Details of the Drug

General Information of Drug (ID: DM462BT)

Drug Name

Milchsaure

Synonyms

(+/-)-Lactic acid; 1-Hydroxyethanecarboxylic acid; 2-hydroxypropanoic acid; 2-hydroxypropionic acid; 26100-51-6; Acidum lacticum; Aethylidenmilchsaeure; DL-Lactic acid; DL-Milchsaeure; Ethylidenelactic acid; Kyselina 2-hydroxypropanova; Kyselina mlecna; Lactic acid; Lactic acid (natural); Lactic acid USP; Lacticum acidum; Lactovagan; Milchsaeure; Milchsaure; Milchsaure [German]; Milk acid; Ordinary lactic acid; Polylactic acid; Propanoic acid, 2-hydroxy-; Racemic lactic acid; Tonsillosan; alpha-Hydroxypropionic acid; lactate; lactic acid

Indication

Disease Entry	ICD 11	Status	REF
Pruritus	EC90	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

90.078

Logarithm of the Partition Coefficient (xlogp)

-0.7

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C3H6O3
IUPAC Name: 2-hydroxypropanoic acid
Canonical SMILES: CC(C(=O)O)O
InChI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)
InChIKey: JVTAAEKCZFNVCJ-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 612
ChEBI ID: CHEBI:78320
CAS Number: 50-21-5
DrugBank ID: DB04398
VARIDT ID: DR01241

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Monocarboxylate transporter 4 (SLC16A3)	DTAKRNM	MOT4_HUMAN	Substrate	[2]
Monocarboxylate transporter 2 (SLC16A7)	DTLT3UG	MOT2_HUMAN	Substrate	[3]
Monocarboxylate transporter 1 (SLC16A1)	DT342ZG	MOT1_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Gene/Protein Processing	[5]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Gene/Protein Processing	[5]
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Gene/Protein Processing	[5]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[5]
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)	OT5CTQKO	PLCD_HUMAN	Gene/Protein Processing	[5]
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3)	OTAUR5TG	PLCC_HUMAN	Gene/Protein Processing	[5]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)	OTY829Z3	ABHD5_HUMAN	Gene/Protein Processing	[5]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (PLCD3)	OTB22A4J	PLCD3_HUMAN	Gene/Protein Processing	[5]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2)	OTYERO80	PLCH2_HUMAN	Gene/Protein Processing	[5]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J. 2000 Aug 15;350 Pt 1:219-27.
3	Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35.
4	Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9.
5	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.