Details of the Drug Combination

General Information of Drug Combination (ID: DCG9GD8)

Drug Combination Name
Ulipristal Misoprostol
Indication
Disease Entry Status REF
Induction of Second Trimester Abortion Phase 4 [1]
Component Drugs Ulipristal   DMBNI20 Misoprostol   DMHVJFK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ulipristal
Disease Entry ICD 11 Status REF
Contraception QA21 Approved [2]
Ulipristal Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Modulator [2]
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Ulipristal Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [6]
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Indication(s) of Misoprostol
Disease Entry ICD 11 Status REF
Medical abortion JA00.1Z Approved [3]
Postpartum haemorrhage JA43 Approved [4]
Misoprostol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostacyclin receptor (PTGIR) TTOFYT1 PI2R_HUMAN Antagonist [7]
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Misoprostol Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [8]
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References

1 ClinicalTrials.gov (NCT04989400) Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion
2 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1936).
4 Misoprostol FDA Label
5 Emergency contraception. Gynecol Endocrinol. 2013 Mar;29 Suppl 1:1-14.
6 The clinical pharmacology and pharmacokinetics of ulipristal acetate for the treatment of uterine fibroids. Reprod Sci. 2015 Apr;22(4):476-83.
7 Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J Biol Chem. 2003 Feb 28;278(9):6947-58.
8 Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.