General Information of Disease (ID: DISVZBI4)

Disease Name Neuroblastoma
Synonyms NB; neuroblastoma; neural Crest tumor, malignant; neuroblastoma (Schwannian Stroma-poor); neuroblastoma, malignant
Disease Class 2D11: Adrenal cancer
Definition
Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system.|NB is a disease of the sympaticoadrenal lineage of the neural crest, with tumors forming anywhere in the sympathetic nervous system. The tumors most commonly arise in the abdomen (65%), however, they also occur in the neck, chest, and pelvis. Approximately 50% of patients present with evidence of metastasis. Frequent metastasis sites include cortical bone, bone marrow, liver, and lymph nodes. The most common genetic change is MYCN amplification, which occurs in approximately 20% of patients, and is strongly correlated with advanced stage NB. Additionally, deletions of the short arm of chromosome 1 (1p) are found in 25?5% of patients and can be correlated with MYCN amplification. Outside of MYC linked changes, allelic loss of 11q is present in 35?5% of patients and is also associated with high-risk disease features.
Disease Hierarchy
DISKWPS1: Neuroblastic tumor
DIS2IQBH: Neurocristopathy
DISVZBI4: Neuroblastoma
ICD Code
ICD-11
ICD-11: 2D11.2
ICD-9
ICD-9: 194
Expand ICD-9
194
Disease Identifiers
MONDO ID
MONDO_0005072
MESH ID
D009447
UMLS CUI
C0027819
MedGen ID
18012
HPO ID
HP:0003006
Orphanet ID
635
SNOMED CT ID
432328008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 24 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Alemtuzumab DMZL3IV Approved Antibody [1]
Busulfan DMXYJ9C Approved Small molecular drug [2]
Carboplatin DMG281S Approved Small molecular drug [3]
Cyclophosphamide DM4O2Z7 Approved Small molecular drug [4]
Dacarbazine DMNPZL4 Approved Small molecular drug [5]
Doxorubicin DMVP5YE Approved Small molecular drug [6]
Entrectinib DMMPTLH Approved Small molecular drug [7]
Erlotinib DMCMBHA Approved Small molecular drug [8]
Etoposide DMNH3PG Approved Small molecular drug [9]
Everolimus DM8X2EH Approved Small molecular drug [10]
Fludarabine DMVRLT7 Approved Small molecular drug [11]
Ifosfamide DMCT3I8 Approved Small molecular drug [12]
Irinotecan DMP6SC2 Approved Small molecular drug [13]
Isotretinoin DM4QTBN Approved Small molecular drug [14]
Melphalan DMOLNHF Approved Small molecular drug [15]
Naxitamab DMXB7V8 Approved NA [16]
Pertuzumab DMHJV0X Approved Monoclonal antibody [1]
Sirolimus DMGW1ID Approved Small molecular drug [17]
Temozolomide DMKECZD Approved Small molecular drug [18]
Thiotepa DMIZKOP Approved Small molecular drug [19]
Topotecan DMP6G8T Approved Small molecular drug [20]
Tretinoin DM49DUI Approved Small molecular drug [21]
Vidarabine DM0N85H Approved Small molecular drug [22]
Vincristine DMINOX3 Approved Small molecular drug [23]
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⏷ Show the Full List of 24 Drug(s)
This Disease is Treated as An Indication in 28 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Ch14.18 mab DMMDBF5 Phase 3 Monoclonal antibody [24]
131 I-omburtamab DM12UX6 Phase 2/3 Antibody [25]
C-Cure DMLDN6J Phase 2/3 NA [26]
Dinutuximab DMWBWNG Phase 2/3 NA [27]
Omburtamab DMTIESG Phase 2/3 Antibody [25]
Omburtamab I-131 DMPDA17 Phase 2/3 NA [28]
Anti-GD2 CART DMVQHBK Phase 2 CAR T Cell Therapy [29]
APN-301 DM32YTJ Phase 2 NA [30]
APN301 DMGNFBC Phase 2 Antibody [31]
GD2-GD3 vaccine DMQ3S7Q Phase 2 Vaccine [32]
Hu3F8 mAb DM9MKQ5 Phase 2 NA [30]
Metaiodobenzylguanidine I-131 DMNST69 Phase 2 Small molecular drug [33]
SARTATE DMAXB1A Phase 2 Radiopharmaceutical [34]
67Cu-SARTATE DMJ8UXO Phase 1/2 Small molecular drug [35]
BEL-0222 DMHGDOO Phase 1/2 NA [7]
CUDC-907 DMHIQDC Phase 1/2 Small molecular drug [36]
GD2-CART01 DM5VF04 Phase 1/2 CAR T Cell Therapy [37]
Anti-GD2 T-cells (1RG-CART) DMBVUFL Phase 1 CAR T Cell Therapy [38]
Anti-GD2-CAR engineered T cells DMCNFZG Phase 1 CAR T Cell Therapy [39]
C7R-GD2.CART cells DMSO3JA Phase 1 CAR T Cell Therapy [40]
CD171 specific CAR T cells expressing EGFRt DM2AHXW Phase 1 CAR T Cell Therapy [41]
GD2 T cells DM9TD2N Phase 1 CAR T Cell Therapy [42]
IC9-GD2-CD28-OX40 DMRYHWA Phase 1 CAR T Cell Therapy [43]
IC9.GD2.CAR.IL-15 T-cells DMMPFZO Phase 1 CAR T Cell Therapy [44]
JCAR023 DM324RM Phase 1 NA [30]
KUR-501 DMKMN5R Phase 1 CAR-NKT Cell therapy [45]
LY294002 DMY1AFS Phase 1 Small molecular drug [46]
GD2-targeted CAR-T cells DM87BTM Clinical trial CAR T Cell Therapy [47]
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⏷ Show the Full List of 28 Drug(s)
This Disease is Treated as An Indication in 1 Investigative Agents
Drug Name Drug ID Highest Status Drug Type REF
Valproic Acid DMS49KH Investigative Small molecular drug [48]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 657 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCC4 TTUEAFL Limited Biomarker [49]
ACVRL1 TTGYPTC Limited Genetic Variation [50]
ADAM17 TT6AZXG Limited Biomarker [51]
ADCY2 TTBQ9IM Limited Altered Expression [52]
ADH1A TT5AHZ0 Limited Biomarker [53]
ADM TTV14YH Limited Altered Expression [54]
ADRA2A TTWG9A4 Limited Altered Expression [55]
AIMP2 TTXWHGF Limited Altered Expression [56]
AKT2 TTH24WI Limited Biomarker [57]
ALCAM TT2AFT6 Limited Altered Expression [58]
ALOX15 TTN9T81 Limited Altered Expression [59]
ALPI TTHYMUV Limited Biomarker [60]
ANG TTURHFP Limited Genetic Variation [61]
ANXA5 TT2Z83I Limited Biomarker [62]
APOE TTKS9CB Limited Biomarker [63]
ASIC1 TTRJYB6 Limited Biomarker [64]
ATAT1 TTWUHQ1 Limited Biomarker [65]
ATG7 TTLVB9Z Limited Biomarker [66]
ATRAID TTFLIKM Limited Biomarker [67]
AXL TTZPY6J Limited Genetic Variation [68]
BACE1 TTJUNZF Limited Altered Expression [69]
BAK1 TTFM7V0 Limited Biomarker [70]
BAZ2A TT2MV0R Limited Biomarker [71]
BCL11A TTR61MW Limited Altered Expression [72]
BGN TT0JPVF Limited Biomarker [73]
BLK TTNDSC3 Limited Biomarker [74]
BMPR2 TTGKF90 Limited Biomarker [75]
BRD4 TTSRAOU Limited Biomarker [76]
C1QBP TTWTD7F Limited Genetic Variation [77]
C9orf72 TTA4SHR Limited Biomarker [78]
CA2 TTANPDJ Limited Genetic Variation [79]
CACNA1C TTZIFHC Limited Altered Expression [80]
CAMKK2 TTV298Y Limited Biomarker [81]
CASR TTBUYHA Limited Genetic Variation [82]
CCNE1 TTCEJ4F Limited Biomarker [83]
CCR6 TTFDB30 Limited Posttranslational Modification [84]
CD248 TTYJWT7 Limited Altered Expression [85]
CD276 TT6CQUM Limited Biomarker [86]
CD80 TT89Z17 Limited Altered Expression [87]
CD9 TTZEIBV Limited Biomarker [88]
CDC20 TTBKFDV Limited Posttranslational Modification [89]
CDK7 TTQYF7G Limited Altered Expression [90]
CDKN1C TTBSUAR Limited Genetic Variation [91]
CDKN2C TTBRUGA Limited Biomarker [92]
CENPE TTZD5QR Limited Biomarker [93]
CFLAR TTJZQYH Limited Posttranslational Modification [84]
CHRNA7 TTLA931 Limited Biomarker [94]
CLN3 TTORF9W Limited Altered Expression [95]
CMKLR1 TT4UGZL Limited Biomarker [96]
COASY TT4YO0Z Limited Posttranslational Modification [97]
CRBN TTDKGTC Limited Altered Expression [98]
CRHR1 TT7EFHR Limited Biomarker [99]
CRK TTFEUYR Limited Altered Expression [56]
CRLF1 TT6YF5K Limited Biomarker [100]
CRYZ TTP6UO8 Limited Biomarker [101]
CS TTZA6B3 Limited Altered Expression [102]
CSF3R TTC70AJ Limited Altered Expression [103]
CSNK1E TTA8PLI Limited Biomarker [104]
CTCFL TTY0RZT Limited Biomarker [105]
CTSD TTPT2QI Limited Altered Expression [106]
CYP3A5 TTHS0OK Limited Biomarker [107]
DAPK3 TTERVQN Limited Altered Expression [108]
DFFA TTYVQ9C Limited Biomarker [109]
DICER1 TTTEOPU Limited Biomarker [110]
DKK1 TTE3RAC Limited Altered Expression [111]
DLG4 TT9PB26 Limited Altered Expression [112]
DOT1L TTSZ8T1 Limited Biomarker [113]
DUSP5 TTZN92A Limited Biomarker [114]
E2F1 TTASI04 Limited Altered Expression [115]
ECE2 TT5U914 Limited Biomarker [116]
EGR1 TTE8LGD Limited Altered Expression [117]
EHMT2 TTS6RZT Limited Biomarker [118]
EIF2AK3 TT79U1M Limited Biomarker [119]
EML4 TT92GY4 Limited Biomarker [120]
EPHA2 TTRJB2G Limited Biomarker [121]
EPHB1 TT8MDAC Limited Biomarker [122]
EPHB2 TTKPV6O Limited Biomarker [57]
ERAP2 TTVGS1C Limited Biomarker [123]
ERBB4 TTWALCO Limited Genetic Variation [124]
ESRRA TTPNQAC Limited Altered Expression [125]
ETS1 TTTGPSD Limited Biomarker [126]
FDXR TT3W4IX Limited Biomarker [127]
FFAR1 TTB8FUC Limited Altered Expression [128]
FGF21 TTQ916P Limited Biomarker [129]
FLT3 TTGJCWZ Limited Genetic Variation [130]
FOSL1 TTY8LZG Limited Biomarker [131]
FPR1 TT5Y4EM Limited Biomarker [132]
FUS TTKGYZ9 Limited Biomarker [133]
G6PC TTBQMJ8 Limited Altered Expression [134]
GABRB2 TTZA1NY Limited Altered Expression [135]
GADD45B TTMDW9L Limited Biomarker [121]
GBA TT1B5PU Limited Altered Expression [136]
GCLM TTNFESW Limited Altered Expression [137]
GDF2 TTAP4T1 Limited Biomarker [138]
GDF5 TT37XV9 Limited Biomarker [139]
GDNF TTF23ML Limited Altered Expression [140]
GFRA3 TT63XRS Limited Altered Expression [141]
GJA5 TTFQKZ7 Limited Genetic Variation [142]
GLI1 TTJOMH6 Limited Biomarker [143]
GLI2 TT045OH Limited Biomarker [143]
GLP1R TTVIMDE Limited Biomarker [144]
GLRX TTRJCNG Limited Altered Expression [145]
GPA33 TT96HUR Limited Biomarker [146]
GRM1 TTVBPDM Limited Biomarker [147]
GRN TT0LWE3 Limited Altered Expression [148]
GRPR TTC1MVT Limited Biomarker [149]
GUSB TTHS7CM Limited Biomarker [150]
HBB TTM6HK1 Limited Altered Expression [151]
HBEGF TT15SL0 Limited Altered Expression [152]
HCRTR1 TT60Q8D Limited Altered Expression [153]
HDAC10 TTYHPU6 Limited Biomarker [154]
HDAC11 TT8K17W Limited Biomarker [155]
HDAC2 TTSHTOI Limited Biomarker [156]
HDAC6 TT5ZKDI Limited Biomarker [157]
HLA-G TTLKFB3 Limited Biomarker [158]
HNF4A TT2F3CD Limited Altered Expression [159]
HNRNPA1 TTPJ9XK Limited Biomarker [160]
HPSE TTR7GJO Limited Biomarker [150]
HSPB8 TTY0OJN Limited Altered Expression [161]
HSPE1 TTWYMFE Limited Altered Expression [162]
HTR2A TTJQOD7 Limited Altered Expression [163]
HTT TTIWZ0O Limited Biomarker [164]
IAPP TTHN8EM Limited Biomarker [60]
ID2 TTW8A5N Limited Altered Expression [165]
IFNAR1 TTSYFMA Limited Biomarker [166]
IGFBP5 TTDWEA8 Limited Biomarker [167]
IGFBP6 TTLAYV8 Limited Biomarker [168]
IL15 TTJFA35 Limited Biomarker [169]
IL2 TTF89GD Limited Biomarker [170]
IL24 TT1EPXZ Limited Altered Expression [171]
IL31RA TT9HPX0 Limited Genetic Variation [172]
IRAK1 TTXAJWN Limited Altered Expression [173]
IRS2 TTF95B8 Limited Biomarker [174]
ITGA2 TTSJ542 Limited Biomarker [175]
ITGA4 TTJMF9P Limited Biomarker [176]
ITGAV TTT1R2L Limited Biomarker [177]
KAT2B TTVK7SB Limited Biomarker [178]
KCNH2 TTQ6VDM Limited Biomarker [179]
KITLG TTDJ51N Limited Biomarker [180]
KLRK1 TTLRN4A Limited Biomarker [181]
KNG1 TTDJ4MY Limited Biomarker [182]
KRAS TTM8FR7 Limited Genetic Variation [120]
L1CAM TTC9D3K Limited Altered Expression [183]
LAG3 TTNVXAW Limited Biomarker [184]
LCK TT860QF Limited Biomarker [185]
LDHA TTW76JE Limited Altered Expression [186]
LDLR TTH0DUS Limited Biomarker [187]
LGR5 TTTSGRH Limited Biomarker [188]
LIMK2 TTASMD8 Limited Altered Expression [189]
LRRK2 TTK0FEA Limited Genetic Variation [190]
MAGEA1 TT63M7Q Limited Biomarker [191]
MAGEA3 TTWSKHD Limited Biomarker [191]
MANF TT56RYE Limited Biomarker [192]
MAP2K7 TT6QY3J Limited Biomarker [193]
MAP3K1 TTW8TJI Limited Altered Expression [194]
MAPK10 TT056SO Limited Altered Expression [175]
MAPK14 TTQBR95 Limited Altered Expression [56]
MAPK3 TT1MG9E Limited Altered Expression [195]
MAPK7 TTU6FSC Limited Biomarker [120]
MAPKAPK2 TTMUG9D Limited Altered Expression [196]
MAPT TTS87KH Limited Biomarker [197]
MAZ TT059DA Limited Biomarker [198]
MCAM TTHRE05 Limited Altered Expression [199]
MCHR1 TTX4RTB Limited Altered Expression [200]
MGAT2 TTJOW1I Limited Biomarker [201]
MLH1 TTISG27 Limited Biomarker [202]
MSH2 TTCAWRT Limited Biomarker [202]
MSR1 TT2TDH9 Limited Biomarker [178]
MTDH TTH6SA5 Limited Biomarker [203]
NCAM1 TTVXPHT Limited Biomarker [204]
NGF TTDN3LF Limited Posttranslational Modification [205]
NGFR TTEDJN4 Limited Biomarker [206]
NOX4 TTQRBSJ Limited Biomarker [207]
NPFFR2 TTXYNDJ Limited Biomarker [208]
NPTX2 TTNJ5A6 Limited Biomarker [209]
NPY TT64REZ Limited Biomarker [210]
NPY1R TTRK9JT Limited Altered Expression [211]
NPY2R TTJ6WK9 Limited Biomarker [212]
NPY5R TTY6EWA Limited Biomarker [212]
NQO2 TTJLP0R Limited Altered Expression [213]
NTF3 TTZHKV9 Limited Altered Expression [214]
NTN1 TT0AH4L Limited Biomarker [215]
OGDH TTH8T6I Limited Biomarker [216]
OPRK1 TTQW87Y Limited Biomarker [217]
OPRM1 TTKWM86 Limited Altered Expression [218]
OXTR TTSCIUP Limited Biomarker [219]
P2RX1 TTJW7B3 Limited Altered Expression [220]
P2RX3 TT2THBD Limited Altered Expression [220]
P2RX4 TT1NLOA Limited Altered Expression [220]
P2RY1 TTA93TL Limited Altered Expression [220]
P2RY2 TTOZHQC Limited Altered Expression [220]
PADI4 TTQHAXM Limited Altered Expression [221]
PARP1 TTVDSZ0 Limited Biomarker [222]
PARP2 TTQ4V96 Limited Altered Expression [223]
PARP3 TTD8MEH Limited Biomarker [224]
PAWR TT3I4WV Limited Altered Expression [225]
PDK1 TTCZOF2 Limited Altered Expression [226]
PDXP TT9UYG4 Limited Biomarker [227]
PEBP1 TT1BGU8 Limited Biomarker [228]
PIM1 TTTN5QW Limited Biomarker [229]
PLA2G2A TTO8QRU Limited Biomarker [230]
PLA2G4A TTT1JVS Limited Altered Expression [231]
PLCB1 TTLPGU7 Limited Altered Expression [232]
PNPLA6 TTWAQU2 Limited Altered Expression [233]
PPARD TT2JWF6 Limited Altered Expression [234]
PPM1D TTENJAB Limited Altered Expression [235]
PPT1 TTSQC14 Limited Biomarker [236]
PRDX5 TTLPJWH Limited Biomarker [237]
PRKCZ TTBSN0L Limited Biomarker [238]
PRNP TTY5F9C Limited Altered Expression [239]
PSEN1 TTZ3S8C Limited Genetic Variation [240]
PTGES TTYLQ8V Limited Biomarker [241]
PTH1R TTFPD47 Limited Biomarker [242]
PTK2 TTON5IT Limited Biomarker [243]
PTN TTA9EJK Limited Altered Expression [244]
PTPN11 TT7WUAV Limited Genetic Variation [245]
RAB7A TTF6WAQ Limited Biomarker [246]
RACK1 TTJ10AL Limited Biomarker [247]
RALBP1 TTVSRUA Limited Biomarker [248]
RECK TTRZBW7 Limited Biomarker [249]
RHO TTH0KSX Limited Biomarker [250]
ROCK1 TTZN7RP Limited Biomarker [251]
RORA TT1TYN7 Limited Altered Expression [252]
ROS1 TTSZ6Y3 Limited Biomarker [253]
RPSA TTLUW5B Limited Biomarker [254]
RUNX3 TTKCVO7 Limited Altered Expression [255]
S100A6 TT716MY Limited Biomarker [256]
SCG3 TTY5R9H Limited Biomarker [257]
SELPLG TTS5K8U Limited Biomarker [258]
SENP1 TTW9HY5 Limited Biomarker [259]
SIRPA TTBRJS9 Limited Biomarker [260]
SIRT5 TTH0IOD Limited Biomarker [261]
SLC12A3 TTP362L Limited Genetic Variation [262]
SLC18A2 TTNZRI3 Limited Altered Expression [263]
SLC19A1 TT09I7D Limited Biomarker [264]
SLC1A1 TTG2A6F Limited Altered Expression [265]
SLC6A3 TTVBI8W Limited Biomarker [266]
SLC6A8 TTYUHB5 Limited Altered Expression [267]
SMC2 TTS8D17 Limited Biomarker [268]
SNAP25 TTYQWA0 Limited Biomarker [269]
SOX5 TTXHSZK Limited Biomarker [270]
SPTBN1 TTS9BDA Limited Genetic Variation [271]
SST TTWF7UG Limited Biomarker [272]
ST8SIA4 TTDP8YM Limited Biomarker [273]
STAB1 TTJFEOC Limited Altered Expression [274]
SULF2 TTLQTHB Limited Biomarker [275]
TACR1 TTZPO1L Limited Altered Expression [276]
TARDBP TT9RZ03 Limited Altered Expression [277]
TBXA2R TT2O84V Limited Biomarker [278]
THRA TTTSEPU Limited Biomarker [279]
TMPRSS15 TTXL0GC Limited Biomarker [280]
TMSB4X TTMVAIU Limited Altered Expression [281]
TNFRSF25 TTDV6BQ Limited Biomarker [282]
TNKS TTVUSO7 Limited Biomarker [283]
TPH1 TTZSJHV Limited Altered Expression [284]
TPT1 TT3PTB6 Limited Altered Expression [285]
TRH TT2Z39D Limited Genetic Variation [286]
TRPA1 TTELV3W Limited Biomarker [287]
TXN TTZJ5U9 Limited Biomarker [288]
TXNRD1 TTR7UJ3 Limited Biomarker [289]
UBE3A TTUZX6V Limited Biomarker [290]
UTRN TTNO1VA Limited Biomarker [291]
VHL TTEMWSD Limited Altered Expression [292]
VIP TTGTWLF Limited Biomarker [293]
WDR5 TT7OFWB Limited Altered Expression [294]
XIAP TTK3WBU Limited Altered Expression [295]
ADK TTL732K Disputed Biomarker [195]
CA1 TTHQPL7 Disputed Biomarker [296]
CDKL1 TTBTI6P Disputed Biomarker [297]
CHN2 TT39YVO Disputed Biomarker [298]
GSTO1 TTWO3SH Disputed Biomarker [299]
HOXA7 TTMRE4Q Disputed Biomarker [300]
MGLL TTZ963I Disputed Altered Expression [301]
PHB TT6U071 Disputed Biomarker [302]
PRMT1 TTVOJAI Disputed Biomarker [303]
PTK2B TTTEFBV Disputed Biomarker [304]
SEMA3A TTVKD3S Disputed Biomarker [305]
SLC34A2 TTQPZTM Disputed Biomarker [306]
SREBF1 TTER0UB Disputed Altered Expression [69]
TPP1 TTOVYPT Disputed Biomarker [307]
TRIM59 TT613U4 Disputed Biomarker [62]
USP14 TTVSYP9 Disputed Biomarker [308]
ABCB4 TTJUXV6 moderate Altered Expression [309]
ADH7 TT3LE7P moderate Biomarker [310]
ALOX12 TT12ABZ moderate Biomarker [311]
AMACR TTLN1AP moderate Biomarker [312]
APEH TTYWEDQ moderate Biomarker [313]
BCL2L2 TTQ79W8 moderate Altered Expression [314]
BIRC2 TTQ5LRD moderate Altered Expression [315]
BMP6 TT07RIB moderate Biomarker [316]
C5 TTKANGO moderate Altered Expression [317]
C5AR1 TTHXFA1 moderate Altered Expression [317]
CDC25B TTR0SWN moderate Biomarker [318]
CDH2 TT1WS0T moderate Altered Expression [319]
CDH5 TTXLCFO moderate Altered Expression [320]
CDK5R1 TTBYM6V moderate Biomarker [321]
CHM TTOA18V moderate Genetic Variation [322]
CMA1 TT8VUE0 moderate Biomarker [323]
CXCR5 TTIW59R moderate Biomarker [324]
DFFB TT2SRE0 moderate Genetic Variation [325]
DNM2 TTVRA5G moderate Biomarker [326]
ENPP2 TTSCIM2 moderate Biomarker [327]
EPCAM TTZ8WH4 moderate Biomarker [328]
EYA2 TTUY9C6 moderate Biomarker [329]
FKBP4 TTHY0FT moderate Biomarker [330]
FST TTDNM9W moderate Biomarker [331]
GCH1 TTLSWP6 moderate Altered Expression [332]
HCAR3 TT8WFXV moderate Altered Expression [333]
HEXIM1 TTFOKAH moderate Biomarker [334]
IFNAR2 TTMQB37 moderate Biomarker [335]
IL12A TTRTK6Y moderate Biomarker [321]
IMP3 TTEJA2R moderate Altered Expression [336]
KCNQ4 TT8HGRW moderate Biomarker [337]
KIR2DS2 TTV3CFI moderate Biomarker [338]
LIFR TTID542 moderate Altered Expression [339]
LPAR1 TTQ6S1K moderate Biomarker [340]
MAG TT9XFON moderate Biomarker [341]
MCHR2 TTS17MG moderate Altered Expression [342]
MET TTNDSF4 moderate Altered Expression [343]
MFGE8 TT1GLAJ moderate Biomarker [344]
MTAP TTDBX7N moderate Biomarker [345]
NACC1 TT4AQ5F moderate Altered Expression [346]
NES TTHZ752 moderate Altered Expression [347]
NTF4 TTIM2WO moderate Biomarker [348]
P2RY4 TT24DGP moderate Biomarker [349]
P2RY6 TTNVSKA moderate Altered Expression [350]
PAK4 TT7Y3BZ moderate Biomarker [351]
PCSK6 TT75LN9 moderate Altered Expression [352]
PGRMC1 TTY3LAZ moderate Biomarker [353]
PHGDH TT8DRCK moderate Biomarker [354]
PNMT TT0NZIC moderate Altered Expression [355]
PNP TTMCF1Y moderate Genetic Variation [356]
PPP2CA TTHTKNY moderate Genetic Variation [357]
PPP5C TTTW7FJ moderate Altered Expression [353]
PRKCE TT57MT2 moderate Biomarker [358]
PTGDR TTNVEIR moderate Biomarker [359]
PTGER2 TT1ZAVI moderate Posttranslational Modification [359]
PTP4A3 TT7YM8D moderate Altered Expression [360]
QPCT TTJ7YTV moderate Genetic Variation [361]
RAF1 TTAN5W2 moderate Biomarker [131]
REL TT1ZCTH moderate Biomarker [362]
RGS16 TTFRES8 moderate Biomarker [363]
RGS2 TTKB7T3 moderate Altered Expression [364]
RPS6KA3 TTUM2ZR moderate Altered Expression [365]
RTN4R TTVRZUO moderate Altered Expression [366]
RUNX1 TTWIN3H moderate Biomarker [367]
RXRB TTKLV96 moderate Biomarker [368]
SAA1 TTY0DN9 moderate Altered Expression [369]
SCN1A TTANOZH moderate Altered Expression [346]
SDHD TTVH9W8 moderate Biomarker [370]
SERPING1 TTVQ6R9 moderate Biomarker [371]
SGCB TTEDCQ0 moderate Biomarker [372]
SLC23A2 TTOP832 moderate Altered Expression [373]
SLC25A1 TTTD730 moderate Altered Expression [374]
SREBF2 TTRQ4AP moderate Biomarker [375]
STC2 TT4EFTR moderate Biomarker [376]
TAF2 TTHMP8B moderate Biomarker [377]
TERF2 TT5XSLT moderate Biomarker [378]
THPO TTCG5PE moderate Biomarker [379]
TOP1 TTGTQHC moderate Genetic Variation [380]
TOP2A TTCGY2K moderate Biomarker [381]
TRIM24 TT9Q7AE moderate Altered Expression [382]
TRPM8 TTXDKTO moderate Altered Expression [383]
UCP3 TT12RJK moderate Altered Expression [384]
VIPR1 TTCL30I moderate Biomarker [385]
VIPR2 TT4O5P0 moderate Altered Expression [386]
WNT7A TT8NARC moderate Altered Expression [387]
XPA TTGT87E moderate Biomarker [388]
ACAT1 TTK3C21 Strong Biomarker [389]
ACHE TT1RS9F Strong Biomarker [390]
ACTG1 TTGAZF9 Strong Altered Expression [391]
ADAM10 TTVXEGU Strong Altered Expression [392]
ADRB3 TTMXGCW Strong Altered Expression [393]
AGRP TT4DE1O Strong Biomarker [394]
AHCY TTE2KUJ Strong Genetic Variation [395]
AKT3 TTO6SGY Strong Altered Expression [396]
ANXA2 TT4YANI Strong Biomarker [397]
ARG1 TT7ZQEV Strong Biomarker [398]
ARG2 TTV1AG6 Strong Altered Expression [56]
ARRB2 TT8SO2I Strong Altered Expression [399]
ASIC2 TTVMWLP Strong Biomarker [400]
ASIC3 TTLGDIS Strong Genetic Variation [401]
ASPA TT6TLZP Strong Biomarker [402]
ASPH TT2KHP7 Strong Altered Expression [403]
ATF4 TTQCKWT Strong Biomarker [404]
ATR TT8ZYBQ Strong Biomarker [405]
ATXN3 TT6A17J Strong Genetic Variation [406]
AURKB TT9RTBL Strong Biomarker [407]
B2M TTY7FKA Strong Biomarker [408]
BACH1 TT2ME4S Strong Biomarker [409]
BBC3 TT7JUKC Strong Biomarker [410]
BIRC5 TTTPU1G Strong Biomarker [411]
BMI1 TTIPNSR Strong Biomarker [412]
CALCR TTLWS2O Strong Altered Expression [413]
CALR TTUZ7OA Strong Biomarker [267]
CASP1 TTCQIBE Strong Biomarker [414]
CASP2 TT12VNG Strong Altered Expression [415]
CASP4 TT6KIOT Strong Biomarker [416]
CCK TT90CMU Strong Altered Expression [417]
CD19 TTW640A Strong Biomarker [418]
CD24 TTCTYNP Strong Altered Expression [419]
CD47 TT28S46 Strong Biomarker [420]
CD55 TT5Z9WY Strong Biomarker [421]
CD59 TTBGTEJ Strong Biomarker [422]
CDK1 TTH6V3D Strong Biomarker [423]
CDK2 TT7HF4W Strong Biomarker [423]
CDK5 TTL4Q97 Strong Biomarker [424]
CDK6 TTO0FDJ Strong Altered Expression [425]
CDK9 TT1LVF2 Strong Biomarker [426]
CGA TTFC29G Strong Genetic Variation [427]
CHAT TTKYFSB Strong Biomarker [428]
CHEK1 TTTU902 Strong Biomarker [429]
CHKA TT10AWB Strong Altered Expression [430]
CHRNA4 TT4H1MQ Strong Altered Expression [431]
CLU TTRL76H Strong Genetic Variation [432]
CREB1 TTH4AN3 Strong Altered Expression [433]
CSK TTX6F0Q Strong Biomarker [434]
CTAG1A TTE5ITK Strong Biomarker [435]
CTH TTLQUZS Strong Altered Expression [436]
CXCL12 TT4UGTF Strong Biomarker [437]
CXCL13 TT0NIZ1 Strong Altered Expression [438]
DBH TTYIP79 Strong Biomarker [439]
DCLK1 TTOHTCY Strong Biomarker [440]
DCLK3 TTMYK4Z Strong Biomarker [441]
DDC TTN451K Strong Altered Expression [442]
DHCR24 TTTK0NH Strong Biomarker [443]
DHPS TTBO2A9 Strong Biomarker [444]
DIABLO TTN74LE Strong Biomarker [445]
DPYSL2 TTZCW3T Strong Biomarker [446]
E2F2 TT5FYX0 Strong Biomarker [113]
EBP TT4VQZX Strong Altered Expression [447]
EDNRB TT3ZTGU Strong Biomarker [448]
EGF TTED8JB Strong Biomarker [449]
EIF5A TTIVCNR Strong Biomarker [444]
EPHA3 TTHS2LR Strong Altered Expression [450]
EPHB6 TTZEMUY Strong Biomarker [121]
EPOR TTAUX24 Strong Biomarker [451]
ERN1 TTKIAT3 Strong Biomarker [452]
ESR1 TTZAYWL Strong Biomarker [453]
F10 TTCIHJA Strong Altered Expression [454]
FASLG TTO7014 Strong Genetic Variation [455]
FGF2 TTGKIED Strong Biomarker [456]
FGF8 TTIUF3J Strong Altered Expression [457]
FOS TTOM5AU Strong Biomarker [279]
FTH1 TT975ZT Strong Biomarker [458]
GAL TTXZAJ5 Strong Altered Expression [459]
GALR2 TTBPW3J Strong Biomarker [460]
GAPDH TTUGSWA Strong Biomarker [461]
GATA3 TT45KOB Strong Biomarker [462]
GPC3 TTJTSX4 Strong Altered Expression [463]
GRB2 TTEYRJ9 Strong Biomarker [464]
GREM1 TTOUZN5 Strong Biomarker [465]
GRIA2 TTWM461 Strong Altered Expression [466]
GRK2 TTAZ3MN Strong Altered Expression [228]
GRM2 TTXJ47W Strong Altered Expression [466]
GRM3 TT8A9EF Strong Altered Expression [467]
GRM8 TT0IFKL Strong Biomarker [468]
GUCY2D TTWNFC2 Strong Genetic Variation [469]
HDAC5 TTUELN5 Strong Biomarker [470]
HDAC8 TTT6LFV Strong Altered Expression [471]
HDAC9 TT8M4E1 Strong Biomarker [472]
HGF TT4V2JM Strong Altered Expression [343]
HHAT TT1VNCG Strong Biomarker [473]
HIPK2 TTOB49C Strong Biomarker [474]
HK2 TTK02H8 Strong Biomarker [475]
HMGA1 TTBA219 Strong Biomarker [396]
HSPA9 TTMTPG3 Strong Biomarker [476]
HSPB1 TT9AZWY Strong Biomarker [477]
HSPB3 TTLH8WG Strong Biomarker [477]
HTR1A TTSQIFT Strong Biomarker [478]
HTR1B TTK8CXU Strong Altered Expression [479]
HTR4 TT07C3Y Strong Biomarker [479]
HTR7 TTO9X1H Strong Biomarker [480]
ICA1 TTMX06B Strong Biomarker [481]
IFNB1 TT4TZ8J Strong Biomarker [482]
IGFBP2 TTU4QSN Strong Biomarker [483]
IL2RB TT9721Y Strong Altered Expression [194]
IL7R TTAWI51 Strong Altered Expression [484]
ITGA5 TTHIZP9 Strong Altered Expression [485]
JUN TTS7IR5 Strong Biomarker [279]
KCNJ3 TTGM19J Strong Biomarker [486]
KCNJ5 TTEO25X Strong Biomarker [486]
KDM1A TTNR0UQ Strong Biomarker [487]
KDM3A TTKXS4A Strong Biomarker [488]
KDM5B TTCLI75 Strong Biomarker [489]
KDM6B TTDIJUQ Strong Biomarker [490]
KIR2DL2 TTU0P73 Strong Altered Expression [491]
KLF4 TTTI53X Strong Biomarker [492]
KRT6A TT2FX8W Strong Biomarker [493]
LGALS1 TTO3NYT Strong Biomarker [494]
LGALS3 TTFPQV7 Strong Biomarker [495]
LGMN TTPTWV5 Strong Altered Expression [496]
LIF TTGZ5WN Strong Biomarker [497]
LILRB1 TTC0QRJ Strong Biomarker [498]
LIN28A TTO50LN Strong Genetic Variation [499]
LNPEP TTY2KP7 Strong Biomarker [500]
LYN TT1RWNJ Strong Altered Expression [501]
MAOA TT3WG5C Strong Biomarker [502]
MAOB TTGP7BY Strong Altered Expression [503]
MAP3K5 TTOQCD8 Strong Biomarker [504]
MAPK8 TT0K6EO Strong Biomarker [505]
MAPKAP1 TTWDKCL Strong Biomarker [506]
MARCKS TTHRM39 Strong Posttranslational Modification [507]
MAT2A TTSMPXQ Strong Biomarker [508]
MDK TTV8UE7 Strong Altered Expression [509]
MDM4 TT9OUDQ Strong Biomarker [88]
MECP2 TTTAU9R Strong Altered Expression [510]
MELK TTBZOTY Strong Altered Expression [511]
MIA TT5HNVS Strong Genetic Variation [512]
MLANA TT362RB Strong Biomarker [513]
MMP14 TTJ4QE7 Strong Altered Expression [514]
MSI1 TTSM4BA Strong Altered Expression [515]
MYB TT8V13P Strong Altered Expression [516]
NAGLU TTDM6HZ Strong Biomarker [517]
NCL TTK1V5Q Strong Biomarker [518]
NDUFAF2 TTCHGVF Strong Biomarker [519]
NEDD9 TT1UREA Strong Biomarker [520]
NELL1 TT7H4BF Strong Altered Expression [521]
NLRP1 TTQX29T Strong Biomarker [522]
NME1 TTDY8JH Strong Biomarker [523]
NPM1 TTHBS98 Strong Biomarker [524]
NR0B1 TTTK36V Strong Genetic Variation [525]
NR1I3 TTRANFM Strong Genetic Variation [82]
NR4A2 TT9HKN3 Strong Biomarker [526]
NRAS TTW2R9X Strong Genetic Variation [527]
NRP1 TTIPJCB Strong Altered Expression [528]
NRP2 TTRXUVC Strong Altered Expression [529]
NT5E TTK0O6Y Strong Altered Expression [233]
NTRK1 TTTDVOJ Strong Biomarker [530]
NTRK2 TTKN7QR Strong Biomarker [531]
NTRK3 TTXABCW Strong Genetic Variation [532]
ODC1 TTUMGNO Strong Biomarker [533]
OPRL1 TTNT7K8 Strong Altered Expression [534]
P2RX7 TT473XN Strong Altered Expression [182]
PABPC1 TTHC8EF Strong Biomarker [535]
PAH TTGSVH2 Strong Biomarker [536]
PCNA TTLG1PD Strong Altered Expression [515]
PDGFA TTSM78N Strong Altered Expression [537]
PFKFB3 TTTHMQJ Strong Biomarker [538]
PKMYT1 TTB4PAZ Strong Biomarker [395]
PLA2G1B TT9V5JH Strong Altered Expression [230]
PLK1 TTH4IP0 Strong Biomarker [539]
PLK4 TTGPNZQ Strong Biomarker [540]
PML TTLH9NY Strong Biomarker [541]
PREP TTNGKET Strong Biomarker [528]
PRKCA TTFJ8Q1 Strong Biomarker [481]
PRKCB TTYPXQF Strong Biomarker [481]
PRKCI TTWJTHX Strong Biomarker [481]
PRKDC TTK3PY9 Strong Biomarker [542]
PROM1 TTXMZ81 Strong Biomarker [543]
PSEN2 TTWN3F4 Strong Altered Expression [544]
PSIP1 TTH9LDP Strong Altered Expression [194]
PTBP1 TTWMX0U Strong Altered Expression [545]
PTPN1 TTELIN2 Strong Biomarker [546]
PTPN14 TTNIR6C Strong Altered Expression [547]
PTPRC TTUS45N Strong Altered Expression [548]
RARA TTW38KT Strong Biomarker [549]
RARB TTISP28 Strong Altered Expression [550]
RARG TT1Q3IE Strong Altered Expression [551]
RBPJ TT72D4Z Strong Biomarker [552]
RENBP TTZCG0Q Strong Biomarker [553]
RET TT4DXQT Strong Genetic Variation [554]
RGS6 TTJ96M8 Strong Altered Expression [555]
RHD TTLCKI8 Strong Biomarker [556]
RNPEP TTD74YX Strong Biomarker [500]
ROCK2 TTGWKQJ Strong Altered Expression [557]
ROR1 TTDEJAU Strong Biomarker [558]
ROR2 TTUDPCI Strong Altered Expression [558]
RORB TTGB2LZ Strong Altered Expression [559]
RXRA TT6PEUO Strong Biomarker [560]
S100A12 TTQ4ESF Strong Biomarker [561]
S100B TTQ0V86 Strong Biomarker [562]
S1PR1 TT9JZCK Strong Biomarker [563]
S1PR2 TTVSMOH Strong Altered Expression [393]
SCN10A TT90XZ8 Strong Biomarker [564]
SERPINH1 TTPSWQG Strong Posttranslational Modification [565]
SIRT6 TTUXYWF Strong Biomarker [566]
SKP2 TT5B2EO Strong Altered Expression [567]
SLC11A2 TT2IS7P Strong Biomarker [568]
SLC1A5 TTF7WRM Strong Biomarker [569]
SLC3A2 TT5CZSM Strong Biomarker [533]
SLC6A2 TTAWNKZ Strong Biomarker [570]
SMN1 TT8QL6X Strong Biomarker [571]
SORD TTLSRBZ Strong Biomarker [572]
SP1 TTZEP6S Strong Altered Expression [413]
SPARC TTBQFM7 Strong Biomarker [274]
SPHK1 TTOHFIY Strong Altered Expression [573]
SPHK2 TTCN0M9 Strong Altered Expression [393]
SRC TT6PKBN Strong Biomarker [434]
STMN1 TT7W5OT Strong Altered Expression [547]
TCF3 TTULOD8 Strong Altered Expression [194]
TERT TTQY2EJ Strong Biomarker [574]
TFRC TT8MG4S Strong Biomarker [575]
TGFBR1 TTP4520 Strong Altered Expression [576]
TIAM1 TTNU6I5 Strong Biomarker [577]
TLR3 TTD24Y0 Strong Biomarker [578]
TMEM97 TT9NXW4 Strong Altered Expression [579]
TNFRSF1B TT63WSF Strong Altered Expression [194]
TNFSF10 TTA5MS9 Strong Biomarker [580]
TPCN1 TTODQE2 Strong Biomarker [581]
TPX2 TT0PHL4 Strong Biomarker [582]
TRPC1 TTA76X0 Strong Altered Expression [583]
TRPC3 TTNVC34 Strong Altered Expression [584]
TRPM2 TTEBMN7 Strong Biomarker [585]
TRPM7 TTFPVZO Strong Altered Expression [586]
TTR TTPOYU7 Strong Altered Expression [587]
TYRP1 TTFRV98 Strong Biomarker [588]
UCHL1 TTX9IFP Strong Altered Expression [589]
ULK1 TT4D7MJ Strong Biomarker [590]
USP7 TTXU3EQ Strong Altered Expression [591]
UTS2 TTERU0T Strong Altered Expression [592]
WAS TTE8T73 Strong Biomarker [593]
WEE1 TTJFOAL Strong Posttranslational Modification [594]
YAP1 TT8UN2D Strong Altered Expression [595]
BIRC7 TTHZ8TA Definitive Biomarker [596]
CASP10 TTX5HEK Definitive Biomarker [597]
CDA TTQ12RK Definitive Altered Expression [598]
CDK11B TT5Q79O Definitive Genetic Variation [599]
CEBPA TT5LWG1 Definitive Altered Expression [600]
CERK TT9XRNV Definitive Biomarker [601]
CNTF TTGEM5Q Definitive Biomarker [602]
CUL7 TTI8R0P Definitive Altered Expression [603]
CX3CL1 TT1OFBQ Definitive Biomarker [604]
CYP26A1 TTD7Q0R Definitive Altered Expression [605]
DCK TTJOCE4 Definitive Altered Expression [374]
DKK3 TTY2ZV6 Definitive Biomarker [606]
DNASE1 TTYWGOJ Definitive Biomarker [607]
E2F3 TTWIJYH Definitive Altered Expression [608]
ECE1 TTQ9RYT Definitive Biomarker [116]
EIF2AK2 TTXEZJ4 Definitive Genetic Variation [609]
F2RL3 TTD0652 Definitive Altered Expression [225]
FLT4 TTDCBX5 Definitive Biomarker [610]
FYN TT2B9KF Definitive Altered Expression [112]
HDAC3 TT4YWTO Definitive Biomarker [611]
HTR2C TTWJBZ5 Definitive Biomarker [612]
ISG15 TTVOH3T Definitive Biomarker [613]
ITPR1 TT5HWAT Definitive Altered Expression [614]
ITPR2 TTK9OV3 Definitive Altered Expression [614]
ITPR3 TTH1769 Definitive Altered Expression [614]
KCNJ2 TTH7UO3 Definitive Altered Expression [615]
KRT19 TT3JF9E Definitive Altered Expression [616]
LRP1 TTF2V7I Definitive Biomarker [254]
MAD1L1 TTNE9U7 Definitive Biomarker [617]
MAPK9 TT3IVG2 Definitive Biomarker [618]
MCM7 TT1RM3F Definitive Altered Expression [619]
METAP2 TTZL0OI Definitive Biomarker [620]
NOTCH3 TTVX7IA Definitive Altered Expression [621]
NSD1 TTTSJ3H Definitive Posttranslational Modification [622]
PAM TTF4ZPC Definitive Biomarker [623]
PCSK1 TTED9LZ Definitive Biomarker [624]
PIN1 TTJNTSI Definitive Altered Expression [625]
RGS4 TTGTKX9 Definitive Altered Expression [626]
SLC16A1 TTN1J82 Definitive Biomarker [627]
SYVN1 TT8XKYM Definitive Biomarker [628]
TOP2B TT4NVEM Definitive Altered Expression [629]
VDAC1 TTAMKGB Definitive Altered Expression [630]
VEGFD TTOM5H4 Definitive Altered Expression [631]
------------------------------------------------------------------------------------
⏷ Show the Full List of 657 DTT(s)
This Disease Is Related to 21 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA2 DTJ4NEG Limited Altered Expression [187]
SLC16A7 DTLT3UG Limited Altered Expression [632]
SLC24A3 DTO18LP Limited Genetic Variation [633]
SLC25A27 DT0HW5C Limited Biomarker [634]
SLC2A3 DT9SQ3L Limited Posttranslational Modification [635]
SLC30A10 DTYBI73 Limited Altered Expression [636]
SLC30A3 DTKMECW Limited Altered Expression [637]
SLC39A8 DTLPQGT Limited Biomarker [638]
SLC44A1 DT3I2SU Limited Biomarker [639]
SLC9A6 DTN0JXW Limited Altered Expression [640]
SLCO6A1 DTIFXNS Limited Altered Expression [641]
SLC11A1 DT650XW Disputed Altered Expression [106]
SLC8A3 DTYFRQT Disputed Altered Expression [642]
ATP7A DT0LT17 moderate Altered Expression [643]
SLC18A1 DTM953D moderate Altered Expression [644]
SLC2A5 DTOR02F moderate Biomarker [645]
SLC45A1 DTMSNOU moderate Altered Expression [646]
SLC16A5 DT3I124 Strong Posttranslational Modification [647]
SLC25A21 DT2UQYR Strong Biomarker [648]
SLC31A1 DTP8L4F Strong Biomarker [413]
SLC52A1 DT7NOKR Definitive Altered Expression [649]
------------------------------------------------------------------------------------
⏷ Show the Full List of 21 DTP(s)
This Disease Is Related to 37 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CES2 DETHCPD Limited Altered Expression [650]
DIO3 DET89OV Limited Altered Expression [651]
EGLN3 DEMQTKH Limited Altered Expression [226]
GLDC DEIN8FB Limited Biomarker [652]
GLS DE3E0VT Limited Altered Expression [653]
GSTZ1 DEQPEMB Limited Biomarker [654]
HSD17B12 DE915QP Limited Genetic Variation [655]
LDHC DEQG7F9 Limited Altered Expression [186]
MGST1 DEAPJSO Limited Altered Expression [656]
NMNAT2 DE2HB58 Limited Biomarker [657]
NNMT DECVGJ3 Limited Altered Expression [658]
NT5C2 DE1DOKJ Limited Biomarker [659]
PARK7 DEPOVCH Limited Biomarker [660]
PER1 DE9HF0I Limited Altered Expression [661]
SMOX DEOH5V3 Limited Biomarker [662]
CYP26B1 DEZT8FM moderate Altered Expression [605]
DHRS3 DEXPVUN moderate Biomarker [310]
LAP3 DENZF0O moderate Altered Expression [663]
NAT1 DE7OAB3 moderate Biomarker [664]
SULT1C2 DEYMAD4 moderate Altered Expression [665]
XPNPEP1 DE8E6X9 moderate Biomarker [666]
ALDH1A2 DEKN1H4 Strong Altered Expression [667]
APRT DE2MV1R Strong Biomarker [668]
BCO1 DE6BOK3 Strong Biomarker [669]
CMPK1 DEMPH4I Strong Genetic Variation [670]
CRMP1 DE0EUXB Strong Altered Expression [671]
DTYMK DEOTVYU Strong Altered Expression [672]
HPRT1 DEVXTP5 Strong Biomarker [673]
MAT2B DEKF1OH Strong Biomarker [508]
MSRA DEU2ZBY Strong Altered Expression [674]
SPR DEJVDAT Strong Altered Expression [675]
UCK1 DE478BP Strong Altered Expression [676]
UCK2 DETN1O0 Strong Biomarker [676]
WARS1 DEPVE0M Strong Altered Expression [677]
WARS2 DEPTKBQ Strong Altered Expression [677]
GCLC DESYL1F Definitive Biomarker [678]
MAT1A DEQ6NC9 Definitive Altered Expression [679]
------------------------------------------------------------------------------------
⏷ Show the Full List of 37 DME(s)
This Disease Is Related to 996 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AAAS OTJT9T23 Limited Biomarker [680]
AACS OTGGPR6J Limited Altered Expression [681]
ACADM OTA4P0FC Limited Biomarker [682]
ACTB OT1MCP2F Limited Biomarker [562]
AGO1 OTD3R434 Limited Altered Expression [683]
AHSA1 OTC7AFHT Limited Altered Expression [56]
AIPL1 OT4VBD78 Limited Biomarker [684]
ALDH1A3 OT1C9NKQ Limited Altered Expression [667]
ALKAL2 OTTLHL64 Limited Biomarker [685]
ALPP OTZU4G9W Limited Biomarker [60]
APAF1 OTJWIVY0 Limited Biomarker [686]
APBB1 OTZPVSSC Limited Altered Expression [687]
APBB2 OT1VD51B Limited Biomarker [688]
APLP1 OTD176ZS Limited Altered Expression [689]
APOC1 OTA58CED Limited Biomarker [690]
ARMC12 OTBT9GZ8 Limited Biomarker [691]
ARSF OTC0L12N Limited Biomarker [692]
ASAH2 OT47TIF3 Limited Biomarker [693]
ASH1L OTUT5NLJ Limited Biomarker [257]
ATE1 OT3QNM39 Limited Biomarker [694]
ATL1 OTR2788Y Limited Biomarker [695]
ATP13A2 OTKWBUGK Limited Genetic Variation [696]
ATP2B4 OTMWFDAC Limited Genetic Variation [697]
AXIN2 OTRMGQNU Limited Altered Expression [698]
B3GNT3 OTVT1Q25 Limited Biomarker [699]
B4GALNT1 OTCY80HS Limited Biomarker [700]
B4GALT3 OTHX77K8 Limited Altered Expression [701]
BAG2 OTI6LD27 Limited Biomarker [702]
BCS1L OT5PY5CY Limited Biomarker [257]
BEX3 OTW1V1L5 Limited Biomarker [703]
BEX4 OT3LXD15 Limited Biomarker [703]
BIRC6 OTCQJAB0 Limited Biomarker [445]
BLM OTEJOAJX Limited Genetic Variation [395]
BNIP3 OT4SO7J4 Limited Biomarker [704]
BRK1 OTTUB5KS Limited Biomarker [705]
BTRC OT2EZDGR Limited Biomarker [180]
C1D OTI9PMN1 Limited Altered Expression [88]
C1orf52 OT8RQW3W Limited Biomarker [706]
CA11 OT8RX3AJ Limited Altered Expression [707]
CA8 OT9Y8GA8 Limited Altered Expression [406]
CACYBP OTJMZD2T Limited Altered Expression [708]
CALB1 OTM7IXDG Limited Biomarker [709]
CALM2 OTNYA92F Limited Biomarker [710]
CAMKMT OTLJBRUW Limited Biomarker [710]
CAST OTBXZZGF Limited Genetic Variation [711]
CAVIN3 OTOLBK79 Limited Biomarker [712]
CBLIF OTNE20WU Limited Altered Expression [484]
CC2D1A OTVPU04K Limited Biomarker [713]
CCM2 OT2I5DOW Limited Altered Expression [714]
CD177 OTS79FNF Limited Altered Expression [158]
CD226 OT4UG0KB Limited Altered Expression [715]
CD2AP OTC76KQM Limited Altered Expression [716]
CD8A OTDWQJXK Limited Genetic Variation [77]
CDKL5 OTGL5HRV Limited Altered Expression [717]
CDKN2D OT2TTZPZ Limited Altered Expression [718]
CFC1 OT5DHGI8 Limited Biomarker [719]
CHAC1 OTJGE772 Limited Altered Expression [720]
CHD9 OTWNFDKJ Limited Altered Expression [698]
CHERP OTJL4OB3 Limited Biomarker [721]
CHGA OTXYX5JH Limited Biomarker [722]
CHGB OT7SAQT2 Limited Biomarker [723]
CHN1 OTM196M3 Limited Biomarker [724]
CHP1 OTHTXN1A Limited Biomarker [725]
CHRNA3 OTCZQY1U Limited Altered Expression [726]
CISD1 OT0MTVGF Limited Biomarker [727]
CISD2 OTVS7S2H Limited Biomarker [728]
CLEC4D OTT7X1UC Limited Biomarker [729]
CLMN OT7U5J3T Limited Altered Expression [730]
CLPB OT1I0IBK Limited Altered Expression [731]
CNMD OTHND8EL Limited Biomarker [732]
CNOT1 OTTEU05F Limited Biomarker [733]
COL11A2 OT3BQUBH Limited Altered Expression [223]
COL5A2 OT5VOSQE Limited Biomarker [168]
COMMD1 OT7WUD5R Limited Biomarker [734]
COPS4 OTNK2KS1 Limited Biomarker [735]
COX2 OTTMVBJJ Limited Altered Expression [389]
CPD OT2CS64Y Limited Biomarker [736]
CPZ OT5HUR28 Limited Genetic Variation [737]
CSH1 OT33HTRR Limited Biomarker [476]
CSH2 OTW8JVAN Limited Biomarker [476]
CTBP2 OTGZGT87 Limited Biomarker [738]
CTTNBP2 OT4CL1EW Limited Altered Expression [739]
CUL1 OTXPE1UZ Limited Biomarker [180]
CUX1 OTU1LCNJ Limited Biomarker [198]
CYLD OT37FKH0 Limited Altered Expression [740]
DAPK2 OTWODUQG Limited Biomarker [291]
DAXX OTX6O7PL Limited Biomarker [741]
DCDC2 OTSUFH1H Limited Biomarker [742]
DDT OTF5HTYL Limited Biomarker [743]
DDX4 OTQOV093 Limited Genetic Variation [172]
DEAF1 OTCLX3ZW Limited Biomarker [713]
DENR OTXP9HOY Limited Biomarker [291]
DEPDC5 OTE70JLY Limited Biomarker [744]
DHX9 OT5AAOQI Limited Biomarker [745]
DNAAF4 OTVDYBJE Limited Altered Expression [746]
DNAH8 OTGES2OU Limited Altered Expression [747]
DNLZ OT48CG1W Limited Biomarker [748]
DNM1L OTXK1Q1G Limited Biomarker [291]
DPP6 OTWW3H0K Limited Biomarker [749]
DSC3 OTYG47F8 Limited Altered Expression [750]
DUSP23 OTE2PG54 Limited Biomarker [712]
DUSP26 OTI7WIYN Limited Biomarker [751]
DVL3 OTPRROHJ Limited Biomarker [752]
DYM OTQ670WI Limited Genetic Variation [753]
E2F4 OTB3JFH4 Limited Biomarker [168]
EEF1E1 OTRA6XOB Limited Biomarker [67]
EEF2 OTZ7SZ39 Limited Altered Expression [754]
EFNB2 OT0DCUOM Limited Altered Expression [755]
EFNB3 OT12WTXQ Limited Biomarker [121]
EGR2 OTAVQ78J Limited Altered Expression [756]
ELOC OT0XHHWP Limited Genetic Variation [757]
ELP1 OTYEWBF7 Limited Altered Expression [758]
ENDOG OT5IM7B3 Limited Biomarker [759]
ERCC4 OTFIOPG1 Limited Genetic Variation [760]
ERCC6 OT2QZKSF Limited Biomarker [476]
ERCC8 OT0T4WKI Limited Biomarker [476]
ERP44 OT7ZI7AG Limited Altered Expression [761]
ETV5 OTE2OBM4 Limited Altered Expression [762]
FABP7 OTRE2H4G Limited Biomarker [763]
FAIM2 OT6QINVO Limited Biomarker [764]
FBXO5 OTTR957W Limited Biomarker [765]
FGF13 OTHNNVSG Limited Altered Expression [766]
FGF6 OTRJ679P Limited Biomarker [767]
FH OTEQWU6Q Limited Biomarker [729]
FIG4 OT501PY9 Limited Biomarker [768]
FLOT1 OT0JPPJZ Limited Altered Expression [769]
FNDC5 OT5CSK9X Limited Altered Expression [770]
FOSB OTW6C05J Limited Biomarker [279]
FOXP2 OTVX6A59 Limited Altered Expression [771]
FTMT OTIUX6XG Limited Altered Expression [772]
FZD6 OTBCPII8 Limited Biomarker [773]
GAB2 OTBFN705 Limited Altered Expression [774]
GABRB3 OT80C3D4 Limited Altered Expression [726]
GALNT14 OT9BSDDQ Limited Biomarker [775]
GAREM2 OTQNQAC7 Limited Altered Expression [776]
GCA OTAJ7ZHG Limited Biomarker [777]
GCNT1 OTF6OC66 Limited Altered Expression [778]
GDPD5 OTUM65JL Limited Altered Expression [779]
GLS2 OT08MSHL Limited Altered Expression [780]
GLUD2 OTF3GGYY Limited Biomarker [781]
GMCL1 OTRZHUFV Limited Biomarker [777]
GNB2 OT3JPRCQ Limited Biomarker [782]
GOLPH3 OTDLGYM3 Limited Biomarker [582]
GPC2 OT3WSQE1 Limited Altered Expression [783]
GPM6A OT8G13EG Limited Biomarker [784]
GPR78 OT8TKE6F Limited Genetic Variation [785]
GRAP2 OTS5NIZ3 Limited Altered Expression [56]
GRB10 OTCKXGRC Limited Altered Expression [786]
GRHL1 OTZ4MNEW Limited Altered Expression [787]
GRP OT8JDFNI Limited Biomarker [788]
GSTK1 OTDNGWAF Limited Altered Expression [641]
GTSE1 OTPP742Z Limited Altered Expression [688]
GYPE OTBHAG6A Limited Biomarker [789]
H1-2 OT0AVI4M Limited Altered Expression [790]
H4C1 OTB71W46 Limited Altered Expression [135]
HAS3 OTPM8IL8 Limited Biomarker [791]
HCFC1 OT0UCK62 Limited Altered Expression [792]
HCN3 OTMO1ZYQ Limited Altered Expression [793]
HDX OTXD5MU6 Limited Altered Expression [794]
HENMT1 OTM5I26B Limited Biomarker [795]
HES2 OTMWY2KV Limited Posttranslational Modification [796]
HGS OTCYYCAC Limited Biomarker [797]
HHIP OT77RQYS Limited Posttranslational Modification [798]
HLA-E OTX1CTFB Limited Biomarker [799]
HNRNPR OT3FITK2 Limited Biomarker [800]
HOXD1 OTN4V9ZF Limited Altered Expression [801]
HOXD13 OTWSC8TF Limited Altered Expression [651]
HOXD9 OTZ4GVR1 Limited Altered Expression [801]
HSPA2 OTSDET7B Limited Altered Expression [802]
HSPA4 OT5HR0AR Limited Altered Expression [803]
HTRA2 OTC7616F Limited Biomarker [804]
IARS1 OT9WXH5N Limited Biomarker [805]
ICAM2 OT3E070F Limited Genetic Variation [806]
IGF2BP1 OT9G360P Limited Biomarker [807]
IMMT OTBDSLE7 Limited Altered Expression [808]
ING1 OTEZBRKW Limited Altered Expression [809]
ING2 OT6H0EWF Limited Genetic Variation [77]
ING5 OTRNNSFM Limited Biomarker [810]
INSM1 OTG8RV8E Limited Altered Expression [195]
ITGA3 OTBCH21D Limited Biomarker [175]
ITLN1 OT7ZLJVV Limited Altered Expression [811]
ITM2B OTMXEPXB Limited Biomarker [812]
ITSN1 OT8YF3S5 Limited Biomarker [813]
JMJD6 OTILR7E4 Limited Biomarker [90]
JUNB OTG2JXV5 Limited Biomarker [279]
JUND OTNKACJD Limited Biomarker [279]
KANK2 OT3SZIWM Limited Altered Expression [708]
KCNIP3 OTCQPEM4 Limited Biomarker [814]
KDM4B OT5P1UPY Limited Altered Expression [815]
KIR3DL1 OTPOSXFX Limited Biomarker [816]
KRIT1 OT58AP1I Limited Biomarker [710]
KRT1 OTIOJWA4 Limited Biomarker [817]
LAMTOR1 OTIBJBW9 Limited Biomarker [67]
LBR OT1HG3HG Limited Biomarker [201]
LCMT1 OTRJQ16X Limited Biomarker [818]
LDHB OT9B1CT3 Limited Biomarker [186]
LGALS4 OTKQCG0H Limited Biomarker [819]
LIG3 OT48SKET Limited Biomarker [820]
LIG4 OT40DNXU Limited Biomarker [821]
LMAN2 OT8UQKS6 Limited Altered Expression [822]
LMO3 OTR7AJHN Limited Altered Expression [823]
LOXL3 OTLLY1QI Limited Altered Expression [485]
LRG1 OTLD0KWA Limited Posttranslational Modification [808]
LRP8 OTZ71YV2 Limited Altered Expression [824]
LRRC4 OT7XJ70N Limited Biomarker [706]
LRSAM1 OTOKWR6C Limited Altered Expression [825]
LYAR OTQNA67C Limited Biomarker [720]
MAD2L1 OTXNGZCG Limited Altered Expression [826]
MAFK OTZJUE4P Limited Biomarker [67]
MAGED4B OTO37U7W Limited Biomarker [191]
MAGT1 OTQSAV5C Limited Biomarker [60]
MAP1LC3B OTUYHB84 Limited Altered Expression [827]
MAP2 OT6UYT3X Limited Altered Expression [828]
MAP3K12 OT5HODDD Limited Altered Expression [108]
MASTL OTQ7YKK5 Limited Biomarker [829]
MB OTYWYL2D Limited Altered Expression [830]
MCRS1 OT8K2X8P Limited Biomarker [831]
MEIS2 OTG4ADLM Limited Biomarker [832]
MICA OTPEIEAR Limited Biomarker [833]
MLF1 OTC5BKHU Limited Biomarker [785]
MMUT OTBBBV70 Limited Altered Expression [834]
MNAT1 OTXLOYCB Limited Biomarker [321]
MNX1 OTXP9FH1 Limited Altered Expression [835]
MPHOSPH9 OTNUNDQN Limited Biomarker [836]
MPPED2 OT7XLMJ6 Limited Altered Expression [837]
MPST OTCDPH5D Limited Biomarker [436]
MRE11 OTGU8TZM Limited Altered Expression [838]
MSX1 OT5U41ZP Limited Biomarker [839]
MT3 OTVCZ7HI Limited Altered Expression [840]
MTG1 OTC9U1LI Limited Biomarker [841]
MVP OTJGHJRB Limited Biomarker [254]
MXD1 OTS5CTHX Limited Biomarker [842]
MYBL2 OTZ3JX8Q Limited Altered Expression [843]
MYCL OT1MFQ5U Limited Biomarker [844]
MYEOV OTDC7UHL Limited Biomarker [845]
MYO10 OTHB78ZQ Limited Biomarker [846]
MYO5A OTMWLP3E Limited Biomarker [847]
MZF1 OTMVZCPW Limited Biomarker [222]
N4BP1 OTN2TL6N Limited Altered Expression [848]
NANOG OTUEY1FM Limited Altered Expression [849]
NAV1 OT667KTL Limited Altered Expression [698]
NCS1 OT6JHAWM Limited Altered Expression [850]
NDUFA4L2 OTK0PG7R Limited Altered Expression [292]
NDUFB11 OTFG5777 Limited Genetic Variation [851]
NECTIN1 OTTE5ZR6 Limited Altered Expression [852]
NEFH OTMSCW5I Limited Altered Expression [853]
NEGR1 OT57ECW9 Limited Biomarker [845]
NEUROD1 OTZQ7QJ2 Limited Biomarker [854]
NFYA OTWFFOVH Limited Biomarker [855]
NGB OTW0SIUY Limited Altered Expression [856]
NHLH1 OTXN5B9R Limited Biomarker [795]
NHLH2 OT88N84O Limited Altered Expression [857]
NKAIN2 OTI4H30Z Limited Biomarker [858]
NKX2-2 OTDCOYNG Limited Biomarker [798]
NLGN3 OTKDEC1Q Limited Altered Expression [859]
NLK OT2LETFS Limited Biomarker [860]
NMB OT4NLN6H Limited Biomarker [118]
NME2 OTCYGLHV Limited Altered Expression [861]
NME3 OT0CA0GF Limited Biomarker [862]
NME4 OT2JTT42 Limited Biomarker [863]
NOL3 OT1K0L0D Limited Altered Expression [864]
NPC1 OTRIPICX Limited Biomarker [865]
NPFF OT3WXFPR Limited Biomarker [208]
NPRL3 OTS4HE8E Limited Biomarker [744]
NSF OTKRJ2ZT Limited Altered Expression [866]
NUBP1 OTE8RAKZ Limited Posttranslational Modification [97]
NUCB2 OTHO6JWN Limited Biomarker [867]
NUP98 OTNT12G2 Limited Genetic Variation [868]
OAZ2 OTV1XSWG Limited Altered Expression [869]
OPTN OT2UXWH9 Limited Biomarker [870]
P2RX2 OT0LF34A Limited Altered Expression [220]
P2RX5 OTLBR20R Limited Altered Expression [220]
P2RX6 OT1FNTXA Limited Altered Expression [220]
PAEP OTQA0NV4 Limited Biomarker [528]
PAG1 OTFOJUIQ Limited Altered Expression [871]
PANK2 OTFBW889 Limited Biomarker [872]
PCDH7 OTP091X8 Limited Biomarker [873]
PCDHB1 OTFPKRA5 Limited Biomarker [873]
PCF11 OT54GCY6 Limited Altered Expression [874]
PCMT1 OTGYVSGU Limited Altered Expression [875]
PDIA2 OTC2WMXS Limited Altered Expression [876]
PDIA3 OTHPQ0Q3 Limited Biomarker [877]
PDLIM5 OTLQVV22 Limited Genetic Variation [485]
PER3 OTVKYVJA Limited Biomarker [878]
PES1 OTMZK7XE Limited Altered Expression [879]
PGP OT6QQ7OR Limited Altered Expression [880]
PHF20 OTCBVH5P Limited Biomarker [881]
PHF6 OT8DXI40 Limited Biomarker [882]
PHLDA1 OTFTWMIQ Limited Biomarker [883]
PHOX2A OTVS3R2X Limited Biomarker [884]
PIAS2 OTJLSC3V Limited Biomarker [121]
PIK3C2B OTY2PROB Limited Biomarker [885]
PKNOX1 OTUDMNHX Limited Biomarker [763]
PLA2G6 OT5FL0WU Limited Biomarker [568]
POLDIP2 OT8SZSJ6 Limited Altered Expression [56]
PPP1R12A OT4AVU95 Limited Biomarker [886]
PPP2R2B OTSFVC82 Limited Altered Expression [887]
PPP3R1 OTGQNFJQ Limited Biomarker [888]
PRB1 OTV0SYMD Limited Biomarker [889]
PRB2 OTAD4JZ0 Limited Altered Expression [890]
PRDM2 OT8L7CGX Limited Biomarker [891]
PRDX1 OTZ3BEC4 Limited Biomarker [892]
PRDX2 OTLWCY9T Limited Biomarker [893]
PRDX3 OTLB2WEU Limited Biomarker [894]
PRICKLE2 OTWBA48T Limited Biomarker [895]
PRPF31 OTSJ0Z1Y Limited Biomarker [896]
PRPS1 OTN3A6CN Limited Biomarker [897]
PRUNE2 OTGW2974 Limited Altered Expression [898]
PSMD4 OTH1VZTM Limited Biomarker [692]
QPRT OT6SKKLL Limited Biomarker [899]
RAB10 OT8ZN26V Limited Biomarker [900]
RAB15 OTU0GGR3 Limited Biomarker [901]
RAB1A OTKPHRD0 Limited Biomarker [870]
RAB29 OTDZT6LP Limited Biomarker [902]
RAB40B OTCA9ZF5 Limited Altered Expression [903]
RAB7B OT60A0E9 Limited Biomarker [246]
RAB8A OTPB54Y3 Limited Genetic Variation [904]
RAG1 OTV131E4 Limited Biomarker [905]
RALYL OT232N7Q Limited Biomarker [906]
RAPGEF1 OTZ0TBN1 Limited Biomarker [907]
RASL11B OTHEVZS6 Limited Biomarker [175]
RASSF10 OTGB7EBG Limited Biomarker [908]
RASSF6 OT25GVWY Limited Biomarker [908]
RBBP4 OTG3BT3M Limited Altered Expression [691]
RBM14 OTO9GMBD Limited Altered Expression [708]
RBX1 OTYA1UIO Limited Biomarker [909]
REEP3 OTM7YVIE Limited Altered Expression [739]
RELN OTLKMW1O Limited Altered Expression [824]
RFC2 OTJ9N6BD Limited Biomarker [910]
RFX1 OTZUDMPR Limited Altered Expression [911]
RGS14 OTYN79AG Limited Biomarker [912]
RHOV OTW4N3QN Limited Biomarker [725]
RITA1 OTUH8IPS Limited Biomarker [913]
RNF11 OTFBJSKQ Limited Genetic Variation [914]
RNF19A OTKWCV80 Limited Altered Expression [56]
ROBO2 OTFJ9FQW Limited Biomarker [915]
RRBP1 OT4ZTPTM Limited Altered Expression [796]
RSAD2 OTCA9WCM Limited Biomarker [916]
RYR2 OT0PF19E Limited Altered Expression [917]
S100A1 OT1F2G4J Limited Biomarker [562]
SBNO1 OTNX3RL0 Limited Biomarker [918]
SBNO2 OT1C6J3K Limited Biomarker [918]
SCG2 OTXWUQQL Limited Biomarker [919]
SCNN1A OTE2KVZV Limited Biomarker [712]
SDHAF2 OT0UG9H5 Limited Biomarker [920]
SEC61B OTY1X6A2 Limited Altered Expression [137]
SELENOS OTUEWIU9 Limited Biomarker [921]
SERF2 OTZQDYCZ Limited Biomarker [922]
SFRP1 OT0U9G41 Limited Biomarker [923]
SH2B1 OTJZO2CI Limited Biomarker [924]
SH2D5 OTJDS1NN Limited Biomarker [925]
SHMT2 OT5NCAZN Limited Altered Expression [926]
SIN3A OTM8OZWV Limited Biomarker [927]
SIRT4 OT5S0J23 Limited Biomarker [928]
SKIL OTNBXH32 Limited Biomarker [918]
SKP1 OT5BPAZ4 Limited Biomarker [929]
SMAD2 OTC6VB4K Limited Posttranslational Modification [576]
SNAP23 OTY2MYBX Limited Biomarker [930]
SNIP1 OTL3RA91 Limited Altered Expression [541]
SNRPN OTQB1ID1 Limited Biomarker [931]
SOD3 OTIOZQAB Limited Biomarker [932]
SP3 OTYDQZ1T Limited Biomarker [933]
SPINK1 OTSUVAL2 Limited Altered Expression [487]
SRGAP3 OT9ZS72C Limited Biomarker [934]
SRSF1 OTF61HOV Limited Biomarker [692]
SRSF3 OTOFT707 Limited Biomarker [935]
SSBP1 OTH2PZWH Limited Biomarker [936]
STAG2 OTR6X1Q7 Limited Genetic Variation [937]
STAU1 OTTR5311 Limited Altered Expression [938]
STIM2 OTYNXAW0 Limited Altered Expression [939]
STK25 OT4YPNTF Limited Altered Expression [940]
STMN4 OT7ZUKW6 Limited Biomarker [915]
SUZ12 OT655XF8 Limited Biomarker [941]
SYN1 OTMNPWC1 Limited Posttranslational Modification [942]
SYNCRIP OTRNDZXB Limited Biomarker [800]
SYNJ1 OTTE02XC Limited Altered Expression [943]
SYP OTFJKMO4 Limited Biomarker [944]
TAC1 OTM842YW Limited Biomarker [945]
TAF1 OTDYS5G4 Limited Altered Expression [857]
TAS2R10 OT4RWZZD Limited Biomarker [946]
TAS2R13 OTSTOX5G Limited Altered Expression [947]
TEAD4 OTJS0T2B Limited Altered Expression [948]
TESC OTI8C76M Limited Genetic Variation [262]
TFAP2B OTR1T8E9 Limited Biomarker [949]
TFAP2C OTUDIW05 Limited Biomarker [950]
TFAP4 OT1KQIUX Limited Biomarker [951]
THBS2 OTXET551 Limited Biomarker [541]
TIMP2 OT8S1RRP Limited Altered Expression [952]
TLE1 OT50MRZ1 Limited Biomarker [953]
TMOD1 OTTRYF9Y Limited Altered Expression [954]
TNFAIP8L2 OTII0RM0 Limited Biomarker [955]
TNFRSF10D OTOSRDJT Limited Posttranslational Modification [84]
TNIP1 OTRAOTEW Limited Biomarker [848]
TPD52 OTPKSK43 Limited Altered Expression [956]
TPI1 OT14KP4B Limited Genetic Variation [957]
TPM3 OT5RU5G6 Limited Biomarker [958]
TPPP2 OTI3WA6X Limited Biomarker [67]
TRAF2 OT1MEZZN Limited Altered Expression [661]
TRAP1 OTNG0L8J Limited Altered Expression [959]
TREX1 OTQG7K12 Limited Biomarker [960]
TSACC OT3QW6PH Limited Altered Expression [708]
TSPAN5 OTHCCHHV Limited Biomarker [284]
TSPYL2 OTGGW2EF Limited Biomarker [961]
ADAM12 OTZKOTDB Disputed Biomarker [962]
AGO2 OT4JY32Q Disputed Altered Expression [963]
CABIN1 OT4G5CIK Disputed Biomarker [964]
CTNNA2 OTJ8G92T Disputed Biomarker [965]
DUSP6 OT4H6RKW Disputed Biomarker [966]
EIF6 OTEXMUED Disputed Biomarker [296]
ELF4 OT167PR5 Disputed Altered Expression [967]
FRS2 OTDMD800 Disputed Altered Expression [968]
GADL1 OTJM4A0R Disputed Biomarker [969]
GDF1 OTZ1VRBH Disputed Biomarker [970]
GFRA2 OT34CXNN Disputed Biomarker [971]
KDM2B OTDMCVW7 Disputed Altered Expression [430]
KLF9 OTBFEJRQ Disputed Altered Expression [972]
LEMD2 OT0YLT7L Disputed Biomarker [973]
LIN28B OTVWP0FN Disputed Altered Expression [974]
LYPD5 OTGP7UKA Disputed Altered Expression [975]
MATR3 OTESJ5S7 Disputed Biomarker [976]
MCU OTQZAYWQ Disputed Altered Expression [977]
NPDC1 OT788NC8 Disputed Biomarker [296]
PPP1R13L OTNCPLWE Disputed Biomarker [970]
PPP3CB OTEGNEHW Disputed Altered Expression [964]
PRIMA1 OT9ITT3P Disputed Biomarker [978]
PTPN5 OT2H1KDK Disputed Altered Expression [979]
RAD52 OT0OTDHI Disputed Biomarker [980]
RDM1 OTBSJEAG Disputed Biomarker [980]
RNH1 OT6EC79B Disputed Biomarker [970]
RRM2B OTE8GBUR Disputed Biomarker [423]
SHC1 OT1J5IRN Disputed Biomarker [970]
SNW1 OTKWG3PS Disputed Biomarker [552]
SOX6 OTT0W0LE Disputed Biomarker [424]
STAT2 OTO9G2RZ Disputed Altered Expression [981]
SUGCT OTA8L0TN Disputed Biomarker [982]
TAS2R16 OT67HLNS Disputed Altered Expression [983]
TCERG1 OTH1LCGH Disputed Biomarker [984]
TMEM59 OTX4EKES Disputed Biomarker [985]
ACP1 OTJ9CKLU moderate Altered Expression [986]
ADAM23 OTVWT6JZ moderate Altered Expression [987]
AGTPBP1 OTR92JFR moderate Altered Expression [988]
ALDOC OTEC13I5 moderate Altered Expression [989]
ALX3 OTXZ25PZ moderate Posttranslational Modification [990]
APOBEC3B OTHLNI51 moderate Altered Expression [991]
ARF3 OTYYQX85 moderate Biomarker [992]
ARFGEF2 OTM3CQZT moderate Biomarker [993]
ARHGEF18 OTOXEK8Y moderate Biomarker [994]
ARHGEF2 OTBQTFRT moderate Biomarker [994]
ARID1B OTILK3Q7 moderate Genetic Variation [995]
ARID3B OTUP9MS4 moderate Altered Expression [996]
ARNT2 OTAQD3YV moderate Biomarker [997]
ARSH OTG0X9UQ moderate Biomarker [464]
ASXL3 OTNDJWEZ moderate Altered Expression [998]
ATF1 OT251CI0 moderate Altered Expression [999]
ATF5 OT03QCLM moderate Altered Expression [1000]
BACH2 OT17GS18 moderate Biomarker [1001]
BAD OT63ERYM moderate Altered Expression [1002]
BCAR1 OTKT2C2N moderate Biomarker [1003]
BCL11B OT8KKCVJ moderate Biomarker [1004]
BIK OTTH1T3D moderate Altered Expression [1005]
BMPR1A OTQOA4ZH moderate Altered Expression [1006]
BNIP2 OTVZD4H6 moderate Genetic Variation [1007]
BPTF OTD1RZAD moderate Biomarker [1008]
C1QL1 OTNQ0G3E moderate Altered Expression [1009]
CCDC115 OT04AZNZ moderate Altered Expression [988]
CCL18 OT7JYSK9 moderate Altered Expression [1010]
CCNG1 OT17IA9L moderate Altered Expression [1011]
CCNG2 OTII38K2 moderate Altered Expression [1012]
CCNT1 OTDYVGCP moderate Altered Expression [1013]
CD1D OT3ROU4J moderate Biomarker [1014]
CDC6 OTX93FE7 moderate Altered Expression [1015]
CDCA5 OTZLCQ5U moderate Biomarker [321]
CEBPZ OT11BATG moderate Biomarker [372]
CENPS OTZ4J391 moderate Genetic Variation [377]
CLTC OTBFASMA moderate Biomarker [1016]
CNN1 OTVPG39Z moderate Biomarker [1017]
CORT OTX3GUHB moderate Genetic Variation [1018]
CREM OTJIJ5AL moderate Biomarker [1019]
CRYGC OTYSTQWI moderate Biomarker [1020]
CTNNBIP1 OTX9SBJG moderate Genetic Variation [1021]
CUL9 OTPUCLZT moderate Altered Expression [1010]
CYGB OTX153DQ moderate Altered Expression [1022]
CYTL1 OTLYUPUY moderate Biomarker [1023]
DAP OT5YLL7E moderate Biomarker [353]
DLGAP1 OTF2PUUI moderate Biomarker [353]
DLGAP5 OTWCN39U moderate Altered Expression [1024]
DNAJC10 OTD2EG0R moderate Biomarker [1025]
DR1 OTR081M4 moderate Biomarker [1026]
DVL1 OTD67RF1 moderate Altered Expression [387]
DYNLL1 OTR69LHT moderate Altered Expression [1027]
EBF1 OTZ61YYH moderate Altered Expression [1028]
ECEL1 OTJ6GNUP moderate Altered Expression [1029]
EIF4G2 OTEO98CR moderate Biomarker [1024]
EPB41 OTGCFPV8 moderate Biomarker [1030]
ERRFI1 OT7VZ2IZ moderate Biomarker [1031]
ESCO1 OTZ9P12A moderate Biomarker [1032]
ETV1 OT6PMJIK moderate Altered Expression [1033]
ETV4 OT8C98UZ moderate Altered Expression [1034]
EVI5 OTOPAP55 moderate Posttranslational Modification [1035]
FANCL OTJC7QPQ moderate Genetic Variation [1036]
FCN2 OTTHJBKZ moderate Biomarker [321]
FGA OTMIHY80 moderate Biomarker [1037]
FHL2 OT0OAYWT moderate Altered Expression [165]
FLII OT7G9JG6 moderate Biomarker [1038]
FLT3LG OTU0YGC4 moderate Altered Expression [1039]
FMR1 OTWEV0T5 moderate Biomarker [1040]
FZD1 OTZATHVS moderate Biomarker [1041]
FZD5 OTXFFY56 moderate Biomarker [1041]
GADD45A OTDRV63V moderate Biomarker [1042]
GAS1 OTKJXG52 moderate Altered Expression [1043]
GCHFR OTEOT8GI moderate Biomarker [321]
GGNBP2 OT7K9YZV moderate Biomarker [1044]
GHRH OT94U6MO moderate Altered Expression [615]
GMEB1 OT4F8RFH moderate Biomarker [1045]
GNAS OTMH8BKJ moderate Biomarker [1046]
HERC2 OTNQYKOB moderate Biomarker [1047]
HOXC11 OT8NMHM6 moderate Altered Expression [1048]
HPCAL1 OTOBBFRD moderate Biomarker [1049]
HSD17B6 OTSB55D2 moderate Biomarker [310]
IGFBP4 OT2HZRBD moderate Biomarker [1050]
IL12RB1 OTM1IJO2 moderate Biomarker [1051]
IL3 OT0CQ35N moderate Biomarker [379]
INA OT1D33T4 moderate Altered Expression [1052]
ISL1 OTVNVKAX moderate Biomarker [1053]
ITGA2B OT4Y17PY moderate Genetic Variation [1026]
KIF3C OTTXKIWA moderate Altered Expression [1054]
KIFBP OT1XADKG moderate Altered Expression [1055]
LGALS7 OTMSVI7R moderate Biomarker [1056]
LMO1 OTB59SKB moderate Genetic Variation [1057]
LZIC OTT07ZC7 moderate Altered Expression [646]
MAP1B OTVXW089 moderate Biomarker [1058]
MCAT OTH07FIW moderate Biomarker [323]
MCPH1 OTYT3TT5 moderate Biomarker [323]
MCTS1 OT7SAOJP moderate Biomarker [323]
MGAT5 OTU4DD4G moderate Biomarker [1059]
MGAT5B OT5HP73K moderate Altered Expression [1059]
MMP20 OT16S5S3 moderate Genetic Variation [1060]
MSH6 OT46FP09 moderate Biomarker [1061]
MYOG OTPLJKFA moderate Altered Expression [1062]
NAALADL1 OTQNOZBP moderate Biomarker [1063]
NAV2 OTGAOL01 moderate Biomarker [1064]
NCKAP1 OTEZQXXJ moderate Altered Expression [1065]
NCOA7 OT2CNBOG moderate Biomarker [1066]
NCOR2 OTY917X0 moderate Biomarker [382]
NEUROG1 OTMJZP9G moderate Biomarker [1067]
NEUROG2 OTAEMIGT moderate Biomarker [1068]
NFIA OTDHQ9CG moderate Biomarker [1032]
NFIB OTX94PD0 moderate Biomarker [1032]
NFIC OTLMCUIB moderate Biomarker [1069]
NFIX OT1DPZAE moderate Biomarker [1032]
NFYB OTXSE7KW moderate Altered Expression [663]
NGRN OTP51NME moderate Biomarker [1070]
NIF3L1 OT4MP90J moderate Altered Expression [332]
NOA1 OT9GTOAC moderate Biomarker [1071]
NOP53 OTA2YKO6 moderate Biomarker [1072]
NPAS4 OTA3HH6W moderate Biomarker [997]
NRSN1 OT1KKXC8 moderate Genetic Variation [1073]
NXF1 OTEFHXG6 moderate Altered Expression [1074]
OAZ1 OTPT0PKZ moderate Biomarker [869]
OCA2 OTDWIGBF moderate Biomarker [1047]
OSBPL1A OTQ33OQV moderate Altered Expression [1075]
OTUD4 OT7U62SW moderate Biomarker [1076]
PABPC4 OTICKKBQ moderate Biomarker [666]
PAK5 OT32WQGL moderate Altered Expression [1077]
PDYN OTEJ6430 moderate Altered Expression [1078]
PEG3 OTHQW98S moderate Genetic Variation [1079]
PITX3 OTE2KT8P moderate Biomarker [1080]
PLEKHG5 OTL0S21W moderate Biomarker [1081]
PNPT1 OTBR2Q0F moderate Biomarker [1079]
POM121 OTIA7ZOQ moderate Altered Expression [1082]
POMGNT1 OTBNOUZC moderate Altered Expression [1083]
PPP1R11 OTSHYPPW moderate Biomarker [1084]
PPP1R15A OTYG179K moderate Biomarker [1042]
PSENEN OTJ7M7G9 moderate Biomarker [1085]
PTBP2 OTF4S7NE moderate Biomarker [1086]
PTMA OT2W4T1M moderate Biomarker [1087]
PTPRT OTV5TXNN moderate Altered Expression [1003]
PVR OT3N91T7 moderate Altered Expression [1088]
QSOX2 OTMLKYFP moderate Biomarker [1089]
RAB1B OTAFCUAS moderate Biomarker [992]
RAE1 OT54OKC3 moderate Biomarker [1090]
RAMP1 OT7UT2XB moderate Biomarker [1091]
RAP1B OTHEIIMM moderate Biomarker [992]
RAP2B OTD2NDQP moderate Biomarker [992]
RASGRF1 OTNWJ7EN moderate Biomarker [1092]
RASSF5 OT6Q41I2 moderate Biomarker [908]
RBL2 OTBQSOE6 moderate Biomarker [1093]
RBP7 OT0J3CPT moderate Biomarker [1031]
RCBTB2 OTECBF4R moderate Biomarker [1094]
RFLNB OTI7ZM75 moderate Biomarker [315]
RIOX2 OT2YFPI2 moderate Biomarker [1095]
RNF8 OTRR43PZ moderate Biomarker [1044]
RP1 OTDDT69Y moderate Altered Expression [1075]
RSRC1 OTFCJ4S0 moderate Genetic Variation [737]
SAA2 OTYAVJWG moderate Altered Expression [369]
SCGB3A1 OTIR98RB moderate Biomarker [1076]
SDHA OTOJ8QFF moderate Altered Expression [1096]
SDHC OTC8G2MX moderate Biomarker [1097]
SEPTIN1 OT4GVSU3 moderate Altered Expression [1098]
SET OTGYYQJO moderate Genetic Variation [1099]
SH2D3C OTAGXO0N moderate Biomarker [1047]
SIX1 OT70YYWM moderate Biomarker [1100]
SMG1 OTTS3SXE moderate Biomarker [327]
SMR3B OTL5HNM8 moderate Altered Expression [360]
SNCB OTELSEK6 moderate Altered Expression [1101]
SORL1 OTQ8FFNS moderate Altered Expression [1102]
SPRY2 OTH0CRCZ moderate Biomarker [1103]
SRCIN1 OTQZNQQ5 moderate Biomarker [1104]
SSR2 OTQJSL7M moderate Biomarker [1105]
SSX2 OT2Z6RLL moderate Biomarker [1106]
SSX4 OT0E4H2D moderate Biomarker [1106]
SUMO1 OTJFD4P5 moderate Biomarker [353]
TAF12 OTQZII5O moderate Altered Expression [1107]
TAPBP OTL81AVZ moderate Altered Expression [1074]
TBPL1 OT4I143E moderate Biomarker [378]
TCF7 OT1ID822 moderate Altered Expression [387]
TENM2 OTPLUYEF moderate Biomarker [1108]
TLK2 OTZ09CG8 moderate Genetic Variation [1109]
TLX1 OTVN0MNW moderate Biomarker [1110]
TMED2 OTBLO7RW moderate Genetic Variation [1073]
TNFSF9 OTV9L89D moderate Altered Expression [1111]
TOB1 OTNW949D moderate Altered Expression [1112]
TOR2A OT1EGCDU moderate Altered Expression [1113]
TPPP OTCFMSUF moderate Genetic Variation [1073]
TTL OTSS1CK4 moderate Altered Expression [1114]
TTLL1 OTCE097J moderate Altered Expression [1114]
AATF OT1QOKLD Strong Biomarker [662]
ACIN1 OTK81F92 Strong Biomarker [1115]
ACO1 OT2VUR7L Strong Biomarker [1116]
ACTR1B OTGBCKLO Strong Biomarker [493]
ACY1 OT9WU7X3 Strong Biomarker [402]
ACY3 OTZWAB73 Strong Biomarker [402]
ADAP1 OTM4CHU1 Strong Biomarker [1117]
APH1A OT97F1TU Strong Genetic Variation [1118]
APLP2 OTTFE53M Strong Altered Expression [1119]
APOD OTT77XW8 Strong Altered Expression [1120]
ARC OTN2QQPG Strong Biomarker [1121]
ARID1A OTRWDV3P Strong Biomarker [1122]
ARR3 OTRZ00CH Strong Genetic Variation [82]
ARTN OTWIWGL6 Strong Biomarker [394]
ASCC1 OTH4VAP9 Strong Altered Expression [1123]
ASCL1 OTI4X44G Strong Biomarker [1053]
ASIC4 OT5POMCQ Strong Genetic Variation [401]
ASPSCR1 OTXTOD10 Strong Genetic Variation [1124]
ATN1 OTNZFLKY Strong Altered Expression [576]
ATRX OT77RSQW Strong Biomarker [1125]
B3GAT1 OTXFP98E Strong Altered Expression [1126]
BBS2 OTPF9JIB Strong Biomarker [1127]
BCL2L11 OTNQQWFJ Strong Biomarker [1128]
BCOR OTG013AX Strong Biomarker [1129]
BRINP1 OTEUVSCP Strong Altered Expression [1130]
BTG2 OTZF6K1H Strong Biomarker [493]
CADM1 OTRWG9QS Strong Biomarker [1131]
CAMK2B OTS9YK3E Strong Biomarker [1132]
CAMK2G OTHD9KJG Strong Biomarker [1132]
CAMK4 OT47RDGV Strong Biomarker [1133]
CAMSAP2 OT9KXWE7 Strong Altered Expression [1134]
CAMTA1 OTAN1S5B Strong Biomarker [1135]
CAPG OTJ86KI6 Strong Altered Expression [1136]
CBX8 OT4U5V1T Strong Biomarker [493]
CCAR2 OTLUDG5T Strong Biomarker [1130]
CCDC174 OTA0Z9RZ Strong Biomarker [1137]
CCL7 OTDIS99H Strong Biomarker [1138]
CCT4 OT5D452X Strong Altered Expression [1139]
CD99 OTPUZ5DE Strong Biomarker [562]
CDC42 OT5QBC5M Strong Biomarker [1140]
CDCA2 OTX8UF9J Strong Altered Expression [1141]
CDK11A OTN5TSGQ Strong Genetic Variation [1142]
CEBPD OTNBIPMY Strong Altered Expression [1143]
CEND1 OTPHOC22 Strong Biomarker [1144]
CERS1 OT6EYRM3 Strong Altered Expression [1145]
CHAF1A OTXSSY4H Strong Biomarker [178]
CHD5 OTS5EVHH Strong Altered Expression [1146]
CHD6 OTEHW1U2 Strong Biomarker [320]
CHL1 OT6E6E8P Strong Biomarker [1147]
CHPT1 OT4FJ0K3 Strong Biomarker [1148]
CIC OTFXCHNZ Strong Genetic Variation [1129]
CIP2A OTVS2GXA Strong Biomarker [1149]
CIR1 OTKP5JKH Strong Biomarker [486]
CLCN4 OT4A2UWF Strong Altered Expression [1150]
CLTA OTLHOXMQ Strong Genetic Variation [469]
CLYBL OTXZLTST Strong Biomarker [1151]
CPQ OTTNZNLD Strong Biomarker [500]
CRABP1 OTISDG5X Strong Altered Expression [1152]
CRABP2 OTY01V9G Strong Altered Expression [1153]
CRKL OTOYSD1R Strong Biomarker [1154]
CRYGD OTW29JC4 Strong Genetic Variation [572]
CTAG1B OTIQGW6U Strong Biomarker [435]
CTCF OT8ZB70U Strong Biomarker [1155]
CTNNBL1 OT6KLHPA Strong Altered Expression [1156]
CXADR OT9ZP02A Strong Genetic Variation [82]
DCC OT2C1SHW Strong Genetic Variation [1157]
DCTN6 OTI8PIN9 Strong Altered Expression [955]
DCX OTISR7K3 Strong Biomarker [1158]
DDIT3 OTI8YKKE Strong Altered Expression [1159]
DDX1 OT3U8FD0 Strong Altered Expression [1160]
DECR1 OTCDIR6X Strong Altered Expression [1161]
DEPP1 OTB36PHJ Strong Biomarker [1162]
DES OTI09KBW Strong Altered Expression [1163]
DHDDS OTVLYBUS Strong Biomarker [1148]
DHX58 OT19BYB1 Strong Biomarker [578]
DLD OT378CU9 Strong Biomarker [1164]
DMBT1 OTVNU9D9 Strong Biomarker [1165]
DNER OT2GH2E5 Strong Altered Expression [1166]
DOCK4 OTH3XY8B Strong Biomarker [1167]
DOCK8 OTNQLL21 Strong Biomarker [1168]
DPYS OTLTUIVL Strong Altered Expression [1169]
DPYSL3 OTINJV20 Strong Biomarker [1169]
E2F5 OT1XWING Strong Biomarker [1170]
EDIL3 OTDVVNS0 Strong Genetic Variation [1171]
EIF3I OTE07WND Strong Altered Expression [903]
ELAVL4 OT3YH6J6 Strong Altered Expression [1172]
EMP3 OTODMJ1D Strong Biomarker [1173]
ENC1 OTJEUB6U Strong Altered Expression [1174]
ENDOU OTB7OF7Y Strong Genetic Variation [1175]
ERVW-1 OTWV8DXJ Strong Altered Expression [1176]
ETFA OTXX61VZ Strong Genetic Variation [469]
EWSR1 OT7SRHV3 Strong Biomarker [198]
EXOSC6 OTAC10N6 Strong Genetic Variation [1175]
FAM107A OTBG61YZ Strong Biomarker [734]
FAM163A OT0MYZ0F Strong Altered Expression [1177]
FAM3B OTC2S91N Strong Biomarker [1178]
FBXL5 OT93D50X Strong Biomarker [1179]
FBXW11 OT2A6RLR Strong Biomarker [765]
FLI1 OT0EV3LX Strong Genetic Variation [1180]
FOXD3 OTXYV6GO Strong Biomarker [1155]
FOXO3 OTHXQG4P Strong Biomarker [1181]
FOXR1 OTL8V888 Strong Altered Expression [1182]
FRMD7 OTJ11849 Strong Altered Expression [1183]
FRYL OTBN3XHN Strong Altered Expression [1184]
FUBP1 OT77SC9N Strong Biomarker [1185]
GABPA OT9YB2SA Strong Biomarker [1186]
GALNT9 OTFRD9RI Strong Altered Expression [1187]
GDAP1 OTQE1O25 Strong Biomarker [1188]
GDE1 OTU6FSBF Strong Biomarker [1189]
HACE1 OTEZULKD Strong Biomarker [655]
HAND2 OTCXYW4Y Strong Biomarker [1190]
HCLS1 OTX7WGYN Strong Altered Expression [194]
HES4 OTCGMQDT Strong Biomarker [1191]
HEY1 OTJQL0I3 Strong Altered Expression [1192]
HFE OTDD93KB Strong Altered Expression [1193]
HLA-C OTV38BUJ Strong Altered Expression [848]
HNRNPC OT47AK4C Strong Altered Expression [1194]
HNRNPDL OTB3BFCV Strong Altered Expression [1194]
HNRNPK OTNPRM8U Strong Biomarker [1195]
HOXB1 OTGC0EKI Strong Altered Expression [1196]
HOXB2 OTTD6HMV Strong Altered Expression [1196]
HOXB3 OT9UC5PE Strong Altered Expression [1196]
HOXB4 OTH1HRW5 Strong Altered Expression [1196]
HOXB5 OTU74TB8 Strong Altered Expression [1197]
HOXB6 OT3TFQ0U Strong Altered Expression [1196]
HOXB7 OTC7WYU8 Strong Altered Expression [1196]
HOXB8 OTKHOD17 Strong Altered Expression [1196]
HOXB9 OTMVHQOU Strong Altered Expression [1196]
HOXC9 OT60K4M0 Strong Biomarker [490]
HPR OTXSC9UB Strong Biomarker [1198]
HSPA14 OTZCA5LK Strong Biomarker [1130]
HSPA1A OTKGIE76 Strong Altered Expression [802]
HSPB2 OTS01646 Strong Biomarker [477]
HSPB6 OTFPLGZI Strong Biomarker [1199]
ID3 OTUULW5Z Strong Biomarker [1200]
IFI27 OTI2XGIT Strong Altered Expression [955]
IFIH1 OTZA2AHA Strong Altered Expression [578]
IFNA1 OTPMKY0L Strong Biomarker [1201]
INCENP OT9HFRYK Strong Biomarker [1202]
INTS6 OT6GDV46 Strong Altered Expression [1203]
IQCJ OTOC5U9H Strong Altered Expression [1204]
IREB2 OT747D24 Strong Biomarker [1179]
IRF2 OTAZRUW3 Strong Biomarker [1205]
ITIH4 OT460OO1 Strong Biomarker [1206]
KHSRP OTDHZARB Strong Altered Expression [194]
KIDINS220 OTLBH2MA Strong Biomarker [1207]
KLC1 OTSTTTW7 Strong Altered Expression [1208]
LEF1 OTWS5I5H Strong Altered Expression [860]
LGI1 OTPS77HO Strong Altered Expression [1209]
LIG1 OTEEQS43 Strong Biomarker [820]
LRP10 OT8490HT Strong Altered Expression [1210]
LRRC17 OT3NZSX3 Strong Altered Expression [1211]
MAX OTKZ0YKM Strong Biomarker [1212]
MBD2 OTUQPP0R Strong Posttranslational Modification [490]
MCF2L2 OTOGFMIH Strong Biomarker [1213]
MED25 OTDBY87B Strong Biomarker [1214]
MEGF10 OTILSPJ6 Strong Biomarker [1215]
MEIS1 OTH9DKAD Strong Biomarker [622]
MFAP1 OTZN4FT3 Strong Biomarker [668]
MFN2 OTPYN8A3 Strong Biomarker [1216]
MFSD12 OT54Y9TN Strong Biomarker [1217]
MOK OTQK7M9V Strong Biomarker [206]
MOS OTNMQPFJ Strong Biomarker [1218]
MPHOSPH6 OT6E2S48 Strong Biomarker [1219]
MPZ OTAR2YXH Strong Biomarker [1219]
MSH3 OTD3YPVL Strong Biomarker [88]
MXD3 OT4U88UP Strong Altered Expression [1220]
MZB1 OT071TET Strong Biomarker [293]
NAA50 OTFJ8S47 Strong Biomarker [1221]
NANS OTMQ2FUH Strong Biomarker [1222]
NAV3 OT97M1TR Strong Genetic Variation [1223]
NBAS OTW9IBRI Strong Genetic Variation [1224]
NBPF1 OTAZ55UQ Strong Biomarker [401]
NDN OTYBYJ82 Strong Altered Expression [1225]
NDRG2 OT5L6KD7 Strong Altered Expression [811]
NDUFV2 OTSZF7D6 Strong Altered Expression [1226]
NELL2 OTS4MJZ7 Strong Altered Expression [521]
NEO1 OTGJ1997 Strong Biomarker [1227]
NEU4 OTM16O9F Strong Altered Expression [1228]
NFATC2 OTK5T6HZ Strong Biomarker [1129]
NLN OTFRITPU Strong Altered Expression [1229]
NNAT OTNRLO7G Strong Altered Expression [1230]
NOVA2 OTQ2X3Q4 Strong Biomarker [1231]
NRDC OTWBBCXO Strong Altered Expression [1117]
NRF1 OTOXWNV8 Strong Posttranslational Modification [1232]
NRGN OTVGE10W Strong Altered Expression [1204]
NRIP1 OTIZOJQV Strong Altered Expression [1233]
NTN4 OTDRRMP3 Strong Biomarker [1227]
NUMBL OTWMTMMH Strong Biomarker [1234]
OPN4 OT1LZ7TS Strong Altered Expression [1229]
OSCP1 OTZ4IFGJ Strong Altered Expression [526]
OXA1L OTS0BFRD Strong Altered Expression [1235]
OXT OT48M72Z Strong Biomarker [1236]
P4HB OTTYNYPF Strong Altered Expression [876]
PA2G4 OT7IG7HT Strong Biomarker [1237]
PACRG OT1NYNNW Strong Biomarker [1238]
PAX3 OTN5PJZV Strong Genetic Variation [1239]
PCLAF OTMVIOUU Strong Biomarker [1240]
PCNP OTJUQ122 Strong Biomarker [1241]
PEA15 OTKCKTSX Strong Biomarker [1242]
PENK OT8P3HMP Strong Biomarker [1243]
PGK1 OT6V1ICH Strong Altered Expression [1244]
PHLDA2 OTMV9DPP Strong Biomarker [1245]
PI15 OTPJL6ML Strong Altered Expression [1246]
PIK3C2G OTW3LY1C Strong Genetic Variation [711]
PIK3R2 OTZSUQK5 Strong Altered Expression [1156]
PINK1 OT50NR57 Strong Biomarker [1247]
PIP OTH719AH Strong Biomarker [1248]
PIWIL1 OT7CRGZ3 Strong Altered Expression [1249]
PIWIL4 OTDA9MY0 Strong Altered Expression [1249]
PLAAT4 OTI66SAJ Strong Biomarker [578]
PLB1 OTZ6TTYV Strong Altered Expression [230]
PMAIP1 OTXEE550 Strong Biomarker [1250]
PMCH OT3D9SA4 Strong Altered Expression [1251]
PNOC OTJEAADN Strong Altered Expression [1252]
POU4F1 OTMHYGWQ Strong Altered Expression [1253]
POU4F2 OT6SW5H0 Strong Altered Expression [1254]
PPARGC1A OTHCDQ22 Strong Biomarker [1186]
PPT2 OTD5VJ9A Strong Altered Expression [1255]
PRICKLE1 OT9HHEM9 Strong Altered Expression [1256]
PRRT2 OTCJUBDO Strong Biomarker [481]
PSMD9 OT6Y5CC3 Strong Altered Expression [955]
PTHLH OTI1JF13 Strong Altered Expression [242]
PTPA OTRGFOI7 Strong Altered Expression [1257]
PXN OTVMMUOF Strong Altered Expression [1258]
QRICH1 OTPVAX04 Strong Altered Expression [1259]
QRSL1 OTJDU2UG Strong Genetic Variation [1260]
RABGEF1 OTWC3Z3R Strong Altered Expression [1261]
RAN OT2TER5M Strong Biomarker [1262]
RAP1A OT5RH6TI Strong Altered Expression [1261]
RBM3 OTAJ7R31 Strong Biomarker [1263]
RCAN1 OT1MVXC7 Strong Altered Expression [1264]
RD3 OT2L9Y6M Strong Biomarker [1265]
REST OTLL92LQ Strong Biomarker [1266]
RFC1 OT3L5PK3 Strong Genetic Variation [1267]
RGS5 OTUY0Q2I Strong Biomarker [1268]
RHOT1 OTBIRR8Q Strong Biomarker [1269]
RRP1 OT4A8HR3 Strong Biomarker [1270]
RRP1B OTHDRVML Strong Biomarker [1270]
RTL1 OTOT33IM Strong Biomarker [513]
S100A10 OTI71243 Strong Genetic Variation [1175]
SARDH OTQ49Q27 Strong Biomarker [572]
SART3 OTC1AM7S Strong Biomarker [1271]
SCAPER OT7S3B3P Strong Altered Expression [1272]
SCN7A OTK05PXY Strong Biomarker [517]
SDS OT5WTJ2M Strong Biomarker [660]
SEL1L OTC0FB7T Strong Biomarker [628]
SEMA3B OTCZCPMS Strong Altered Expression [1273]
SERPINA5 OTTZXPGD Strong Genetic Variation [1274]
SERPINE2 OTYF5340 Strong Biomarker [1275]
SESN2 OT889IXY Strong Altered Expression [1276]
SFPQ OTLCIAPJ Strong Biomarker [1118]
SGSM3 OTIB1P8A Strong Altered Expression [114]
SIGLEC7 OTNDLURR Strong Altered Expression [194]
SLC12A9 OTR7VRAK Strong Altered Expression [1277]
SLFN11 OTJWFPMY Strong Altered Expression [1278]
SMN2 OT54RLO1 Strong Biomarker [571]
SMOC1 OTJG2JQY Strong Altered Expression [1279]
SMS OT8JYKNH Strong Biomarker [847]
SNAI2 OT7Y8EJ2 Strong Altered Expression [849]
SNCAIP OTH8VNOK Strong Altered Expression [1280]
SPART OTIVOS2I Strong Altered Expression [1281]
SPG7 OT8OY9ST Strong Genetic Variation [82]
SRSF6 OTGLOSYE Strong Biomarker [1282]
ST8SIA1 OTGND2YZ Strong Altered Expression [1283]
STMN2 OT0FUHLH Strong Altered Expression [1284]
SUCLA2 OTMZD4PW Strong Altered Expression [69]
TAF13 OT1XMYAD Strong Biomarker [1285]
TBCEL OT2PZLLL Strong Biomarker [1231]
TBP OT6C0S52 Strong Biomarker [1286]
TBX2 OTTOT7A9 Strong Altered Expression [392]
TBX5 OT70PISV Strong Biomarker [556]
TERF2IP OT3M5P3G Strong Altered Expression [1261]
TFAP2E OTA4B1SG Strong Biomarker [1287]
TFE3 OTM99ZWH Strong Genetic Variation [1124]
TGFBR3 OTQOOUC4 Strong Biomarker [1288]
TICAM2 OTK7GIJ5 Strong Altered Expression [955]
TLX2 OTPFAUM8 Strong Genetic Variation [1289]
TMED7 OTONO8E6 Strong Altered Expression [955]
TMEM132D OTV6I4Z0 Strong Genetic Variation [1290]
TNFAIP1 OT37EWR0 Strong Biomarker [1291]
TP53BP2 OTOWJ2Y4 Strong Biomarker [1292]
TP53INP1 OT2363Z9 Strong Biomarker [1293]
TPPP3 OTU8VUIG Strong Altered Expression [1117]
TRAT1 OTMPUNPD Strong Biomarker [1294]
TRIB3 OTG5OS7X Strong Biomarker [1295]
TRIM13 OTQIUACB Strong Genetic Variation [82]
TRIM16 OTLRXYOZ Strong Biomarker [1296]
TRIM32 OTJOV0PG Strong Altered Expression [1297]
TSPAN3 OT7WS6ZI Strong Biomarker [1298]
TSPAN31 OT8WQ83R Strong Biomarker [1222]
TSPAN8 OT1F68WQ Strong Genetic Variation [1299]
AADAC OT8VACT2 Definitive Biomarker [1300]
ADGRB1 OTJSEXRC Definitive Altered Expression [1301]
AJAP1 OTAAW121 Definitive Biomarker [282]
AMBRA1 OTY0YGT9 Definitive Biomarker [1302]
ANK2 OTWB4R1Y Definitive Altered Expression [1303]
APTX OTPAS5G8 Definitive Genetic Variation [1304]
ARHGEF7 OT9BPJCL Definitive Altered Expression [1305]
ATF2 OTNIZPEA Definitive Altered Expression [365]
BAG3 OTVXYUDQ Definitive Biomarker [1306]
BAMBI OTCEJ8W5 Definitive Biomarker [1307]
BARD1 OTTC0Z9Y Definitive Biomarker [839]
CASZ1 OTWJ2OR8 Definitive Altered Expression [1308]
CD82 OTH8MC64 Definitive Altered Expression [1309]
CDKN3 OTBE3H07 Definitive Biomarker [1310]
CFL1 OTT6D5MH Definitive Biomarker [1311]
CMPK2 OTOG90R0 Definitive Genetic Variation [1312]
CMYA5 OTYV0RME Definitive Biomarker [1313]
CNBP OTTGM9NK Definitive Altered Expression [1314]
CRISP2 OT8HLTV5 Definitive Posttranslational Modification [1315]
DAB1 OTPL9MA3 Definitive Biomarker [824]
DDI1 OTNFQSKQ Definitive Biomarker [290]
DNAJC11 OTYLMZWW Definitive Genetic Variation [1316]
DTNBP1 OT9UQT2S Definitive Biomarker [611]
EDC3 OTYS7O69 Definitive Biomarker [1317]
EFS OT06O7XL Definitive Biomarker [1318]
ELK1 OTH9MXD6 Definitive Biomarker [1319]
ENO1 OTB1KWJS Definitive Altered Expression [1320]
ERAL1 OTSH78HD Definitive Biomarker [1321]
FBXW4 OTEGSZOX Definitive Biomarker [1300]
HES5 OTW7JEHV Definitive Posttranslational Modification [796]
HIC1 OTI9TWY4 Definitive Biomarker [1322]
HOXC6 OTBCRAZV Definitive Altered Expression [1048]
HOXD8 OTJ5H7AT Definitive Altered Expression [1323]
IFIT2 OTI4EOAR Definitive Biomarker [1324]
INSRR OT3F75WA Definitive Altered Expression [1325]
KCNH4 OTHJ8WTU Definitive Biomarker [1319]
KCNH8 OT3I5FLB Definitive Biomarker [1319]
KIF1A OT3JVEGV Definitive Altered Expression [726]
KIF5B OTT34MT8 Definitive Biomarker [1326]
LGALS3BP OT9AGQKH Definitive Biomarker [1327]
LMO4 OT5NDCT9 Definitive Altered Expression [1328]
LRRN1 OT6MMO6L Definitive Biomarker [1329]
LRRN3 OT7X0AA7 Definitive Biomarker [1330]
MADD OTUFYVGG Definitive Altered Expression [1331]
MAP2K4 OTZPZX11 Definitive Altered Expression [194]
MATK OTVOJJLJ Definitive Altered Expression [1332]
MXI1 OTUQ9E0D Definitive Altered Expression [1333]
NAP1L1 OTI7WBZV Definitive Biomarker [1334]
NCAN OT8OO6ZE Definitive Altered Expression [1335]
NCSTN OT5QBTA4 Definitive Biomarker [1336]
NEFL OTQESJV4 Definitive Altered Expression [1337]
NFE2L1 OT1QHOS2 Definitive Biomarker [705]
NT5C3A OT67KZJA Definitive Biomarker [1338]
PACC1 OTKBS8CC Definitive Biomarker [1339]
PDIK1L OTISF4KG Definitive Altered Expression [1340]
PEX14 OT98BZHE Definitive Biomarker [645]
PLXNA2 OTNNBJMQ Definitive Biomarker [1341]
PRAF2 OT1QN4LV Definitive Biomarker [1342]
PROX1 OT68R6IO Definitive Altered Expression [1343]
PRPH OT6VUH78 Definitive Altered Expression [1052]
PRSS55 OTXXWI5Y Definitive Posttranslational Modification [1315]
PRUNE1 OTQ3UHWQ Definitive Biomarker [1344]
PSMC5 OTJOORMR Definitive Biomarker [382]
PTPRA OTZA82J1 Definitive Biomarker [254]
PTPRD OTZPJ3GX Definitive Genetic Variation [1345]
PTPRF OTH5KF2D Definitive Biomarker [1346]
PVALB OTZW1WVQ Definitive Biomarker [1347]
RAB6B OT5N57RK Definitive Biomarker [992]
RASSF7 OT0V4EIZ Definitive Biomarker [908]
SIAH1 OT29A838 Definitive Biomarker [1348]
SMARCB1 OT2LP7LJ Definitive Posttranslational Modification [84]
SPZ1 OTQH8HJ5 Definitive Posttranslational Modification [1315]
ST8SIA2 OTRBBBD8 Definitive Genetic Variation [1349]
SYNM OTOI8TRJ Definitive Altered Expression [112]
TAT OT2CJ91O Definitive Biomarker [1350]
TMSB10 OTLVZ13T Definitive Altered Expression [1351]
TMSB15A OTSBWCES Definitive Altered Expression [1352]
TNFRSF10C OTVHOL9B Definitive Posttranslational Modification [84]
------------------------------------------------------------------------------------
⏷ Show the Full List of 996 DOT(s)

References

1 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
2 Busulfan FDA Label
3 Carboplatin FDA Label
4 Cyclophosphamide FDA Label
5 Dacarbazine FDA Label
6 Doxorubicin FDA Label
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Erlotinib FDA Label
9 Etoposide FDA Label
10 Everolimus FDA Label
11 Fludarabine FDA Label
12 Ifosfamide FDA Label
13 Irinotecan FDA Label
14 Isotretinoin FDA Label
15 Melphalan FDA Label
16 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
17 Sirolimus FDA Label
18 Temozolomide FDA Label
19 Thiotepa FDA Label
20 Topotecan FDA Label
21 Tretinoin FDA Label
22 Vidarabine FDA Label
23 Vincristine FDA Label
24 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7979).
25 ClinicalTrials.gov (NCT03275402) 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases. U.S. National Institutes of Health.
26 ClinicalTrials.gov (NCT00810238) C-Cure Clinical Trial. U.S. National Institutes of Health.
27 Overview and recent advances in the treatment of neuroblastoma. Expert Rev Anticancer Ther. 2017 Apr;17(4):369-386.
28 ClinicalTrials.gov (NCT03275402) 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases. U.S. National Institutes of Health.
29 ClinicalTrials.gov (NCT02765243) Anti-GD2 4th Generation CART Cells Targeting Refractory and/or Recurrent Neuroblastoma
30 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
31 Clinical pipeline report, company report or official report of Apeiron Biologics.
32 Clinical pipeline report, company report or official report of Y-mAbs Therapeutics.
33 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004852)
34 ClinicalTrials.gov (NCT04438304) Positron Emission Tomography Imaging of Participants With Known or Suspected Neuroendocrine Tumours Using 64Cu SARTATE: A Multi-Centre, Single Arm, Non-Randomised, Blinded-Review, Phase II Study. U.S.National Institutes of Health.
35 ClinicalTrials.gov (NCT04023331) 67Cu-SARTATE Peptide Receptor Radionuclide Therapy Administered to Pediatric Patients With High-Risk Neuroblastoma. U.S. National Institutes of Health.
36 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
37 ClinicalTrials.gov (NCT03373097) Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma
38 ClinicalTrials.gov (NCT02761915) A Cancer Research UK Trial of Anti-GD2 T-cells (1RG-CART)
39 ClinicalTrials.gov (NCT02107963) A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors
40 ClinicalTrials.gov (NCT03635632) C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma (GAIL-N)
41 ClinicalTrials.gov (NCT02311621) Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01
42 ClinicalTrials.gov (NCT01953900) iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma
43 ClinicalTrials.gov (NCT01822652) 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN
44 ClinicalTrials.gov (NCT03721068) Phase I Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma
45 Clinical pipeline report, company report or official report of Kuur Therapeutics.
46 ClinicalTrials.gov (NCT02337309) SF1126 for Patients With Relapsed or Refractory Neuroblastoma. U.S. National Institutes of Health.
47 ClinicalTrials.gov (NCT02919046) Study Evaluating the Efficacy and Safety With CAR-T for Relapsed or Refractory Neuroblastoma in Children
48 Valproic Acid FDA Label
49 Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan invivo.Eur J Cancer. 2017 Sep;83:132-141. doi: 10.1016/j.ejca.2017.06.024. Epub 2017 Jul 20.
50 Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas.PLoS One. 2014 Sep 4;9(9):e106575. doi: 10.1371/journal.pone.0106575. eCollection 2014.
51 Carnosic acid suppresses the production of amyloid- 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.Neurosci Res. 2013 Feb;75(2):94-102. doi: 10.1016/j.neures.2012.11.007. Epub 2012 Dec 17.
52 Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity.Biochem J. 1996 Sep 15;318 ( Pt 3)(Pt 3):1033-9. doi: 10.1042/bj3181033.
53 N-cadherin in neuroblastoma disease: expression and clinical significance.PLoS One. 2012;7(2):e31206. doi: 10.1371/journal.pone.0031206. Epub 2012 Feb 15.
54 Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome.Oncotarget. 2017 Nov 6;8(63):106820-106832. doi: 10.18632/oncotarget.22423. eCollection 2017 Dec 5.
55 Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.Pain. 2017 Feb;158(2):230-239. doi: 10.1097/j.pain.0000000000000742.
56 Macrophage-Derived IL1 and TNF Regulate Arginine Metabolism in Neuroblastoma.Cancer Res. 2019 Feb 1;79(3):611-624. doi: 10.1158/0008-5472.CAN-18-2139. Epub 2018 Dec 13.
57 Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma.Oncotarget. 2019 Sep 24;10(54):5645-5659. doi: 10.18632/oncotarget.27210. eCollection 2019 Sep 24.
58 Prognostic Impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM/CD166) in Infantile Neuroblastoma.Anticancer Res. 2016 Aug;36(8):3991-5.
59 Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochem Res. 2018 Mar;43(3):540-555.
60 Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells.Oncotarget. 2015 Dec 8;6(39):41522-34. doi: 10.18632/oncotarget.6308.
61 The secretion of the angiogenic and neurotrophic factor angiogenin is COPII and microtubule dependent.Exp Cell Res. 2019 Aug 15;381(2):265-279. doi: 10.1016/j.yexcr.2019.05.025. Epub 2019 May 22.
62 TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/-catenin signaling pathway in neuroblastoma.Biosci Rep. 2019 Jan 18;39(1):BSR20181277. doi: 10.1042/BSR20181277. Print 2019 Jan 31.
63 Neuron-Specific Apolipoprotein E4 (1-272) Fragment Induces Tau Hyperphosphorylation and Axonopathy via Triggering Endoplasmic Reticulum Stress.J Alzheimers Dis. 2019;71(2):597-611. doi: 10.3233/JAD-190419.
64 ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway.Oncotarget. 2017 Jan 31;8(5):8283-8293. doi: 10.18632/oncotarget.14164.
65 Adenovirus with hexon Tat-protein transduction domain modification exhibits increased therapeutic effect in experimental neuroblastoma and neuroendocrine tumors.J Virol. 2011 Dec;85(24):13114-23. doi: 10.1128/JVI.05759-11. Epub 2011 Sep 28.
66 MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma.Cancer Cell Int. 2018 Jan 4;18:5. doi: 10.1186/s12935-017-0499-2. eCollection 2018.
67 The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance.Cancer Lett. 1996 Jul 12;104(2):183-92. doi: 10.1016/0304-3835(96)04250-4.
68 ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT.Oncogene. 2016 Jul 14;35(28):3681-91. doi: 10.1038/onc.2015.434. Epub 2015 Nov 30.
69 Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis.Mol Neurobiol. 2019 Jul;56(7):5256-5269. doi: 10.1007/s12035-018-1451-8. Epub 2018 Dec 19.
70 Therapeutic potential of BAK gene silencing in aluminum induced neural cell degeneration.J Inorg Biochem. 2009 Nov;103(11):1514-20. doi: 10.1016/j.jinorgbio.2009.06.010. Epub 2009 Aug 14.
71 The involvement of tau in nucleolar transcription and the stress response.Acta Neuropathol Commun. 2018 Jul 31;6(1):70. doi: 10.1186/s40478-018-0565-6.
72 miR-146a induces apoptosis in neuroblastoma cells by targeting BCL11A.Med Hypotheses. 2018 Aug;117:21-27. doi: 10.1016/j.mehy.2018.05.019. Epub 2018 May 26.
73 Biglycan, a Nitric Oxide-Downregulated Proteoglycan, Prevents Nitric Oxide-Induced Neuronal Cell Apoptosis via Targeting Erk1/2 and p38 Signaling Pathways.J Mol Neurosci. 2018 Sep;66(1):68-76. doi: 10.1007/s12031-018-1151-x. Epub 2018 Aug 7.
74 Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells.FEBS J. 2012 Jul;279(14):2579-94. doi: 10.1111/j.1742-4658.2012.08641.x. Epub 2012 Jun 14.
75 Downregulation of bone morphogenetic protein receptor 2 promotes the development of neuroblastoma.Biochem Biophys Res Commun. 2017 Jan 29;483(1):609-616. doi: 10.1016/j.bbrc.2016.12.095. Epub 2016 Dec 18.
76 Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma.Neoplasia. 2018 Oct;20(10):965-974. doi: 10.1016/j.neo.2018.08.002. Epub 2018 Aug 25.
77 Prognostic relevance of genetic alterations in the p32 region of chromosome 1 in neuroblastoma.Eur J Cancer. 1997 Oct;33(12):1983-5. doi: 10.1016/s0959-8049(97)00239-6.
78 C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner.Cells. 2019 Oct 10;8(10):1233. doi: 10.3390/cells8101233.
79 Modulation of human -synuclein aggregation by a combined effect of calcium and dopamine.Neurobiol Dis. 2014 Mar;63:115-28. doi: 10.1016/j.nbd.2013.11.004. Epub 2013 Nov 20.
80 Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology.Schizophr Res. 2018 Sep;199:168-175. doi: 10.1016/j.schres.2018.02.036. Epub 2018 Feb 28.
81 Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation.RNA Biol. 2011 Nov-Dec;8(6):1061-72. doi: 10.4161/rna.8.6.16691. Epub 2011 Nov 1.
82 Efficiency of CAR-T Therapy for Treatment of Solid Tumor in Clinical Trials: A Meta-Analysis.Dis Markers. 2019 Feb 11;2019:3425291. doi: 10.1155/2019/3425291. eCollection 2019.
83 Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.Oncogene. 2012 Aug 16;31(33):3785-95. doi: 10.1038/onc.2011.536. Epub 2011 Nov 28.
84 Methylation of tumor-suppressor genes in neuroblastoma: The RASSF1A gene is almost always methylated in primary tumors.Pediatr Blood Cancer. 2008 Jan;50(1):29-32. doi: 10.1002/pbc.21279.
85 Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma.Oncotarget. 2017 Jul 22;8(36):60368-60377. doi: 10.18632/oncotarget.19499. eCollection 2017 Sep 1.
86 Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine.J Nucl Med. 2019 Sep;60(Suppl 2):13S-19S. doi: 10.2967/jnumed.118.220566.
87 TFH cells promote B cell maturation and antibody production in neuroblastoma.BMC Immunol. 2017 Jul 7;18(1):36. doi: 10.1186/s12865-017-0216-x.
88 NDRG1 promotes the multidrug resistance of neuroblastoma cells with upregulated expression of drug resistant proteins.Biomed Pharmacother. 2015 Dec;76:46-51. doi: 10.1016/j.biopha.2015.10.015. Epub 2015 Nov 10.
89 CDC20siRNA and paclitaxel co-loaded nanometric liposomes of a nipecotic acid-derived cationic amphiphile inhibit xenografted neuroblastoma.Nanoscale. 2017 Jan 19;9(3):1201-1212. doi: 10.1039/c6nr07532k.
90 JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma.Nat Commun. 2019 Jul 25;10(1):3319. doi: 10.1038/s41467-019-11132-w.
91 Phenotype, cancer risk, and surveillance in Beckwith-Wiedemann syndrome depending on molecular genetic subgroups.Am J Med Genet A. 2016 Sep;170(9):2248-60. doi: 10.1002/ajmg.a.37801. Epub 2016 Jul 15.
92 Structural and functional analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in neuroblastoma.Pediatr Res. 1998 Jan;43(1):139-44. doi: 10.1203/00006450-199801000-00021.
93 Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.Int J Cancer. 2013 Feb 1;132(3):E149-57. doi: 10.1002/ijc.27781. Epub 2012 Sep 28.
94 Arctic A40 blocks the nicotine-induced neuroprotective effect of CHRNA7 by inhibiting the ERK1/2 pathway in human neuroblastoma cells.Neurochem Int. 2017 Nov;110:49-56. doi: 10.1016/j.neuint.2017.09.005. Epub 2017 Sep 8.
95 Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers.Biochim Biophys Acta. 2011 Feb;1810(2):186-91. doi: 10.1016/j.bbagen.2010.09.004. Epub 2010 Oct 7.
96 Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo.Oncotarget. 2017 Jul 27;8(56):95135-95151. doi: 10.18632/oncotarget.19619. eCollection 2017 Nov 10.
97 L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in APP/PS1-Alzheimer's transgenic mice.J Alzheimers Dis. 2012;29(2):379-91. doi: 10.3233/JAD-2011-111577.
98 Nuclear cereblon modulates transcriptional activity of Ikaros and regulates its downstream target, enkephalin, in human neuroblastoma cells.Biochem Biophys Res Commun. 2016 Aug 26;477(3):388-94. doi: 10.1016/j.bbrc.2016.06.091. Epub 2016 Jun 18.
99 The activation of type 1 corticotropin releasing factor receptor (CRF-R1) inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27(Kip1) protein up-regulation and c-Myc mRNA down-regulation.Mol Cell Endocrinol. 2015 Sep 5;412:205-15. doi: 10.1016/j.mce.2015.05.004. Epub 2015 May 7.
100 Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway.PLoS One. 2013 Jun 20;8(6):e66548. doi: 10.1371/journal.pone.0066548. Print 2013.
101 Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chem Biol Interact. 2018 Jan 5;279:10-20.
102 Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma.BMC Cancer. 2010 Apr 19;10:149. doi: 10.1186/1471-2407-10-149.
103 G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic.Cancer Res. 2013 Jul 1;73(13):4134-46. doi: 10.1158/0008-5472.CAN-12-4056. Epub 2013 May 16.
104 Functional genomics identifies therapeutic targets for MYC-driven cancer.Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9545-50. doi: 10.1073/pnas.1121119109. Epub 2012 May 23.
105 Down-regulation of BORIS/CTCFL efficiently regulates cancer stemness and metastasis in MYCN amplified neuroblastoma cell line by modulating Wnt/-catenin signaling pathway.Biochem Biophys Res Commun. 2017 Feb 26;484(1):93-99. doi: 10.1016/j.bbrc.2017.01.066. Epub 2017 Jan 17.
106 Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPP(+) )-induced -synuclein accumulation and neurotoxicity.Neuropathol Appl Neurobiol. 2019 Feb;45(2):157-173. doi: 10.1111/nan.12493. Epub 2018 May 15.
107 Association of CYP3A4/5 genotypes and expression with the survival of patients with neuroblastoma.Mol Med Rep. 2015 Feb;11(2):1462-8. doi: 10.3892/mmr.2014.2835. Epub 2014 Oct 31.
108 Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma.Mod Pathol. 2005 May;18(5):656-62. doi: 10.1038/modpathol.3800335.
109 DFF45/ICAD restores cisplatin-induced nuclear fragmentation but not DNA cleavage in DFF45-deficient neuroblastoma cells.Oncogene. 2007 Aug 16;26(38):5669-73. doi: 10.1038/sj.onc.1210352. Epub 2007 Mar 12.
110 MiR-192 directly binds and regulates Dicer1 expression in neuroblastoma.PLoS One. 2013 Nov 1;8(11):e78713. doi: 10.1371/journal.pone.0078713. eCollection 2013.
111 LncRNA XIST facilitates cell growth, migration and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma.Cell Cycle. 2019 Aug;18(16):1882-1892. doi: 10.1080/15384101.2019.1632134. Epub 2019 Jul 7.
112 ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.Toxicology. 2018 Dec 1;410:222-230. doi: 10.1016/j.tox.2018.08.009. Epub 2018 Aug 18.
113 The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription.Cancer Res. 2017 May 1;77(9):2522-2533. doi: 10.1158/0008-5472.CAN-16-1663. Epub 2017 Feb 16.
114 DUSP5 expression associates with poor prognosis in human neuroblastoma.Exp Mol Pathol. 2018 Dec;105(3):272-278. doi: 10.1016/j.yexmp.2018.08.008. Epub 2018 Aug 30.
115 Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma.Biochem Biophys Res Commun. 2019 Jan 1;508(1):9-16. doi: 10.1016/j.bbrc.2018.11.103. Epub 2018 Nov 20.
116 Endothelin-converting enzymes degrade -synuclein and are reduced in dementia with Lewy bodies.J Neurochem. 2017 Apr;141(2):275-286. doi: 10.1111/jnc.13974. Epub 2017 Mar 29.
117 Lead Neurotoxicity on Human Neuroblastoma Cell Line SH-SY5Y is Mediated via Transcription Factor EGR1/Zif268 Induced Disrupted in Scherophernia-1 Activation.Neurochem Res. 2018 Jul;43(7):1308-1316. doi: 10.1007/s11064-018-2539-2. Epub 2018 Jun 4.
118 Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.Anticancer Drugs. 2013 Jun;24(5):484-93. doi: 10.1097/CAD.0b013e32835ffdbb.
119 Aluminum Activates PERK-EIF2 Signaling and Inflammatory Proteins in Human Neuroblastoma SH-SY5Y Cells.Biol Trace Elem Res. 2016 Jul;172(1):108-119. doi: 10.1007/s12011-015-0553-7. Epub 2015 Nov 7.
120 MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas.Sci Signal. 2017 Nov 28;10(507):eaam7550. doi: 10.1126/scisignal.aam7550.
121 Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin.Int J Mol Med. 2014 Jan;33(1):35-42. doi: 10.3892/ijmm.2013.1545. Epub 2013 Nov 1.
122 Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKC Activation.Cell Physiol Biochem. 2018;45(6):2283-2292. doi: 10.1159/000488174. Epub 2018 Mar 13.
123 NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells.Cancer Res. 2010 Feb 1;70(3):916-24. doi: 10.1158/0008-5472.CAN-09-2582. Epub 2010 Jan 26.
124 Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations.Ann Surg. 2018 Jan;267(1):149-156. doi: 10.1097/SLA.0000000000001999.
125 Differential regulation of HIF-1 and HIF-2 in neuroblastoma: Estrogen-related receptor alpha (ERR) regulates HIF2A transcription and correlates to poor outcome.Biochem Biophys Res Commun. 2015 Jun 5;461(3):560-7. doi: 10.1016/j.bbrc.2015.04.083. Epub 2015 Apr 23.
126 Estrogen receptor enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner.BMC Cancer. 2015 Jun 30;15:491. doi: 10.1186/s12885-015-1495-3.
127 TAT-mediated transduction of bacterial redox proteins generates a cytoprotective effect on neuronal cells.PLoS One. 2017 Sep 8;12(9):e0184617. doi: 10.1371/journal.pone.0184617. eCollection 2017.
128 GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells.Hippocampus. 2014 Jul;24(7):733-9. doi: 10.1002/hipo.22263. Epub 2014 Feb 27.
129 Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta(1-42)-Induced Toxicity in SH-SY5Y Cells.Neurotox Res. 2018 Oct;34(3):574-583. doi: 10.1007/s12640-018-9914-2. Epub 2018 Jun 5.
130 Duplication of Philadelphia chromosome and trisomy of chromosome 21 in a pediatric patient with acute lymphoblastic leukemia.Med Oncol. 2011 Dec;28 Suppl 1:S501-4. doi: 10.1007/s12032-010-9689-7. Epub 2010 Oct 7.
131 HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells.Oncotarget. 2016 Feb 9;7(6):6727-47. doi: 10.18632/oncotarget.6797.
132 The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis.BMC Cancer. 2016 Jul 18;16:490. doi: 10.1186/s12885-016-2545-1.
133 MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines.Oncol Rep. 2016 May;35(5):2943-51. doi: 10.3892/or.2016.4640. Epub 2016 Feb 26.
134 Inhibition of glycogen synthase kinase-3 by falcarindiol isolated from Japanese Parsley (Oenanthe javanica).J Agric Food Chem. 2013 Aug 7;61(31):7515-21. doi: 10.1021/jf401042m. Epub 2013 Jul 29.
135 Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia.J Psychiatr Res. 2017 May;88:9-17. doi: 10.1016/j.jpsychires.2016.12.019. Epub 2016 Dec 28.
136 GBA deficiency promotes SNCA/-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Autophagy. 2015;11(10):1803-20. doi: 10.1080/15548627.2015.1086055.
137 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells.J Cell Physiol. 2018 Feb;233(2):1671-1684. doi: 10.1002/jcp.26080. Epub 2017 Aug 23.
138 Peptides derived from the knuckle epitope of BMP-9 induce the cholinergic differentiation and inactivate GSk3beta in human SH-SY5Y neuroblastoma cells.Sci Rep. 2017 Jul 5;7(1):4695. doi: 10.1038/s41598-017-04835-x.
139 Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line.Neurotox Res. 2012 Apr;21(3):256-65. doi: 10.1007/s12640-011-9266-7. Epub 2011 Aug 20.
140 MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.J Mol Neurosci. 2020 Mar;70(3):328-339. doi: 10.1007/s12031-019-01416-7. Epub 2019 Nov 13.
141 Paired Expression Analysis of Tumor Cell Surface Antigens.Front Oncol. 2017 Aug 21;7:173. doi: 10.3389/fonc.2017.00173. eCollection 2017.
142 A connexin40 mutation associated with a malignant variant of progressive familial heart block type I.Circ Arrhythm Electrophysiol. 2012 Feb;5(1):163-72. doi: 10.1161/CIRCEP.111.967604. Epub 2012 Jan 13.
143 The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK.Oncotarget. 2018 Jan 13;9(18):14413-14427. doi: 10.18632/oncotarget.24214. eCollection 2018 Mar 6.
144 Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in Alzheimer's disease.Neuropharmacology. 2020 Jan 1;162:107813. doi: 10.1016/j.neuropharm.2019.107813. Epub 2019 Oct 16.
145 Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells.Biochim Biophys Acta. 2014 Jan;1840(1):255-61. doi: 10.1016/j.bbagen.2013.09.008. Epub 2013 Sep 13.
146 Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma.Theranostics. 2018 Oct 6;8(18):5106-5125. doi: 10.7150/thno.26585. eCollection 2018.
147 Human synaptic plasticity gene expression profile and dendritic spine density changes in HIV-infected human CNS cells: role in HIV-associated neurocognitive disorders (HAND).PLoS One. 2013 Apr 19;8(4):e61399. doi: 10.1371/journal.pone.0061399. Print 2013.
148 Suppression of Progranulin Expression Leads to Formation of Intranuclear TDP-43 Inclusions In Vitro: A Cell Model of Frontotemporal Lobar Degeneration.J Neuropathol Exp Neurol. 2019 Dec 1;78(12):1124-1129. doi: 10.1093/jnen/nlz102.
149 Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.Pediatr Blood Cancer. 2015 Apr;62(4):581-6. doi: 10.1002/pbc.25348. Epub 2015 Jan 28.
150 Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase.Sci Rep. 2016 Sep 6;6:32628. doi: 10.1038/srep32628.
151 Neuronal Hemoglobin Expression and Its Relevance to Multiple Sclerosis Neuropathology.J Mol Neurosci. 2016 May;59(1):1-17. doi: 10.1007/s12031-015-0711-6. Epub 2016 Jan 25.
152 Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation.FASEB J. 2017 May;31(5):1903-1915. doi: 10.1096/fj.201600828R. Epub 2017 Feb 7.
153 Ghrelin Through GHSR1a and OX1R Heterodimers Reveals a Gs-cAMP-cAMP Response Element Binding Protein Signaling Pathway in Vitro.Front Mol Neurosci. 2018 Jul 17;11:245. doi: 10.3389/fnmol.2018.00245. eCollection 2018.
154 Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.J Med Chem. 2019 May 9;62(9):4426-4443. doi: 10.1021/acs.jmedchem.8b01936. Epub 2019 Apr 29.
155 Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.Cell Death Dis. 2017 Mar 2;8(3):e2635. doi: 10.1038/cddis.2017.49.
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157 Development of Thiazolidinedione-Based HDAC6 Inhibitors to Overcome Methamphetamine Addiction.Int J Mol Sci. 2019 Dec 9;20(24):6213. doi: 10.3390/ijms20246213.
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279 Downregulation of Type 3 Deiodinase in the Hypothalamus During Inflammation.Thyroid. 2019 Sep;29(9):1336-1343. doi: 10.1089/thy.2019.0201. Epub 2019 Aug 15.
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312 Expression of the platelet-derived growth factor receptor in prostate cancer and treatment implications with tyrosine kinase inhibitors.Neoplasia. 2004 Sep-Oct;6(5):503-12. doi: 10.1593/neo.04157.
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659 Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility.Clin Cancer Res. 2017 Jan 15;23(2):466-477. doi: 10.1158/1078-0432.CCR-16-0354. Epub 2016 Jul 7.
660 Free radicals impair the anti-oxidative stress activity of DJ-1 through the formation of SDS-resistant dimer.Free Radic Res. 2017 Apr;51(4):397-412. doi: 10.1080/10715762.2017.1324201.
661 Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells.FEBS J. 2018 Aug;285(16):2987-3001. doi: 10.1111/febs.14595. Epub 2018 Jul 5.
662 Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma.Int J Oncol. 2019 Nov;55(5):1149-1156. doi: 10.3892/ijo.2019.4878. Epub 2019 Sep 13.
663 Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice.Mamm Genome. 2008 Feb;19(2):69-76. doi: 10.1007/s00335-007-9089-2. Epub 2008 Jan 23.
664 Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma.Pharmacogenet Genomics. 2007 Sep;17(9):709-17. doi: 10.1097/FPC.0b013e3280e1cc92.
665 Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.Biol Pharm Bull. 2001 Nov;24(11):1258-62. doi: 10.1248/bpb.24.1258.
666 A dinucleotide deletion in amyloid precursor protein (APP) mRNA associated with sporadic Alzheimer's disease results in efficient secretion of truncated APP isoforms from neuroblastoma cell cultures.J Neurochem. 2001 Mar;76(5):1308-14. doi: 10.1046/j.1471-4159.2001.00122.x.
667 Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.BMC Cancer. 2016 Oct 10;16(1):781. doi: 10.1186/s12885-016-2820-1.
668 Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells.Exp Neurol. 2009 Feb;215(2):236-42. doi: 10.1016/j.expneurol.2008.10.007. Epub 2008 Oct 28.
669 -Carotene 15,15'-oxygenase inhibits cancer cell stemness and metastasis by regulating differentiation-related miRNAs in human neuroblastoma.J Nutr Biochem. 2019 Jul;69:31-43. doi: 10.1016/j.jnutbio.2019.03.010. Epub 2019 Mar 28.
670 Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.J Biol Chem. 1996 Oct 11;271(41):25107-16. doi: 10.1074/jbc.271.41.25107.
671 Level of Seven Neuroblastoma-Associated mRNAs Detected by Droplet Digital PCR Is Associated with Tumor Relapse/Regrowth of High-Risk Neuroblastoma Patients.J Mol Diagn. 2020 Feb;22(2):236-246. doi: 10.1016/j.jmoldx.2019.10.012. Epub 2019 Dec 16.
672 Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth.DNA Cell Biol. 1994 May;13(5):461-71. doi: 10.1089/dna.1994.13.461.
673 MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease?.Hum Mol Genet. 2012 Feb 1;21(3):609-22. doi: 10.1093/hmg/ddr495. Epub 2011 Oct 31.
674 Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function.Neurochem Int. 2010 Mar;56(4):597-602. doi: 10.1016/j.neuint.2010.01.002. Epub 2010 Jan 11.
675 Anti-tumor effect of sulfasalazine in neuroblastoma.Biochem Pharmacol. 2019 Apr;162:237-249. doi: 10.1016/j.bcp.2019.01.007. Epub 2019 Jan 9.
676 Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines.Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):613-618. doi: 10.1080/15257770.2015.1124998.
677 Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease.Mol Immunol. 2007 Jan;44(4):541-57. doi: 10.1016/j.molimm.2006.02.006. Epub 2006 Apr 17.
678 Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.Free Radic Biol Med. 2013 Apr;57:141-53. doi: 10.1016/j.freeradbiomed.2012.12.019. Epub 2013 Jan 4.
679 S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.Cancer Res. 1999 Apr 15;59(8):1852-6.
680 Deficiency of ALADIN impairs redox homeostasis in human adrenal cells and inhibits steroidogenesis.Endocrinology. 2013 Sep;154(9):3209-18. doi: 10.1210/en.2013-1241. Epub 2013 Jul 3.
681 Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells.Biochem Biophys Res Commun. 2018 Jan 1;495(1):652-658. doi: 10.1016/j.bbrc.2017.11.068. Epub 2017 Nov 11.
682 Quantitative Proteomics of Th-MYCN Transgenic Mice Reveals Aurora Kinase Inhibitor Altered Metabolic Pathways and Enhanced ACADM To Suppress Neuroblastoma Progression.J Proteome Res. 2019 Nov 1;18(11):3850-3866. doi: 10.1021/acs.jproteome.9b00245. Epub 2019 Oct 11.
683 Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells.FEBS Lett. 2011 Oct 3;585(19):2965-71. doi: 10.1016/j.febslet.2011.08.003. Epub 2011 Aug 11.
684 The Leber congenital amaurosis protein AIPL1 and EB proteins co-localize at the photoreceptor cilium.PLoS One. 2015 Mar 23;10(3):e0121440. doi: 10.1371/journal.pone.0121440. eCollection 2015.
685 Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUG) in neuroblastoma patient samples with chromosome arm 2p rearrangements.Genes Chromosomes Cancer. 2020 Jan;59(1):50-57. doi: 10.1002/gcc.22790. Epub 2019 Sep 2.
686 Exogenous expression of miRNA-3613-3p causes APAF1 downregulation and affects several proteins involved in apoptosis in BE(2)-C human neuroblastoma cells.Int J Oncol. 2018 Oct;53(4):1787-1799. doi: 10.3892/ijo.2018.4509. Epub 2018 Jul 31.
687 Nuclear localization of amyloid- precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.PLoS One. 2017 Mar 21;12(3):e0173888. doi: 10.1371/journal.pone.0173888. eCollection 2017.
688 The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.Oncotarget. 2017 Jan 31;8(5):8189-8205. doi: 10.18632/oncotarget.14138.
689 Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.Oncogene. 2007 Nov 15;26(52):7302-12. doi: 10.1038/sj.onc.1210542. Epub 2007 May 28.
690 Truncated apolipoprotein C-I induces apoptosis in neuroblastoma by activating caspases in the extrinsic and intrinsic pathways.Oncol Rep. 2017 Sep;38(3):1797-1805. doi: 10.3892/or.2017.5819. Epub 2017 Jul 14.
691 Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.Nat Commun. 2018 Jul 19;9(1):2829. doi: 10.1038/s41467-018-05286-2.
692 MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2/ASF).J Biol Chem. 2011 Feb 11;286(6):4150-64. doi: 10.1074/jbc.M110.167817. Epub 2010 Nov 30.
693 Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells.J Biochem. 2012 Jun;151(6):611-20. doi: 10.1093/jb/mvs033. Epub 2012 Mar 26.
694 Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity.Aging (Albany NY). 2019 Aug 24;11(16):6134-6152. doi: 10.18632/aging.102177. Epub 2019 Aug 24.
695 Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.Cancer Res. 2017 Sep 15;77(18):5142-5157. doi: 10.1158/0008-5472.CAN-16-2586. Epub 2017 Jul 7.
696 ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.Hum Mol Genet. 2017 May 1;26(9):1656-1669. doi: 10.1093/hmg/ddx070.
697 PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion.Brain Behav. 2015 Apr;5(4):e00321. doi: 10.1002/brb3.321. Epub 2015 Feb 16.
698 Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression.Oncotarget. 2016 Apr 19;7(16):21840-52. doi: 10.18632/oncotarget.8187.
699 B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma.Cancer Sci. 2013 Dec;104(12):1600-8. doi: 10.1111/cas.12294. Epub 2013 Oct 28.
700 Prospective investigation of applicability and the prognostic significance of bone marrow involvement in patients with neuroblastoma detected by quantitative reverse transcription PCR.Pediatr Blood Cancer. 2018 Nov;65(11):e27354. doi: 10.1002/pbc.27354. Epub 2018 Jul 14.
701 -1,4-Galactosyltransferase III enhances invasive phenotypes via 1-integrin and predicts poor prognosis in neuroblastoma.Clin Cancer Res. 2013 Apr 1;19(7):1705-16. doi: 10.1158/1078-0432.CCR-12-2367. Epub 2013 Feb 26.
702 BAG2 Is Repressed by NF-B Signaling, and Its Overexpression Is Sufficient to Shift A1-42 from Neurotrophic to Neurotoxic in Undifferentiated SH-SY5Y Neuroblastoma.J Mol Neurosci. 2015 Sep;57(1):83-9. doi: 10.1007/s12031-015-0579-5. Epub 2015 May 19.
703 Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.Sci Rep. 2017 Feb 1;7:41420. doi: 10.1038/srep41420.
704 Neuroprotective role of BNIP3 under oxidative stress through autophagy in neuroblastoma cells.Mol Biol Rep. 2014 Sep;41(9):5729-34. doi: 10.1007/s11033-014-3444-7. Epub 2014 Jun 14.
705 Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.Gene. 2013 Oct 15;529(1):7-15. doi: 10.1016/j.gene.2013.08.006. Epub 2013 Aug 9.
706 BAG-1L Protects SH-SY5Y Neuroblastoma Cells Against Hypoxia/Re-oxygenation Through Up-Regulating HSP70 and Activating PI3K/AKT Signaling Pathway.Neurochem Res. 2017 Oct;42(10):2861-2868. doi: 10.1007/s11064-017-2304-y. Epub 2017 May 18.
707 Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3.Cerebellum. 2013 Jun;12(3):338-49. doi: 10.1007/s12311-012-0430-2.
708 CacyBP/SIP phosphatase activity in neuroblastoma NB2a and colon cancer HCT116 cells.Biochem Cell Biol. 2012 Aug;90(4):558-64. doi: 10.1139/o2012-011. Epub 2012 Apr 5.
709 Calcipotriol inhibits -synuclein aggregation in SH-SY5Y neuroblastoma cells by a Calbindin-D28k-dependent mechanism.J Neurochem. 2017 Apr;141(2):263-274. doi: 10.1111/jnc.13971.
710 SPARC overexpression combined with radiation retards angiogenesis by suppressing VEGF-A via miR?10 in human neuroblastoma cells.Int J Oncol. 2016 Oct;49(4):1394-406. doi: 10.3892/ijo.2016.3646. Epub 2016 Aug 3.
711 Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.Int J Oncol. 2019 Dec;55(6):1372-1384. doi: 10.3892/ijo.2019.4896. Epub 2019 Oct 7.
712 Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma.BMC Cancer. 2011 Feb 11;11:66. doi: 10.1186/1471-2407-11-66.
713 17-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells.Cell Mol Neurobiol. 2012 May;32(4):517-21. doi: 10.1007/s10571-012-9809-3. Epub 2012 Feb 11.
714 CCM2 mediates death signaling by the TrkA receptor tyrosine kinase.Neuron. 2009 Sep 10;63(5):585-91. doi: 10.1016/j.neuron.2009.08.020.
715 Diminished cytolytic activity of T cells with reduced DNAM-1 expression in neuroblastoma patients.Clin Immunol. 2019 Jun;203:63-71. doi: 10.1016/j.clim.2019.04.006. Epub 2019 Apr 15.
716 Effects of CD2-associated protein deficiency on amyloid- in neuroblastoma cells and in an APP transgenic mouse model.Mol Neurodegener. 2015 Mar 19;10:12. doi: 10.1186/s13024-015-0006-y.
717 CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.Biochim Biophys Acta. 2012 Nov-Dec;1819(11-12):1173-85. doi: 10.1016/j.bbagrm.2012.08.001. Epub 2012 Aug 19.
718 p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas.Hum Mol Genet. 2014 Dec 20;23(25):6826-37. doi: 10.1093/hmg/ddu406. Epub 2014 Aug 7.
719 CFC1 is a cancer stemness-regulating factor in neuroblastoma.Oncotarget. 2017 Jul 11;8(28):45046-45059. doi: 10.18632/oncotarget.18464.
720 Upregulation of LYAR induces neuroblastoma cell proliferation and survival.Cell Death Differ. 2017 Sep;24(9):1645-1654. doi: 10.1038/cdd.2017.98. Epub 2017 Jul 7.
721 Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction.Oncotarget. 2017 Sep 15;8(46):80956-80970. doi: 10.18632/oncotarget.20898. eCollection 2017 Oct 6.
722 Chromogranin A regulates neuroblastoma proliferation and phenotype.Biol Open. 2019 Mar 4;8(3):bio036566. doi: 10.1242/bio.036566.
723 Chromogranin A and neuron-specific enolase in neuroblastoma: Correlation to stage and prognostic factors.Pediatr Hematol Oncol. 2018 Mar;35(2):156-165. doi: 10.1080/08880018.2018.1464087. Epub 2018 May 8.
724 The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia.Mol Cell Biol. 1996 Sep;16(9):5069-80. doi: 10.1128/MCB.16.9.5069.
725 Autophagy Promotes Survival of CHP-212 Neuroblastoma Cells Treated With Casiopenas.Anticancer Res. 2019 Jul;39(7):3687-3695. doi: 10.21873/anticanres.13517.
726 Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells.Oncol Rep. 2013 Apr;29(4):1629-36. doi: 10.3892/or.2013.2286. Epub 2013 Feb 12.
727 Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development.Dev Neurobiol. 2019 Apr;79(4):370-386. doi: 10.1002/dneu.22684. Epub 2019 May 9.
728 CDGSH Iron Sulfur Domain 2 Deficiency Inhibits Cell Proliferation and Induces Cell Differentiation of Neuroblastoma.Pathol Oncol Res. 2020 Jul;26(3):1725-1733. doi: 10.1007/s12253-019-00753-7. Epub 2019 Oct 22.
729 MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN.Oncotarget. 2018 Apr 6;9(26):18160-18179. doi: 10.18632/oncotarget.24793. eCollection 2018 Apr 6.
730 The all-trans retinoic acid (atRA)-regulated gene Calmin (Clmn) regulates cell cycle exit and neurite outgrowth in murine neuroblastoma (Neuro2a) cells.Exp Cell Res. 2012 Jan 1;318(1):85-93. doi: 10.1016/j.yexcr.2011.10.002. Epub 2011 Oct 6.
731 Recombinant heat shock protein 78 enhances enterovirus 71 propagation in Vero cells and is induced in SK-N-SH cells during the infection.Arch Virol. 2017 Jun;162(6):1649-1660. doi: 10.1007/s00705-017-3287-3. Epub 2017 Feb 24.
732 Dual Roles of Ascidian Chondromodulin-1: Promoting Cell Proliferation Whilst Suppressing the Growth of Tumor Cells.Mar Drugs. 2018 Feb 11;16(2):59. doi: 10.3390/md16020059.
733 Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients.Oncotarget. 2015 May 30;6(15):13295-308. doi: 10.18632/oncotarget.3745.
734 A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-B degradation and cell growth suppression in neuroblastoma.Oncogene. 2017 Oct 12;36(41):5745-5756. doi: 10.1038/onc.2017.181. Epub 2017 Jun 12.
735 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.EMBO J. 2011 Jan 5;30(1):181-93. doi: 10.1038/emboj.2010.285. Epub 2010 Nov 19.
736 Differential DNA damage response to UV and hydrogen peroxide depending of differentiation stage in a neuroblastoma model.Neurotoxicology. 2012 Oct;33(5):1086-95. doi: 10.1016/j.neuro.2012.05.017. Epub 2012 Jun 9.
737 RSRC1 and CPZ gene polymorphisms with neuroblastoma susceptibility in Chinese children.Gene. 2018 Jul 1;662:83-87. doi: 10.1016/j.gene.2018.04.015. Epub 2018 Apr 10.
738 Down-regulation of C-terminal binding protein 2 (CtBP2) inhibits proliferation, migration, and invasion of human SHSY5Y cells in vitro.Neurosci Lett. 2017 Apr 24;647:104-109. doi: 10.1016/j.neulet.2017.02.006. Epub 2017 Feb 6.
739 Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.Nat Commun. 2017 Oct 17;8(1):774. doi: 10.1038/s41467-017-00831-x.
740 Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells.Oncogene. 2015 Apr 23;34(17):2251-60. doi: 10.1038/onc.2014.159. Epub 2014 Jun 9.
741 Clinical features of ATRX or DAXX mutated neuroblastoma.J Pediatr Surg. 2014 Dec;49(12):1835-8. doi: 10.1016/j.jpedsurg.2014.09.029. Epub 2014 Nov 14.
742 Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis.PLoS Pathog. 2018 Jan 11;14(1):e1006778. doi: 10.1371/journal.ppat.1006778. eCollection 2018 Jan.
743 Overexpression of Macrophage Migration Inhibitory Factor and Its Homologue D-Dopachrome Tautomerase as Negative Prognostic Factor in Neuroblastoma.Brain Sci. 2019 Oct 19;9(10):284. doi: 10.3390/brainsci9100284.
744 DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons.Neurobiol Dis. 2018 Jun;114:184-193. doi: 10.1016/j.nbd.2018.02.013. Epub 2018 Feb 24.
745 RNA helicase A is a downstream mediator of KIF1B tumor-suppressor function in neuroblastoma.Cancer Discov. 2014 Apr;4(4):434-51. doi: 10.1158/2159-8290.CD-13-0362. Epub 2014 Jan 27.
746 The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor and DNA methylation.Mol Endocrinol. 2012 Apr;26(4):619-29. doi: 10.1210/me.2011-1376. Epub 2012 Mar 1.
747 Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer's Disease.Cells. 2019 Nov 28;8(12):1539. doi: 10.3390/cells8121539.
748 The Structure in Solution of Fibronectin Type III Domain 14 Reveals Its Synergistic Heparin Binding Site.Biochemistry. 2018 Oct 23;57(42):6045-6049. doi: 10.1021/acs.biochem.8b00771. Epub 2018 Oct 11.
749 A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2.
750 X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism.Hum Mol Genet. 2013 Mar 1;22(5):941-51. doi: 10.1093/hmg/dds499. Epub 2012 Nov 25.
751 NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.Cell Death Dis. 2015 Aug 6;6(8):e1841. doi: 10.1038/cddis.2015.207.
752 MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.Cancer Lett. 2010 Mar 28;289(2):195-207. doi: 10.1016/j.canlet.2009.08.019. Epub 2009 Oct 7.
753 Incorporation of high-dose (131)I-metaiodobenzylguanidine treatment into tandem high-dose chemotherapy and autologous stem cell transplantation for high-risk neuroblastoma: results of the SMC NB-2009 study.J Hematol Oncol. 2017 May 16;10(1):108. doi: 10.1186/s13045-017-0477-0.
754 MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.Cell Death Differ. 2017 Sep;24(9):1564-1576. doi: 10.1038/cdd.2017.79. Epub 2017 Jun 2.
755 De novo identification of MIZ-1 (ZBTB17) encoding a MYC-interacting zinc-finger protein as a new favorable neuroblastoma gene.Clin Cancer Res. 2007 Oct 15;13(20):6001-9. doi: 10.1158/1078-0432.CCR-07-0071.
756 Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism.Hum Mol Genet. 2009 Feb 1;18(3):525-34. doi: 10.1093/hmg/ddn380. Epub 2008 Nov 10.
757 Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.Arch Pathol Lab Med. 2016 Oct;140(10):1026-37. doi: 10.5858/arpa.2016-0218-RA.
758 Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.Front Cell Neurosci. 2017 May 1;11:122. doi: 10.3389/fncel.2017.00122. eCollection 2017.
759 Endonuclease G mediates -synuclein cytotoxicity during Parkinson's disease.EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15.
760 Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children.EBioMedicine. 2018 Apr;30:113-119. doi: 10.1016/j.ebiom.2018.03.003. Epub 2018 Mar 7.
761 ERP44 inhibits human lung cancer cell migration mainly via IP3R2.Aging (Albany NY). 2016 Jun;8(6):1276-86. doi: 10.18632/aging.100984.
762 Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.Oncogene. 2018 Mar;37(11):1417-1429. doi: 10.1038/s41388-017-0039-5. Epub 2018 Jan 11.
763 Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance.Nucleic Acids Res. 2003 Jun 1;31(11):2769-77. doi: 10.1093/nar/gkg396.
764 MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.Cell Death Dis. 2014 Sep 4;5(9):e1401. doi: 10.1038/cddis.2014.356.
765 A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.Target Oncol. 2015 Dec;10(4):523-33. doi: 10.1007/s11523-014-0354-5. Epub 2015 Jan 6.
766 Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death.J Cell Physiol. 2011 Jul;226(7):1763-70. doi: 10.1002/jcp.22505.
767 DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis.PLoS One. 2012;7(11):e48401. doi: 10.1371/journal.pone.0048401. Epub 2012 Nov 7.
768 Enhanced Neurogenic Biomarker Expression and Reinnervation in HumanAcute Skin Wounds Treated by Electrical Stimulation.J Invest Dermatol. 2017 Mar;137(3):737-747. doi: 10.1016/j.jid.2016.09.038. Epub 2016 Nov 14.
769 Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.Cancer Res. 2014 Jul 15;74(14):3790-801. doi: 10.1158/0008-5472.CAN-14-0241. Epub 2014 May 15.
770 PGC-1 or FNDC5 Is Involved in Modulating the Effects of A(1-42) Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, A Deposition and Cognitive Decline of APP/PS1 Tg Mice.Front Aging Neurosci. 2017 Mar 21;9:65. doi: 10.3389/fnagi.2017.00065. eCollection 2017.
771 Functional characterization of two enhancers located downstream FOXP2.BMC Med Genet. 2019 May 2;20(1):65. doi: 10.1186/s12881-019-0810-2.
772 Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage.Aging Dis. 2017 Jul 21;8(4):458-470. doi: 10.14336/AD.2016.1108. eCollection 2017 Jul.
773 Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.Oncotarget. 2011 Dec;2(12):976-83. doi: 10.18632/oncotarget.410.
774 Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Cell Rep. 2017 Mar 21;18(12):2932-2942. doi: 10.1016/j.celrep.2017.02.065.
775 Identification of GALNT14 as a novel neuroblastoma predisposition gene.Oncotarget. 2015 Sep 22;6(28):26335-46. doi: 10.18632/oncotarget.4501.
776 A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.J Biol Chem. 2013 Oct 11;288(41):29934-42. doi: 10.1074/jbc.M113.492520. Epub 2013 Sep 3.
777 Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase.J Neurochem. 2010 May;113(4):819-25. doi: 10.1111/j.1471-4159.2010.06648.x. Epub 2010 Feb 17.
778 Aberrant O-glycosylation modulates aggressiveness in neuroblastoma.Oncotarget. 2018 Sep 25;9(75):34176-34188. doi: 10.18632/oncotarget.26169. eCollection 2018 Sep 25.
779 Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells.FEBS Lett. 2007 Feb 20;581(4):712-8. doi: 10.1016/j.febslet.2007.01.035. Epub 2007 Jan 24.
780 Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2.Oncotarget. 2015 Dec 1;6(38):40655-66. doi: 10.18632/oncotarget.5821.
781 Glutamate receptor 2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome.Neurology. 2018 Aug 21;91(8):e714-e723. doi: 10.1212/WNL.0000000000006035. Epub 2018 Jul 25.
782 Exome sequencing identifies predisposing and fusion gene in ganglioneuroma, ganglioneuroblastoma and neuroblastoma.Math Biosci Eng. 2019 Aug 8;16(6):7217-7229. doi: 10.3934/mbe.2019362.
783 Scratching the Surface of Immunotherapeutic Targets in Neuroblastoma.Cancer Cell. 2017 Sep 11;32(3):271-273. doi: 10.1016/j.ccell.2017.08.011.
784 Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia.Front Mol Neurosci. 2018 Sep 4;11:314. doi: 10.3389/fnmol.2018.00314. eCollection 2018.
785 Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.PLoS Genet. 2017 May 18;13(5):e1006787. doi: 10.1371/journal.pgen.1006787. eCollection 2017 May.
786 Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells.DNA Cell Biol. 2018 Dec;37(12):1044-1054. doi: 10.1089/dna.2018.4336. Epub 2018 Oct 30.
787 GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.Cancer Res. 2014 May 1;74(9):2604-16. doi: 10.1158/0008-5472.CAN-13-1904. Epub 2014 Jan 13.
788 Akt2 regulates metastatic potential in neuroblastoma.PLoS One. 2013;8(2):e56382. doi: 10.1371/journal.pone.0056382. Epub 2013 Feb 26.
789 (R)--Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.Neuropeptides. 2017 Dec;66:52-58. doi: 10.1016/j.npep.2017.09.001. Epub 2017 Oct 2.
790 Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.Oncotarget. 2016 Nov 22;7(47):76816-76826. doi: 10.18632/oncotarget.12713.
791 Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy.Cancer Med. 2019 Aug;8(10):4821-4835. doi: 10.1002/cam4.2389. Epub 2019 Jul 5.
792 The Cellular Coactivator HCF-1 Is Required for Glucocorticoid Receptor-Mediated Transcription of Bovine Herpesvirus 1 Immediate Early Genes.J Virol. 2018 Aug 16;92(17):e00987-18. doi: 10.1128/JVI.00987-18. Print 2018 Sep 1.
793 MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1 and p53 pathways.Sci Rep. 2016 Nov 8;6:36268. doi: 10.1038/srep36268.
794 Promoter-associated proteins of EPAS1 identified by enChIP-MS - A putative role of HDX as a negative regulator.Biochem Biophys Res Commun. 2018 May 5;499(2):291-298. doi: 10.1016/j.bbrc.2018.03.150. Epub 2018 Mar 26.
795 HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6. doi: 10.1073/pnas.89.18.8492.
796 Notch pathway activation induces neuroblastoma tumor cell growth arrest.Pediatr Blood Cancer. 2012 May;58(5):682-9. doi: 10.1002/pbc.23202. Epub 2011 Jul 8.
797 UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors.Cancer. 2013 Feb 15;119(4):915-23. doi: 10.1002/cncr.27785. Epub 2012 Sep 18.
798 Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors.Tumour Biol. 2011 Feb;32(1):113-27. doi: 10.1007/s13277-010-0105-x. Epub 2010 Sep 10.
799 Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study.Oncoimmunology. 2018 May 10;7(8):e1461305. doi: 10.1080/2162402X.2018.1461305. eCollection 2018.
800 Systematic Analysis of Gene Expression Profiles Controlled by hnRNP Q and hnRNP R, Two Closely Related Human RNA Binding Proteins Implicated in mRNA Processing Mechanisms.Front Mol Biosci. 2018 Aug 30;5:79. doi: 10.3389/fmolb.2018.00079. eCollection 2018.
801 Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation.Tumour Biol. 1996;17(1):34-47. doi: 10.1159/000217965.
802 Recombinant human Tat-Hsp70-2: A tool for neuroprotection.Protein Expr Purif. 2017 Oct;138:18-24. doi: 10.1016/j.pep.2016.07.005. Epub 2016 Jul 9.
803 Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.Microb Pathog. 2019 Mar;128:106-111. doi: 10.1016/j.micpath.2018.12.032. Epub 2018 Dec 21.
804 Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.Mol Neurobiol. 2015 Dec;52(3):1077-1092. doi: 10.1007/s12035-014-8906-3. Epub 2014 Oct 8.
805 A-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and A Secretion in Neural Cells.Neurosci Bull. 2016 Jun;32(3):227-38. doi: 10.1007/s12264-016-0034-9. Epub 2016 May 20.
806 ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with -actinin.Oncogene. 2015 Mar 19;34(12):1553-62. doi: 10.1038/onc.2014.87. Epub 2014 Apr 7.
807 IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma.J Clin Oncol. 2015 Apr 10;33(11):1285-93. doi: 10.1200/JCO.2014.55.9880. Epub 2015 Mar 9.
808 MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF- signalling pathway.Carcinogenesis. 2012 May;33(5):976-85. doi: 10.1093/carcin/bgs114. Epub 2012 Mar 1.
809 Decreased expression of the candidate tumor suppressor gene ING1 is associated with poor prognosis in advanced neuroblastomas.Oncol Rep. 2004 Oct;12(4):811-6.
810 ING5-mediated antineuroblastoma effects of suberoylanilide hydroxamic acid.Cancer Med. 2018 Sep;7(9):4554-4569. doi: 10.1002/cam4.1634. Epub 2018 Aug 9.
811 Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2.Mol Cancer. 2015 Feb 21;14:47. doi: 10.1186/s12943-015-0320-6.
812 BRI2 ectodomain affects A42 fibrillation and tau truncation in human neuroblastoma cells.Cell Mol Life Sci. 2015 Apr;72(8):1599-611. doi: 10.1007/s00018-014-1769-y. Epub 2014 Oct 22.
813 Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice.J Pediatr Hematol Oncol. 2017 Nov;39(8):e413-e418. doi: 10.1097/MPH.0000000000000931.
814 Calsenilin regulates presenilin 1/-secretase-mediated N-cadherin -cleavage and -catenin signaling.FASEB J. 2011 Dec;25(12):4174-83. doi: 10.1096/fj.11-185926. Epub 2011 Aug 18.
815 The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.J Natl Cancer Inst. 2015 Apr 29;107(6):djv080. doi: 10.1093/jnci/djv080. Print 2015 Jun.
816 KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.J Clin Oncol. 2016 Jul 20;34(21):2443-51. doi: 10.1200/JCO.2015.64.9558. Epub 2016 Apr 11.
817 Alleles of keratin 1 in families and populations.Hum Immunol. 2013 Nov;74(11):1453-8. doi: 10.1016/j.humimm.2013.05.003. Epub 2013 May 23.
818 Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.J Biol Chem. 2013 Sep 20;288(38):27396-27405. doi: 10.1074/jbc.M113.490102. Epub 2013 Aug 13.
819 Novel Notch signaling inhibitor NSI? suppresses nuclear translocation of the Notch intracellular domain.Int J Mol Med. 2019 Oct;44(4):1574-1584. doi: 10.3892/ijmm.2019.4280. Epub 2019 Jul 19.
820 Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.Mol Cancer Res. 2015 Mar;13(3):470-82. doi: 10.1158/1541-7786.MCR-14-0337. Epub 2015 Jan 6.
821 Different profiles of the mRNA levels of DNA repair genes in MCF-7 and SH-SY5Y cells after treatment with combination of cisplatin, 50-Hz electromagnetic field and bleomycin.Biomed Pharmacother. 2017 Oct;94:564-568. doi: 10.1016/j.biopha.2017.07.115. Epub 2017 Aug 4.
822 Overexpression of quality control proteins reduces prion conversion in prion-infected cells.J Biol Chem. 2018 Oct 12;293(41):16069-16082. doi: 10.1074/jbc.RA118.002754. Epub 2018 Aug 28.
823 Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.PLoS One. 2011 May 5;6(5):e19297. doi: 10.1371/journal.pone.0019297.
824 Reelin signalling in neuroblastoma: migratory switch in metastatic stages.Int J Oncol. 2012 Aug;41(2):681-9. doi: 10.3892/ijo.2012.1488. Epub 2012 May 18.
825 LRSAM1 Depletion Affects Neuroblastoma SH-SY5Y Cell Growth and Morphology: The LRSAM1 c.2047-1G>A Loss-of-Function Variant Fails to Rescue The Phenotype.Cell J. 2018 Oct;20(3):340-347. doi: 10.22074/cellj.2018.5352. Epub 2018 May 15.
826 HsMAD2 mRNA expression may be a predictor of sensitivity to paclitaxel and survival in neuroblastoma.Pediatr Surg Int. 2011 Feb;27(2):217-23. doi: 10.1007/s00383-010-2780-5.
827 Autophagy is associated with chemoresistance in neuroblastoma.BMC Cancer. 2016 Nov 15;16(1):891. doi: 10.1186/s12885-016-2906-9.
828 Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line.Bone. 2015 Oct;79:150-61. doi: 10.1016/j.bone.2015.05.033. Epub 2015 May 29.
829 Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.Cancer Lett. 2016 Feb 1;371(1):79-89. doi: 10.1016/j.canlet.2015.11.025. Epub 2015 Nov 23.
830 Interactions between amyloid- and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease.PLoS One. 2012;7(3):e33120. doi: 10.1371/journal.pone.0033120. Epub 2012 Mar 6.
831 Downregulation of MSP58 suppresses cell proliferation in neuroblastoma cell lines.Neuroreport. 2012 Nov 14;23(16):932-6. doi: 10.1097/WNR.0b013e328359566e.
832 Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma.Cancer Res. 2018 Apr 15;78(8):1935-1947. doi: 10.1158/0008-5472.CAN-17-1860. Epub 2018 Jan 30.
833 Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma.Neoplasia. 2004 Sep-Oct;6(5):558-68. doi: 10.1593/neo.04316.
834 Label-Free Quantitative Proteomics in a Methylmalonyl-CoA Mutase-Silenced Neuroblastoma Cell Line.Int J Mol Sci. 2018 Nov 13;19(11):3580. doi: 10.3390/ijms19113580.
835 HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line.PLoS One. 2014 Aug 19;9(8):e105481. doi: 10.1371/journal.pone.0105481. eCollection 2014.
836 Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication.BMC Cancer. 2010 May 5;10:181. doi: 10.1186/1471-2407-10-181.
837 The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma.Cell Cycle. 2012 Feb 1;11(3):569-81. doi: 10.4161/cc.11.3.19063. Epub 2012 Feb 1.
838 MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.Cell Death Dis. 2018 Aug 30;9(9):895. doi: 10.1038/s41419-018-0924-z.
839 Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease.Genes (Basel). 2019 Aug 30;10(9):663. doi: 10.3390/genes10090663.
840 Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin.Oncotarget. 2017 Dec 16;9(4):4427-4439. doi: 10.18632/oncotarget.23333. eCollection 2018 Jan 12.
841 Mouse Neuroblastoma CB(1) Cannabinoid Receptor-Stimulated [(35)S]GTPS Binding: Total and Antibody-Targeted G Protein-Specific Scintillation Proximity Assays.Methods Enzymol. 2017;593:1-21. doi: 10.1016/bs.mie.2017.06.028. Epub 2017 Jul 19.
842 Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.Nat Genet. 2011 Jun 19;43(7):663-7. doi: 10.1038/ng.861.
843 A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma.Oncotarget. 2012 May;3(5):535-45. doi: 10.18632/oncotarget.498.
844 Molecular evaluation of abnormalities of the short arm of chromosome 1 in neuroblastoma.Genes Chromosomes Cancer. 1990 Jul;2(2):137-46. doi: 10.1002/gcc.2870020210.
845 Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.Cancer Sci. 2011 Sep;102(9):1645-50. doi: 10.1111/j.1349-7006.2011.01995.x. Epub 2011 Jul 3.
846 miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10.Biomed Pharmacother. 2018 Jul;103:1312-1318. doi: 10.1016/j.biopha.2018.04.153. Epub 2018 May 7.
847 Myosin Va interacts with the exosomal protein spermine synthase.Biosci Rep. 2019 Mar 1;39(3):BSR20182189. doi: 10.1042/BSR20182189. Print 2019 Mar 29.
848 Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.Cancer Res. 2018 Dec 1;78(23):6621-6631. doi: 10.1158/0008-5472.CAN-18-0545. Epub 2018 Sep 13.
849 Prokineticin signaling is required for the maintenance of a de novo population of c-KIT?cells to sustain neuroblastoma progression.Oncogene. 2015 Feb 19;34(8):1019-34. doi: 10.1038/onc.2014.24. Epub 2014 Mar 17.
850 Inhibition of paclitaxel-induced decreases in calcium signaling.J Biol Chem. 2012 Nov 2;287(45):37907-16. doi: 10.1074/jbc.M112.385070. Epub 2012 Sep 17.
851 The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells.Biochim Biophys Acta. 2013 Feb;1829(2):211-8. doi: 10.1016/j.bbagrm.2012.12.001. Epub 2012 Dec 12.
852 Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma.PLoS One. 2013 Oct 10;8(10):e77753. doi: 10.1371/journal.pone.0077753. eCollection 2013.
853 Calreticulin Regulates VEGF-A in Neuroblastoma Cells.Mol Neurobiol. 2015 Aug;52(1):758-70. doi: 10.1007/s12035-014-8901-8. Epub 2014 Oct 7.
854 Neurogenic differentiation factor 1 promotes colorectal cancer cell proliferation and tumorigenesis by suppressing the p53/p21 axis.Cancer Sci. 2020 Jan;111(1):175-185. doi: 10.1111/cas.14233. Epub 2019 Dec 10.
855 Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma.J Exp Clin Cancer Res. 2019 Dec 5;38(1):482. doi: 10.1186/s13046-019-1481-8.
856 Neuroglobin overexpression plays a pivotal role in neuroprotection through mitochondrial raft-like microdomains in neuroblastoma SK-N-BE2 cells.Mol Cell Neurosci. 2018 Apr;88:167-176. doi: 10.1016/j.mcn.2018.01.007. Epub 2018 Jan 31.
857 NHLH2: at the intersection of obesity and fertility.Trends Endocrinol Metab. 2013 Aug;24(8):385-90. doi: 10.1016/j.tem.2013.04.003. Epub 2013 May 17.
858 High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma.PLoS One. 2013 Oct 25;8(10):e78481. doi: 10.1371/journal.pone.0078481. eCollection 2013.
859 NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway.Eur J Pharmacol. 2019 Aug 15;857:172423. doi: 10.1016/j.ejphar.2019.172423. Epub 2019 May 28.
860 microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.Clin Cancer Res. 2017 Jun 1;23(11):2905-2918. doi: 10.1158/1078-0432.CCR-16-1591. Epub 2016 Dec 21.
861 Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.Genomics. 2006 Apr;87(4):483-9. doi: 10.1016/j.ygeno.2005.11.004. Epub 2006 Jan 25.
862 DR-nm23 gene expression in neuroblastoma cells: relationship to integrin expression, adhesion characteristics, and differentiation.J Natl Cancer Inst. 1997 Sep 3;89(17):1300-10. doi: 10.1093/jnci/89.17.1300.
863 Acetylation of NDPK-D Regulates Its Subcellular Localization and Cell Survival.PLoS One. 2015 Oct 1;10(10):e0139616. doi: 10.1371/journal.pone.0139616. eCollection 2015.
864 A new potent analgesic agent with reduced liability to produce morphine tolerance.Brain Res Bull. 2015 Aug;117:32-8. doi: 10.1016/j.brainresbull.2015.07.005. Epub 2015 Jul 30.
865 Stimulation of adenosine A2A receptors reduces intracellular cholesterol accumulation and rescues mitochondrial abnormalities in human neural cell models of Niemann-Pick C1.Neuropharmacology. 2016 Apr;103:155-62. doi: 10.1016/j.neuropharm.2015.11.022. Epub 2015 Nov 26.
866 Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.J Neurosci Res. 2002 Sep 1;69(5):642-52. doi: 10.1002/jnr.10330.
867 CRHR1 Mediates the Up-Regulation of Synapsin I Induced by Nesfatin-1 Through ERK 1/2 Signaling in SH-SY5Y Cells.Cell Mol Neurobiol. 2018 Apr;38(3):627-633. doi: 10.1007/s10571-017-0509-x. Epub 2017 Jun 12.
868 Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review.Oncol Lett. 2017 May;13(5):3066-3070. doi: 10.3892/ol.2017.5823. Epub 2017 Mar 7.
869 The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.Int J Cancer. 2010 May 1;126(9):2012-24. doi: 10.1002/ijc.25074.
870 Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.J Neurosci Res. 2018 Mar;96(3):407-415. doi: 10.1002/jnr.24143. Epub 2017 Aug 26.
871 Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.Oncotarget. 2016 Apr 26;7(17):24018-26. doi: 10.18632/oncotarget.8116.
872 Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models.PLoS One. 2018 Mar 9;13(3):e0192028. doi: 10.1371/journal.pone.0192028. eCollection 2018.
873 The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome.BMC Neurosci. 2011 Aug 8;12:81. doi: 10.1186/1471-2202-12-81.
874 Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.Nat Commun. 2018 Dec 14;9(1):5331. doi: 10.1038/s41467-018-07580-5.
875 The protein l-isoaspartyl (d-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells.Neuroscience. 2015 Jun 4;295:139-50. doi: 10.1016/j.neuroscience.2015.03.026. Epub 2015 Mar 20.
876 Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology.Brain Res. 2004 Oct 1;1022(1-2):164-72. doi: 10.1016/j.brainres.2004.07.026.
877 Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity.Biochimie. 2018 Apr;147:122-129. doi: 10.1016/j.biochi.2018.01.008. Epub 2018 Feb 6.
878 ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.Exp Neurol. 2014 Nov;261:217-29. doi: 10.1016/j.expneurol.2014.05.024. Epub 2014 Jun 4.
879 Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.Cancer Sci. 2015 Mar;106(3):237-43. doi: 10.1111/cas.12598. Epub 2015 Feb 4.
880 Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.Clin Cancer Res. 2000 Feb;6(2):551-8.
881 PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.J Mol Cell Biol. 2018 Apr 1;10(2):147-160. doi: 10.1093/jmcb/mjy007.
882 RNA Interference Silencing of Glycogen Synthase Kinase 3 Inhibites Tau Phosphorylation in Mice with Alzheimer Disease.Neurochem Res. 2016 Sep;41(9):2470-80. doi: 10.1007/s11064-016-1960-7. Epub 2016 Jun 2.
883 Downregulation of the PHLDA1 gene in IMR-32 neuroblastoma cells increases levels of AuroraA, TRKB and affects proteins involved in apoptosis and autophagy pathways.Int J Oncol. 2016 Aug;49(2):823-37. doi: 10.3892/ijo.2016.3572. Epub 2016 Jun 8.
884 PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.Exp Cell Res. 2016 Mar 1;342(1):62-71. doi: 10.1016/j.yexcr.2016.02.014. Epub 2016 Feb 19.
885 Intersectin 1 is required for neuroblastoma tumorigenesis.Oncogene. 2012 Nov 15;31(46):4828-34. doi: 10.1038/onc.2011.643. Epub 2012 Jan 23.
886 Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex.PLoS One. 2017 May 9;12(5):e0177046. doi: 10.1371/journal.pone.0177046. eCollection 2017.
887 PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications.Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):124-9. doi: 10.1002/ajmg.b.30785.
888 Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson's disease.J Mol Neurosci. 2013 Nov;51(3):863-70. doi: 10.1007/s12031-013-0075-8. Epub 2013 Jul 31.
889 Assessing LINE-1 retrotransposition activity in neuroblastoma cells exposed to extremely low-frequency pulsed magnetic fields.Mutat Res. 2012 Dec 12;749(1-2):76-81. doi: 10.1016/j.mrgentox.2012.07.004. Epub 2012 Sep 7.
890 Retinoblastoma-related protein pRb2/p130 and its binding to the B-myb promoter increase during human neuroblastoma differentiation.J Cell Biochem. 1997 Dec 1;67(3):297-303.
891 Suppression of RIZ in biologically unfavourable neuroblastomas.Int J Oncol. 2010 Nov;37(5):1323-30. doi: 10.3892/ijo_00000784.
892 The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.J Mol Neurosci. 2009 Feb;37(2):135-45. doi: 10.1007/s12031-008-9139-6. Epub 2008 Aug 27.
893 A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.Cancer Res. 2011 Jan 15;71(2):404-12. doi: 10.1158/0008-5472.CAN-10-2627. Epub 2010 Dec 1.
894 Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+.Neurosci Lett. 2008 Mar 15;433(3):219-24. doi: 10.1016/j.neulet.2007.12.068. Epub 2008 Jan 17.
895 Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells.Methods Mol Biol. 2012;839:173-85. doi: 10.1007/978-1-61779-510-7_14.
896 Regulatory effects of the long noncoding RNA RP11?43N12.1 and microRNA?24?p axis on the neuronal apoptosis induced by the inflammatory reactions of microglia.Int J Mol Med. 2018 Sep;42(3):1741-1755. doi: 10.3892/ijmm.2018.3736. Epub 2018 Jun 20.
897 Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation.Cells. 2019 Aug 22;8(9):955. doi: 10.3390/cells8090955.
898 Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.BMC Cancer. 2019 Jun 6;19(1):542. doi: 10.1186/s12885-019-5772-4.
899 Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.Mol Autism. 2018 Nov 6;9:56. doi: 10.1186/s13229-018-0239-z. eCollection 2018.
900 Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.Genome Med. 2017 Nov 29;9(1):100. doi: 10.1186/s13073-017-0486-1.
901 Rab15 alternative splicing is altered in spheres of neuroblastoma cells.Oncol Rep. 2012 Jun;27(6):2045-9. doi: 10.3892/or.2012.1731. Epub 2012 Mar 15.
902 C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.Brain. 2017 Apr 1;140(4):887-897. doi: 10.1093/brain/awx024.
903 Expression of co-factors (SMRT and Trip-1) for retinoic acid receptors in human neuroectodermal cell lines.Biochem Biophys Res Commun. 1997 May 8;234(1):278-82. doi: 10.1006/bbrc.1997.6626.
904 New 2-Oxoindolin Phosphonates as Novel Agents to Treat Cancer: A Green Synthesis and Molecular Modeling.Molecules. 2018 Aug 8;23(8):1981. doi: 10.3390/molecules23081981.
905 A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma.Int J Cancer. 2014 Mar 15;134(6):1335-45. doi: 10.1002/ijc.28463. Epub 2013 Sep 14.
906 Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes.BMC Cancer. 2015 Jul 10;15:514. doi: 10.1186/s12885-015-1463-y.
907 Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells.Biochim Biophys Acta. 2011 Mar;1813(3):456-65. doi: 10.1016/j.bbamcr.2011.01.004. Epub 2011 Jan 9.
908 The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma.Mol Cancer. 2012 Jun 13;11:40. doi: 10.1186/1476-4598-11-40.
909 RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.Mol Cell Biochem. 2018 Sep;446(1-2):1-9. doi: 10.1007/s11010-017-3267-7. Epub 2018 Jan 2.
910 Garlic-derived diallyl disulfide modulates peroxisome proliferator activated receptor gamma co-activator 1 alpha in neuroblastoma cells.Biochem Pharmacol. 2013 Feb 1;85(3):335-44. doi: 10.1016/j.bcp.2012.11.007. Epub 2012 Nov 23.
911 Regulatory factor X1-induced down-regulation of transforming growth factor 2 transcription in human neuroblastoma cells.J Biol Chem. 2012 Jun 29;287(27):22730-9. doi: 10.1074/jbc.M111.338590. Epub 2012 May 11.
912 Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus.PLoS One. 2017 Sep 21;12(9):e0184497. doi: 10.1371/journal.pone.0184497. eCollection 2017.
913 Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.Clin Cancer Res. 2013 Sep 15;19(18):5092-103. doi: 10.1158/1078-0432.CCR-12-2211. Epub 2013 Jul 17.
914 Focal DNA copy number changes in neuroblastoma target MYCN regulated genes.PLoS One. 2013;8(1):e52321. doi: 10.1371/journal.pone.0052321. Epub 2013 Jan 4.
915 Identification and characterisation of STMN4 and ROBO2 gene involvement in neuroblastoma cell differentiation.Cancer Lett. 2013 Jan 1;328(1):168-75. doi: 10.1016/j.canlet.2012.08.015. Epub 2012 Aug 17.
916 RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions.J Virol. 2018 Feb 26;92(6):e01914-17. doi: 10.1128/JVI.01914-17. Print 2018 Mar 15.
917 Amyloid production is regulated by 2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.J Biol Chem. 2017 Jun 16;292(24):10153-10168. doi: 10.1074/jbc.M116.743070. Epub 2017 May 5.
918 A-affected pathogenic induction of S-nitrosylation of OGT and identification of Cys-NO linkage triplet.Biochim Biophys Acta. 2016 May;1864(5):609-21. doi: 10.1016/j.bbapap.2016.02.003. Epub 2016 Feb 5.
919 Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells.Cell Death Differ. 2008 May;15(5):879-88. doi: 10.1038/cdd.2008.8. Epub 2008 Feb 1.
920 Valproate robustly enhances AP-1 mediated gene expression.Brain Res Mol Brain Res. 1999 Jan 22;64(1):52-8. doi: 10.1016/s0169-328x(98)00303-9.
921 Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.Biochem Biophys Res Commun. 2017 Apr 29;486(2):444-450. doi: 10.1016/j.bbrc.2017.03.060. Epub 2017 Mar 16.
922 Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2.Sci Rep. 2018 Oct 5;8(1):14891. doi: 10.1038/s41598-018-33143-1.
923 miR-1303 promotes the proliferation of neuroblastoma cell SH-SY5Y by targeting GSK3 and SFRP1.Biomed Pharmacother. 2016 Oct;83:508-513. doi: 10.1016/j.biopha.2016.07.010. Epub 2016 Jul 18.
924 Circulating SH2B1 is associated with an increased risk of gastric cancer.Oncol Lett. 2018 May;15(5):7305-7311. doi: 10.3892/ol.2018.8196. Epub 2018 Mar 7.
925 Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.J Biol Chem. 2014 Dec 19;289(51):35397-408. doi: 10.1074/jbc.M114.615112. Epub 2014 Oct 20.
926 Serine catabolism regulates mitochondrial redox control during hypoxia.Cancer Discov. 2014 Dec;4(12):1406-17. doi: 10.1158/2159-8290.CD-14-0250. Epub 2014 Sep 3.
927 ARID1A-SIN3A drives retinoic acid-induced neuroblastoma differentiation by transcriptional repression of TERT.Mol Carcinog. 2019 Nov;58(11):1998-2007. doi: 10.1002/mc.23091. Epub 2019 Jul 31.
928 Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage.Cancer Manag Res. 2018 Nov 9;10:5591-5603. doi: 10.2147/CMAR.S172509. eCollection 2018.
929 A cullin-RING ubiquitin ligase targets exogenous -synuclein and inhibits Lewy body-like pathology.Sci Transl Med. 2019 Jun 5;11(495):eaau6722. doi: 10.1126/scitranslmed.aau6722.
930 Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells.Oncotarget. 2016 May 31;7(22):33220-8. doi: 10.18632/oncotarget.8903.
931 Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins.RNA Biol. 2014;11(11):1430-46. doi: 10.1080/15476286.2014.996494.
932 SOD3 Ameliorates A(25-35)-Induced Oxidative Damage in SH-SY5Y Cells by Inhibiting the Mitochondrial Pathway.Cell Mol Neurobiol. 2017 Apr;37(3):513-525. doi: 10.1007/s10571-016-0390-z. Epub 2016 Jun 7.
933 Nrf2-regulated miR-380-3p Blocks the Translation of Sp3 Protein and Its Mediation of Paraquat-Induced Toxicity in Mouse Neuroblastoma N2a Cells.Toxicol Sci. 2019 Oct 1;171(2):515-529. doi: 10.1093/toxsci/kfz162.
934 The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.PLoS One. 2013;8(3):e57865. doi: 10.1371/journal.pone.0057865. Epub 2013 Mar 7.
935 Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus.PLoS Pathog. 2011 Jul;7(7):e1002127. doi: 10.1371/journal.ppat.1002127. Epub 2011 Jul 14.
936 Time-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdown.PLoS One. 2012;7(12):e50988. doi: 10.1371/journal.pone.0050988. Epub 2012 Dec 12.
937 Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene.BMC Med Genet. 2013 Oct 2;14:102. doi: 10.1186/1471-2350-14-102.
938 Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression.Cell Death Differ. 2018 Feb;25(2):432-443. doi: 10.1038/cdd.2017.182. Epub 2017 Nov 3.
939 Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington's Disease.Front Cell Neurosci. 2018 Oct 26;12:381. doi: 10.3389/fncel.2018.00381. eCollection 2018.
940 STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin.J Biol Chem. 2012 Aug 24;287(35):29285-9. doi: 10.1074/jbc.C112.345397. Epub 2012 Jul 10.
941 CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.J Clin Invest. 2018 Jan 2;128(1):446-462. doi: 10.1172/JCI90793. Epub 2017 Dec 4.
942 Schwann cells protect against CaMKII- and PKA-dependent Acrylamide-induced Synapsin I phosphorylation.Brain Res. 2018 Dec 15;1701:18-27. doi: 10.1016/j.brainres.2018.07.019. Epub 2018 Jul 17.
943 Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes.Hum Mol Genet. 2012 Jul 15;21(14):3156-72. doi: 10.1093/hmg/dds142. Epub 2012 Apr 17.
944 Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours.BMC Cancer. 2019 Oct 21;19(1):970. doi: 10.1186/s12885-019-6149-4.
945 Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.J Cell Biochem. 2008 Oct 1;105(2):414-23. doi: 10.1002/jcb.21837.
946 Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.PLoS One. 2017 May 3;12(5):e0176851. doi: 10.1371/journal.pone.0176851. eCollection 2017.
947 Matrine Inhibits Neuroblastoma Cell Proliferation and Migration by Enhancing Tribbles 3 Expression.Oncol Res. 2018 Aug 23;26(7):1133-1142. doi: 10.3727/096504018X15168461629558. Epub 2018 Jan 31.
948 Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.Cancer Discov. 2018 May;8(5):582-599. doi: 10.1158/2159-8290.CD-16-0861. Epub 2018 Mar 6.
949 Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma.Mol Oncol. 2016 Feb;10(2):344-59. doi: 10.1016/j.molonc.2015.10.020. Epub 2015 Nov 7.
950 miR-200a inhibits tumor proliferation by targeting AP-2 in neuroblastoma cells.Asian Pac J Cancer Prev. 2014;15(11):4671-6. doi: 10.7314/apjcp.2014.15.11.4671.
951 Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma.Oncogene. 2018 Oct;37(40):5451-5465. doi: 10.1038/s41388-018-0326-9. Epub 2018 Jun 7.
952 The neuroprotective role of tissue inhibitor of metalloproteinase-2 in MPP+- or 6-OHDA-treated SK-N-BE(2)C and SH-SY5Y human neuroblastoma cells.Neurosci Lett. 2010 Jan 4;468(2):136-40. doi: 10.1016/j.neulet.2009.10.084. Epub 2009 Nov 4.
953 Ginsenoside Rg1 attenuates tau phosphorylation in SK-N-SH induced by A-stimulated THP-1 supernatant and the involvement of p38 pathway activation.Life Sci. 2012 Oct 22;91(15-16):809-15. doi: 10.1016/j.lfs.2012.08.028. Epub 2012 Sep 6.
954 Favorable prognostic role of tropomodulins in neuroblastoma.Oncotarget. 2018 Jun 5;9(43):27092-27103. doi: 10.18632/oncotarget.25491. eCollection 2018 Jun 5.
955 TIPE? suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3kinase/AKT signaling pathway.Mol Med Rep. 2018 May;17(5):7017-7026. doi: 10.3892/mmr.2018.8789. Epub 2018 Mar 20.
956 All-Trans-Retinoic Acid Stimulates Overexpression of Tumor Protein D52 (TPD52, Isoform 3) and Neuronal Differentiation of IMR-32 Cells.J Cell Biochem. 2017 Dec;118(12):4358-4369. doi: 10.1002/jcb.26090. Epub 2017 May 8.
957 Methylglyoxal produced by amyloid- peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.J Alzheimers Dis. 2014;41(1):273-88. doi: 10.3233/JAD-131685.
958 Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma.Drug Des Devel Ther. 2018 Oct 23;12:3549-3561. doi: 10.2147/DDDT.S147384. eCollection 2018.
959 A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma.Cancer Res. 2019 Dec 15;79(24):6166-6177. doi: 10.1158/0008-5472.CAN-19-0008. Epub 2019 Oct 15.
960 Inhibition of neuroblastoma cell growth by TREX1-mutated human lymphocytes.Oncol Rep. 2012 May;27(5):1689-94. doi: 10.3892/or.2012.1696. Epub 2012 Feb 22.
961 TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons.Mol Neurobiol. 2019 Apr;56(4):2640-2652. doi: 10.1007/s12035-018-1238-y. Epub 2018 Jul 26.
962 Carvacrol Depends on Heme Oxygenase-1 (HO-1) to Exert Antioxidant, Anti-inflammatory, and Mitochondria-Related Protection in the Human Neuroblastoma SH-SY5Y Cells Line Exposed to Hydrogen Peroxide.Neurochem Res. 2019 Apr;44(4):884-896. doi: 10.1007/s11064-019-02724-5. Epub 2019 Jan 16.
963 Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.Cell Death Differ. 2019 Jul;26(7):1346-1364. doi: 10.1038/s41418-018-0220-6. Epub 2018 Oct 19.
964 PPP3CB contributes to poor prognosis through activating nuclear factor of activated T-cells signaling in neuroblastoma.Mol Carcinog. 2019 Mar;58(3):426-435. doi: 10.1002/mc.22939. Epub 2018 Dec 13.
965 Identification of -N-catenin as a novel tumor suppressor in neuroblastoma.Oncotarget. 2019 Aug 20;10(49):5028-5040. doi: 10.18632/oncotarget.27096. eCollection 2019 Aug 20.
966 The testosterone metabolite 3-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism.Neurosci Lett. 2019 Mar 23;696:60-66. doi: 10.1016/j.neulet.2018.12.012. Epub 2018 Dec 12.
967 ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State.Mol Cancer Res. 2020 Jan;18(1):68-78. doi: 10.1158/1541-7786.MCR-19-0187. Epub 2019 Oct 17.
968 Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients.Genes Chromosomes Cancer. 2020 May;59(5):277-285. doi: 10.1002/gcc.22827. Epub 2019 Dec 3.
969 Effects of GADL1 overexpression on cell migration and the associated morphological changes.Sci Rep. 2019 Mar 28;9(1):5298. doi: 10.1038/s41598-019-41689-x.
970 The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells.J Cell Physiol. 2018 May;233(5):4282-4293. doi: 10.1002/jcp.26247. Epub 2017 Nov 24.
971 GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.Biochem Biophys Res Commun. 2019 Mar 12;510(3):339-344. doi: 10.1016/j.bbrc.2018.12.169. Epub 2019 Feb 2.
972 Krppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway.Pediatr Blood Cancer. 2020 Mar;67(3):e28108. doi: 10.1002/pbc.28108. Epub 2019 Nov 29.
973 New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma.Cancer Lett. 2019 Apr 1;446:90-102. doi: 10.1016/j.canlet.2019.01.014. Epub 2019 Jan 19.
974 LIN28B increases neural crest cell migration and leads to transformation of trunk sympathoadrenal precursors.Cell Death Differ. 2020 Apr;27(4):1225-1242. doi: 10.1038/s41418-019-0425-3. Epub 2019 Oct 10.
975 FGF represses metastasis of neuroblastoma regulated by MYCN and TGF-1 induced LMO1 via control of let-7 expression.Brain Res. 2019 Feb 1;1704:219-228. doi: 10.1016/j.brainres.2018.10.015. Epub 2018 Oct 12.
976 RNA-Binding Proteomics Reveals MATR3 Interacting with lncRNA SNHG1 To Enhance Neuroblastoma Progression.J Proteome Res. 2019 Jan 4;18(1):406-416. doi: 10.1021/acs.jproteome.8b00693. Epub 2018 Dec 14.
977 High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells.Oxid Med Cell Longev. 2019 Feb 18;2019:7192798. doi: 10.1155/2019/7192798. eCollection 2019.
978 PRIMA-1(MET)-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level.J Exp Clin Cancer Res. 2019 Feb 12;38(1):69. doi: 10.1186/s13046-019-1066-6.
979 The activity of the Striatal-enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A(2A) receptor.J Neurochem. 2020 Feb;152(3):284-298. doi: 10.1111/jnc.14866. Epub 2019 Oct 10.
980 RDM1 promotes neuroblastoma growth through the RAS-Raf-MEK-ERK pathway.FEBS Open Bio. 2019 Jan 28;9(3):490-497. doi: 10.1002/2211-5463.12586. eCollection 2019 Mar.
981 Role of SNHG7-miR-653-5p-STAT2 feedback loop in regulating neuroblastoma progression.J Cell Physiol. 2019 Aug;234(8):13403-13412. doi: 10.1002/jcp.28017. Epub 2019 Jan 8.
982 Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model.J Cell Mol Med. 2019 Feb;23(2):1086-1094. doi: 10.1111/jcmm.14009. Epub 2018 Nov 19.
983 Integrated olfaction, gustation and toxicity detection by a versatile bioengineered cell-based biomimetic sensor.Bioelectrochemistry. 2019 Aug;128:1-8. doi: 10.1016/j.bioelechem.2019.02.009. Epub 2019 Feb 21.
984 Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes Associated with Cellular Morphology and Cytoskeleton Dynamics and Is Required for Neurite Outgrowth in Neuroblastoma Cells and Primary Neuronal Cultures.Mol Neurobiol. 2017 Dec;54(10):7808-7823. doi: 10.1007/s12035-016-0284-6. Epub 2016 Nov 14.
985 Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway.Oncol Rep. 2019 Jan;41(1):103-112. doi: 10.3892/or.2018.6796. Epub 2018 Oct 16.
986 Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.Biochem Biophys Res Commun. 2005 Sep 2;334(3):875-83. doi: 10.1016/j.bbrc.2005.06.176.
987 Characterization of a specific interaction between ADAM23 and cellular prion protein.Neurosci Lett. 2009 Sep 11;461(1):16-20. doi: 10.1016/j.neulet.2009.05.049. Epub 2009 May 27.
988 Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.BMC Cancer. 2010 Nov 30;10:657. doi: 10.1186/1471-2407-10-657.
989 The transcription of the human fructose-bisphosphate aldolase C gene is activated by nerve-growth-factor-induced B factor in human neuroblastoma cells.Biochem J. 1997 Apr 1;323 ( Pt 1)(Pt 1):245-50. doi: 10.1042/bj3230245.
990 Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma.Genes Chromosomes Cancer. 2002 Mar;33(3):285-94. doi: 10.1002/gcc.10030.
991 In-situ cytidine-deaminase activity and chromosome 1P deletion in human neuroblastoma cells.Anticancer Res. 1997 Jan-Feb;17(1A):457-9.
992 HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway.J Neurochem. 2004 Nov;91(3):613-22. doi: 10.1111/j.1471-4159.2004.02754.x.
993 Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.J Comp Neurol. 2006 Jan 20;494(3):476-84. doi: 10.1002/cne.20806.
994 Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.Mol Biol Cell. 2010 Oct 15;21(20):3590-600. doi: 10.1091/mbc.E10-02-0095. Epub 2010 Sep 1.
995 ARID1B alterations identify aggressive tumors in neuroblastoma.Oncotarget. 2017 Jul 11;8(28):45943-45950. doi: 10.18632/oncotarget.17500.
996 Differential expression of ARID3B in normal adult tissue and carcinomas.Gene. 2014 Jun 10;543(1):174-80. doi: 10.1016/j.gene.2014.04.007. Epub 2014 Apr 3.
997 Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression.Gastroenterology. 2011 Feb;140(2):572-582.e2. doi: 10.1053/j.gastro.2010.10.044. Epub 2010 Oct 25.
998 Identification and characterization of ASXL3 gene in silico.Int J Oncol. 2004 Jun;24(6):1617-22.
999 The promoter of human acetylcholinesterase is activated by a cyclic adenosine 3',5'-monophosphate-dependent pathway in cultured NG108-15 neuroblastoma cells.Neurosci Lett. 2000 Jul 7;288(1):81-5. doi: 10.1016/s0304-3940(00)01200-3.
1000 The transcription factor ATF5: role in neurodevelopment and neural tumors.J Neurochem. 2009 Jan;108(1):11-22. doi: 10.1111/j.1471-4159.2008.05749.x. Epub 2008 Nov 15.
1001 Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells.Exp Cell Res. 2006 Jul 15;312(12):2264-78. doi: 10.1016/j.yexcr.2006.03.018. Epub 2006 Apr 24.
1002 Sensitive Ewing sarcoma and neuroblastoma cell lines have increased levels of BAD expression and decreased levels of BAR expression compared to resistant cell lines.Cancer Lett. 2007 Mar 8;247(1):110-4. doi: 10.1016/j.canlet.2006.03.033. Epub 2006 May 11.
1003 Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.Oncogene. 2008 Feb 28;27(10):1439-48. doi: 10.1038/sj.onc.1210770. Epub 2007 Sep 10.
1004 CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene.J Biol Chem. 2006 Oct 27;281(43):32272-83. doi: 10.1074/jbc.M602776200. Epub 2006 Sep 1.
1005 Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. J Toxicol Environ Health A. 2008;71(22):1457-67. doi: 10.1080/15287390802329364.
1006 Intact or broken-apart RNA: an alternative concept for ALK fusion screening in non-small cell lung cancer (NSCLC).Appl Immunohistochem Mol Morphol. 2015 Jan;23(1):60-70. doi: 10.1097/PAI.0000000000000028.
1007 Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas.Oncogene. 2006 Mar 23;25(13):1931-42. doi: 10.1038/sj.onc.1209225.
1008 DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation.Biochem Biophys Res Commun. 1999 Jul 14;260(3):785-9. doi: 10.1006/bbrc.1999.0986.
1009 A requirement for the POU transcription factor, Brn-2, in corticotropin-releasing hormone expression in a neuronal cell line.Mol Endocrinol. 1999 Aug;13(8):1237-48. doi: 10.1210/mend.13.8.0327.
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1011 Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.J Neuroimmunol. 2008 Dec 15;205(1-2):86-93. doi: 10.1016/j.jneuroim.2008.09.012. Epub 2008 Oct 22.
1012 Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects.Oncogene. 2010 Nov 4;29(44):5957-68. doi: 10.1038/onc.2010.332. Epub 2010 Aug 9.
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1014 Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.J Clin Invest. 2009 Jun;119(6):1524-36. doi: 10.1172/JCI37869.
1015 Cdc6 knockdown inhibits human neuroblastoma cell proliferation.Mol Cell Biochem. 2008 Apr;311(1-2):189-97. doi: 10.1007/s11010-008-9709-5. Epub 2008 Feb 8.
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1018 Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors.Cytogenet Cell Genet. 2000;89(1-2):62-6. doi: 10.1159/000015566.
1019 DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.Mol Cell Biol. 2000 Dec;20(24):9120-6. doi: 10.1128/MCB.20.24.9120-9126.2000.
1020 Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models.Clin Cancer Res. 2003 Oct 1;9(12):4595-605.
1021 Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2.Oncogene. 2003 Apr 17;22(15):2343-51. doi: 10.1038/sj.onc.1206324.
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1024 DAP-5 is involved in MycN/IFNgamma-induced apoptosis in human neuroblastoma cells.Cancer Lett. 2001 Jan 26;162(2):237-43. doi: 10.1016/s0304-3835(00)00644-3.
1025 ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis.J Biol Chem. 2009 Mar 6;284(10):6282-90. doi: 10.1074/jbc.M806189200. Epub 2009 Jan 4.
1026 Involvement of GTA protein NC2beta in neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation.Mol Cancer. 2008 Jun 6;7:52. doi: 10.1186/1476-4598-7-52.
1027 Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology.Eur J Cancer. 2005 Mar;41(4):635-46. doi: 10.1016/j.ejca.2004.12.021.
1028 Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression.BMC Cancer. 2004 Nov 15;4:80. doi: 10.1186/1471-2407-4-80.
1029 High expression of the novel endothelin-converting enzyme genes, Nbla03145/ECEL1alpha and beta, is associated with favorable prognosis in human neuroblastomas.Int J Oncol. 2003 Apr;22(4):815-22.
1030 Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas.Eur J Clin Invest. 2001 Oct;31(10):907-14. doi: 10.1046/j.1365-2362.2001.00892.x.
1031 Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. Br J Cancer. 2007 Nov 19;97(10):1416-24. doi: 10.1038/sj.bjc.6604032. Epub 2007 Oct 16.
1032 Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.J Biol Chem. 1999 May 14;274(20):13818-23. doi: 10.1074/jbc.274.20.13818.
1033 Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter.Brain Res Mol Brain Res. 2003 May 12;113(1-2):57-66. doi: 10.1016/s0169-328x(03)00090-1.
1034 Two transcription factors, E1AF and N-myc, correlate with the invasiveness of neuroblastoma cell lines.Jpn J Cancer Res. 1997 Apr;88(4):394-400. doi: 10.1111/j.1349-7006.1997.tb00395.x.
1035 The NBPF1 promoter has been recruited from the unrelated EVI5 gene before simian radiation.Mol Biol Evol. 2009 Jun;26(6):1321-32. doi: 10.1093/molbev/msp047. Epub 2009 Mar 12.
1036 Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study.J Pediatr Hematol Oncol. 2000 May-Jun;22(3):197-205. doi: 10.1097/00043426-200005000-00003.
1037 Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells.Eur Neuropsychopharmacol. 2009 May;19(5):356-62. doi: 10.1016/j.euroneuro.2008.12.012. Epub 2009 Feb 3.
1038 Anaplastic large cell neuroblastoma.Pediatr Dev Pathol. 2009 Jan-Feb;12(1):1-5. doi: 10.2350/07-04-0255.1.
1039 Flt-3 and its ligand are expressed in neural crest-derived tumors and promote survival and proliferation of their cell lines.Lab Invest. 2001 Jul;81(7):1025-37. doi: 10.1038/labinvest.3780314.
1040 FMRP RNA targets: identification and validation.Genes Brain Behav. 2005 Aug;4(6):341-9. doi: 10.1111/j.1601-183X.2005.00144.x.
1041 The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.Oncogene. 2009 Jun 11;28(23):2245-56. doi: 10.1038/onc.2009.80. Epub 2009 May 4.
1042 Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.Free Radic Biol Med. 2001 Jan 15;30(2):213-21. doi: 10.1016/s0891-5849(00)00461-5.
1043 Gas1 is induced during and participates in excitotoxic neuronal death.Mol Cell Neurosci. 2002 Mar;19(3):417-29. doi: 10.1006/mcne.2001.1092.
1044 Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif.J Hum Genet. 1998;43(4):272-4. doi: 10.1007/s100380050088.
1045 GMEB1, a novel endogenous caspase inhibitor, prevents hypoxia- and oxidative stress-induced neuronal apoptosis.Neurosci Lett. 2008 Jun 13;438(1):34-7. doi: 10.1016/j.neulet.2008.04.023. Epub 2008 Apr 11.
1046 Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype.PLoS One. 2010 Sep 17;5(9):e12825. doi: 10.1371/journal.pone.0012825.
1047 Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells.Mol Genet Metab. 1998 Oct;65(2):155-64. doi: 10.1006/mgme.1998.2747.
1048 HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells.J Cell Mol Med. 2007 Mar-Apr;11(2):299-306. doi: 10.1111/j.1582-4934.2007.00020.x.
1049 Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.Oncogene. 2014 Jun 19;33(25):3316-24. doi: 10.1038/onc.2013.290. Epub 2013 Jul 22.
1050 Retinoic acid stimulates IGF binding protein (IGFBP)-6 and depresses IGFBP-2 and IGFBP-4 in SK-N-SH human neuroblastoma cells.J Endocrinol. 1998 Nov;159(2):227-32. doi: 10.1677/joe.0.1590227.
1051 Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells.J Biol Chem. 2004 Jun 18;279(25):26789-96. doi: 10.1074/jbc.M401517200. Epub 2004 Apr 15.
1052 A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.Appl Immunohistochem Mol Morphol. 2008 Jul;16(4):344-8. doi: 10.1097/PAI.0b013e318165fe78.
1053 ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.Nat Commun. 2019 Dec 9;10(1):5622. doi: 10.1038/s41467-019-13515-5.
1054 Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.J Neurochem. 2001 May;77(3):741-53. doi: 10.1046/j.1471-4159.2001.00277.x.
1055 KBP-cytoskeleton interactions underlie developmental anomalies in Goldberg-Shprintzen syndrome.Hum Mol Genet. 2013 Jun 15;22(12):2387-99. doi: 10.1093/hmg/ddt083. Epub 2013 Feb 19.
1056 Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells.Oncogene. 2003 Sep 18;22(40):6277-88. doi: 10.1038/sj.onc.1206631.
1057 LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies.J Cell Mol Med. 2020 Jan;24(2):1160-1168. doi: 10.1111/jcmm.14836. Epub 2019 Dec 12.
1058 Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.FEBS Lett. 2008 Aug 20;582(19):2826-32. doi: 10.1016/j.febslet.2008.07.021. Epub 2008 Jul 24.
1059 High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis.FEBS Lett. 2006 Jan 23;580(2):627-32. doi: 10.1016/j.febslet.2005.12.089. Epub 2006 Jan 5.
1060 Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk.Nat Commun. 2017 Sep 18;8(1):569. doi: 10.1038/s41467-017-00408-8.
1061 Induction of two DNA mismatch repair proteins, MSH2 and MSH6, in differentiated human neuroblastoma SH-SY5Y cells exposed to doxorubicin.J Neurochem. 1999 Mar;72(3):974-9. doi: 10.1046/j.1471-4159.1999.0720974.x.
1062 Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts.J Biol Chem. 2000 Jun 2;275(22):16560-8. doi: 10.1074/jbc.M001312200.
1063 Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion.Endocrinology. 2005 Oct;146(10):4445-55. doi: 10.1210/en.2005-0467. Epub 2005 Jun 30.
1064 A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3422-7. doi: 10.1073/pnas.052017399.
1065 Human Nck-associated protein 1 and its binding protein affect the metabolism of beta-amyloid precursor protein with Swedish mutation.Neurosci Lett. 2001 Dec 4;316(1):50-4. doi: 10.1016/s0304-3940(01)02370-9.
1066 ERAP140/Nbla10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid.Oncol Rep. 2008 Jun;19(6):1381-8.
1067 Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells.Exp Mol Med. 2002 Dec 31;34(6):469-75. doi: 10.1038/emm.2002.65.
1068 Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury.Transl Res. 2017 May;183:121-136.e9. doi: 10.1016/j.trsl.2016.12.010. Epub 2016 Dec 29.
1069 Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. J Neural Transm (Vienna). 2012 Jan;119(1):17-24.
1070 Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells.Biochem Biophys Res Commun. 2000 Dec 20;279(2):526-33. doi: 10.1006/bbrc.2000.3971.
1071 mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells.Biochim Biophys Acta. 2008 Jun;1780(6):921-6. doi: 10.1016/j.bbagen.2008.02.006. Epub 2008 Mar 4.
1072 Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.Mol Biol Cell. 2006 Nov;17(11):4888-95. doi: 10.1091/mbc.e06-04-0301. Epub 2006 Sep 13.
1073 Two regions of deletion in 9p22- p24 in neuroblastoma are frequently observed in favorable tumors.Cancer Genet Cytogenet. 2002 May;135(1):42-7. doi: 10.1016/s0165-4608(01)00640-9.
1074 Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression.Tissue Antigens. 2001 Feb;57(2):110-7. doi: 10.1034/j.1399-0039.2001.057002110.x.
1075 Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.J Lipid Res. 1999 Dec;40(12):2204-11.
1076 Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.Clin Cancer Res. 2007 Jun 1;13(11):3191-7. doi: 10.1158/1078-0432.CCR-06-2846.
1077 Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties.Mol Cell Biol. 2006 Apr;26(8):3215-30. doi: 10.1128/MCB.26.8.3215-3230.2006.
1078 PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain.Biochim Biophys Acta. 2014 Nov;1839(11):1226-32. doi: 10.1016/j.bbagrm.2014.09.001. Epub 2014 Sep 8.
1079 Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma.J Cell Physiol. 2009 Jun;219(3):707-15. doi: 10.1002/jcp.21719.
1080 Pitx3 promoter directs Cre-recombinase specifically in a human neuroblastoma cell line.Mol Cell Biochem. 2008 Feb;309(1-2):223-7. doi: 10.1007/s11010-007-9655-7. Epub 2007 Nov 30.
1081 The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.Oncogene. 2001 Nov 1;20(50):7307-17. doi: 10.1038/sj.onc.1204921.
1082 Noninvasive monitoring of apoptosis versus necrosis in a neuroblastoma cell line expressing a nuclear pore protein tagged with the green fluorescent protein.Exp Cell Res. 1998 Feb 1;238(2):371-6. doi: 10.1006/excr.1997.3846.
1083 Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb.Exp Cell Res. 2006 Sep 10;312(15):2837-50. doi: 10.1016/j.yexcr.2006.05.022. Epub 2006 Jun 21.
1084 Silencing DJ-1 reveals its contribution in paraquat-induced autophagy.J Neurochem. 2009 May;109(3):889-98. doi: 10.1111/j.1471-4159.2009.06020.x.
1085 Different kinases desensitize the human delta-opioid receptor (hDOP-R) in the neuroblastoma cell line SK-N-BE upon peptidic and alkaloid agonists.Cell Signal. 2008 Jun;20(6):1209-20. doi: 10.1016/j.cellsig.2008.02.010. Epub 2008 Feb 19.
1086 Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines.Oncogene. 2002 Aug 29;21(38):5823-34. doi: 10.1038/sj.onc.1205735.
1087 Expression of the prothymosin alpha mRNA correlated with that of N-myc in neuroblastoma.Cancer Lett. 2001 Jul 26;168(2):191-5. doi: 10.1016/s0304-3835(01)00540-7.
1088 Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus.Int J Oncol. 2012 Sep;41(3):893-902. doi: 10.3892/ijo.2012.1514. Epub 2012 Jun 12.
1089 Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/Quiescin6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells.Cancer Res. 2003 Nov 15;63(22):7742-52.
1090 Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.Oncogene. 2008 May 22;27(23):3339-44. doi: 10.1038/sj.onc.1210987. Epub 2008 Jan 21.
1091 Interaction of receptor-activity-modifying protein1 with tubulin.Biochim Biophys Acta. 2007 Aug;1770(8):1145-50. doi: 10.1016/j.bbagen.2007.04.002. Epub 2007 Apr 11.
1092 The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells.J Neurochem. 2008 Dec;107(5):1424-35. doi: 10.1111/j.1471-4159.2008.05710.x. Epub 2008 Oct 24.
1093 RB2/p130 ectopic gene expression in neuroblastoma stem cells: evidence of cell-fate restriction and induction of differentiation.Biochem J. 2001 Dec 15;360(Pt 3):569-77. doi: 10.1042/0264-6021:3600569.
1094 A culture device demonstrates that hydrostatic pressure increases mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells.Cells Tissues Organs. 2003;174(4):155-61. doi: 10.1159/000072718.
1095 Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma.J Pediatr Surg. 2007 Nov;42(11):1831-40. doi: 10.1016/j.jpedsurg.2007.07.008.
1096 Reliable transcript quantification by real-time reverse transcriptase-polymerase chain reaction in primary neuroblastoma using normalization to averaged expression levels of the control genes HPRT1 and SDHA.J Mol Diagn. 2005 Feb;7(1):89-96. doi: 10.1016/S1525-1578(10)60013-X.
1097 Neuronal cell lines transfected with the dopamine D2 receptor gene promoter as a model for studying the effects of antidepressant drugs.Brain Res Mol Brain Res. 2004 Sep 10;128(1):75-82. doi: 10.1016/j.molbrainres.2004.06.006.
1098 Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system.Neuroscience. 2003;121(4):899-906. doi: 10.1016/s0306-4522(03)00487-1.
1099 Profiling of nuclear extract proteins from human neuroblastoma cell lines: the search for fingerprints.J Pediatr Surg. 2005 Feb;40(2):349-58. doi: 10.1016/j.jpedsurg.2004.10.032.
1100 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
1101 Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?.J Neurol. 2009 Aug;256 Suppl 3:286-92. doi: 10.1007/s00415-009-5246-8.
1102 Markedly induced expression of LR11 in atherosclerosis.J Atheroscler Thromb. 2000;7(1):21-5. doi: 10.5551/jat1994.7.21.
1103 Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.Cancer Sci. 2007 Jun;98(6):815-21. doi: 10.1111/j.1349-7006.2007.00457.x. Epub 2007 Mar 27.
1104 The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.Cell Death Differ. 2020 Feb;27(2):790-807. doi: 10.1038/s41418-019-0386-6. Epub 2019 Jul 8.
1105 SSR2(a) receptor expression and adrenergic/cholinergic characteristics in differentiated SH-SY5Y cells.Neurochem Res. 2003 Apr;28(3-4):449-60. doi: 10.1023/a:1022848718109.
1106 Expression of SSX-2 and SSX-4 genes in neuroblastoma.Int J Biol Markers. 2002 Oct-Dec;17(4):219-23. doi: 10.1177/172460080201700401.
1107 Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.J Natl Cancer Inst. 2007 Jul 18;99(14):1107-19. doi: 10.1093/jnci/djm044. Epub 2007 Jul 10.
1108 Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro.Development. 2002 Oct;129(20):4697-705. doi: 10.1242/dev.129.20.4697.
1109 Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients.Genes Chromosomes Cancer. 2002 Oct;35(2):113-20. doi: 10.1002/gcc.10034.
1110 Specific alternative HOX11 transcripts are expressed in paediatric neural tumours and T-cell acute lymphoblastic leukaemia.Gene. 2003 Dec 24;323:89-99. doi: 10.1016/j.gene.2003.09.001.
1111 Induction of a VLA-2 (CD49b)-expressing effector T cell population by a cell-based neuroblastoma vaccine expressing CD137L.J Immunol. 2008 Oct 1;181(7):4621-31. doi: 10.4049/jimmunol.181.7.4621.
1112 Genes modulated by histone acetylation as new effectors of butyrate activity.FEBS Lett. 2001 Jun 22;499(3):199-204. doi: 10.1016/s0014-5793(01)02539-x.
1113 Expression of prosalusin in human neuroblastoma cells.Peptides. 2009 Jul;30(7):1362-7. doi: 10.1016/j.peptides.2009.03.021. Epub 2009 Apr 9.
1114 Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.Int J Cancer. 2004 Nov 10;112(3):365-75. doi: 10.1002/ijc.20431.
1115 Angiogenesis in a human neuroblastoma xenograft model: mechanisms and inhibition by tumour-derived interferon-gamma.Br J Cancer. 2006 Jun 19;94(12):1845-52. doi: 10.1038/sj.bjc.6603186. Epub 2006 May 23.
1116 Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1.Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2202-2209. doi: 10.1016/j.bbadis.2017.05.015. Epub 2017 May 11.
1117 Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin 1; ADAP1) in neuroblastoma cells.Neurochem Int. 2011 Nov;59(6):936-44. doi: 10.1016/j.neuint.2011.07.004. Epub 2011 Jul 23.
1118 Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.Am J Surg Pathol. 2009 Sep;33(9):1416-20. doi: 10.1097/PAS.0b013e3181a9cd6c.
1119 Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases. FEBS J. 2005 Nov;272(22):5808-20. doi: 10.1111/j.1742-4658.2005.04976.x.
1120 p53 family members regulate the expression of the apolipoprotein D gene.J Biol Chem. 2009 Jan 9;284(2):872-83. doi: 10.1074/jbc.M807185200. Epub 2008 Nov 11.
1121 The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells.Oxid Med Cell Longev. 2017;2017:7984327. doi: 10.1155/2017/7984327. Epub 2017 Feb 6.
1122 ARID1A gene knockdown promotes neuroblastoma migration and invasion.Neoplasma. 2017;64(3):367-376. doi: 10.4149/neo_2017_307.
1123 N-myc suppresses major histocompatibility complex class I gene expression through down-regulation of the p50 subunit of NF-kappa B.EMBO J. 1993 Jan;12(1):195-200. doi: 10.1002/j.1460-2075.1993.tb05645.x.
1124 Second Reported Case of Pediatric Bladder Alveolar Soft Part Sarcoma as Secondary Malignancy After Prior Cytotoxic Chemotherapy.Urology. 2019 Aug;130:148-150. doi: 10.1016/j.urology.2019.04.002. Epub 2019 Apr 12.
1125 Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.Int J Cancer. 2019 Nov 15;145(10):2781-2791. doi: 10.1002/ijc.32361. Epub 2019 May 31.
1126 HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.Mol Neurobiol. 2017 Jan;54(1):188-199. doi: 10.1007/s12035-015-9644-x. Epub 2016 Jan 6.
1127 Bombesin induces angiogenesis and neuroblastoma growth.Cancer Lett. 2007 Aug 18;253(2):273-81. doi: 10.1016/j.canlet.2007.02.007. Epub 2007 Mar 26.
1128 Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer's Disease and Neuronal Cell Death.ACS Chem Neurosci. 2019 Aug 21;10(8):3555-3564. doi: 10.1021/acschemneuro.9b00177. Epub 2019 Jun 12.
1129 Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, "undifferentiated small round cell tumors". A clinicopathologic, immunophenotypic and molecular analysis.Ann Diagn Pathol. 2018 Jun;34:1-12. doi: 10.1016/j.anndiagpath.2017.11.011. Epub 2017 Nov 29.
1130 CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells.Int J Mol Sci. 2019 Jan 1;20(1):131. doi: 10.3390/ijms20010131.
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1133 Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells.J Cell Biochem. 2019 Sep;120(9):15119-15130. doi: 10.1002/jcb.28774. Epub 2019 Apr 25.
1134 The potential role of CAMSAP1L1 in symptomatic epilepsy.Neurosci Lett. 2013 Nov 27;556:146-51. doi: 10.1016/j.neulet.2013.10.020. Epub 2013 Oct 20.
1135 CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.Cancer Res. 2011 Apr 15;71(8):3142-51. doi: 10.1158/0008-5472.CAN-10-3014. Epub 2011 Mar 8.
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1138 Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.Oncogene. 1995 Mar 16;10(6):1087-93.
1139 HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2.J Neurochem. 2019 May;149(3):413-426. doi: 10.1111/jnc.14638. Epub 2019 Jan 4.
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1141 CDCA2 promotes lung adenocarcinoma cell proliferation and predicts poor survival in lung adenocarcinoma patients.Oncotarget. 2017 Mar 21;8(12):19768-19779. doi: 10.18632/oncotarget.15519.
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1143 CCAAT/enhancer binding protein is a transcriptional repressor of -synuclein.Cell Death Differ. 2020 Feb;27(2):509-524. doi: 10.1038/s41418-019-0368-8. Epub 2019 Jun 17.
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1145 Autosomal recessive progressive myoclonus epilepsy due to impaired ceramide synthesis.Epileptic Disord. 2016 Sep 1;18(S2):120-127. doi: 10.1684/epd.2016.0857.
1146 Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.Oncotarget. 2016 Mar 29;7(13):15977-85. doi: 10.18632/oncotarget.7434.
1147 CHL1 gene acts as a tumor suppressor in human neuroblastoma.Oncotarget. 2018 May 25;9(40):25903-25921. doi: 10.18632/oncotarget.25403. eCollection 2018 May 25.
1148 Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model.Clin Cancer Res. 2018 Jun 1;24(11):2585-2593. doi: 10.1158/1078-0432.CCR-17-3811. Epub 2018 Mar 7.
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