Details of the Drug Combination

General Information of Drug Combination (ID: DC7R8BR)

Drug Combination Name

TEM Pentostatin

Indication

Disease Entry	Status	REF
Adenocarcinoma	Investigative	[1]

Component Drugs

TEM DMLNFWU

Pentostatin DM0HXDS

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: HCT-15

Zero Interaction Potency (ZIP) Score: 10.37

Bliss Independence Score: 13.89

Loewe Additivity Score: 9.1

LHighest Single Agent (HSA) Score: 4.79

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of TEM

Disease Entry	ICD 11	Status	REF
Postherpetic neuralgia	1E91.5	Phase 2	[2]

Indication(s) of Pentostatin

Disease Entry	ICD 11	Status	REF
Acute graft versus host disease	4B24.0	Approved	[3]
Hairy cell leukaemia	2A82.2	Approved	[4]
Leukemia	N.A.	Approved	[3]

Pentostatin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Adenosine deaminase (ADA)	TTLP57V	ADA_HUMAN	Inhibitor	[5]
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Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCBR687	HL-60(TB)	Investigative	[6]
Clear cell renal cell carcinoma	DCHZUNG	A498	Investigative	[6]
Glioma	DCW8RMC	SF-539	Investigative	[6]
Carcinoma	DC142LO	RXF 393	Investigative	[7]
Colon adenocarcinoma	DC3IXES	COLO 205	Investigative	[7]
Invasive ductal carcinoma	DCDWS2U	HS 578T	Investigative	[7]
Amelanotic melanoma	DCR6041	MDA-MB-435	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCLK6HM	OVCAR-8	Investigative	[1]
Lung adenocarcinoma	DC25OME	EKVX	Investigative	[1]
Melanoma	DC16Z77	MALME-3M	Investigative	[1]
Minimally invasive lung adenocarcinoma	DC02LMR	NCI-H322M	Investigative	[1]
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⏷ Show the Full List of 11 DrugCom(s)

References

1	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3	Pentostatin FDA Label
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
5	Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
6	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
7	Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.