Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVEH7V5)

• DOT Name: LRP2-binding protein (LRP2BP)
• Synonyms: Megalin-binding protein; MegBP
• Gene Name: LRP2BP
• Related Disease:
  Arteriosclerosis
  Atherosclerosis
  Autism spectrum disorder
  Asthma
  Intellectual disability
  Schizophrenia
  facioscapulohumeral muscular dystrophy
• UniProt ID: LR2BP_HUMAN
• Pfam ID: PF08238
• Sequence:
  MKLTSEKLPKNPFYASVSQYAAKNQKFFQWKKEKTDYTHANLVDKALQLLKERILKGDTL
  AYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKI
  LDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLG
  LYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAER
  GNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFIGRGMAMAS
  FYHARCLQLGLGITRDETTAKHYYSKACRLNPALADELHSLLIRQRI
• Function: May act as an adapter that regulates LRP2 function.

Molecular Interaction Atlas (MIA) of This DOT

7 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Arteriosclerosis	DISK5QGC	Strong	Biomarker	[1]
Atherosclerosis	DISMN9J3	Strong	Biomarker	[1]
Autism spectrum disorder	DISXK8NV	Strong	Biomarker	[2]
Asthma	DISW9QNS	moderate	Genetic Variation	[3]
Intellectual disability	DISMBNXP	Disputed	Genetic Variation	[4]
Schizophrenia	DISSRV2N	Disputed	Genetic Variation	[4]
facioscapulohumeral muscular dystrophy	DISSE0H0	Limited	Altered Expression	[5]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 increases the expression of LRP2-binding protein (LRP2BP).	[6]

References

• [1] LncRNA-RP11-714G18.1 suppresses vascular cell migration via directly targeting LRP2BP.Immunol Cell Biol. 2018 Feb;96(2):175-189. doi: 10.1111/imcb.1028. Epub 2017 Dec 7.
• [2] Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.Sci Rep. 2018 Mar 9;8(1):4277. doi: 10.1038/s41598-018-22753-4.
• [3] Asthma-susceptibility variants identified using probands in case-control and family-based analyses.BMC Med Genet. 2010 Aug 10;11:122. doi: 10.1186/1471-2350-11-122.
• [4] Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome.Transl Psychiatry. 2017 Aug 29;7(8):e1221. doi: 10.1038/tp.2017.181.
• [5] Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy.Neurology. 2007 Feb 20;68(8):569-77. doi: 10.1212/01.wnl.0000251269.31442.d9. Epub 2006 Dec 6.
• [6] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.