Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZZ0CA8)

• DOT Name: Cadherin-related family member 3 (CDHR3)
• Synonyms: Cadherin-like protein 28
• Gene Name: CDHR3
• Related Disease:
  Allergic asthma
  Asthma
• UniProt ID: CDHR3_HUMAN
• PDB ID: 6PPO; 6PSF; 7KNV
• Pfam ID: PF00028
• Sequence:
  MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP
  QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT
  VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS
  FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT
  RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR
  DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK
  GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN
  LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV
  GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ
  ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR
  SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD
  RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS
  ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE
  AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE
  DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK
• Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.; (Microbial infection) Acts as a receptor for human rhinovirus C.
• Tissue Specificity: Expressed in bronchial epithelium from adults and in fetal lung tissue.

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Allergic asthma	DISHF0H3	Strong	Genetic Variation	[1]
Asthma	DISW9QNS	Limited	Biomarker	[2]

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Triclosan	DMZUR4N	Approved	Triclosan decreases the expression of Cadherin-related family member 3 (CDHR3).	[3]
Urethane	DM7NSI0	Phase 4	Urethane decreases the expression of Cadherin-related family member 3 (CDHR3).	[4]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Cadherin-related family member 3 (CDHR3).	[5]

References

• [1] Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population.Tissue Antigens. 2015 Dec;86(6):443-7. doi: 10.1111/tan.12688. Epub 2015 Oct 22.
• [2] Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations.J Allergy Clin Immunol. 2019 Oct;144(4):962-971. doi: 10.1016/j.jaci.2019.01.052. Epub 2019 Mar 29.
• [3] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [4] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [5] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.