Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTI8Y0C1)

• DOT Name: Protein shisa-8 (SHISA8)
• Synonyms: Shisa family member 8
• Gene Name: SHISA8
• Related Disease:
  Kaposi sarcoma
  Plasma cell myeloma
• UniProt ID: SHSA8_HUMAN
• Pfam ID: PF13908
• Sequence:
  MARAGARGLLGGRRPPGLRLALALRLALLLARPPSGRAGAPEAQGPAAPGTTAPEGGDRC
  RGYYDVMGQWDPPFNCSSGAYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTPAWVQTGRP
  PARARDTAAPRDPGRERSHTAVYAVCGVAALLVLAGIGARLGLERAHSPRARRTVTRALT
  ELLKQPGPQEPLPPTLGPPLGGCVQVQMGDGLPRGSPHNSADKKRLNNAPRGSAAPGPPR
  GPRLQGGGSLTLQPDYAKYATFKAAALKAAEAAPRDFCQRFPALEPSPRQPPARAPRPSP
  DLPAPLDACPWAPPVYAPPAAPGPYAAWTSSRPARPAPLSHPTARAFQVPRRPGHAARRQ
  FSVKMPETFNPQLPGLYGSAGRGSRYLRTNSKTEVTV
• Function: May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Kaposi sarcoma	DISC1H1Z	Definitive	Genetic Variation	[1]
Plasma cell myeloma	DIS0DFZ0	Strong	Biomarker	[2]

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Triclosan	DMZUR4N	Approved	Triclosan increases the expression of Protein shisa-8 (SHISA8).	[3]
Demecolcine	DMCZQGK	Approved	Demecolcine decreases the expression of Protein shisa-8 (SHISA8).	[4]

References

• [1] Molecular epidemiology of human herpesvirus 8 variants in Kaposi's sarcoma from Iranian patients.Virus Res. 2012 Feb;163(2):644-9. doi: 10.1016/j.virusres.2011.09.027. Epub 2011 Sep 22.
• [2] Human herpesvirus 8 open reading frame 26 and open reading frame 65 sequences from multiple myeloma patients: a shared pattern not found in Kaposi's sarcoma or primary effusion lymphoma.Clin Cancer Res. 2000 Nov;6(11):4226-33.
• [3] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [4] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.