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Diflunisal FDA Label
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4535).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2745).
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Histamine Phosphate FDA Label
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Indomethacin FDA Label
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7564).
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Oxaprozin FDA Label
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Oxycodone FDA Label
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Piroxicam FDA Label
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2893).
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ClinicalTrials.gov (NCT01960621) Effect of Cyclodextrin on Sensory Nerve Activity: A Novel Anti-tussive Therapy. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025057)
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ClinicalTrials.gov (NCT01438918) X-Ray Study Investigating The Safety And Efficacy Of SD-6010 In Subjects With Osteoarthritis Of The Knee. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00484120) Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02087904) A Phase 2a Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019505)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037435)
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ClinicalTrials.gov (NCT01624376) Randomized, Double-blind, Placebo-controlled Study in Patients With Fistulizing Crohn's Disease. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01091116) A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040063)
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Lithium FDA Label
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ClinicalTrials.gov (NCT04097379) A Randomized, Placebo-controlled, Subject and Investigator Blinded Study Investigating the Safety, Tolerability and Preliminary Efficacy of 8-week Treatment With Intra-articular LRX712 to Regenerate Articular Cartilage in Patients With Mild/Moderate Knee Osteoarthritis. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT05100225) A Multiple Arm, Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase 2 Study of Intra-Articular Administration of an Allogeneic Human Placental Tissue Particulate (PTP-001) for the Treatment of Knee Osteoarthritis. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT01598415) Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part II. U.S. National Institutes ofHealth.
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ClinicalTrials.gov (NCT02536833) A Study Evaluating the Safety, Tolerability, and Efficacy of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects.
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ClinicalTrials.gov (NCT01925261) A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01688934) Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis (OA) of the Knee. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01873053) A 12 Week, Phase II Trial to Evaluate the Efficacy and Safety of WIN-34B in Patients With Osteoarthritis of the Knee. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02068599) A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00454298) Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01207973) Safety, Tolerability, Pharmacokinetics and -Dynamics of Multiple Rising Oral Doses of BI 113823 in Patients Patients With Osteoarthritis of the Knee. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01278095) Oral Bioavailability of GLPG0555 in Different Solid Formulations. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05835895) A Phase 1b, Randomized, Double-Blinded, Placebo-Controlled Dose Ranging Study to Evaluate Safety, Tolerability and Pharmacodynamics of a Single Intra-articular Injection of GNSC-001 Gene Therapy in Subjects With Osteoarthritis of the Knee. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04119687) An Open-Label, Single Ascending Dose Study to Assess the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee. U.S.National Institutes of Health.
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Clinical pipeline report, company report or official report of ImmuneCyte
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ClinicalTrials.gov (NCT01010919) A Study of Chicory for Treatment of Osteoarthritis of the Hip or Knee. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034120)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6468).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007310)
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Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart fail... Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003927)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019710)
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone. 2012 Jun;50(6):1250-9.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7823).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015853)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018241)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).
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Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.JCI Insight. 2019 Sep 19;4(18):e128568. doi: 10.1172/jci.insight.128568.
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Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.Mol Cell Proteomics. 2009 Jan;8(1):172-89. doi: 10.1074/mcp.M800292-MCP200. Epub 2008 Sep 9.
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Skeletal malformations and developmental arthropathy in individuals who have fibrodysplasia ossificans progressiva.Bone. 2020 Jan;130:115116. doi: 10.1016/j.bone.2019.115116. Epub 2019 Oct 23.
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Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression.Cell Commun Signal. 2019 Oct 22;17(1):134. doi: 10.1186/s12964-019-0443-2.
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Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration.Theranostics. 2019 Sep 21;9(24):7108-7121. doi: 10.7150/thno.38182. eCollection 2019.
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Critical role for arginase II in osteoarthritis pathogenesis.Ann Rheum Dis. 2019 Mar;78(3):421-428. doi: 10.1136/annrheumdis-2018-214282. Epub 2019 Jan 4.
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Urine Proteomics Profiling and Functional Characterization of Knee Osteoarthritis Using iTRAQ Technology.Horm Metab Res. 2019 Nov;51(11):735-740. doi: 10.1055/a-1012-8571. Epub 2019 Nov 4.
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Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.J Cell Biochem. 2019 Aug;120(8):12653-12664. doi: 10.1002/jcb.28533. Epub 2019 Mar 4.
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Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level.Mol Med Rep. 2019 Oct;20(4):3308-3316. doi: 10.3892/mmr.2019.10559. Epub 2019 Aug 6.
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Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.Clin Rheumatol. 2020 Feb;39(2):523-532. doi: 10.1007/s10067-019-04768-y. Epub 2019 Oct 17.
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Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment.Sci Rep. 2019 Nov 26;9(1):17570. doi: 10.1038/s41598-019-54147-5.
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Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis.J Cell Physiol. 2019 Jun;234(6):8908-8917. doi: 10.1002/jcp.27557. Epub 2018 Oct 14.
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Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis.Arthritis Res Ther. 2019 Jan 11;21(1):18. doi: 10.1186/s13075-018-1801-y.
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Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis.Mol Immunol. 2017 Oct;90:211-218. doi: 10.1016/j.molimm.2017.08.006. Epub 2017 Aug 23.
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GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-B Signaling.Arthritis Rheumatol. 2020 Apr;72(4):620-631. doi: 10.1002/art.41152. Epub 2020 Mar 5.
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The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover.Sci Rep. 2017 Dec 1;7(1):16693. doi: 10.1038/s41598-017-17028-3.
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Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genomewide gene expression profiling analysis.Mol Med Rep. 2019 Jan;19(1):30-40. doi: 10.3892/mmr.2018.9677. Epub 2018 Nov 20.
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Pharmacological blockade of PCAF ameliorates osteoarthritis development via dual inhibition of TNF--driven inflammation and ER stress.EBioMedicine. 2019 Dec;50:395-407. doi: 10.1016/j.ebiom.2019.10.054. Epub 2019 Nov 14.
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Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.Arthritis Res Ther. 2019 Apr 3;21(1):87. doi: 10.1186/s13075-019-1865-3.
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Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug.Biomaterials. 2020 Jan;226:119541. doi: 10.1016/j.biomaterials.2019.119541. Epub 2019 Oct 12.
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NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-B signaling.Int Immunopharmacol. 2019 Jun;71:7-13. doi: 10.1016/j.intimp.2019.03.001. Epub 2019 Mar 9.
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The pro-inflammatory effect of NR4A3 in osteoarthritis.J Cell Mol Med. 2020 Jan;24(1):930-940. doi: 10.1111/jcmm.14804. Epub 2019 Nov 7.
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The clinical outcomes and the ability to sit straight in the Japanese style following high tibial osteotomy combined with osteochondral autologous transfer for osteonecrosis of the medial femoral condyle.J Orthop Sci. 2019 Jan;24(1):136-141. doi: 10.1016/j.jos.2018.08.005. Epub 2018 Sep 21.
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MicroRNA-455-3p promotes TGF- signaling and inhibits osteoarthritis development by directly targeting PAK2.Exp Mol Med. 2019 Oct 4;51(10):1-13. doi: 10.1038/s12276-019-0322-3.
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Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis.Biochem Biophys Res Commun. 2020 Feb 12;522(3):731-735. doi: 10.1016/j.bbrc.2019.11.112. Epub 2019 Nov 30.
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Metformin Inhibit Lung Cancer Cell Growth and Invasion in Vitro as Well as Tumor Formation in Vivo Partially by Activating PP2A.Med Sci Monit. 2019 Jan 29;25:836-846. doi: 10.12659/MSM.912059.
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Nanosome-Mediated Delivery Of Protein Kinase D Inhibitor Protects Chondrocytes From Interleukin-1-Induced Stress And Apoptotic Death.Int J Nanomedicine. 2019 Nov 11;14:8835-8846. doi: 10.2147/IJN.S218901. eCollection 2019.
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PTPN14 phosphatase and YAP promote TGF signalling in rheumatoid synoviocytes.Ann Rheum Dis. 2019 May;78(5):600-609. doi: 10.1136/annrheumdis-2018-213799. Epub 2019 Feb 26.
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Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity.Genes Immun. 2007 Sep;8(6):480-91. doi: 10.1038/sj.gene.6364400. Epub 2007 Jun 14.
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Oral shea nut oil triterpene concentrate supplement ameliorates pain and histological assessment of articular cartilage deterioration in an ACLT injured rat knee osteoarthritis model.PLoS One. 2019 Apr 19;14(4):e0215812. doi: 10.1371/journal.pone.0215812. eCollection 2019.
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Eccentric and Concentric Resistance Exercise Comparison for Knee Osteoarthritis.Med Sci Sports Exerc. 2019 Oct;51(10):1977-1986. doi: 10.1249/MSS.0000000000002010.
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Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery.J Clin Med. 2019 Nov 20;8(12):2028. doi: 10.3390/jcm8122028.
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The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis.Ir J Med Sci. 2019 Aug;188(3):867-872. doi: 10.1007/s11845-018-1945-4. Epub 2018 Dec 7.
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Upregulation of stanniocalcin-1 inhibits the development of osteoarthritis by inhibiting survival and inflammation of fibroblast-like synovial cells.J Cell Biochem. 2019 Jun;120(6):9768-9780. doi: 10.1002/jcb.28257. Epub 2018 Dec 23.
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Human Synovia Contains Trefoil Factor Family (TFF) Peptides 1-3 Although Synovial Membrane Only Produces TFF3: Implications in Osteoarthritis and Rheumatoid Arthritis.Int J Mol Sci. 2019 Dec 3;20(23):6105. doi: 10.3390/ijms20236105.
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Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nat Genet. 2019 Feb;51(2):230-236.
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Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis.J Med Chem. 2019 Feb 14;62(3):1468-1483. doi: 10.1021/acs.jmedchem.8b01615. Epub 2019 Jan 28.
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USP14-mediated IB degradation exacerbates NF-B activation and IL-1-stimulated chondrocyte dedifferentiation.Life Sci. 2019 Feb 1;218:147-152. doi: 10.1016/j.lfs.2018.12.014. Epub 2018 Dec 11.
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RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family.Nat Commun. 2019 Jan 8;10(1):77. doi: 10.1038/s41467-018-08035-7.
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Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factorB signaling in chondrocytes.Int J Mol Med. 2018 Sep;42(3):1548-1558. doi: 10.3892/ijmm.2018.3729. Epub 2018 Jun 13.
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Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis.Lasers Med Sci. 2017 Jan;32(1):87-94. doi: 10.1007/s10103-016-2089-2. Epub 2016 Oct 10.
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Genome-wide expression and methylation profiling reveal candidate genes in osteoarthritis.Clin Exp Rheumatol. 2017 Nov-Dec;35(6):983-990. Epub 2017 Jun 29.
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Protective Effects of Peucedanum japonicum Extract against Osteoarthritis in an Animal Model Using a Combined Systems Approach for Compound-Target Prediction.Nutrients. 2018 Jun 11;10(6):754. doi: 10.3390/nu10060754.
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The ClC-7 Chloride Channel Is Downregulated by Hypoosmotic Stress in Human Chondrocytes.Mol Pharmacol. 2015 Jul;88(1):113-20. doi: 10.1124/mol.115.098160. Epub 2015 May 5.
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The involvement of regulated in development and DNA damage response 1 (REDD1) in the pathogenesis of intervertebral disc degeneration.Exp Cell Res. 2018 Nov 15;372(2):188-197. doi: 10.1016/j.yexcr.2018.10.001. Epub 2018 Oct 9.
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Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice.Osteoarthritis Cartilage. 2019 Mar;27(3):513-525. doi: 10.1016/j.joca.2018.11.008. Epub 2018 Dec 1.
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Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury.BMC Musculoskelet Disord. 2018 Sep 15;19(1):334. doi: 10.1186/s12891-018-2253-x.
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PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes.Redox Biol. 2018 Apr;14:72-81. doi: 10.1016/j.redox.2017.08.011. Epub 2017 Aug 24.
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Curcumin Inhibits the PERK-eIF2-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model.Oxid Med Cell Longev. 2019 May 16;2019:8574386. doi: 10.1155/2019/8574386. eCollection 2019.
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Systematic Analysis of Transcriptomic Profile of Chondrocytes in Osteoarthritic Knee Using Next-Generation Sequencing and Bioinformatics.J Clin Med. 2018 Dec 10;7(12):535. doi: 10.3390/jcm7120535.
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GPR120 is an important inflammatory regulator in the development of osteoarthritis.Arthritis Res Ther. 2018 Aug 3;20(1):163. doi: 10.1186/s13075-018-1660-6.
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The role of the fibroblast growth factor family in bone-related diseases.Chem Biol Drug Des. 2019 Oct;94(4):1740-1749. doi: 10.1111/cbdd.13588. Epub 2019 Aug 4.
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Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter.J Orthop Res. 2019 Dec;37(12):2550-2560. doi: 10.1002/jor.24432. Epub 2019 Aug 13.
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BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway.Exp Ther Med. 2018 Dec;16(6):4623-4631. doi: 10.3892/etm.2018.6754. Epub 2018 Sep 18.
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Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women.Ann Rheum Dis. 2014 Feb;73(2):433-6. doi: 10.1136/annrheumdis-2012-202713. Epub 2013 Jun 5.
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DAla2GIP antagonizes H(2)O(2)-induced chondrocyte apoptosis and inflammatory factor secretion.Bone. 2019 Oct;127:656-663. doi: 10.1016/j.bone.2019.05.026. Epub 2019 Jul 5.
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Combined bioinformatics analysis reveals gene expression and DNA methylation patterns in osteoarthritis.Mol Med Rep. 2018 Jun;17(6):8069-8078. doi: 10.3892/mmr.2018.8874. Epub 2018 Apr 12.
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Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling.Yonsei Med J. 2018 Aug;59(6):760-768. doi: 10.3349/ymj.2018.59.6.760.
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Activation of G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits degradation of type II collagen and aggrecan in human chondrocytes.Eur J Pharmacol. 2019 Aug 5;856:172387. doi: 10.1016/j.ejphar.2019.05.016. Epub 2019 May 7.
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Orexin A prevents degradation of the articular matrixes in human primary chondrocyte culture.Mol Immunol. 2018 Sep;101:102-107. doi: 10.1016/j.molimm.2018.05.012. Epub 2018 Jun 15.
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Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways.Int J Mol Med. 2018 Apr;41(4):2117-2127. doi: 10.3892/ijmm.2018.3410. Epub 2018 Jan 22.
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TGF- type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis.Sci Transl Med. 2019 May 8;11(491):eaan2585. doi: 10.1126/scitranslmed.aan2585.
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Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis.PLoS One. 2017 Apr 20;12(4):e0175802. doi: 10.1371/journal.pone.0175802. eCollection 2017.
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DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis.Life Sci. 2019 Jul 1;228:274-284. doi: 10.1016/j.lfs.2019.05.018. Epub 2019 May 9.
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