Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTL8V888)

DOT Name Forkhead box protein R1 (FOXR1)
Synonyms Forkhead box protein N5
Gene Name FOXR1
Related Disease
Bone osteosarcoma ( )
Neuroblastoma ( )
Osteosarcoma ( )
UniProt ID
FOXR1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00250
Sequence
MGNELFLAFTTSHLPLAEQKLARYKLRIVKPPKLPLEKKPNPDKDGPDYEPNLWMWVNPN
IVYPPGKLEVSGRRKREDLTSTLPSSQPPQKEEDASCSEAAGVESLSQSSSKRSPPRKRF
AFSPSTWELTEEEEAEDQEDSSSMALPSPHKRAPLQSRRLRQASSQAGRLWSRPPLNYFH
LIALALRNSSPCGLNVQQIYSFTRKHFPFFRTAPEGWKNTVRHNLCFRDSFEKVPVSMQG
GASTRPRSCLWKLTEEGHRRFAEEARALASTRLESIQQCMSQPDVMPFLFDL
Function
Transcription factor which acts as both an activator and a repressor. Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress. Required for normal brain development.
Tissue Specificity Expressed in testis (at protein level).

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Bone osteosarcoma DIST1004 Strong Altered Expression [1]
Neuroblastoma DISVZBI4 Strong Altered Expression [1]
Osteosarcoma DISLQ7E2 Strong Altered Expression [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Arsenic DMTL2Y1 Approved Arsenic affects the methylation of Forkhead box protein R1 (FOXR1). [2]
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References

1 Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma.Oncogene. 2012 Mar 22;31(12):1571-81. doi: 10.1038/onc.2011.344. Epub 2011 Aug 22.
2 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.