Molecular Interaction Atlas (MIA) |
|
Indication(s) of Selexipag |
Disease Entry |
ICD 11 |
Status |
REF |
Pulmonary arterial hypertension |
BB01.0
|
Approved |
[2] |
|
|
Selexipag Interacts with 1 DTT Molecule(s)
DTT Name |
DTT ID |
UniProt ID |
Mode of Action |
REF |
Prostacyclin receptor (PTGIR)
|
TTOFYT1
|
PI2R_HUMAN
|
Agonist
|
[5] |
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Selexipag Interacts with 1 DME Molecule(s)
DME Name |
DME ID |
UniProt ID |
Mode of Action |
REF |
Cytochrome P450 2C8 (CYP2C8)
|
DES5XRU
|
CP2C8_HUMAN
|
Metabolism
|
[6] |
------------------------------------------------------------------------------------ |
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|
Indication(s) of Tadalafil |
Disease Entry |
ICD 11 |
Status |
REF |
Benign prostatic hyperplasia |
GA90
|
Approved |
[3] |
Erectile dysfunction |
HA01.1
|
Approved |
[4] |
Plasma cell myeloma |
2A83.1
|
Approved |
[3] |
Pulmonary hypertension |
BB01
|
Approved |
[3] |
Priapism |
N.A.
|
Investigative |
[3] |
|
|
Tadalafil Interacts with 1 DTT Molecule(s)
DTT Name |
DTT ID |
UniProt ID |
Mode of Action |
REF |
Phosphodiesterase 5A (PDE5A)
|
TTJ0IQB
|
PDE5A_HUMAN
|
Inhibitor
|
[7] |
------------------------------------------------------------------------------------ |
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Tadalafil Interacts with 1 DTP Molecule(s)
DTP Name |
DTP ID |
UniProt ID |
Mode of Action |
REF |
P-glycoprotein 1 (ABCB1)
|
DTUGYRD
|
MDR1_HUMAN
|
Substrate
|
[8] |
------------------------------------------------------------------------------------ |
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|
Tadalafil Interacts with 2 DME Molecule(s)
DME Name |
DME ID |
UniProt ID |
Mode of Action |
REF |
Cytochrome P450 3A4 (CYP3A4)
|
DE4LYSA
|
CP3A4_HUMAN
|
Metabolism
|
[9] |
Cytochrome P450 3A5 (CYP3A5)
|
DEIBDNY
|
CP3A5_HUMAN
|
Metabolism
|
[9] |
------------------------------------------------------------------------------------ |
|
|
|
|
|
Tadalafil Interacts with 1 DOT Molecule(s)
DOT Name |
DOT ID |
UniProt ID |
Mode of Action |
REF |
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)
|
OTT8Q1AP
|
PDE5A_HUMAN
|
Decreases Activity
|
[10] |
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