| DOT Name |
Ribosomal protein uL16-like (RPL10L)
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| Synonyms |
60S ribosomal protein L10-like; Large ribosomal subunit protein uL16-like |
| Gene Name |
RPL10L
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| Related Disease |
- Male infertility ( )
- Spermatogenic failure 63 ( )
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| UniProt ID |
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| 3D Structure |
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| PDB ID |
4UG0 ; 4V6X ; 5LKS ; 5T2C ; 6IP5 ; 6IP6 ; 6IP8 ; 6LQM ; 6QZP ; 6XA1 ; 6Y0G ; 6Y2L ; 6Y57 ; 6Y6X ; 6Z6L ; 6Z6M ; 6Z6N ; 6ZM7 ; 6ZME ; 6ZMI ; 6ZMO ; 7BHP ; 7OW7 ; 7QVP ; 8JDJ ; 8JDK ; 8JDL ; 8JDM |
| Pfam ID |
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| Sequence |
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQL
SSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
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| Function |
Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I. Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome. It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm.
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| Tissue Specificity |
Almost testis-specific . Also expressed in pre- and postmenopausal ovary . |
| KEGG Pathway |
- Ribosome (hsa03010 )
- Coro.virus disease - COVID-19 (hsa05171 )
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| Reactome Pathway |
- Peptide chain elongation (R-HSA-156902 )
- SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339 )
- Viral mRNA Translation (R-HSA-192823 )
- Selenocysteine synthesis (R-HSA-2408557 )
- Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 )
- Formation of a pool of free 40S subunits (R-HSA-72689 )
- GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 )
- Eukaryotic Translation Termination (R-HSA-72764 )
- Regulation of expression of SLITs and ROBOs (R-HSA-9010553 )
- Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012 )
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956 )
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957 )
- L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )
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