Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTJE3RRR)

• DOT Name: Forkhead box protein B2 (FOXB2)
• Gene Name: FOXB2
• Related Disease:
  Prostate cancer
  Prostate carcinoma
  Neoplasm
  Pancreatic cancer
  Pancreatic ductal carcinoma
• UniProt ID: FOXB2_HUMAN
• Pfam ID: PF00250
• Sequence:
  MPRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNS
  LRHNLSFNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHTHLH
  AGSTKSAPGAGPGGHLHPHHHHHPHHHHHHHAAAHHHHHHHPPQPPPPPPPPPPHMVHYF
  HQQPPTAPQPPPHLPSQPPQQPPQQSQPQQPSHPGKMQEAAAVAAAAAAAAAAAVGSVGR
  LSQFPPYGLGSAAAAAAAAAASTSGFKHPFAIENIIGRDYKGVLQAGGLPLASVMHHLGY
  PVPGQLGNVVSSVWPHVGVMDSVAAAAAAAAAAGVPVGPEYGAFGVPVKSLCHSASQSLP
  AMPVPIKPTPALPPVSALQPGLTVPAASQQPPAPSTVCSAAAASPVASLLEPTAPTSAES
  KGGSLHSVLVHS
• Function: Transcription factor.

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Prostate cancer	DISF190Y	Strong	Biomarker	[1]
Prostate carcinoma	DISMJPLE	Strong	Biomarker	[1]
Neoplasm	DISZKGEW	Disputed	Biomarker	[2]
Pancreatic cancer	DISJC981	Disputed	Biomarker	[2]
Pancreatic ductal carcinoma	DIS26F9Q	Disputed	Biomarker	[2]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Fulvestrant	DM0YZC6	Approved	Fulvestrant increases the methylation of Forkhead box protein B2 (FOXB2).	[3]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Forkhead box protein B2 (FOXB2).	[4]

References

• [1] Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer.Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22189-22195. doi: 10.1073/pnas.1906484116. Epub 2019 Oct 14.
• [2] Forkhead box B2 inhibits the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro.Genes Cells. 2019 Oct;24(10):674-681. doi: 10.1111/gtc.12717. Epub 2019 Oct 7.
• [3] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [4] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.