Details of the Drug Combination

General Information of Drug Combination (ID: DC5C9SU)

• Drug Combination Name: Dexrazoxane + Bleomycin
• Indication: Adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Dexrazoxane (DMD7X1O): Small molecular drug
  Bleomycin (DMNER5S): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: HCT-15
  Zero Interaction Potency (ZIP) Score: 1.29
  Bliss Independence Score: 4.46
  Loewe Additivity Score: 5.41
  LHighest Single Agent (HSA) Score: 8.57

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Dexrazoxane

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[2]
Chemoprotection	N.A.	Approved	[3]
Inflammatory breast cancer	2C62	Approved	[4]
Respiratory tract disease	CB7Z	Investigative	[5]

Dexrazoxane Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II beta (TOP2B)	TT4NVEM	TOP2B_HUMAN	Inhibitor	[8]
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[9]

Dexrazoxane Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Dihydropyrimidinase-related protein 1 (DRP1)	DE0EUXB	DPYL1_HUMAN	Metabolism	[10]

Dexrazoxane Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Activity	[11]

Indication(s) of Bleomycin

Disease Entry	ICD 11	Status	REF
Cervical cancer	2C77.0	Approved	[6]
Head and neck cancer	2D42	Approved	[6]
Hodgkin lymphoma	2B30	Approved	[7]
Penile cancer	N.A.	Approved	[6]
Testicular germ cell tumor	N.A.	Approved	[6]
Classic Hodgkin lymphoma	N.A.	Investigative	[6]
Follicular lymphoma	2A80	Investigative	[6]

Bleomycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[16]

Bleomycin Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Bleomycin hydrolase (BLMH)	DECH1VP	BLMH_HUMAN	Metabolism	[17]

Bleomycin Interacts with 41 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Bleomycin hydrolase (BLMH)	OT2QPWQJ	BLMH_HUMAN	Affects Response To Substance	[18]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[19]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[19]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[19]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[20]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Increases Expression	[20]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[20]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Increases Expression	[20]
Mucin-5AC (MUC5AC)	OTJV8O04	MUC5A_HUMAN	Increases Expression	[20]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Increases Expression	[20]
Transmembrane protein 250 (TMEM250)	OTLJ4G5G	TM250_HUMAN	Increases Expression	[12]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Decreases Expression	[21]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[22]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[13]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[23]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[13]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Increases Expression	[13]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[24]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[13]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[25]
Cathepsin S (CTSS)	OT3PXIPM	CATS_HUMAN	Increases Expression	[26]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[27]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Decreases Expression	[12]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Increases Expression	[13]
Unconventional myosin-Ie (MYO1E)	OTM9YSIZ	MYO1E_HUMAN	Decreases Expression	[12]
Transcription intermediary factor 1-beta (TRIM28)	OTE38OBF	TIF1B_HUMAN	Increases Phosphorylation	[22]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Phosphorylation	[22]
Structural maintenance of chromosomes protein 1A (SMC1A)	OT9ZMRK9	SMC1A_HUMAN	Increases Phosphorylation	[22]
7SK snRNA methylphosphate capping enzyme (MEPCE)	OTRBQEYP	MEPCE_HUMAN	Increases Expression	[12]
Transmembrane protein 87A (TMEM87A)	OT8ATDVX	TM87A_HUMAN	Increases Expression	[12]
Terminal nucleotidyltransferase 4B (TENT4B)	OTUF6FWW	PAPD5_HUMAN	Decreases Expression	[12]
Lipase member H (LIPH)	OTRGYLKL	LIPH_HUMAN	Decreases Expression	[12]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Decreases Expression	[12]
Small integral membrane protein 14 (SMIM14)	OT47IF19	SIM14_HUMAN	Decreases Expression	[12]
Kelch-like protein 42 (KLHL42)	OTK6WARI	KLH42_HUMAN	Increases Expression	[12]
Inactive cell surface hyaluronidase CEMIP2 (CEMIP2)	OT9I1XUO	CEIP2_HUMAN	Decreases Expression	[12]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Decreases Expression	[12]
Transmembrane and coiled-coil domain protein 3 (TMCC3)	OTAIQ6V6	TMCC3_HUMAN	Decreases Expression	[12]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)	OT27CCUF	SIAT9_HUMAN	Decreases Expression	[12]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Response To Substance	[28]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Affects Response To Substance	[29]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DC6SQHE	HL-60(TB)	Investigative	[30]
Adult T acute lymphoblastic leukemia	DC4RZEE	MOLT-4	Investigative	[30]
Anaplastic large cell lymphoma	DCXJGV9	SR	Investigative	[30]
Astrocytoma	DCUV45F	U251	Investigative	[30]
Astrocytoma	DCMIRRM	SNB-19	Investigative	[30]
Childhood T acute lymphoblastic leukemia	DC49UWX	CCRF-CEM	Investigative	[30]
Chronic myelogenous leukemia	DC0KI6U	K-562	Investigative	[30]
Clear cell renal cell carcinoma	DCQ7AOZ	TK-10	Investigative	[30]
Glioblastoma	DCOQCEH	SNB-75	Investigative	[30]
Glioma	DCC8N4R	SF-539	Investigative	[30]
Glioma	DCIP6XS	SF-268	Investigative	[30]
Glioma	DCFOZMF	SF-295	Investigative	[30]
Papillary renal cell carcinoma	DC0D80K	ACHN	Investigative	[30]
Renal cell carcinoma	DCWG49T	SN12C	Investigative	[30]
Breast adenocarcinoma	DCKLQOT	MDA-MB-468	Investigative	[31]
Carcinoma	DCXM80C	RXF 393	Investigative	[31]
Carcinoma	DCVVOAF	MCF7	Investigative	[31]
Colon adenocarcinoma	DCAJEDQ	COLO 205	Investigative	[31]
Invasive ductal carcinoma	DCYQULA	T-47D	Investigative	[31]
Invasive ductal carcinoma	DC1K7Y9	BT-549	Investigative	[31]
Invasive ductal carcinoma	DCS74O3	HS 578T	Investigative	[31]
Adenocarcinoma	DCXWL8B	DU-145	Investigative	[1]
Adenocarcinoma	DCHKORY	OVCAR3	Investigative	[1]
Adenocarcinoma	DC4T6H2	HCC-2998	Investigative	[1]
Adenocarcinoma	DCXC9B2	SW-620	Investigative	[1]
Amelanotic melanoma	DC4ZGI8	M14	Investigative	[1]
Cutaneous melanoma	DC2QFTK	SK-MEL-5	Investigative	[1]
Cutaneous melanoma	DC8ZDTK	SK-MEL-28	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCDA8MV	OVCAR-8	Investigative	[1]
Large cell lung carcinoma	DC7VZKC	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DC1QT8A	HOP-62	Investigative	[1]
Lung adenocarcinoma	DC7U4JQ	NCI-H522	Investigative	[1]
Malignant melanoma	DC75FA9	UACC62	Investigative	[1]
Malignant melanoma	DC4PIVY	LOX IMVI	Investigative	[1]
Melanoma	DCBEI0C	SK-MEL-2	Investigative	[1]
Melanoma	DCUD8M4	UACC-257	Investigative	[1]
Melanoma	DC0JXLD	MALME-3M	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DC9QT4W	IGROV1	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCXXT5N	SK-OV-3	Investigative	[1]
Prostate carcinoma	DCDOJCP	PC-3	Investigative	[1]

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