General Information of Drug Off-Target (DOT) (ID: OT7BLO6L)

DOT Name Late cornified envelope protein 1B (LCE1B)
Synonyms Late envelope protein 2; Small proline-rich-like epidermal differentiation complex protein 2A
Gene Name LCE1B
UniProt ID
LCE1B_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF14672
Sequence
MSCQQNQQQCQPPPKCIPKCPPKCLTPRCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC
GSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGCC
Function Precursors of the cornified envelope of the stratum corneum.
Tissue Specificity Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
Reactome Pathway
Formation of the cornified envelope (R-HSA-6809371 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
6 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Late cornified envelope protein 1B (LCE1B). [1]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Late cornified envelope protein 1B (LCE1B). [2]
Demecolcine DMCZQGK Approved Demecolcine increases the expression of Late cornified envelope protein 1B (LCE1B). [3]
Nicotine DMWX5CO Approved Nicotine increases the expression of Late cornified envelope protein 1B (LCE1B). [4]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Late cornified envelope protein 1B (LCE1B). [3]
Milchsaure DM462BT Investigative Milchsaure decreases the expression of Late cornified envelope protein 1B (LCE1B). [6]
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⏷ Show the Full List of 6 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Late cornified envelope protein 1B (LCE1B). [5]
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References

1 Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins: implication in skin irritation. J Dermatol Sci. 2014 Nov;76(2):112-9. doi: 10.1016/j.jdermsci.2014.08.003. Epub 2014 Aug 26.
2 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
3 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
4 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
5 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
6 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.