Details of the Drug

General Information of Drug (ID: DMH61ZB)

Drug Name
Cimetidine
Synonyms
Acibilin; Acinil; Altramet; Brumetidina; Cimal; Cimetadine; Cimetag; Cimetidina; Cimetidinum; Cimetum; Dyspamet; Edalene; Eureceptor; Evicer; Gastrobitan; Gastromet; Histodil; Magicul; Metracin; Peptol; Sigmetadine; Tagamet; Tametin; Tratul; Ulcedin; Ulcedine; Ulcestop; Ulcimet; Ulcofalk; Ulcomedina; Ulcomet; Ulhys; Valmagen; Venopex; Ci metum; Cimetidine Hcl; Tagamet Hb; Biomet400; C 4522; FPF 1002; SKF 92334; Tagamet Hb 200; CIMETIDINE A/AB; Cimetidina [INN-Spanish]; Cimetidinum [INN-Latin]; DRG-0150; SKF-92334; Tagamet (TN); Tagamet HB (TN); Tagamet HB200 (TN); SK&F-92334; Cimetidine (JP15/USP/INN); Cimetidine [USAN:INN:BAN:JAN]; Tagamet, SKF-92334, Tratul, Tametin, Dyspamet, Acinil, Cimetidine; N-Cyano-N'-methyl-[2-[[[5-methyl-1H-imidazol-4-yl]methyl]thio]ethyl]guanidine; N''-Cyano-N-methyl-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]guanidine; N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine; N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine; N-cyano-N'-methyl-N''-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine; N-Cyano-N'-Methyl-N''-(2-(((5-Methyl-1H-Imidazol-4-YL)Methyl)Thio)Ethyl) Guanidine; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1 H-imidazol-4-yl) methyl)thio)ethyl)guanidine; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine; N''-cyano-N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)-ethyl)guanidine; 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine; 1-Cyano-2-methyl-3-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]guanidine; 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine; 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine; 2-Cyano-1-methyl-3-[2-(5-methyl-1H-imidazol-4-yl-methylthio)ethyl]guanidine; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine
Indication
Disease Entry ICD 11 Status REF
Acid-reflux disorder DA22 Approved [1]
Gastric ulcer DA60 Approved [2]
Gastrinoma 2C10.1 Approved [2]
Therapeutic Class
Antiulcer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 252.34
Logarithm of the Partition Coefficient (xlogp) 0.4
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 6-12 h []
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
Bioavailability
The bioavailability of drug is 64-90% []
Clearance
The sytemic clearance of drug is 500-600 mL/min [4]
Elimination
62% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 2 hours [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 158.51427 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.78% [7]
Vd
The volume of distribution (Vd) of drug is 1 L/kg [4]
Water Solubility
The ability of drug to dissolve in water is measured as 6.2 mg/mL [3]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Haemolytic anaemia Not Available LDHB OT9B1CT3 [8]
Haemolytic anaemia Not Available UGT1A1 OTH1C8OJ [8]
Hyperparathyroidism secondary Not Available PTH OTD721UF [8]
Hyperparathyroidism secondary Not Available PPP3R1 OTGQNFJQ [8]
Thrombocytopenia Not Available LDHC? OTBX9DI5 [8]
Thrombocytopenia Not Available EPHX2 OTPTRCNW [8]
⏷ Show the Full List of 6 ADR Information of This Drug
Chemical Identifiers
Formula
C10H16N6S
IUPAC Name
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
Canonical SMILES
CC1=C(N=CN1)CSCCNC(=NC)NC#N
InChI
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
InChIKey
AQIXAKUUQRKLND-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2756
ChEBI ID
CHEBI:3699
CAS Number
51481-61-9
DrugBank ID
DB00501
TTD ID
D02DPA
VARIDT ID
DR00037
INTEDE ID
DR2272
ACDINA ID
D00130
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H2 receptor (H2R) TTQHJ1K HRH2_HUMAN Antagonist [9]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [10]
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [11]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [11]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [12]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [13]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [14]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [15]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [16]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [16]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Gene/Protein Processing [17]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [18]
Bifunctional epoxide hydrolase 2 (EPHX2) OTPTRCNW HYES_HUMAN Drug Response [8]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Regulation of Drug Effects [19]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Drug Response [8]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Gene/Protein Processing [20]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [17]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [17]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Cimetidine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Cisapride DMY7PED Major Decreased metabolism of Cimetidine caused by Cisapride mediated inhibition of CYP450 enzyme. Gastro-oesophageal reflux disease [DA22] [21]
Coadministration of a Drug Treating the Disease Different from Cimetidine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sodium bicarbonate DMMU6BJ Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Sodium bicarbonate. Acidosis [5C73] [22]
Cefuroxime DMSIMD8 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Cefuroxime. Acute bronchitis [CA42] [23]
Repaglinide DM5SXUV Moderate Decreased metabolism of Cimetidine caused by Repaglinide mediated inhibition of CYP450 enzyme. Acute diabete complication [5A2Y] [24]
Glibenclamide DM8JXPZ Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Glibenclamide. Acute diabete complication [5A2Y] [25]
Tolazamide DMIHRNA Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Tolazamide. Acute diabete complication [5A2Y] [25]
Glipizide DMZA5PQ Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Glipizide. Acute diabete complication [5A2Y] [25]
Midostaurin DMI6E0R Moderate Decreased metabolism of Cimetidine caused by Midostaurin mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [26]
Gilteritinib DMTI0ZO Moderate Decreased metabolism of Cimetidine caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [27]
Galantamine DMEO794 Moderate Antagonize the effect of Cimetidine when combined with Galantamine. Alzheimer disease [8A20] [28]
Rivastigmine DMG629M Moderate Antagonize the effect of Cimetidine when combined with Rivastigmine. Alzheimer disease [8A20] [28]
Donepezil DMIYG7Z Moderate Antagonize the effect of Cimetidine when combined with Donepezil. Alzheimer disease [8A20] [28]
Metronidazole DMTIVEN Minor Decreased metabolism of Cimetidine caused by Metronidazole mediated inhibition of CYP450 enzyme. Amoebiasis [1A36] [29]
Ivabradine DM0L594 Moderate Decreased metabolism of Cimetidine caused by Ivabradine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [27]
Dronedarone DMA8FS5 Moderate Decreased metabolism of Cimetidine caused by Dronedarone mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [30]
Nifedipine DMSVOZT Moderate Decreased metabolism of Cimetidine caused by Nifedipine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [31]
Clorazepate DMC3JST Moderate Decreased metabolism of Cimetidine caused by Clorazepate mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [32]
Methylphenobarbital DMDSWAG Minor Altered absorption of Cimetidine caused by Methylphenobarbital. Anxiety disorder [6B00-6B0Z] [33]
Hydroxyzine DMF8Y74 Minor Decreased metabolism of Cimetidine caused by Hydroxyzine mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [34]
Halazepam DMPFWO6 Moderate Decreased metabolism of Cimetidine caused by Halazepam mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [35]
Cilostazol DMZMSCT Moderate Decreased metabolism of Cimetidine caused by Cilostazol mediated inhibition of CYP450 enzyme. Arterial occlusive disease [BD40] [36]
Aminophylline DML2NIB Moderate Decreased metabolism of Cimetidine caused by Aminophylline mediated inhibition of CYP450 enzyme. Asthma [CA23] [37]
Roflumilast DMPGHY8 Moderate Decreased metabolism of Cimetidine caused by Roflumilast mediated inhibition of CYP450 enzyme. Asthma [CA23] [27]
Desipramine DMT2FDC Moderate Decreased metabolism of Cimetidine caused by Desipramine mediated inhibition of CYP450 enzyme. Attention deficit hyperactivity disorder [6A05] [38]
Tindamax DM3OWT4 Minor Decreased metabolism of Cimetidine caused by Tindamax mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [29]
Cefpodoxime DMJUNY5 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Cefpodoxime. Bacterial infection [1A00-1C4Z] [23]
Bacampicillin DMP54C7 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Bacampicillin. Bacterial infection [1A00-1C4Z] [23]
Cefditoren DMSUVM1 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Cefditoren. Bacterial infection [1A00-1C4Z] [39]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Cimetidine caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [40]
Vismodegib DM5IXKQ Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Vismodegib. Basal cell carcinoma [2C32] [40]
Pexidartinib DMS2J0Z Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [41]
Loperamide DMOJZQ9 Major Decreased clearance of Cimetidine due to the transporter inhibition by Loperamide. Bowel habit change [ME05] [42]
Ixabepilone DM2OZ3G Moderate Decreased metabolism of Cimetidine caused by Ixabepilone mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [43]
Lapatinib DM3BH1Y Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Lapatinib. Breast cancer [2C60-2C6Y] [27]
HKI-272 DM6QOVN Major Decreased absorption of Cimetidine due to altered gastric pH caused by HKI-272. Breast cancer [2C60-2C6Y] [40]
Esterified estrogens DM9KZDO Minor Decreased metabolism of Cimetidine caused by Esterified estrogens. Breast cancer [2C60-2C6Y] [44]
Palbociclib DMD7L94 Moderate Decreased metabolism of Cimetidine caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [27]
Quinestrol DMJ6H1Z Minor Decreased metabolism of Cimetidine caused by Quinestrol. Breast cancer [2C60-2C6Y] [44]
Tamoxifen DMLB0EZ Major Decreased metabolism of Cimetidine caused by Tamoxifen mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [45]
Toremifene DMQYUWG Moderate Decreased metabolism of Cimetidine caused by Toremifene mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [46]
Bosutinib DMTI8YE Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Bosutinib. Breast cancer [2C60-2C6Y] [27]
Estradiol DMUNTE3 Minor Decreased metabolism of Cimetidine caused by Estradiol. Breast cancer [2C60-2C6Y] [44]
Moricizine DMOMBJW Moderate Decreased metabolism of Cimetidine caused by Moricizine mediated inhibition of CYP450 enzyme. Cardiac arrhythmia [BC9Z] [47]
Atorvastatin DMF28YC Moderate Decreased metabolism of Cimetidine caused by Atorvastatin mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [48]
Macitentan DMP79A1 Moderate Decreased metabolism of Cimetidine caused by Macitentan mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [49]
PF-04449913 DMSB068 Moderate Decreased metabolism of Cimetidine caused by PF-04449913 mediated inhibition of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [50]
Anisindione DM2C48U Moderate Decreased metabolism of Cimetidine caused by Anisindione mediated inhibition of CYP450 enzyme. Coagulation defect [3B10] [51]
Irinotecan DMP6SC2 Moderate Decreased metabolism of Cimetidine caused by Irinotecan mediated inhibition of CYP450 enzyme. Colorectal cancer [2B91] [52]
Mestranol DMG3F94 Minor Decreased metabolism of Cimetidine caused by Mestranol. Contraceptive management [QA21] [44]
Levobupivacaine DM783CH Moderate Decreased metabolism of Cimetidine caused by Levobupivacaine mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [27]
Thiopental DMGP8AX Minor Altered absorption of Cimetidine caused by Thiopental. Corneal disease [9A76-9A78] [33]
Alfentanil DMVO0UB Moderate Decreased metabolism of Cimetidine caused by Alfentanil mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [53]
Oxtriphylline DMLHSE3 Moderate Decreased metabolism of Cimetidine caused by Oxtriphylline mediated inhibition of CYP450 enzyme. Cough [MD12] [37]
Dextromethorphan DMUDJZM Moderate Decreased metabolism of Cimetidine caused by Dextromethorphan mediated inhibition of CYP450 enzyme. Cough [MD12] [40]
Mifepristone DMGZQEF Moderate Decreased metabolism of Cimetidine caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [54]
Osilodrostat DMIJC9X Moderate Decreased metabolism of Cimetidine caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [27]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Cimetidine caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [55]
Ethanol DMDRQZU Minor Decreased metabolism of Cimetidine caused by Ethanol mediated inhibition of non-CYP450 enzyme. Cystitis [GC00] [56]
Rivaroxaban DMQMBZ1 Moderate Decreased metabolism of Cimetidine caused by Rivaroxaban mediated inhibition of CYP450 enzyme. Deep vein thrombosis [BD71] [57]
Nortriptyline DM4KDYJ Moderate Decreased metabolism of Cimetidine caused by Nortriptyline mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Paroxetine DM5PVQE Moderate Decreased metabolism of Cimetidine caused by Paroxetine. Depression [6A70-6A7Z] [58]
Escitalopram DMFK9HG Moderate Decreased metabolism of Cimetidine caused by Escitalopram mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [52]
Desvenlafaxine DMHD4PE Minor Decreased metabolism of Cimetidine caused by Desvenlafaxine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [59]
OPC-34712 DMHG57U Major Decreased metabolism of Cimetidine caused by OPC-34712 mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [60]
Clomipramine DMINRKW Moderate Decreased metabolism of Cimetidine caused by Clomipramine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Amoxapine DMKITQE Moderate Decreased metabolism of Cimetidine caused by Amoxapine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Doxepin DMPI98T Moderate Decreased metabolism of Cimetidine caused by Doxepin mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Polatuzumab vedotin DMF6Y0L Moderate Decreased metabolism of Cimetidine caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [61]
[3H]estrone-3-sulphate DMGPF0N Minor Decreased metabolism of Cimetidine caused by [3H]estrone-3-sulphate. Discovery agent [N.A.] [44]
PMID28870136-Compound-49 DMTUC9E Moderate Decreased metabolism of Cimetidine caused by PMID28870136-Compound-49 mediated inhibition of CYP450 enzyme. Discovery agent [N.A.] [62]
Diazepam DM08E9O Moderate Decreased metabolism of Cimetidine caused by Diazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Zonisamide DM0DTF7 Moderate Decreased metabolism of Cimetidine caused by Zonisamide mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [63]
Primidone DM0WX6I Minor Altered absorption of Cimetidine caused by Primidone. Epilepsy/seizure [8A61-8A6Z] [33]
Stiripentol DMMSDOY Moderate Decreased metabolism of Cimetidine caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [27]
Fosphenytoin DMOX3LB Major Decreased metabolism of Cimetidine caused by Fosphenytoin mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [64]
Clonazepam DMTO13J Moderate Decreased metabolism of Cimetidine caused by Clonazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Phenobarbital DMXZOCG Minor Altered absorption of Cimetidine caused by Phenobarbital. Epilepsy/seizure [8A61-8A6Z] [33]
Carbamazepine DMZOLBI Moderate Decreased metabolism of Cimetidine caused by Carbamazepine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [65]
Nicardipine DMCDYW7 Moderate Decreased metabolism of Cimetidine caused by Nicardipine mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [31]
Nadolol DMW6GVL Moderate Decreased metabolism of Cimetidine caused by Nadolol mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [66]
Tazemetostat DMWP1BH Moderate Decreased metabolism of Cimetidine caused by Tazemetostat mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [67]
Solifenacin DMG592Q Moderate Decreased metabolism of Cimetidine caused by Solifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [68]
Mirabegron DMS1GYT Minor Decreased metabolism of Cimetidine caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [69]
Tolterodine DMSHPW8 Moderate Decreased metabolism of Cimetidine caused by Tolterodine mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [70]
Itraconazole DMCR1MV Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Itraconazole. Fungal infection [1F29-1F2F] [71]
Terbinafine DMI6HUW Minor Decreased metabolism of Cimetidine caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [72]
Ketoconazole DMPZI3Q Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Ketoconazole. Fungal infection [1F29-1F2F] [73]
Ripretinib DM958QB Moderate Decreased metabolism of Cimetidine caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [40]
Avapritinib DMK2GZX Moderate Decreased metabolism of Cimetidine caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [27]
Carteolol DMFMDOB Moderate Decreased metabolism of Cimetidine caused by Carteolol mediated inhibition of CYP450 enzyme. Glaucoma [9C61] [66]
Colchicine DM2POTE Moderate Decreased metabolism of Cimetidine caused by Colchicine mediated inhibition of CYP450 enzyme. Gout [FA25] [74]
Ergotamine DMKR3C5 Moderate Decreased metabolism of Cimetidine caused by Ergotamine mediated inhibition of CYP450 enzyme. Headache [8A80-8A84] [75]
Carvedilol DMHTEAO Moderate Decreased metabolism of Cimetidine caused by Carvedilol mediated inhibition of CYP450 enzyme. Heart failure [BD10-BD1Z] [66]
MK-1439 DM215WE Minor Decreased metabolism of Cimetidine caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [76]
Delavirdine DM3NF5G Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Delavirdine. Human immunodeficiency virus disease [1C60-1C62] [77]
Fosamprenavir DM4W9B3 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Fosamprenavir. Human immunodeficiency virus disease [1C60-1C62] [78]
Dolutegravir DMCZGRE Minor Decreased metabolism of Cimetidine caused by Dolutegravir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [79]
Etravirine DMGV8QU Moderate Decreased metabolism of Cimetidine caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [80]
Lopinavir DMITQS0 Minor Decreased metabolism of Cimetidine caused by Lopinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [27]
Rilpivirine DMJ0QOW Major Decreased absorption of Cimetidine due to altered gastric pH caused by Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [81]
Amprenavir DMLMXE0 Minor Decreased metabolism of Cimetidine caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [82]
Atazanavir DMSYRBX Major Decreased absorption of Cimetidine due to altered gastric pH caused by Atazanavir. Human immunodeficiency virus disease [1C60-1C62] [27]
Maraviroc DMTL94F Moderate Decreased clearance of Cimetidine due to the transporter inhibition by Maraviroc. Human immunodeficiency virus disease [1C60-1C62] [83]
Raltegravir DMYURI6 Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Raltegravir. Human immunodeficiency virus disease [1C60-1C62] [84]
Simvastatin DM30SGU Moderate Decreased metabolism of Cimetidine caused by Simvastatin mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [48]
BMS-201038 DMQTAGO Moderate Decreased metabolism of Cimetidine caused by BMS-201038 mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [85]
Acebutolol DM0TI4U Moderate Decreased metabolism of Cimetidine caused by Acebutolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Bisoprolol DM3UZ95 Moderate Decreased metabolism of Cimetidine caused by Bisoprolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Penbutolol DM4ES8F Moderate Decreased metabolism of Cimetidine caused by Penbutolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Verapamil DMA7PEW Moderate Decreased metabolism of Cimetidine caused by Verapamil mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [31]
Pindolol DMD2NV7 Moderate Decreased metabolism of Cimetidine caused by Pindolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Labetalol DMK8U72 Moderate Decreased metabolism of Cimetidine caused by Labetalol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Felodipine DMOSW35 Moderate Decreased metabolism of Cimetidine caused by Felodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [31]
Pirfenidone DM6VZFQ Moderate Decreased metabolism of Cimetidine caused by Pirfenidone mediated inhibition of CYP450 enzyme. Idiopathic interstitial pneumonitis [CB03] [27]
Retapamulin DM9JXB7 Minor Decreased metabolism of Cimetidine caused by Retapamulin mediated inhibition of CYP450 enzyme. Impetigo [1B72] [86]
Suvorexant DM0E6S3 Moderate Decreased metabolism of Cimetidine caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [40]
Amobarbital DM0GQ8N Minor Altered absorption of Cimetidine caused by Amobarbital. Insomnia [7A00-7A0Z] [33]
Ramelteon DM7IW9J Moderate Decreased metabolism of Cimetidine caused by Ramelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [87]
Flurazepam DMAL4G0 Moderate Decreased metabolism of Cimetidine caused by Flurazepam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Triazolam DMETYK5 Moderate Decreased metabolism of Cimetidine caused by Triazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Zaleplon DMGFWSM Moderate Decreased metabolism of Cimetidine caused by Zaleplon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [88]
Melatonin DMKWFBT Minor Decreased metabolism of Cimetidine caused by Melatonin mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [40]
Tasimelteon DMLOQ1V Moderate Decreased metabolism of Cimetidine caused by Tasimelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [89]
ITI-007 DMUQ1DO Moderate Decreased metabolism of Cimetidine caused by ITI-007 mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [90]
Quazepam DMY4D87 Moderate Decreased metabolism of Cimetidine caused by Quazepam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Estazolam DMZGXUM Moderate Decreased metabolism of Cimetidine caused by Estazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Iron DMAP8MV Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Iron. Iron deficiency anaemia [3A00] [91]
Alosetron DML2A03 Moderate Decreased metabolism of Cimetidine caused by Alosetron mediated inhibition of CYP450 enzyme. Irritable bowel syndrome [DD91] [92]
Naloxegol DML0B41 Minor Decreased metabolism of Cimetidine caused by Naloxegol mediated inhibition of CYP450 enzyme. Large intestine motility disorder [DB32] [93]
Physostigmine DM2N0TO Moderate Antagonize the effect of Cimetidine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [28]
Pemigatinib DM819JF Moderate Decreased metabolism of Cimetidine caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [27]
Ceritinib DMB920Z Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Ceritinib. Lung cancer [2C25] [94]
Erlotinib DMCMBHA Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Erlotinib. Lung cancer [2C25] [40]
Lurbinectedin DMEFRTZ Moderate Decreased metabolism of Cimetidine caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [95]
PF-06463922 DMKM7EW Moderate Decreased metabolism of Cimetidine caused by PF-06463922 mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [96]
Dacomitinib DMOH8VY Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Dacomitinib. Lung cancer [2C25] [27]
Osimertinib DMRJLAT Moderate Decreased metabolism of Cimetidine caused by Osimertinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [97]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Cimetidine caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [98]
Selpercatinib DMZR15V Major Decreased absorption of Cimetidine due to altered gastric pH caused by Selpercatinib. Lung cancer [2C25] [27]
Halofantrine DMOMK1V Major Decreased metabolism of Cimetidine caused by Halofantrine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [99]
Chloroquine DMSI5CB Moderate Decreased metabolism of Cimetidine caused by Chloroquine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [27]
Hydroxychloroquine DMSIVND Moderate Decreased metabolism of Cimetidine caused by Hydroxychloroquine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [27]
GDC-0199 DMH0QKA Moderate Decreased metabolism of Cimetidine caused by GDC-0199 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [40]
IPI-145 DMWA24P Moderate Decreased metabolism of Cimetidine caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [100]
Ibrutinib DMHZCPO Moderate Decreased metabolism of Cimetidine caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [101]
Ponatinib DMYGJQO Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Ponatinib. Mature B-cell lymphoma [2A85] [40]
Selumetinib DMC7W6R Moderate Decreased metabolism of Cimetidine caused by Selumetinib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [102]
Dabrafenib DMX6OE3 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Dabrafenib. Melanoma [2C30] [40]
Estrone DM5T6US Minor Decreased metabolism of Cimetidine caused by Estrone. Menopausal disorder [GA30] [44]
Dienestrol DMBSXI0 Minor Decreased metabolism of Cimetidine caused by Dienestrol. Menopausal disorder [GA30] [44]
Ethinyl estradiol DMODJ40 Minor Decreased metabolism of Cimetidine caused by Ethinyl estradiol. Menopausal disorder [GA30] [44]
Ubrogepant DM749I3 Moderate Decreased metabolism of Cimetidine caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [103]
Propranolol DM79NTF Moderate Decreased metabolism of Cimetidine caused by Propranolol mediated inhibition of CYP450 enzyme. Migraine [8A80] [66]
Flibanserin DM70DTN Moderate Decreased metabolism of Cimetidine caused by Flibanserin mediated inhibition of CYP450 enzyme. Mood disorder [6A60-6E23] [104]
Midazolam DMXOELT Moderate Decreased metabolism of Cimetidine caused by Midazolam mediated inhibition of CYP450 enzyme. Mood/affect symptom [MB24] [35]
Panobinostat DM58WKG Moderate Decreased metabolism of Cimetidine caused by Panobinostat mediated inhibition of CYP450 enzyme. Multiple myeloma [2A83] [105]
Thalidomide DM70BU5 Moderate Increased risk of ventricular arrhythmias by the combination of Cimetidine and Thalidomide. Multiple myeloma [2A83] [40]
Siponimod DM2R86O Major Increased risk of atrioventricular block by the combination of Cimetidine and Siponimod. Multiple sclerosis [8A40] [40]
Fingolimod DM5JVAN Moderate Increased risk of bradycardia by the combination of Cimetidine and Fingolimod. Multiple sclerosis [8A40] [106]
Ozanimod DMT6AM2 Moderate Increased risk of atrioventricular block by the combination of Cimetidine and Ozanimod. Multiple sclerosis [8A40] [107]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Cimetidine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [27]
Nilotinib DM7HXWT Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Nilotinib. Myeloproliferative neoplasm [2A20] [40]
Ruxolitinib DM7Q98D Minor Decreased metabolism of Cimetidine caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [27]
Imatinib DM7RJXL Moderate Decreased metabolism of Cimetidine caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [108]
Dasatinib DMJV2EK Major Decreased absorption of Cimetidine due to altered gastric pH caused by Dasatinib. Myeloproliferative neoplasm [2A20] [109]
Prasugrel DM7MT6E Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Prasugrel. Myocardial infarction [BA41-BA43] [110]
Modafinil DMYILBE Minor Decreased metabolism of Cimetidine caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [40]
Dolasetron DMMG26Z Minor Decreased metabolism of Cimetidine caused by Dolasetron mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [111]
Entrectinib DMMPTLH Moderate Decreased metabolism of Cimetidine caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [112]
Sibutramine DMFJTDI Minor Decreased metabolism of Cimetidine caused by Sibutramine mediated inhibition of CYP450 enzyme. Obesity [5B80-5B81] [113]
Levomethadyl Acetate DM06HG5 Major Decreased metabolism of Cimetidine caused by Levomethadyl Acetate mediated inhibition of CYP450 enzyme. Opioid use disorder [6C43] [114]
Valdecoxib DMAY7H4 Moderate Decreased metabolism of Cimetidine caused by Valdecoxib mediated inhibition of CYP450 enzyme. Osteoarthritis [FA00-FA05] [115]
Olaparib DM8QB1D Moderate Decreased metabolism of Cimetidine caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [116]
Buprenorphine DMPRI8G Moderate Decreased metabolism of Cimetidine caused by Buprenorphine mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [117]
Hydrocodone DMQ2JO5 Major Decreased metabolism of Cimetidine caused by Hydrocodone mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [118]
Mebendazole DMO14SG Minor Decreased metabolism of Cimetidine caused by Mebendazole mediated inhibition of CYP450 enzyme. Parasitic worm infestation [1F90] [119]
Istradefylline DM20VSK Moderate Decreased metabolism of Cimetidine caused by Istradefylline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [120]
Rasagiline DM3WKQ4 Moderate Decreased metabolism of Cimetidine caused by Rasagiline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [40]
Pimavanserin DMR7IVC Moderate Decreased metabolism of Cimetidine caused by Pimavanserin mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [121]
Lefamulin DME6G97 Moderate Decreased clearance of Cimetidine due to the transporter inhibition by Lefamulin. Pneumonia [CA40] [122]
Bromfenac DMKB79O Minor Decreased renal excretion of Cimetidine caused by Bromfenac. Postoperative inflammation [1A00-CA43] [123]
Ergonovine DM0VEC1 Moderate Decreased metabolism of Cimetidine caused by Ergonovine mediated inhibition of CYP450 enzyme. Postpartum haemorrhage [JA43] [124]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Cimetidine caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [125]
Darolutamide DMV7YFT Minor Decreased metabolism of Cimetidine caused by Darolutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [126]
Tamsulosin DM5QF9V Moderate Decreased metabolism of Cimetidine caused by Tamsulosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [127]
Silodosin DMJSBT6 Moderate Decreased metabolism of Cimetidine caused by Silodosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [128]
Dutasteride DMQ4TJK Moderate Decreased metabolism of Cimetidine caused by Dutasteride mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [129]
Bosentan DMIOGBU Moderate Decreased metabolism of Cimetidine caused by Bosentan mediated inhibition of CYP450 enzyme. Pulmonary hypertension [BB01] [130]
Everolimus DM8X2EH Moderate Decreased clearance of Cimetidine due to the transporter inhibition by Everolimus. Renal cell carcinoma [2C90] [131]
Axitinib DMGVH6N Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Axitinib. Renal cell carcinoma [2C90] [132]
Temsirolimus DMS104F Moderate Decreased metabolism of Cimetidine caused by Temsirolimus mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [133]
Upadacitinib DM32B5U Moderate Decreased metabolism of Cimetidine caused by Upadacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [134]
Thioridazine DM35M8J Major Decreased metabolism of Cimetidine caused by Thioridazine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [135]
Asenapine DMSQZE2 Moderate Decreased metabolism of Cimetidine caused by Asenapine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [136]
Pimozide DMW83TP Major Decreased metabolism of Cimetidine caused by Pimozide mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [52]
Tadalafil DMJZHT1 Moderate Decreased metabolism of Cimetidine caused by Tadalafil mediated inhibition of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [137]
LDE225 DMM9F25 Moderate Decreased metabolism of Cimetidine caused by LDE225 mediated inhibition of CYP450 enzyme. Skin cancer [2C30-2C37] [138]
Larotrectinib DM26CQR Moderate Decreased metabolism of Cimetidine caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [40]
Docetaxel DMDI269 Moderate Decreased metabolism of Cimetidine caused by Docetaxel mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [139]
Trabectedin DMG3Y89 Moderate Decreased metabolism of Cimetidine caused by Trabectedin mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [27]
Armodafinil DMGB035 Minor Decreased metabolism of Cimetidine caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [40]
LEE011 DMMX75K Moderate Decreased metabolism of Cimetidine caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [40]
Taxol DMUOT9V Moderate Decreased metabolism of Cimetidine caused by Taxol mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [140]
Pitolisant DM8RFNJ Moderate Decreased metabolism of Cimetidine caused by Pitolisant mediated inhibition of CYP450 enzyme. Somnolence [MG42] [27]
Warfarin DMJYCVW Moderate Decreased metabolism of Cimetidine caused by Warfarin mediated inhibition of CYP450 enzyme. Supraventricular tachyarrhythmia [BC81] [51]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Cimetidine caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [141]
Clopidogrel DMOL54H Moderate Decreased metabolism of Cimetidine caused by Clopidogrel mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [142]
Tizanidine DMR2IQ4 Major Decreased metabolism of Cimetidine caused by Tizanidine mediated inhibition of CYP450 enzyme. Tonus and reflex abnormality [MB47] [143]
Trimetrexate DMDEA85 Minor Decreased metabolism of Cimetidine caused by Trimetrexate mediated inhibition of CYP450 enzyme. Toxoplasmosis [1F57] [144]
Sirolimus DMGW1ID Moderate Decreased metabolism of Cimetidine caused by Sirolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [40]
Tacrolimus DMZ7XNQ Moderate Decreased metabolism of Cimetidine caused by Tacrolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [40]
Saxagliptin DMGXENV Moderate Decreased metabolism of Cimetidine caused by Saxagliptin mediated inhibition of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [27]
Chlorpropamide DMPHZQE Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Chlorpropamide. Type 2 diabetes mellitus [5A11] [25]
Elagolix DMB2C0E Moderate Decreased metabolism of Cimetidine caused by Elagolix mediated inhibition of CYP450 enzyme. Uterine fibroid [2E86] [145]
Astemizole DM2HN6Q Major Decreased metabolism of Cimetidine caused by Astemizole mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [146]
Procainamide DMNMXR8 Moderate Decreased elimination of Cimetidine caused by Procainamide mediated competitive inhibition of renal tubular secretion. Ventricular tachyarrhythmia [BC71] [147]
Propafenone DMPIBJK Moderate Decreased metabolism of Cimetidine caused by Propafenone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [148]
Flecainide DMSQDLE Moderate Decreased metabolism of Cimetidine caused by Flecainide mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [149]
⏷ Show the Full List of 217 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 1 E00263 19700 Colorant
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF E00255 17730 Colorant
Vanillin E00049 1183 Flavoring agent
Carmellose sodium E00625 Not Available Disintegrant
Crospovidone E00626 Not Available Disintegrant
Hypromellose E00634 Not Available Coating agent
Magnesium stearate E00208 11177 lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Sodium alginate E00671 Not Available Binding agent; Disintegrant; Suspending agent; Viscosity-controlling agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Triethyl citrate E00128 6506 Plasticizing agent; Solvent
⏷ Show the Full List of 17 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Cimetidine 400 mg tablet 400 mg Oral Tablet Oral
Cimetidine 200 mg tablet 200 mg Oral Tablet Oral
Cimetidine 800 mg tablet 800 mg Oral Tablet Oral
Cimetidine 300 mg tablet 300 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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77 Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
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79 Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
80 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
81 Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
82 Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
83 Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
84 Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.
85 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
86 Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
87 Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
88 Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
89 Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
90 Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
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94 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
95 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
96 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
97 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
98 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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101 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
102 Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
103 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
104 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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107 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
108 Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
109 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
110 Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
111 Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
112 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
113 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
114 Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
115 Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
116 Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
117 Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
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121 Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
122 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
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130 Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
131 Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
132 Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
133 Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
134 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
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137 Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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145 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
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