Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTM0LL34)

DOT Name Cylicin-1 (CYLC1)
Synonyms Cylicin I; Multiple-band polypeptide I
Gene Name CYLC1
Related Disease
Acute erythroid leukemia ( )
Advanced cancer ( )
Neoplasm ( )
UniProt ID
CYLC1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15241
Sequence
MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTR
HDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKD
EKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSE
TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSE
NSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES
EDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKK
KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQK
DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN
AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG
SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV
PPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL
Function Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
Tissue Specificity Testis.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Acute erythroid leukemia DISZFC1O Strong Biomarker [1]
Advanced cancer DISAT1Z9 Strong Altered Expression [2]
Neoplasm DISZKGEW Strong Altered Expression [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Cylicin-1 (CYLC1). [3]
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1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Cylicin-1 (CYLC1). [4]
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References

1 Cloning of a D-type cyclin from murine erythroleukemia cells.Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2444-7. doi: 10.1073/pnas.89.6.2444.
2 Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms.Oncogene. 1992 Dec;7(12):2381-7.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.