Details of the Drug Combination

General Information of Drug Combination (ID: DC142LO)

Drug Combination Name
TEM Pentostatin
Indication
Disease Entry Status REF
Carcinoma Investigative [1]
Component Drugs TEM   DMLNFWU Pentostatin   DM0HXDS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: RXF 393
Zero Interaction Potency (ZIP) Score: 2.33
Bliss Independence Score: 3.6
Loewe Additivity Score: 2.7
LHighest Single Agent (HSA) Score: 1.52

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Pentostatin
Disease Entry ICD 11 Status REF
Acute graft versus host disease 4B24.0 Approved [3]
Hairy cell leukaemia 2A82.2 Approved [4]
Leukemia N.A. Approved [3]
Pentostatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Inhibitor [5]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DCBR687 HL-60(TB) Investigative [6]
Clear cell renal cell carcinoma DCHZUNG A498 Investigative [6]
Glioma DCW8RMC SF-539 Investigative [6]
Colon adenocarcinoma DC3IXES COLO 205 Investigative [1]
Invasive ductal carcinoma DCDWS2U HS 578T Investigative [1]
Adenocarcinoma DC7R8BR HCT-15 Investigative [7]
Amelanotic melanoma DCR6041 MDA-MB-435 Investigative [7]
High grade ovarian serous adenocarcinoma DCLK6HM OVCAR-8 Investigative [7]
Lung adenocarcinoma DC25OME EKVX Investigative [7]
Melanoma DC16Z77 MALME-3M Investigative [7]
Minimally invasive lung adenocarcinoma DC02LMR NCI-H322M Investigative [7]
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⏷ Show the Full List of 11 DrugCom(s)

References

1 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 Pentostatin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
5 Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
6 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
7 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.