Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTGO4GEY)

DOT Name Desmoglein-3 (DSG3)
Synonyms 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6
Gene Name DSG3
Related Disease
Blistering, acantholytic, of oral and laryngeal mucosa ( )
UniProt ID
DSG3_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
5EQX
Pfam ID
PF00028
Sequence
MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCRE
GEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREET
PSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILN
ATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGA
DKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN
WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVI
SRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAA
SNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGT
VYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWS
ITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYP
TTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPD
GSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGME
MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA
DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD
LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQT
LSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVI
VTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Tissue Specificity Epidermis, tongue, tonsil, esophagus and carcinomas. Expressed in skin and mucosa (at protein level) .
Reactome Pathway
Keratinization (R-HSA-6805567 )
Formation of the cornified envelope (R-HSA-6809371 )
Apoptotic cleavage of cell adhesion proteins (R-HSA-351906 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Blistering, acantholytic, of oral and laryngeal mucosa DISIQJUW Limited Unknown [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
11 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Estradiol DMUNTE3 Approved Estradiol decreases the expression of Desmoglein-3 (DSG3). [2]
Calcitriol DM8ZVJ7 Approved Calcitriol increases the expression of Desmoglein-3 (DSG3). [3]
Triclosan DMZUR4N Approved Triclosan increases the expression of Desmoglein-3 (DSG3). [4]
Methotrexate DM2TEOL Approved Methotrexate increases the expression of Desmoglein-3 (DSG3). [5]
Epigallocatechin gallate DMCGWBJ Phase 3 Epigallocatechin gallate decreases the expression of Desmoglein-3 (DSG3). [6]
Seocalcitol DMKL9QO Phase 3 Seocalcitol increases the expression of Desmoglein-3 (DSG3). [7]
Genistein DM0JETC Phase 2/3 Genistein decreases the expression of Desmoglein-3 (DSG3). [6]
Puerarin DMJIMXH Phase 2 Puerarin decreases the expression of Desmoglein-3 (DSG3). [6]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Desmoglein-3 (DSG3). [9]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Desmoglein-3 (DSG3). [10]
Chlorogenic acid DM2Y3P4 Investigative Chlorogenic acid decreases the expression of Desmoglein-3 (DSG3). [6]
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⏷ Show the Full List of 11 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Desmoglein-3 (DSG3). [8]
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References

1 A Homozygous Nonsense Mutation in the DSG3 Gene Causes Acantholytic Blisters in the Oral and?Laryngeal Mucosa. J Invest Dermatol. 2019 May;139(5):1187-1190. doi: 10.1016/j.jid.2018.09.038. Epub 2018 Dec 5.
2 Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
3 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
4 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
5 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
6 Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. 2010;2010.
7 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
8 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
9 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
10 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.