-107 a step forward from imatinib in the treatment of chronic myeloid leukaemia?.Expert Opin Investig Drugs. 2005 Aug;14(8):1063-6. doi: 10.1517/13543784.14.8.1063.
327 APRIL is Involved in the Proliferation and Metastasis of Acute Lymphoblastic Leukemia Cells.J Pediatr Hematol Oncol. 2018 Nov;40(8):588-593. doi: 10.1097/MPH.0000000000001198.
328 Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells.Mol Pharmacol. 2013 Jan;83(1):245-55. doi: 10.1124/mol.112.080788. Epub 2012 Oct 23.
329 Genome-wide identification of microRNA signatures associated with stem/progenitor cells in Philadelphia chromosome-positive acute lymphoblastic leukemia.Mol Biol Rep. 2019 Feb;46(1):1295-1306. doi: 10.1007/s11033-019-04600-5. Epub 2019 Feb 2.
330 ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.Haematologica. 2020 Apr;105(4):925-936. doi: 10.3324/haematol.2018.210286. Epub 2019 Aug 29.
331 Variants in ARID5B gene are associated with the development of acute lymphoblastic leukemia in Mexican children.Ann Hematol. 2019 Oct;98(10):2379-2388. doi: 10.1007/s00277-019-03730-x. Epub 2019 Jun 21.
332 Genomic hypomethylation in human chronic lymphocytic leukemia.Blood. 1992 Oct 15;80(8):2074-80.
333 ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children.Br J Haematol. 2014 Jun;165(6):836-41. doi: 10.1111/bjh.12834. Epub 2014 Mar 15.
334 Human Adipose Tissue Stem Cells Promote the Growth of Acute Lymphoblastic Leukemia Cells in NOD/SCID Mice.Stem Cell Rev Rep. 2018 Jun;14(3):451-460. doi: 10.1007/s12015-018-9806-0.
335 High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia.Blood. 2010 May 6;115(18):3737-44. doi: 10.1182/blood-2009-09-241943. Epub 2010 Jan 11.
336 Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in Tcell acute lymphoblastic leukemia.Asia Pac J Clin Oncol. 2018 Oct;14(5):e259-e265. doi: 10.1111/ajco.12979. Epub 2018 May 11.
337 Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally.Cancer Cell. 2018 Dec 10;34(6):869-871. doi: 10.1016/j.ccell.2018.11.011.
338 BIRC6/Apollon gene expression in childhood acute leukemia: impact on therapeutic response and prognosis.Eur J Haematol. 2012 Feb;88(2):118-27. doi: 10.1111/j.1600-0609.2011.01734.x. Epub 2012 Jan 4.
339 MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2010 Aug;49(8):682-7. doi: 10.1002/gcc.20776.
340 Germline Genetic Predisposition to Hematologic Malignancy.J Clin Oncol. 2017 Mar 20;35(9):1018-1028. doi: 10.1200/JCO.2016.70.8644. Epub 2017 Feb 13.
341 B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.J Biol Chem. 2016 Feb 26;291(9):4723-31. doi: 10.1074/jbc.M115.637835. Epub 2015 Dec 24.
342 Downregulation of DBC1 expression in acute lymphoblastic leukaemia is mediated by aberrant methylation of its promoter.Br J Haematol. 2006 Jul;134(2):137-44. doi: 10.1111/j.1365-2141.2006.06131.x.
343 Classification and regression tree-based prediction of 6-mercaptopurine-induced leucopenia grades in children with acute lymphoblastic leukemia.Cancer Chemother Pharmacol. 2019 May;83(5):875-880. doi: 10.1007/s00280-019-03803-8. Epub 2019 Feb 26.
344 Investigation of NF-B-94ins/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia.Front Endocrinol (Lausanne). 2019 Aug 2;10:501. doi: 10.3389/fendo.2019.00501. eCollection 2019.
345 Synergistic activity of bortezomib and HDACi in preclinical models of B-cell precursor acute lymphoblastic leukemia via modulation of p53, PI3K/AKT, and NF-B.Clin Cancer Res. 2013 Mar 15;19(6):1445-57. doi: 10.1158/1078-0432.CCR-12-1511. Epub 2013 Jan 28.
346 Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis.Cancer Res. 2000 Jun 1;60(11):2775-9.
347 Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways.Nucleic Acids Res. 2014 Jan;42(1):137-52. doi: 10.1093/nar/gkt855. Epub 2013 Sep 24.
348 Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.Genomics. 1996 Mar 1;32(2):253-9. doi: 10.1006/geno.1996.0112.
349 A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.PLoS One. 2012;7(9):e44654. doi: 10.1371/journal.pone.0044654. Epub 2012 Sep 25.
350 G19.4(alpha CD3) x B43(alpha CD19) monoclonal antibody heteroconjugate triggers CD19 antigen-specific lysis of t(4;11) acute lymphoblastic leukemia cells by activated CD3 antigen-positive cytotoxic T cells.Blood. 1992 Dec 1;80(11):2826-34.
351 Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.Leukemia. 1996 Dec;10(12):1897-900.
352 Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin.Leukemia. 1994 Dec;8(12):2127-33.
353 Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome.Blood. 2019 Oct 10;134(15):1227-1237. doi: 10.1182/blood.2018890764.
354 Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment.Genes (Basel). 2019 Mar 1;10(3):191. doi: 10.3390/genes10030191.
355 Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia.Cell Death Dis. 2018 Sep 11;9(9):925. doi: 10.1038/s41419-018-0964-4.
356 Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia.Blood. 2009 Feb 26;113(9):1892-8. doi: 10.1182/blood-2008-02-141002. Epub 2008 Dec 23.
357 The spectrum of acute lymphoblastic leukemia with mature B-cell phenotype.Leuk Res. 2003 Mar;27(3):231-4. doi: 10.1016/s0145-2126(02)00129-7.
358 Oligomeric interface modulation causes misregulation of purine 5-nucleotidase in relapsed leukemia.BMC Biol. 2016 Oct 19;14(1):91. doi: 10.1186/s12915-016-0313-y.
359 Pak1 gene functioned differentially in different BCR-ABL subtypes in leukemiagenesis and treatment response through STAT5 pathway.Leuk Res. 2019 Apr;79:6-16. doi: 10.1016/j.leukres.2019.01.012. Epub 2019 Jan 24.
360 The prognostic potential of coilin in association with p27 expression in pediatric acute lymphoblastic leukemia for disease relapse.Cancer Cell Int. 2018 Jul 27;18:106. doi: 10.1186/s12935-018-0600-5. eCollection 2018.
361 Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia.Leukemia. 2000 Feb;14(2):241-6. doi: 10.1038/sj.leu.2401654.
362 Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia.Blood. 1994 Sep 15;84(6):1731-6.
363 Cyfip1 is downregulated in acute lymphoblastic leukemia and may be a potential biomarker in acute lymphoblastic leukemia.Tumour Biol. 2016 Jul;37(7):9285-8. doi: 10.1007/s13277-016-4786-7. Epub 2016 Jan 15.
364 Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia.Blood. 2007 Apr 15;109(8):3462-9. doi: 10.1182/blood-2006-09-047043. Epub 2006 Dec 5.
365 Epigenetic dysregulation of the DAP kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in acute leukaemias.J Clin Pathol. 2008 Jul;61(7):844-7. doi: 10.1136/jcp.2007.047324.
366 Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia. Cancer Res. 2007 Mar 15;67(6):2617-25.
367 Association between DEFB1 gene haplotype and herpes viruses seroprevalence in children with acute lymphoblastic leukemia.Pediatr Hematol Oncol. 2009 Nov;26(8):573-82. doi: 10.3109/08880010903271705.
368 ETS1 and SP1 drive DHX15 expression in acute lymphoblastic leukaemia.J Cell Mol Med. 2018 May;22(5):2612-2621. doi: 10.1111/jcmm.13525. Epub 2018 Mar 7.
369 T-cell acute lymphoblastic leukemia with natural killer cell phenotype.Am J Hematol. 1986 Aug;22(4):355-64. doi: 10.1002/ajh.2830220404.
370 Down-regulation of DLX3 expression in MLL-AF4 childhood lymphoblastic leukemias is mediated by promoter region hypermethylation.Oncol Rep. 2007 Aug;18(2):417-23.
371 Expression of terminal deoxynucleotidyltransferase gene in a case of adult T-cell leukemia.Int J Hematol. 1991 Feb;54(1):37-40.
372 Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.Oncogene. 2003 Oct 23;22(48):7649-60. doi: 10.1038/sj.onc.1206971.
373 CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.Br J Haematol. 2012 Jan;156(1):89-98. doi: 10.1111/j.1365-2141.2011.08901.x. Epub 2011 Oct 21.
374 Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.PLoS One. 2015 Oct 14;10(10):e0140564. doi: 10.1371/journal.pone.0140564. eCollection 2015.
375 ENO2 Promotes Cell Proliferation, Glycolysis, and Glucocorticoid-Resistance in Acute Lymphoblastic Leukemia.Cell Physiol Biochem. 2018;46(4):1525-1535. doi: 10.1159/000489196. Epub 2018 Apr 19.
376 Acute megakaryoblastic leukemia in a patient with xeroderma pigmentosum: discussion of pathophysiological, prognostic, and toxicological aspects.Acta Haematol. 2013;129(2):121-5. doi: 10.1159/000342897. Epub 2012 Nov 28.
377 Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells.Oncotarget. 2017 Aug 4;8(40):68208-68220. doi: 10.18632/oncotarget.19919. eCollection 2017 Sep 15.
378 Current status of diagnosis and prognosis of infant acute leukemia in China.Pediatr Blood Cancer. 2009 Dec;53(6):973-7. doi: 10.1002/pbc.22145.
379 Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.Cell Oncol. 2008;30(4):299-306. doi: 10.3233/clo-2008-0426.
380 PI3K- inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells.Anticancer Drugs. 2017 Apr;28(4):436-445. doi: 10.1097/CAD.0000000000000477.
381 Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells.J Extracell Vesicles. 2019 Mar 12;8(1):1588538. doi: 10.1080/20013078.2019.1588538. eCollection 2019.
382 F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.Blood. 2012 Mar 29;119(13):3132-41. doi: 10.1182/blood-2011-06-358911. Epub 2012 Feb 8.
383 Identification of promising prognostic genes for relapsed acute lymphoblastic leukemia.Blood Cells Mol Dis. 2019 Jul;77:113-119. doi: 10.1016/j.bcmd.2019.04.010. Epub 2019 Apr 18.
384 Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.Cancer Immunol Immunother. 2009 Jun;58(6):989-96. doi: 10.1007/s00262-008-0589-z. Epub 2008 Sep 19.
385 Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.PLoS One. 2013 May 7;8(5):e62346. doi: 10.1371/journal.pone.0062346. Print 2013.
386 MicroRNA-144 regulates cancer cell proliferation and cell-cycle transition in acute lymphoblastic leukemia through the interaction of FMN2.J Gene Med. 2017 Jun;19(6-7). doi: 10.1002/jgm.2898.
387 FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children.J Cell Biochem. 2020 Feb;121(2):2019-2026. doi: 10.1002/jcb.29436. Epub 2019 Nov 6.
388 Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network.Br J Haematol. 2011 Jun;153(6):741-52. doi: 10.1111/j.1365-2141.2011.08671.x. Epub 2011 Apr 25.
389 Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate.Br J Haematol. 2007 Jan;136(2):212-9. doi: 10.1111/j.1365-2141.2006.06407.x. Epub 2006 Dec 8.
390 G protein subunit G alpha 16 expression is restricted to progenitor B cells during human B-cell differentiation.Blood. 1995 Apr 1;85(7):1836-42.
391 Novel insights into etiologies of leukemia: a HuGE review and meta-analysis of CYP1A1 polymorphisms and leukemia risk.Am J Epidemiol. 2013 Aug 15;178(4):493-507. doi: 10.1093/aje/kwt016. Epub 2013 May 24.
392 Mu class glutathione S-transferase mRNA isoform expression in acute lymphoblastic leukaemia.Br J Haematol. 2003 Jan;120(1):80-8. doi: 10.1046/j.1365-2141.2003.04039.x.
393 Glycophorin A mutations and risk of secondary leukaemia in patients treated for childhood acute lymphoblastic leukaemia.Br J Haematol. 1996 Apr;93(1):117-24. doi: 10.1046/j.1365-2141.1996.4621001.x.
394 Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy.J Hum Genet. 2007;52(4):328-333. doi: 10.1007/s10038-007-0119-4. Epub 2007 Feb 20.
395 Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia.Leuk Lymphoma. 2014 Oct;55(10):2305-11. doi: 10.3109/10428194.2013.878458. Epub 2014 Feb 24.
396 Motor skill delays in pre-school children with leukemia one year after treatment: Hematopoietic stem cell transplantation therapy as an important risk factor.PLoS One. 2017 Oct 24;12(10):e0186787. doi: 10.1371/journal.pone.0186787. eCollection 2017.
397 Transmission of HLA-DP variants from parents to children with B-cell precursor acute lymphoblastic leukemia: log-linear analysis using the case-parent design.Hum Immunol. 2011 Oct;72(10):897-903. doi: 10.1016/j.humimm.2011.05.011. Epub 2011 May 24.
398 High expression of two diverged homeobox genes, HB24 and HB9, in acute leukemias: molecular markers of hematopoietic cell immaturity.Leukemia. 1993 Mar;7(3):446-51.
399 TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.Blood. 2012 Apr 12;119(15):3440-9. doi: 10.1182/blood-2011-06-357939. Epub 2012 Feb 27.
400 Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes.Blood. 1992 Jul 1;80(1):185-93.
401 Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function.Hum Mutat. 2005 Apr;25(4):384-95. doi: 10.1002/humu.20155.
402 Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.J Natl Cancer Inst. 2008 Apr 16;100(8):580-95. doi: 10.1093/jnci/djn076. Epub 2008 Apr 8.
403 Alpha-interferon improves survival and remission duration in P-190BCR-ABL positive adult acute lymphoblastic leukemia.Leukemia. 2000 Jan;14(1):22-7. doi: 10.1038/sj.leu.2401641.
404 Identification of characteristic IGF2BP expression patterns in distinct B-ALL entities.Blood Cells Mol Dis. 2011 Apr 15;46(4):321-6. doi: 10.1016/j.bcmd.2011.02.005. Epub 2011 Mar 17.
405 Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations.Cancer Epidemiol Biomarkers Prev. 2017 Oct;26(10):1531-1539. doi: 10.1158/1055-9965.EPI-17-0360. Epub 2017 Jul 27.
406 Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors.PLoS One. 2016 Aug 22;11(8):e0159477. doi: 10.1371/journal.pone.0159477. eCollection 2016.
407 The effect of adopting pediatric protocols in adolescents and young adults with acute lymphoblastic leukemia in pediatric vs adult centers: An IMPACT Cohort study.Cancer Med. 2019 May;8(5):2095-2103. doi: 10.1002/cam4.2096. Epub 2019 Mar 26.
408 miR-153-3p Suppresses Inhibitor of Growth Protein 2 Expression to Function as Tumor Suppressor in Acute Lymphoblastic Leukemia.Technol Cancer Res Treat. 2019 Jan-Dec;18:1533033819852990. doi: 10.1177/1533033819852990.
409 Effect of IRS4 levels on PI 3-kinase signalling.PLoS One. 2013 Sep 10;8(9):e73327. doi: 10.1371/journal.pone.0073327. eCollection 2013.
410 GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia.Leukemia. 2013 Mar;27(3):578-85. doi: 10.1038/leu.2012.265. Epub 2012 Sep 11.
411 KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.Mol Cell Biol. 2012 Jul;32(14):2917-33. doi: 10.1128/MCB.00133-12. Epub 2012 May 21.
412 Cryptic ETV6-ABL1 Fusion and MLL2 Truncation Revealed by Integrative Clinical Sequencing in Multiply Relapsed Acute Lymphoblastic Leukemia.J Pediatr Hematol Oncol. 2019 Nov;41(8):653-656. doi: 10.1097/MPH.0000000000001249.
413 Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report.Leukemia. 2014 Jun;28(6):1235-41. doi: 10.1038/leu.2013.367. Epub 2013 Dec 4.
414 Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).Oncogene. 2003 Mar 6;22(9):1418-24. doi: 10.1038/sj.onc.1206272.
415 Adaptor molecules expression in normal lymphopoiesis and in childhood leukemia.Immunol Lett. 2009 Feb 21;122(2):185-92. doi: 10.1016/j.imlet.2008.12.008. Epub 2009 Feb 11.
416 Deregulation of linc-PINT in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells.Oncotarget. 2018 Feb 5;9(16):12842-12852. doi: 10.18632/oncotarget.24401. eCollection 2018 Feb 27.
417 Aberrant expression of the LHX4 LIM-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis.Genes Chromosomes Cancer. 2003 Nov;38(3):269-73. doi: 10.1002/gcc.10283.
418 Inv(11)(q21q23); KMT2A-MAML2, a Recurrent Genetic Abnormality in T-Cell Therapy-related Acute Lymphoblastic Leukemia.J Pediatr Hematol Oncol. 2020 May;42(4):e258-e261. doi: 10.1097/MPH.0000000000001572.
419 MLL is fused to EB1 (MAPRE1), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2005 Jun;43(2):206-10. doi: 10.1002/gcc.20174.
420 Acquired EVI1 rearrangement involved in the transformation from 5q- syndrome to pre-B lymphocytic leukemia in a Chinese patient.Int J Hematol. 2012 Dec;96(6):806-9. doi: 10.1007/s12185-012-1185-8. Epub 2012 Oct 9.
421 BCL2 Inhibitor (ABT-737): A Restorer of Prednisolone Sensitivity in Early T-Cell Precursor-Acute Lymphoblastic Leukemia with High MEF2C Expression?.PLoS One. 2015 Jul 14;10(7):e0132926. doi: 10.1371/journal.pone.0132926. eCollection 2015.
422 Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity.Oncogene. 2019 Mar;38(13):2263-2274. doi: 10.1038/s41388-018-0573-9. Epub 2018 Nov 26.
423 The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia.Mol Genet Genomic Med. 2019 Oct;7(10):e00933. doi: 10.1002/mgg3.933. Epub 2019 Aug 20.
424 Bone marrow transplantation for acute leukemia using a histocompatible paternal donor.Acta Haematol. 1979;61(2):80-4. doi: 10.1159/000207636.
425 Successful Treatment of a Very Late Isolated Relapse in an Adolescent With a PICALM-MLLT10 Positive T-lineage Acute Lymphoblastic Leukemia.J Pediatr Hematol Oncol. 2018 Apr;40(3):e191-e194. doi: 10.1097/MPH.0000000000000996.
426 Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement.BMC Cancer. 2018 Apr 12;18(1):409. doi: 10.1186/s12885-018-4327-4.
427 Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies.Blood. 1985 Mar;65(3):730-5.
428 Isodicentric Philadelphia chromosome in acute lymphoblastic leukemia with der(7;12)(q10;q10).Leuk Res. 2007 May;31(5):713-8. doi: 10.1016/j.leukres.2006.05.023. Epub 2006 Sep 18.
429 The EcoRI RFLP of c-mos in patients with non-Hodgkin's lymphoma and acute lymphoblastic leukemia, compared to geriatric and non-geriatric controls.Int J Cancer. 1989 Jun 15;43(6):1034-6. doi: 10.1002/ijc.2910430613.
430 Intracytoplasmic detection of the Tac (p55) chain of interleukin-2 receptor in pre-B leukemic cells associated with a constitutive expression of Tac mRNA.Leukemia. 1990 Dec;4(12):819-25.
431 A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis.Cell Death Differ. 2017 Jan;24(1):83-97. doi: 10.1038/cdd.2016.102. Epub 2016 Nov 11.
432 Association of methylenetetrahydrofolate dehydrogenase 1 polymorphisms with cancer: a meta-analysis.PLoS One. 2013 Jul 19;8(7):e69366. doi: 10.1371/journal.pone.0069366. Print 2013.
433 Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia.Br J Haematol. 2014 Nov;167(4):487-99. doi: 10.1111/bjh.13066. Epub 2014 Sep 8.
434 NBN and XRCC3 genetic variants in childhood acute lymphoblastic leukaemia.Cancer Epidemiol. 2014 Oct;38(5):563-8. doi: 10.1016/j.canep.2014.08.002. Epub 2014 Aug 27.
435 CREBBP mutations in relapsed acute lymphoblastic leukaemia.Nature. 2011 Mar 10;471(7337):235-9. doi: 10.1038/nature09727.
436 NET1 Enhances Proliferation and Chemoresistance in Acute Lymphoblastic Leukemia Cells.Oncol Res. 2019 Aug 8;27(8):935-944. doi: 10.3727/096504019X15555388198071. Epub 2019 Apr 17.
437 Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells.Int J Cancer. 2010 Jan 15;126(2):337-49. doi: 10.1002/ijc.24733.
438 Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23).Cancer Genet Cytogenet. 2010 Feb;197(1):32-8. doi: 10.1016/j.cancergencyto.2009.10.009.
439 An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.Oncogene. 2019 Jan;38(5):671-686. doi: 10.1038/s41388-018-0474-y. Epub 2018 Aug 31.
440 The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.J Pediatr. 2020 Jan;216:150-157.e1. doi: 10.1016/j.jpeds.2019.09.024. Epub 2019 Oct 18.
441 NUP214 in Leukemia: It's More than Transport.Cells. 2019 Jan 21;8(1):76. doi: 10.3390/cells8010076.
442 The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.J Biol Chem. 2019 Aug 2;294(31):11741-11750. doi: 10.1074/jbc.RA118.006357. Epub 2019 Jun 11.
443 Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia.Int J Cancer. 2006 Apr 15;118(8):1945-53. doi: 10.1002/ijc.21584.
444 Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker.Acta Haematol. 2012;128(1):39-46. doi: 10.1159/000337418. Epub 2012 May 17.
445 Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance.Genes Chromosomes Cancer. 2011 Dec;50(12):1043-53. doi: 10.1002/gcc.20922. Epub 2011 Aug 24.
446 Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia.Pediatr Blood Cancer. 2017 Mar;64(3). doi: 10.1002/pbc.26259. Epub 2016 Sep 19.
447 Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia.Anticancer Res. 2015 Dec;35(12):6615-22.
448 P-glycoprotein and BCL-2 levels predict outcome in adult acute lymphoblastic leukaemia.Br J Haematol. 2003 Jun;121(5):730-8. doi: 10.1046/j.1365-2141.2003.04343.x.
449 Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage.Exp Hematol. 2001 Jan;29(1):93-103. doi: 10.1016/s0301-472x(00)00620-2.
450 Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.Cancer Res. 2019 Aug 15;79(16):4184-4195. doi: 10.1158/0008-5472.CAN-18-3038. Epub 2019 Jul 4.
451 Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility.Medicine (Baltimore). 2016 May;95(18):e3542. doi: 10.1097/MD.0000000000003542.
452 IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951.Leukemia. 2015 Nov;29(11):2154-61. doi: 10.1038/leu.2015.134. Epub 2015 Jun 8.
453 RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance.Blood. 2008 Apr 1;111(7):3735-41. doi: 10.1182/blood-2007-07-102533. Epub 2008 Jan 17.
454 Mutations of perforin gene in Chinese patients with acute lymphoblastic leukemia.Leuk Res. 2011 Feb;35(2):196-9. doi: 10.1016/j.leukres.2010.06.016. Epub 2010 Jul 16.
455 The ARTS connection: role of ARTS in apoptosis and cancer.Cell Cycle. 2004 Aug;3(8):1021-3. Epub 2004 Aug 16.
456 MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature.Leuk Res. 2014 Nov;38(11):1316-9. doi: 10.1016/j.leukres.2014.08.011. Epub 2014 Aug 29.
457 Polyclonal hemopoiesis in leukemia patients following molecularly documented remission.Leukemia. 1994 Apr;8 Suppl 1:S137-9.
458 Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11).Leukemia. 2002 Nov;16(11):2205-12. doi: 10.1038/sj.leu.2402671.
459 t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia.Br J Haematol. 2000 Jun;109(4):788-93. doi: 10.1046/j.1365-2141.2000.02106.x.
460 Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848.
461 Residual methylation of tumor suppressor gene promoters, RASSF6 and RASSF10, as novel biomarkers for minimal residual disease detection in adult acute lymphoblastic leukemia.Ann Hematol. 2019 Dec;98(12):2719-2727. doi: 10.1007/s00277-019-03775-y. Epub 2019 Sep 5.
462 The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.Leukemia. 2018 Feb;32(2):323-331. doi: 10.1038/leu.2017.216. Epub 2017 Jul 10.
463 Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.Blood. 2012 Nov 1;120(18):3764-73. doi: 10.1182/blood-2012-03-415349. Epub 2012 Sep 13.
464 Persistent detection of a novel MLL-SACM1L rearrangement in the absence of leukemia.Leuk Res. 2010 Oct;34(10):1398-401. doi: 10.1016/j.leukres.2010.05.001.
465 Related subunits of NF-kappa B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2.Genomics. 1992 Jun;13(2):287-92. doi: 10.1016/0888-7543(92)90244-m.
466 A translocation in acute lymphoblastic leukemia that cytogenetically mimics the recurrent MLL-AFF1 translocation and fuses SEPT11 to MLL.Cancer Genet Cytogenet. 2010 Aug;201(1):48-51. doi: 10.1016/j.cancergencyto.2010.05.002.
467 The CDCREL1 gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) and its frequent expression in myeloid leukemia cell lines.Genes Chromosomes Cancer. 2001 Mar;30(3):230-5. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1084>3.0.co;2-j.
468 Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL. Pharmacogenomics. 2012 Jul;13(9):1001-8.
469 Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia.Hum Mol Genet. 2014 Feb 1;23(3):590-601. doi: 10.1093/hmg/ddt447. Epub 2013 Sep 17.
470 Regulatory network of GATA3 in pediatric acute lymphoblastic leukemia.Oncotarget. 2017 May 30;8(22):36040-36053. doi: 10.18632/oncotarget.16424.
471 Identification of SPAG9 as a novel JAK2 fusion partner gene in pediatric acute lymphoblastic leukemia with t(9;17)(p24;q21).Genes Chromosomes Cancer. 2015 Jul;54(7):401-8. doi: 10.1002/gcc.22251. Epub 2015 May 7.
472 Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer.Cancer Lett. 2013 Aug 9;336(1):85-95. doi: 10.1016/j.canlet.2013.04.007. Epub 2013 Apr 16.
473 Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors.Int J Cancer. 2013 Jul;133(1):260-5. doi: 10.1002/ijc.28011. Epub 2013 Feb 5.
474 Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.Genes Chromosomes Cancer. 2008 Oct;47(10):884-9. doi: 10.1002/gcc.20585.
475 High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia.Sci Rep. 2018 Jan 12;8(1):693. doi: 10.1038/s41598-017-17704-4.
476 Adenosine Deaminase 1 as a Biomarker for Diagnosis and Monitoring of Patients with Acute Lymphoblastic Leukemia.J Med Biochem. 2018 Apr 1;37(2):128-133. doi: 10.1515/jomb-2017-0042. eCollection 2018 Apr.
477 Identification of the TAF15-ZNF384 fusion gene in two new cases of acute lymphoblastic leukemia with a t(12;17)(p13;q12).Cancer Genet. 2011 Mar;204(3):147-52. doi: 10.1016/j.cancergen.2011.01.003.
478 Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells.Blood. 2001 Oct 15;98(8):2456-65. doi: 10.1182/blood.v98.8.2456.
479 Investigation of copy-number variations of C8orf4 in hematological malignancies.Med Oncol. 2011 Dec;28 Suppl 1:S647-52. doi: 10.1007/s12032-010-9698-6. Epub 2010 Sep 29.
480 Rearrangements of the T cell receptor delta gene in T acute lymphoblastic leukemia cells are distinct from those occurring in B lineage acute lymphoblastic leukemia and preferentially involve one V delta gene segment.J Immunol. 1989 May 1;142(9):3305-11.
481 TLE1 as an indicator of adverse prognosis in pediatric acute lymphoblastic leukemia.Leuk Res. 2018 Nov;74:42-46. doi: 10.1016/j.leukres.2018.09.010. Epub 2018 Sep 26.
482 Simultaneous translocation of both TCR Loci (14q11) with rare partner loci (Xq22 and 12p13) in a case of T-lymphoblastic leukemia.Ann Lab Med. 2012 May;32(3):220-4. doi: 10.3343/alm.2012.32.3.220. Epub 2012 Apr 18.
483 Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia.BMC Cancer. 2019 Feb 27;19(1):179. doi: 10.1186/s12885-019-5377-y.
484 Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines.Leukemia. 1994 Dec;8(12):2083-94.
485 Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells.J Extracell Vesicles. 2017 Feb 28;6(1):1294368. doi: 10.1080/20013078.2017.1294368. eCollection 2017.
486 LIM domain proteins in leukaemia and development.Semin Cancer Biol. 1993 Dec;4(6):349-58.
487 Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL).Leuk Res. 2006 Jul;30(7):883-9. doi: 10.1016/j.leukres.2005.11.012. Epub 2006 Jan 6.
488 Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study.Cancer. 2018 Dec 1;124(23):4538-4547. doi: 10.1002/cncr.31758. Epub 2018 Oct 10.
489 Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.Oncogene. 2013 May 16;32(20):2586-91. doi: 10.1038/onc.2012.263. Epub 2012 Jul 2.
490 CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia.Br J Haematol. 2019 Feb;184(3):418-423. doi: 10.1111/bjh.15683. Epub 2018 Nov 28.
491 Characterization of a novel acquired der(1)del(1)(p13p31)t(1;15)(q42;q15) in a high risk t(12;21)-positive acute lymphoblastic leukemia.Gene. 2016 Dec 20;595(1):39-48. doi: 10.1016/j.gene.2016.09.030. Epub 2016 Sep 21.
492 EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.Med Sci Monit. 2019 Aug 29;25:6491-6503. doi: 10.12659/MSM.918295.
493 Chemosensitivity is differentially regulated by the SDF-1/CXCR4 and SDF-1/CXCR7 axes in acute lymphoblastic leukemia with MLL gene rearrangements.Leuk Res. 2018 Dec;75:36-44. doi: 10.1016/j.leukres.2018.11.001. Epub 2018 Nov 3.
494 A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency.Pediatr Blood Cancer. 2019 Jun;66(6):e27649. doi: 10.1002/pbc.27649. Epub 2019 Feb 25.
495 Decreased expression of the augmenter of liver regeneration results in growth inhibition and increased chemosensitivity of acute T lymphoblastic leukemia cells.Oncol Rep. 2017 Nov;38(5):3130-3136. doi: 10.3892/or.2017.5984. Epub 2017 Sep 21.
496 A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo.Cancer Res. 2018 Mar 15;78(6):1549-1560. doi: 10.1158/0008-5472.CAN-17-2106. Epub 2018 Jan 17.
497 HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway.Blood. 2019 May 16;133(20):2222-2232. doi: 10.1182/blood-2018-12-890236. Epub 2019 Feb 28.
498 Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk.Autoimmunity. 2010 Dec;43(8):690-7. doi: 10.3109/08916930903567492.
499 Inhibition of HOXB7 suppresses p27-mediated acute lymphoblastic leukemia by regulating basic fibroblast growth factor and ERK1/2.Life Sci. 2019 Feb 1;218:1-7. doi: 10.1016/j.lfs.2018.12.011. Epub 2018 Dec 8.
500 Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.Epigenomics. 2018 Jan;10(1):59-69. doi: 10.2217/epi-2017-0092. Epub 2017 Oct 10.
501 Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study.Biol Blood Marrow Transplant. 2016 Mar;22(3):423-31. doi: 10.1016/j.bbmt.2015.09.029. Epub 2015 Oct 9.
502 The expression and function of E3 ligase SIAH2 in acute T lymphoblastic leukemia.Leuk Res. 2016 Mar;42:28-36. doi: 10.1016/j.leukres.2016.01.013. Epub 2016 Jan 28.
503 Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias.Clin Chim Acta. 2012 Oct 9;413(19-20):1542-8. doi: 10.1016/j.cca.2012.06.025. Epub 2012 Jun 29.
504 Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia.PLoS One. 2017 Mar 9;12(3):e0173472. doi: 10.1371/journal.pone.0173472. eCollection 2017.
505 Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia.Haematologica. 2016 Aug;101(8):951-8. doi: 10.3324/haematol.2016.143875. Epub 2016 May 5.