Details of the Drug Combination

General Information of Drug Combination (ID: DCHMS1M)

Drug Combination Name
JNJ-39220675 Pseudoephedrine
Indication
Disease Entry Status REF
Allergic Rhinitis Phase 1 [1]
Component Drugs JNJ-39220675   DM0WY3H Pseudoephedrine   DMIVJ0D
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of JNJ-39220675
Disease Entry ICD 11 Status REF
Alcohol dependence 6C40.2 Phase 2 [1]
JNJ-39220675 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Antagonist [4]
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Indication(s) of Pseudoephedrine
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [2]
Common cold CA00 Approved [2]
Headache 8A80-8A84 Approved [2]
Nasal congestion MD11.9 Approved [3]
Rhinitis FA20 Approved [2]
Seasonal allergic rhinitis CA08.01 Approved [2]
Vasomotor/allergic rhinitis CA08 Approved [2]
Sinusitis CA0A.Z Investigative [2]
Pseudoephedrine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Stimulator [5]
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Pseudoephedrine Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [6]
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References

1 ClinicalTrials.gov (NCT00804687) An Efficacy Study of JNJ-39220675 and Pseudoephedrine in Participants With Allergic Rhinitis. U.S. National Institutes of Health.
2 Ephedrine FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7286).
4 JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
5 Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2.
6 Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11.