Details of the Drug

General Information of Drug (ID: DMNER5S)

• Drug Name: Bleomycin
• Synonyms: BLM; Blenoxane; Bleo; Bleocin; Bleogin; Bleomicin; Bleomicina; Bleomycine; Bleomycins; Bleomycinum; Bleomycin sulfate; Bleomycin a2; Pingyangmyvin A2; Zhengguangmycin A2; Zhengguangmycin A2 [Chinese]; Blenoxane (TN); Bleomicina [INN-Spanish]; Bleomycin A(2); Bleomycin A2 & Bleomycin B2; Bleomycin B(2); Bleomycine [INN-French]; Bleomycinum [INN-Latin]; NDC 0015-3010; N(1)-[3-(dimethylsulfonio)propyl]bleomycinamide; N1-(3-(Dimethylsulfonio)propyl)bleomycinamide

Indication

Disease Entry	ICD 11	Status	REF
Cervical cancer	2C77.0	Approved	[1]
Head and neck cancer	2D42	Approved	[1]
Hodgkin lymphoma	2B30	Approved	[2]
Penile cancer	N.A.	Approved	[1]
Testicular germ cell tumor	N.A.	Approved	[1]
Classic Hodgkin lymphoma	N.A.	Investigative	[1]
Follicular lymphoma	2A80	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 5:
  Molecular Weight (mw); 1415.6
  Logarithm of the Partition Coefficient (xlogp); -7.5
  Rotatable Bond Count (rotbonds); 36
  Hydrogen Bond Donor Count (hbonddonor); 20
  Hydrogen Bond Acceptor Count (hbondacc); 31
• ADMET Property:
  Absorption: The systemic absorption of drug is approximately 45% []
  Clearance: The drug present in the plasma can be removed from the body at the rate of 1.26 mL/min/kg [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 115 minutes [3]
  Metabolism: The drug is metabolized via the hepatic []
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.3532 micromolar/kg/day [4]
  Vd: Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.43 L/kg [3]
• Chemical Identifiers:
  Formula: C55H84N17O21S3+
  IUPAC Name: 3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium
  Canonical SMILES: CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
  InChI: InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1
  InChIKey: OYVAGSVQBOHSSS-WXFSZRTFSA-O
• Cross-matching ID:
  PubChem CID: 5360373
  CAS Number: 11056-06-7
  DrugBank ID: DB00290
  TTD ID: D06UVD
  VARIDT ID: DR00409
  INTEDE ID: DR0217
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Bleomycin hydrolase (BLMH) Main DME	DECH1VP	BLMH_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
7SK snRNA methylphosphate capping enzyme (MEPCE)	OTRBQEYP	MEPCE_HUMAN	Gene/Protein Processing	[7]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Gene/Protein Processing	[7]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[8]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Drug Response	[9]
Bleomycin hydrolase (BLMH)	OT2QPWQJ	BLMH_HUMAN	Drug Response	[10]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Gene/Protein Processing	[11]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[12]
Cathepsin S (CTSS)	OT3PXIPM	CATS_HUMAN	Gene/Protein Processing	[13]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[14]
Ceramide glucosyltransferase	OTRT5P5I	CEGT_HUMAN	Gene/Protein Processing	[7]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Bleomycin (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Roflumilast	DMPGHY8	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Roflumilast.	Asthma [CA23]	[15]
Ofloxacin	DM0VQN3	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Ofloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Ciprofloxacin XR	DM2NLS9	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Ciprofloxacin XR.	Bacterial infection [1A00-1C4Z]	[16]
Ceftazidime	DM41GRA	Moderate	Increased risk of nephrotoxicity by the combination of Bleomycin and Ceftazidime.	Bacterial infection [1A00-1C4Z]	[17]
Trovafloxacin	DM6AN32	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Trovafloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Sparfloxacin	DMB4HCT	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Sparfloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Gemifloxacin	DMHT34O	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Norfloxacin	DMIZ6W2	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Norfloxacin.	Bacterial infection [1A00-1C4Z]	[16]
ABT-492	DMJFD2I	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by ABT-492.	Bacterial infection [1A00-1C4Z]	[16]
Levofloxacin	DMS60RB	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Levofloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Lomefloxacin	DMVRH9C	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Grepafloxacin	DMGLX0T	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Grepafloxacin.	Bronchitis [CA20]	[16]
Digoxin	DMQCTIH	Moderate	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Digoxin.	Heart failure [BD10-BD1Z]	[18]
Teriflunomide	DMQ2FKJ	Major	Additive immunosuppressive effects by the combination of Bleomycin and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[19]
Givosiran	DM5PFIJ	Moderate	Increased risk of nephrotoxicity by the combination of Bleomycin and Givosiran.	Inborn porphyrin/heme metabolism error [5C58]	[17]
Denosumab	DMNI0KO	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Denosumab.	Low bone mass disorder [FB83]	[20]
Thalidomide	DM70BU5	Major	Additive thrombogenic effects by the combination of Bleomycin and Thalidomide.	Multiple myeloma [2A83]	[21]
Tecfidera	DM2OVDT	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Tecfidera.	Multiple sclerosis [8A40]	[22]
Siponimod	DM2R86O	Major	Additive immunosuppressive effects by the combination of Bleomycin and Siponimod.	Multiple sclerosis [8A40]	[17]
Fingolimod	DM5JVAN	Major	Additive immunosuppressive effects by the combination of Bleomycin and Fingolimod.	Multiple sclerosis [8A40]	[23]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Ocrelizumab.	Multiple sclerosis [8A40]	[24]
Ozanimod	DMT6AM2	Major	Additive immunosuppressive effects by the combination of Bleomycin and Ozanimod.	Multiple sclerosis [8A40]	[15]
Omacetaxine mepesuccinate	DMPU2WX	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[25]
Gatifloxacin	DMSL679	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[16]
Canakinumab	DM8HLO5	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Canakinumab.	Rheumatoid arthritis [FA20]	[26]
Rilonacept	DMGLUQS	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Rilonacept.	Rheumatoid arthritis [FA20]	[26]
Golimumab	DMHZV7X	Major	Additive immunosuppressive effects by the combination of Bleomycin and Golimumab.	Rheumatoid arthritis [FA20]	[27]
Leflunomide	DMR8ONJ	Major	Additive immunosuppressive effects by the combination of Bleomycin and Leflunomide.	Rheumatoid arthritis [FA20]	[19]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Bleomycin when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[28]
Etoposide	DMNH3PG	Moderate	Additive myelosuppressive effects by the combination of Bleomycin and Etoposide.	Solid tumour/cancer [2A00-2F9Z]	[29]
Cisplatin	DMRHGI9	Moderate	Increased risk of nephrotoxicity by the combination of Bleomycin and Cisplatin.	Solid tumour/cancer [2A00-2F9Z]	[17]
Azathioprine	DMMZSXQ	Moderate	Additive immunosuppressive effects by the combination of Bleomycin and Azathioprine.	Transplant rejection [NE84]	[17]
Cinoxacin	DM4EWNS	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Cinoxacin.	Urinary tract infection [GC08]	[16]
Plazomicin	DMKMBES	Moderate	Increased risk of nephrotoxicity by the combination of Bleomycin and Plazomicin.	Urinary tract infection [GC08]	[17]
Nalidixic acid	DMRM0JV	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Nalidixic acid.	Urinary tract infection [GC08]	[16]
Enoxacin	DMYTE6L	Minor	Decreased absorption of Bleomycin due to intestinal mucosa variation caused by Enoxacin.	Urinary tract infection [GC08]	[16]
Ganciclovir	DM1MBYQ	Moderate	Additive myelosuppressive effects by the combination of Bleomycin and Ganciclovir.	Virus infection [1A24-1D9Z]	[17]
Valganciclovir	DMS2IUH	Moderate	Additive myelosuppressive effects by the combination of Bleomycin and Valganciclovir.	Virus infection [1A24-1D9Z]	[17]

References

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