Details of Drug Off-Target (DOT)
General Information of Drug Off-Target (DOT) (ID: OTW9L6S4)
DOT Name | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72) | ||||
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Synonyms | CTD phosphatase SSU72; EC 3.1.3.16 | ||||
Gene Name | SSU72 | ||||
UniProt ID | |||||
3D Structure | |||||
PDB ID | |||||
EC Number | |||||
Pfam ID | |||||
Sequence |
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTT
YDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVV EDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFE EKSGRTFLHTVCFY |
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Function |
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
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KEGG Pathway | |||||
Reactome Pathway | |||||
Molecular Interaction Atlas (MIA) of This DOT
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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3 Drug(s) Affected the Post-Translational Modifications of This DOT
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7 Drug(s) Affected the Gene/Protein Processing of This DOT
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References