Details of the Drug Combination

General Information of Drug Combination (ID: DCDIRKH)

Drug Combination Name
Meropenem Plazomicin
Indication
Disease Entry Status REF
Bloodstream Infections (BSI) Due to CRE Phase 3 [1]
Component Drugs Meropenem   DM62UHC Plazomicin   DMKMBES
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Meropenem
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [2]
Meningococcal meningitis N.A. Approved [3]
Peritonitis N.A. Approved [3]
Pneumococcal meningitis N.A. Approved [3]
Pseudomonas aeruginosa infectious disease N.A. Approved [3]
Meropenem Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Modulator [5]
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Meropenem Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [6]
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Meropenem Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Beta-lactamase (blaB) DEC3G7M A0A1S7IV31_ENTAS Metabolism [7]
Beta-lactamase (blaB) DENJ2SQ BLAB_BACFG Metabolism [8]
Beta-lactamase (blaB) DEBKS91 A0A1B1FBM9_ACIBA Metabolism [9]
Beta-lactamase (blaB) DECWSA9 AMPC_MORMO Metabolism [10]
Carbapenemase (cphA) DEB90AL BLAB_AERHY Metabolism [11]
New delhi metallo-beta-lactamase NDM-1 (blaNDM) DEBGCYQ A0A345N7K5_SALET Metabolism [12]
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⏷ Show the Full List of 6 DME(s)
Meropenem Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
HLA class II histocompatibility antigen, DO beta chain (HLA-DOB) OTKADDUB DOB_HUMAN Affects Expression [13]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Affects Expression [13]
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Indication(s) of Plazomicin
Disease Entry ICD 11 Status REF
Bronchitis CA20 Approved [4]
Prostate disease GA91 Approved [4]
Urinary tract infection GC08 Approved [4]
Pancreatic cancer 2C10 Phase 3 [1]
Plazomicin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Mitochondrial rRNA methyltransferase 2 (MRM2) TTUQ7WN MRM2_HUMAN Inhibitor [4]
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Plazomicin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Aminoglycoside acetyltransferase (aac) DE69QHT AAC2_PROST Metabolism [14]
Aminoglycoside O-phosphotransferase (aphA6) DESGYWE G9FRK8_PROST Metabolism [14]
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References

1 ClinicalTrials.gov (NCT01970371) A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE). U.S. National Institutes of Health.
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 Meropenem FDA Label
4 In vitro activity of plazomicin against -lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE).J Antimicrob Chemother. 2017 Oct 1;72(10):2792-2795.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Characterization of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem as substrates of human renal transporters. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):41-7.
7 FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972.
8 Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
9 A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367.
10 Molecular investigation of extended-spectrum beta-lactamase genes and potential drug resistance in clinical isolates of Morganella morganii. Ann Saudi Med. 2016 May-Jun;36(3):223-8.
11 A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 beta-lactamase. J Med Microbiol. 2018 Nov;67(11):1535-1537.
12 Genomic characterization of an extensively-drug resistance Salmonella enterica serotype Indiana strain harboring bla NDM-1 gene isolated from a chicken carcass in China. Microbiol Res. 2017 Nov;204:48-54.
13 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
14 Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987.