Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKRQZ1T)

• DOT Name: Pannexin-3 (PANX3)
• Gene Name: PANX3
• Related Disease:
  Duchenne muscular dystrophy
  Hereditary chronic pancreatitis
  Osteoarthritis
  Schizophrenia
  Bone osteosarcoma
  Osteosarcoma
  Advanced cancer
  Neoplasm
• UniProt ID: PANX3_HUMAN
• PDB ID: 7XL6
• Pfam ID: PF00876
• Sequence:
  MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS
  GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL
  MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEK
  ARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
  SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKR
  LLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKH
  NIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
• Function: Regulator of osteoblast differentiation by functionning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors.

Molecular Interaction Atlas (MIA) of This DOT

8 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Duchenne muscular dystrophy	DISRQ3NV	Strong	Altered Expression	[1]
Hereditary chronic pancreatitis	DISF0J1Q	Strong	Altered Expression	[2]
Osteoarthritis	DIS05URM	Strong	Biomarker	[3]
Schizophrenia	DISSRV2N	Strong	Genetic Variation	[4]
Bone osteosarcoma	DIST1004	moderate	Altered Expression	[5]
Osteosarcoma	DISLQ7E2	moderate	Altered Expression	[5]
Advanced cancer	DISAT1Z9	Limited	Biomarker	[6]
Neoplasm	DISZKGEW	Limited	Altered Expression	[6]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Pannexin-3 (PANX3).	[7]

References

• [1] Expression of Pannexin 1 and Pannexin 3 during skeletal muscle development, regeneration, and Duchenne muscular dystrophy.J Cell Physiol. 2018 Oct;233(10):7057-7070. doi: 10.1002/jcp.26629. Epub 2018 May 10.
• [2] Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1.Sci Rep. 2019 Oct 14;9(1):14762. doi: 10.1038/s41598-019-51381-9.
• [3] The Role of Pannexin 3 in Bone Biology.J Dent Res. 2017 Apr;96(4):372-379. doi: 10.1177/0022034516678203. Epub 2016 Nov 13.
• [4] The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes.Eur Arch Psychiatry Clin Neurosci. 2016 Aug;266(5):433-7. doi: 10.1007/s00406-015-0619-8. Epub 2015 Jul 30.
• [5] High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation.Am J Dermatopathol. 2016 Nov;38(11):846-851. doi: 10.1097/DAD.0000000000000583.
• [6] Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.Genome Med. 2016 Aug 9;8(1):83. doi: 10.1186/s13073-016-0334-8.
• [7] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.