Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTBX9DI5)

DOT Name L-lactate dehydrogenase C chain (LDHC)
Synonyms LDH-C; EC 1.1.1.27; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X
Gene Name LDHC
UniProt ID
LDHC_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
7EPM
EC Number
1.1.1.27
Pfam ID
PF02866 ; PF00056
Sequence
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKG
EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSI
IPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGV
HPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYE
IIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGV
SDVVKINLNSEEEALFKKSAETLWNIQKDLIF
Function Possible role in sperm motility.
KEGG Pathway
Glycolysis / Gluconeogenesis (hsa00010 )
Cysteine and methionine metabolism (hsa00270 )
Pyruvate metabolism (hsa00620 )
Propanoate metabolism (hsa00640 )
Metabolic pathways (hsa01100 )
HIF-1 sig.ling pathway (hsa04066 )
Glucagon sig.ling pathway (hsa04922 )
Central carbon metabolism in cancer (hsa05230 )
Reactome Pathway
Pyruvate metabolism (R-HSA-70268 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Cimetidine DMH61ZB Approved L-lactate dehydrogenase C chain (LDHC) increases the Thrombocytopenia ADR of Cimetidine. [5]
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2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin decreases the expression of L-lactate dehydrogenase C chain (LDHC). [1]
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of L-lactate dehydrogenase C chain (LDHC). [3]
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2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of L-lactate dehydrogenase C chain (LDHC). [2]
3R14S-OCHRATOXIN A DM2KEW6 Investigative 3R14S-OCHRATOXIN A decreases the acetylation of L-lactate dehydrogenase C chain (LDHC). [4]
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References

1 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
3 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
4 Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. Arch Toxicol. 2018 Feb;92(2):995-1014.
5 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.