Details of Disease

General Information of Disease (ID: DISZFC1O)

• Disease Name: Acute erythroid leukemia
• Synonyms: acute erythroleukemia; acute erythroleukemia M6b subtype; acute myeloid leukemia FAB-M6; acute myeloid leukaemia FAB-M6; Di Guglielmo's syndrome; AML-M6; acute erythroleukemia M6a subtype; Erythroleukemia; Di Guglielmo syndrome; M6 acute myeloid leukemia; AEL; acute erythroblastic leukemia; acute erythroblastic leukaemia; M6 acute myeloid leukaemia; FAB M6; acute myeloid leukaemia M6; acute erythroid leukemia; AML M6; acute myeloid leukemia M6; erythroblastic leukemia; erythroblastic leukaemia; leukemia, erythroid, malignant
• Definition: An acute myeloid leukemia characterized by a predominant immature erythroid population. There are two subtypes recognized: erythroleukemia and pure erythroid leukemia. (WHO, 2001)
• Disease Hierarchy:
  DIS3I1DX: Erythroid neoplasm
  DIS0BM1I: Acute myeloid leukaemia
  DISZFC1O: Acute erythroid leukemia
• Disease Identifiers:
  MONDO ID: MONDO_0017858
  MESH ID: D004915
  UMLS CUI: C0023440
  MedGen ID: 7316
  Orphanet ID: 318
  SNOMED CT ID: 14317002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 32 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CAD	TT2YT1K	Limited	Biomarker	[1]
CARM1	TTIZQFJ	Limited	Posttranslational Modification	[2]
DHODH	TTLVP78	Limited	Biomarker	[1]
UMPS	TTAFJUD	Limited	Biomarker	[1]
HEXIM1	TTFOKAH	moderate	Altered Expression	[3]
AQP1	TTSF1KH	Strong	Altered Expression	[4]
CNP	TT71P0H	Strong	Altered Expression	[5]
EML4	TT92GY4	Strong	Biomarker	[6]
EPOR	TTAUX24	Strong	Biomarker	[7]
FECH	TTQ6VF4	Strong	Altered Expression	[8]
GP1BA	TTVB0Q9	Strong	Altered Expression	[9]
HBA2	TTQO71U	Strong	Altered Expression	[10]
HBB	TTM6HK1	Strong	Genetic Variation	[11]
HCAR3	TT8WFXV	Strong	Biomarker	[12]
HMOX2	TTWZRL4	Strong	Altered Expression	[13]
IL5RA	TTXH9AD	Strong	Altered Expression	[14]
INHBA	TTVB30D	Strong	Altered Expression	[15]
JAK2	TTRMX3V	Strong	Biomarker	[16]
MAG	TT9XFON	Strong	Biomarker	[5]
NRG1	TTEH395	Strong	Biomarker	[17]
P2RY6	TTNVSKA	Strong	Biomarker	[18]
RARG	TT1Q3IE	Strong	Altered Expression	[19]
RPS6KB2	TTMVQXO	Strong	Biomarker	[20]
S1PR4	TTZ8C5Q	Strong	Altered Expression	[21]
STK38	TT27XFN	Strong	Altered Expression	[22]
TBXA2R	TT2O84V	Strong	Biomarker	[23]
TBXAS1	TTKNWZ4	Strong	Altered Expression	[24]
WWP1	TTBWMKT	Strong	Biomarker	[25]
CR1	TTEA8OW	Definitive	Posttranslational Modification	[26]
FDXR	TT3W4IX	Definitive	Biomarker	[27]
PF4	TTSG7Q5	Definitive	Biomarker	[28]
SRGN	TTCHB06	Definitive	Altered Expression	[29]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A18	DT3VZJO	Strong	Biomarker	[30]
SLC4A1	DTB0Q3P	Strong	Altered Expression	[31]

This Disease Is Related to 5 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CMPK1	DEMPH4I	Strong	Biomarker	[32]
CYP2S1	DE6NMGO	Strong	Altered Expression	[24]
SCLY	DEH4TD6	Strong	Biomarker	[33]
UBASH3B	DE10BJ5	Strong	Biomarker	[20]
ALAS2	DE437BY	Definitive	Altered Expression	[34]

This Disease Is Related to 69 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACSL5	OT3L9XO3	Limited	Genetic Variation	[35]
ACSL6	OT0TT8P8	Limited	Genetic Variation	[35]
NUDC	OT073JKX	Limited	Altered Expression	[36]
GYPA	OTABU4YV	moderate	Biomarker	[37]
HBE1	OTJPKMX4	moderate	Altered Expression	[38]
HBG1	OTVL4NSU	moderate	Altered Expression	[2]
HBG2	OT4J48JJ	moderate	Altered Expression	[2]
ANXA4	OTUCRYXL	Strong	Altered Expression	[39]
CDX4	OTD1SQKM	Strong	Biomarker	[40]
CENPU	OTQ4TZRS	Strong	Biomarker	[41]
CLDN10	OT2CVAKY	Strong	Biomarker	[42]
CNBP	OTTGM9NK	Strong	Altered Expression	[43]
CYLC1	OTM0LL34	Strong	Biomarker	[44]
DERL1	OTJUS74N	Strong	Genetic Variation	[45]
DKC1	OTX7DJR6	Strong	Altered Expression	[37]
E2F4	OTB3JFH4	Strong	Biomarker	[46]
E2F6	OT2PN28R	Strong	Biomarker	[46]
ELF4	OT167PR5	Strong	Biomarker	[47]
FLI1	OT0EV3LX	Strong	Altered Expression	[48]
FLII	OT7G9JG6	Strong	Altered Expression	[48]
FUT8	OTJJCVG1	Strong	Altered Expression	[43]
GAB1	OTQKE6V4	Strong	Genetic Variation	[49]
GATA1	OTX1R7O1	Strong	Altered Expression	[50]
GFI1B	OTRDW8YO	Strong	Altered Expression	[51]
GYPB	OTESHUIX	Strong	Biomarker	[37]
GYPE	OTBHAG6A	Strong	Biomarker	[37]
HBA1	OTW2BQF4	Strong	Altered Expression	[10]
HBD	OTRQG4WA	Strong	Altered Expression	[52]
HBQ1	OTU12ZTW	Strong	Biomarker	[53]
HBZ	OTMHGFSS	Strong	Altered Expression	[54]
HOXC5	OTPQTLKZ	Strong	Altered Expression	[55]
HOXD3	OTBUZ35T	Strong	Altered Expression	[56]
HSF2	OTXNJIJ9	Strong	Biomarker	[57]
ID3	OTUULW5Z	Strong	Altered Expression	[42]
ILF3	OTKMZ5K5	Strong	Altered Expression	[58]
INPPL1	OTCDAVBQ	Strong	Altered Expression	[59]
KRT7	OTLT3JFN	Strong	Biomarker	[33]
LYL1	OTCNOV1M	Strong	Biomarker	[33]
MAFK	OTZJUE4P	Strong	Altered Expression	[60]
ME2	OTO4LL76	Strong	Altered Expression	[61]
MLF1	OTC5BKHU	Strong	Biomarker	[62]
MTUS1	OTBPALMU	Strong	Altered Expression	[43]
NFE2	OTLM94BI	Strong	Biomarker	[63]
NONO	OTN36Q6U	Strong	Biomarker	[64]
NPTN	OTAQKSAU	Strong	Biomarker	[65]
PBX2	OTEBYCAW	Strong	Altered Expression	[66]
PDCD5	OT6T2DDL	Strong	Biomarker	[67]
PEG10	OTWD2278	Strong	Genetic Variation	[68]
PIAS3	OT3TWH9R	Strong	Biomarker	[69]
PRDX3	OTLB2WEU	Strong	Altered Expression	[70]
PSMC5	OTJOORMR	Strong	Biomarker	[71]
PTPMT1	OT9WVC6N	Strong	Altered Expression	[72]
RAB2A	OT6SK83U	Strong	Biomarker	[73]
RAB8A	OTPB54Y3	Strong	Genetic Variation	[74]
RASA3	OT9C54MN	Strong	Biomarker	[75]
RTL1	OTOT33IM	Strong	Genetic Variation	[68]
SETMAR	OTE2MIMZ	Strong	Genetic Variation	[68]
SHMT2	OT5NCAZN	Strong	Biomarker	[37]
SPI1	OTVCA1D0	Strong	Altered Expression	[76]
SPIB	OTO4YKYI	Strong	Altered Expression	[77]
SPTAN1	OT6VY3A3	Strong	Altered Expression	[78]
SRI	OT4R3EAC	Strong	Altered Expression	[70]
TAL1	OTX4K6QZ	Strong	Biomarker	[33]
TFCP2	OTA246TE	Strong	Altered Expression	[79]
TFR2	OTMYCCEO	Strong	Altered Expression	[80]
TRIB2	OTHSX3MX	Strong	Biomarker	[81]
ERVW-1	OTWV8DXJ	Definitive	Biomarker	[82]
HEMGN	OTZPYUOY	Definitive	Altered Expression	[83]
MINDY4	OTBZ2SZB	Definitive	Biomarker	[84]

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