Details of the Drug Combination

General Information of Drug Combination (ID: DCBR687)

• Drug Combination Name: TEM + Pentostatin
• Indication: Adult acute myeloid leukemia; Status: Investigative [1]
• Component Drugs:
  TEM (DMLNFWU): Small molecular drug
  Pentostatin (DM0HXDS): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: HL-60(TB)
  Zero Interaction Potency (ZIP) Score: 0.96
  Bliss Independence Score: 4.88
  Loewe Additivity Score: 5.34
  LHighest Single Agent (HSA) Score: 4.09

Molecular Interaction Atlas of This Drug Combination

Indication(s) of TEM

Disease Entry	ICD 11	Status	REF
Postherpetic neuralgia	1E91.5	Phase 2	[2]

Indication(s) of Pentostatin

Disease Entry	ICD 11	Status	REF
Acute graft versus host disease	4B24.0	Approved	[3]
Hairy cell leukaemia	2A82.2	Approved	[4]
Leukemia	N.A.	Approved	[3]

Pentostatin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Adenosine deaminase (ADA)	TTLP57V	ADA_HUMAN	Inhibitor	[5]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Clear cell renal cell carcinoma	DCHZUNG	A498	Investigative	[1]
Glioma	DCW8RMC	SF-539	Investigative	[1]
Carcinoma	DC142LO	RXF 393	Investigative	[6]
Colon adenocarcinoma	DC3IXES	COLO 205	Investigative	[6]
Invasive ductal carcinoma	DCDWS2U	HS 578T	Investigative	[6]
Adenocarcinoma	DC7R8BR	HCT-15	Investigative	[7]
Amelanotic melanoma	DCR6041	MDA-MB-435	Investigative	[7]
High grade ovarian serous adenocarcinoma	DCLK6HM	OVCAR-8	Investigative	[7]
Lung adenocarcinoma	DC25OME	EKVX	Investigative	[7]
Melanoma	DC16Z77	MALME-3M	Investigative	[7]
Minimally invasive lung adenocarcinoma	DC02LMR	NCI-H322M	Investigative	[7]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
• [3] Pentostatin FDA Label
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
• [5] Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
• [6] Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
• [7] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.