Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZ5O14U)

• DOT Name: Protein MIX23 (MIX23)
• Synonyms: Coiled-coil domain-containing protein 58
• Gene Name: MIX23
• UniProt ID: MIX23_HUMAN
• Pfam ID: PF09774
• Sequence:
  MAAPSGGVNCEEFAEFQELLKVMRTIDDRIVHELNTTVPTASFAGKIDASQTCKQLYESL
  MAAHASRDRVIKNCIAQTSAVVKNLREEREKNLDDLTLLKQLRKEQTKLKWMQSELNVEE
  VVNDRSWKVFNERCRIHFKPPKNE

Molecular Interaction Atlas (MIA) of This DOT

12 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the expression of Protein MIX23 (MIX23).	[1]
Ciclosporin	DMAZJFX	Approved	Ciclosporin increases the expression of Protein MIX23 (MIX23).	[2]
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Protein MIX23 (MIX23).	[3]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Protein MIX23 (MIX23).	[4]
Temozolomide	DMKECZD	Approved	Temozolomide increases the expression of Protein MIX23 (MIX23).	[5]
Cannabidiol	DM0659E	Approved	Cannabidiol increases the expression of Protein MIX23 (MIX23).	[6]
Urethane	DM7NSI0	Phase 4	Urethane decreases the expression of Protein MIX23 (MIX23).	[7]
GSK2110183	DMZHB37	Phase 2	GSK2110183 decreases the expression of Protein MIX23 (MIX23).	[8]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Protein MIX23 (MIX23).	[9]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A increases the expression of Protein MIX23 (MIX23).	[10]
Formaldehyde	DM7Q6M0	Investigative	Formaldehyde decreases the expression of Protein MIX23 (MIX23).	[11]
Coumestrol	DM40TBU	Investigative	Coumestrol increases the expression of Protein MIX23 (MIX23).	[12]

References

• [1] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [2] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [3] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [4] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [5] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [6] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [7] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [8] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [9] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [10] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [11] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [12] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.