Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT8319UQ)

• DOT Name: Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4)
• Synonyms: Coiled-coil-helix-coiled-coil-helix domain-containing protein 8; E2-induced gene 2 protein
• Gene Name: COA4
• UniProt ID: COA4_HUMAN
• Pfam ID: PF06747
• Sequence:
  MSTSVPQGHTWTQRVKKDDEEEDPLDQLISRSGCAASHFAVQECMAQHQDWRQCQPQVQA
  FKDCMSEQQARRQEELQRRQEQAGAHH
• Function: Putative COX assembly factor.
• KEGG Pathway: Thermogenesis (hsa04714)
• Reactome Pathway: Mitochondrial protein import (R-HSA-1268020)

Molecular Interaction Atlas (MIA) of This DOT

5 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4).	[1]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4).	[2]
Temozolomide	DMKECZD	Approved	Temozolomide increases the expression of Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4).	[3]
Menadione	DMSJDTY	Approved	Menadione affects the expression of Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4).	[4]
Urethane	DM7NSI0	Phase 4	Urethane decreases the expression of Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4).	[6]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Fulvestrant	DM0YZC6	Approved	Fulvestrant increases the methylation of Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4).	[5]

References

• [1] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [2] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [3] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [4] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [5] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [6] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.