Details of the Drug Combination

General Information of Drug Combination (ID: DC8B0DI)

Drug Combination Name
Succinylcholine Vecuronium
Indication
Disease Entry Status REF
Anesthesia Phase 4 [1]
Component Drugs Succinylcholine   DM2ET1M Vecuronium   DMP0UK2
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Succinylcholine
Disease Entry ICD 11 Status REF
Plasma cell myeloma 2A83.1 Approved [2]
Spasm MB47.3 Approved [3]
Succinylcholine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Antagonist [5]
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Succinylcholine Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Increases Response To Substance [6]
Myoglobin (MB) OTYWYL2D MYG_HUMAN Increases Secretion [7]
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Indication(s) of Vecuronium
Disease Entry ICD 11 Status REF
Spasm MB47.3 Approved [4]
Vecuronium Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2) TTF4E0J ACHA2_HUMAN Antagonist [8]
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Vecuronium Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]
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References

1 ClinicalTrials.gov (NCT02237443) Mask Ventilation Before and After Neuromuscular Blockade
2 Succinylcholine FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4004).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4002).
5 The involvement of histaminic and muscarinic receptors in the bronchoconstriction induced by myorelaxant administration in sensitized rabbits. Anesth Analg. 2008 Dec;107(6):1899-906.
6 Response of the newborn to succinlycholine injection in homozygotic atypical mothers. Anesthesiology. 1975 Jul;43(1):115-6. doi: 10.1097/00000542-197507000-00028.
7 Midazolam pretreatment does not ameliorate myoglobinemia or the clinical side effects of succinylcholine. J Clin Anesth. 1993 Sep-Oct;5(5):414-8. doi: 10.1016/0952-8180(93)90107-p.
8 Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
9 Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33.