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Clopidogrel FDA Label
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Ezetimibe FDA Label
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Simvastatin FDA Label
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Riboflavin FDA Label
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New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk.Curr Opin Lipidol. 2019 Jun;30(3):205-211. doi: 10.1097/MOL.0000000000000600.
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Tiaopi huxin recipe improved endothelial dysfunction and attenuated atherosclerosis by decreasing the expression of caveolin-1 in ApoE-deficient mice.J Cell Physiol. 2019 Sep;234(9):15369-15379. doi: 10.1002/jcp.28184. Epub 2019 Feb 6.
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Contribution of homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 to coronary artery disease.Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1933-41. doi: 10.1161/ATVBAHA.113.303081. Epub 2014 Jul 2.
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Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice.J Diabetes Complications. 2017 Feb;31(2):311-317. doi: 10.1016/j.jdiacomp.2016.08.021. Epub 2016 Aug 28.
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Association of TAFI gene polymorphisms with severity of coronary stenosis in stable coronary artery disease.Thromb Res. 2018 Nov;171:171-176. doi: 10.1016/j.thromres.2018.10.001. Epub 2018 Oct 3.
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Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice.J Am Heart Assoc. 2017 Feb 20;6(2):e004690. doi: 10.1161/JAHA.116.004690.
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Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.Sci Rep. 2019 Mar 7;9(1):3909. doi: 10.1038/s41598-019-40602-w.
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Identification of atheroprone shear stress responsive regulatory elements in endothelial cells.Cardiovasc Res. 2019 Aug 1;115(10):1487-1499. doi: 10.1093/cvr/cvz027.
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Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E(-/-) mice.Br J Pharmacol. 2017 Nov;174(22):4043-4054. doi: 10.1111/bph.13707. Epub 2017 Feb 14.
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FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):387-401. doi: 10.1161/ATVBAHA.118.311903.
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Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.Cardiovasc Res. 2018 Aug 1;114(10):1385-1399. doi: 10.1093/cvr/cvy078.
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Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications.Acc Chem Res. 2017 Jul 18;50(7):1541-1556. doi: 10.1021/acs.accounts.7b00114. Epub 2017 Jun 9.
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Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis.Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):306-315. doi: 10.1016/j.numecd.2018.12.006. Epub 2019 Jan 9.
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HMGA1 is a novel candidate gene for myocardial infarction susceptibility.Int J Cardiol. 2017 Jan 15;227:331-334. doi: 10.1016/j.ijcard.2016.11.088. Epub 2016 Nov 9.
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Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice.Biochem Biophys Res Commun. 2019 Nov 19;519(4):861-867. doi: 10.1016/j.bbrc.2019.09.085. Epub 2019 Sep 24.
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In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes.Sci Rep. 2019 Feb 25;9(1):2670. doi: 10.1038/s41598-019-38970-4.
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The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis.Signal Transduct Target Ther. 2019 Jul 19;4:23. doi: 10.1038/s41392-019-0058-5. eCollection 2019.
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Interleukin-17/Interleukin-21 and Interferon- producing T cells specific for 2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome.Haematologica. 2019 Dec;104(12):2519-2527. doi: 10.3324/haematol.2018.209536. Epub 2019 Mar 14.
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IL-15 polymorphisms are associated with subclinical atherosclerosis and cardiovascular risk factors. The Genetics of Atherosclerosis Disease (GEA) Mexican Study.Cytokine. 2017 Nov;99:173-178. doi: 10.1016/j.cyto.2017.09.006. Epub 2017 Sep 15.
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Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study.Cytokine. 2019 Feb;114:32-37. doi: 10.1016/j.cyto.2018.11.028. Epub 2018 Dec 26.
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IL-23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice.J Am Heart Assoc. 2018 Apr 4;7(8):e008257. doi: 10.1161/JAHA.117.008257.
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ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions.BMC Immunol. 2019 Dec 10;20(1):47. doi: 10.1186/s12865-019-0330-z.
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LncRNA CASC11 improves atherosclerosis by downregulating IL-9 and regulating vascular smooth muscle cell apoptosis and proliferation.Biosci Biotechnol Biochem. 2019 Jul;83(7):1284-1288. doi: 10.1080/09168451.2019.1597621. Epub 2019 Mar 27.
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IRAK regulates macrophage foam cell formation by modulating genes involved in cholesterol uptake and efflux.Bioessays. 2016 Jul;38(7):591-604. doi: 10.1002/bies.201600085. Epub 2016 Jun 8.
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Genetic contributors and soluble mediators in prediction of autoimmune comorbidity.J Autoimmun. 2019 Nov;104:102317. doi: 10.1016/j.jaut.2019.102317. Epub 2019 Aug 20.
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The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype.Diabetologia. 2017 Sep;60(9):1801-1812. doi: 10.1007/s00125-017-4330-3. Epub 2017 Jun 12.
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Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889. doi: 10.1161/ATVBAHA.118.311238.
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Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis.PLoS One. 2012;7(10):e47985. doi: 10.1371/journal.pone.0047985. Epub 2012 Oct 24.
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Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency.Am J Cardiovasc Drugs. 2017 Jun;17(3):217-231. doi: 10.1007/s40256-017-0216-5.
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Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses.J Immunol. 2016 Dec 15;197(12):4651-4662. doi: 10.4049/jimmunol.1600206. Epub 2016 Nov 11.
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Leukotriene B(4)-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression.Oncoimmunology. 2017 Aug 10;6(12):e1361593. doi: 10.1080/2162402X.2017.1361593. eCollection 2017.
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NLRP3 inflammasome: Its regulation and involvement in atherosclerosis.J Cell Physiol. 2018 Mar;233(3):2116-2132. doi: 10.1002/jcp.25930. Epub 2017 May 23.
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Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26.1.Atherosclerosis. 2019 May;284:11-17. doi: 10.1016/j.atherosclerosis.2019.02.012. Epub 2019 Feb 22.
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Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1368-1380. doi: 10.1161/ATVBAHA.118.310967. Epub 2018 Apr 5.
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LPS enhances expression of CD204 through the MAPK/ERK pathway in murine bone marrow macrophages.Atherosclerosis. 2017 Nov;266:167-175. doi: 10.1016/j.atherosclerosis.2017.10.005. Epub 2017 Oct 6.
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The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial.Atherosclerosis. 2015 Jun;240(2):408-14. doi: 10.1016/j.atherosclerosis.2015.03.014. Epub 2015 Mar 14.
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Muramyl Dipeptide Induces Reactive Oxygen Species Generation Through the NOD2/COX-2/NOX4 Signaling Pathway in Human Umbilical Vein Endothelial Cells.J Cardiovasc Pharmacol. 2018 Jun;71(6):352-358. doi: 10.1097/FJC.0000000000000581.
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Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice.Mol Pharmacol. 2019 Jul;96(1):47-55. doi: 10.1124/mol.119.115840. Epub 2019 May 7.
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Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. J Biol Chem. 2019 May 31;294(22):8732-8744. doi: 10.1074/jbc.RA119.008360. Epub 2019 Apr 17.
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PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice.Atherosclerosis. 2018 Sep;276:171-181. doi: 10.1016/j.atherosclerosis.2018.05.009. Epub 2018 May 16.
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Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.Nat Genet. 2011 Sep 11;43(10):940-7. doi: 10.1038/ng.920.
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Shikonin attenuates hyperhomocysteinemia-induced CD4(+) T cell inflammatory activation and atherosclerosis in ApoE(-/-) mice by metabolic suppression.Acta Pharmacol Sin. 2020 Jan;41(1):47-55. doi: 10.1038/s41401-019-0308-7. Epub 2019 Oct 13.
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Therapeutic effect of irbesartan combined with atorvastatin calcium in the treatment of rats with coronary heart disease.Exp Ther Med. 2018 Nov;16(5):4119-4123. doi: 10.3892/etm.2018.6669. Epub 2018 Aug 30.
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Altered expression of inflammation-related genes in human carotid atherosclerotic plaques.Atherosclerosis. 2012 Jan;220(1):93-101. doi: 10.1016/j.atherosclerosis.2011.10.022. Epub 2011 Oct 25.
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Sildenafil (Viagra) Prevents Cox-1/ TXA2 Pathway-Mediated Vascular Hypercontractility in ApoE-/- Mice.Cell Physiol Biochem. 2017;44(5):1796-1809. doi: 10.1159/000485817. Epub 2017 Dec 7.
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Involvement of RBP4 in Diabetic Atherosclerosis and the Role of Vitamin D Intervention.J Diabetes Res. 2018 Aug 16;2018:7329861. doi: 10.1155/2018/7329861. eCollection 2018.
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A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.Circulation. 2013 Jan 29;127(4):486-99. doi: 10.1161/CIRCULATIONAHA.112.116988. Epub 2012 Dec 14.
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S100A12 and the S100/Calgranulins: Emerging Biomarkers for Atherosclerosis and Possibly Therapeutic Targets.Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2496-507. doi: 10.1161/ATVBAHA.115.302072. Epub 2015 Oct 29.
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Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.Mol Imaging Biol. 2018 Jun;20(3):448-456. doi: 10.1007/s11307-017-1141-3.
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p53 mediates PEDFinduced autophagy in human umbilical vein endothelial cells through sestrin2 signaling.Mol Med Rep. 2019 Aug;20(2):1443-1450. doi: 10.3892/mmr.2019.10319. Epub 2019 Jun 3.
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Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.Free Radic Res. 2019 Feb;53(2):139-149. doi: 10.1080/10715762.2018.1549732. Epub 2018 Dec 26.
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Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells.Biochem Cell Biol. 2020 Apr;98(2):120-129. doi: 10.1139/bcb-2019-0057. Epub 2019 May 7.
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Are SGLT2 polymorphisms linked to diabetes mellitus and cardiovascular disease? Prospective study and meta-analysis.Biosci Rep. 2019 Aug 7;39(8):BSR20190299. doi: 10.1042/BSR20190299. Print 2019 Aug 30.
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Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na(+)/H(+) exchanger 1 inhibition.Vascul Pharmacol. 2019 Apr;115:26-32. doi: 10.1016/j.vph.2019.01.005. Epub 2019 Jan 26.
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Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism.Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E131-E144. doi: 10.1152/ajpendo.00181.2019. Epub 2019 Dec 10.
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The suppression of ox-LDL-induced inflammatory cytokine release and apoptosis of HCAECs by long non-coding RNA-MALAT1 via regulating microRNA-155/SOCS1 pathway.Nutr Metab Cardiovasc Dis. 2018 Nov;28(11):1175-1187. doi: 10.1016/j.numecd.2018.06.017. Epub 2018 Jun 28.
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AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate.Science. 2019 Mar 8;363(6431):1085-1088. doi: 10.1126/science.aav1749. Epub 2019 Jan 31.
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Potential mechanisms underlying the cardiovascular benefits of sodium glucose cotransporter 2 inhibitors: a systematic review of data from preclinical studies.Cardiovasc Res. 2019 Feb 1;115(2):266-276. doi: 10.1093/cvr/cvy295.
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Association between Type I interferon and depletion and dysfunction of endothelial progenitor cells in C57BL/6 mice deficient in both apolipoprotein E and Fas ligand.Curr Res Transl Med. 2018 Sep;66(3):71-82. doi: 10.1016/j.retram.2018.02.002. Epub 2018 Aug 11.
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B Cell-Activating Factor Neutralization Aggravates Atherosclerosis.Circulation. 2018 Nov 13;138(20):2263-2273. doi: 10.1161/CIRCULATIONAHA.117.032790.
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Soluble TWEAK and atheromatosis progression in patients with chronic kidney disease.Atherosclerosis. 2017 May;260:130-137. doi: 10.1016/j.atherosclerosis.2017.03.043. Epub 2017 Mar 31.
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Knockdown of TRIM28 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration.Chem Biol Interact. 2019 Sep 25;311:108772. doi: 10.1016/j.cbi.2019.108772. Epub 2019 Jul 24.
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Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis.Nat Commun. 2018 Jan 15;9(1):231. doi: 10.1038/s41467-017-02657-z.
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Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis - impact of radiochemistry on pharmacokinetics.Biol Chem. 2019 Feb 25;400(3):323-332. doi: 10.1515/hsz-2018-0330.
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VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification.Hum Genet. 2013 Jan;132(1):29-37. doi: 10.1007/s00439-012-1222-y. Epub 2012 Aug 23.
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Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.Mol Metab. 2018 Mar;9:131-140. doi: 10.1016/j.molmet.2018.01.005. Epub 2018 Jan 11.
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Insulin-like growth factor-binding protein 7 (IGFBP 7) as a new biomarker in coronary heart disease.Adv Med Sci. 2019 Mar;64(1):195-201. doi: 10.1016/j.advms.2018.08.017. Epub 2019 Feb 13.
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Ablation of Interferon Regulatory Factor 3 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice.Hypertension. 2017 Mar;69(3):510-520. doi: 10.1161/HYPERTENSIONAHA.116.08395. Epub 2017 Jan 23.
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The renal tubular damage marker urinary N-acetyl--D-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes.Cardiovasc Diabetol. 2017 Jan 26;16(1):16. doi: 10.1186/s12933-017-0497-7.
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OSCAR is a receptor for surfactant protein D that activates TNF- release from human CCR2+ inflammatory monocytes.J Immunol. 2015 Apr 1;194(7):3317-26. doi: 10.4049/jimmunol.1402289. Epub 2015 Feb 25.
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Human epicardial adipose tissue-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels are increased in patients with coronary artery disease.Cardiovasc Diabetol. 2017 Oct 16;16(1):133. doi: 10.1186/s12933-017-0612-9.
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Circulating TNFSF14 (Tumor Necrosis Factor Superfamily 14) Predicts Clinical Outcome in Patients With Stable Coronary Artery Disease.Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1240-1252. doi: 10.1161/ATVBAHA.118.312166.
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Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions.J Biol Chem. 2019 Oct 25;294(43):15836-15849. doi: 10.1074/jbc.RA119.010564. Epub 2019 Sep 8.
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Atypical Chemokine Receptors in Cardiovascular Disease.Thromb Haemost. 2019 Apr;119(4):534-541. doi: 10.1055/s-0038-1676988. Epub 2019 Feb 4.
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ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review.Prog Lipid Res. 2020 Jan;77:101006. doi: 10.1016/j.plipres.2019.101006. Epub 2019 Sep 6.
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Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2.Biochem Biophys Res Commun. 2019 Apr 30;512(2):319-325. doi: 10.1016/j.bbrc.2019.03.037. Epub 2019 Mar 15.
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Adiponectin alleviates NLRP3-inflammasome-mediated pyroptosis of aortic endothelial cells by inhibiting FoxO4 in arteriosclerosis.Biochem Biophys Res Commun. 2019 Jun 18;514(1):266-272. doi: 10.1016/j.bbrc.2019.04.143. Epub 2019 Apr 25.
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The advantageous role of annexin A1 in cardiovascular disease.Cell Adh Migr. 2017 May 4;11(3):261-274. doi: 10.1080/19336918.2016.1259059. Epub 2016 Nov 18.
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Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2.Front Physiol. 2018 Apr 20;9:396. doi: 10.3389/fphys.2018.00396. eCollection 2018.
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B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells.Cardiovasc Res. 2020 Feb 1;116(2):295-305. doi: 10.1093/cvr/cvz129.
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Caspase-1 Activation Is Related With HIV-Associated Atherosclerosis in an HIV Transgenic Mouse Model and HIV Patient Cohort.Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1762-1775. doi: 10.1161/ATVBAHA.119.312603. Epub 2019 Jul 18.
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Protective effect of HSP27 in atherosclerosis and coronary heart disease by inhibiting reactive oxygen species.J Cell Biochem. 2019 Mar;120(3):2859-2868. doi: 10.1002/jcb.26575. Epub 2018 Dec 3.
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Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice.Circulation. 2009 Nov 10;120(19):1893-902. doi: 10.1161/CIRCULATIONAHA.109.866889. Epub 2009 Oct 26.
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Soluble CD163 is a biomarker for accelerated atherosclerosis in systemic lupus erythematosus patients at apparent low risk for cardiovascular disease.Scand J Rheumatol. 2020 Jan;49(1):33-37. doi: 10.1080/03009742.2019.1614213. Epub 2019 Jun 4.
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Cystathionine Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.
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Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.J Am Heart Assoc. 2018 Feb 8;7(4):e008187. doi: 10.1161/JAHA.117.008187.
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Altered Gene Response to Aflatoxin B(1) in the Spleens of Susceptible and Resistant Turkeys.Toxins (Basel). 2019 Apr 28;11(5):242. doi: 10.3390/toxins11050242.
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Piezo Ion Channels in Cardiovascular Mechanobiology.Trends Pharmacol Sci. 2019 Dec;40(12):956-970. doi: 10.1016/j.tips.2019.10.002. Epub 2019 Nov 5.
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Proteolysis of apolipoprotein A-I by secretory phospholipase A? a new link between inflammation and atherosclerosis.J Biol Chem. 2014 Apr 4;289(14):10011-23. doi: 10.1074/jbc.M113.525717. Epub 2014 Feb 12.
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Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins.Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):197-205. doi: 10.1161/ATVBAHA.114.304342. Epub 2014 Nov 13.
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Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.Circulation. 2013 Nov 26;128(22):2351-63. doi: 10.1161/CIRCULATIONAHA.113.004634. Epub 2013 Sep 16.
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MicroRNA-136 Promotes Vascular Muscle Cell Proliferation Through the ERK1/2 Pathway by Targeting PPP2R2A in Atherosclerosis.Curr Vasc Pharmacol. 2015;13(3):405-12. doi: 10.2174/1570161112666141118094612.
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Follicular B Cells Promote Atherosclerosis via T Cell-Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin G.Arterioscler Thromb Vasc Biol. 2018 May;38(5):e71-e84. doi: 10.1161/ATVBAHA.117.310678. Epub 2018 Mar 29.
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Type 1 innate lymphoid cell aggravation of atherosclerosis is mediated through TLR4.Scand J Immunol. 2018 May;87(5):e12661. doi: 10.1111/sji.12661.
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