Details of the Drug Combination

General Information of Drug Combination (ID: DCLVMFC)

Drug Combination Name
Varenicline Nicotine
Indication
Disease Entry Status REF
Nicotine Dependence Phase 1 [1]
Component Drugs Varenicline   DMMUOLJ Nicotine   DMWX5CO
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Varenicline
Disease Entry ICD 11 Status REF
Drug dependence N.A. Approved [2]
Smoking dependence 6C4A.2 Approved [3]
Varenicline Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) TTL1ATN ACHA4_HUMAN; ACHB2_HUMAN Modulator [7]
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Varenicline Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [8]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [9]
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Indication(s) of Nicotine
Disease Entry ICD 11 Status REF
Lung cancer 2C25.0 Approved [4]
Nicotine dependence 6C4A.2 Approved [5]
Pellagra N.A. Approved [4]
Tobacco dependence 6C4A.2 Clinical trial [6]
Nicotine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Nicotinic acetylcholine receptor (nAChR) TTJSZTB NOUNIPROTAC Antagonist [21]
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Nicotine Interacts with 13 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [22]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [22]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [23]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [24]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [22]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [22]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [25]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [22]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [22]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [26]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [22]
Cytochrome P450 2A13 (CYP2A13) DEXZA9U CP2AD_HUMAN Metabolism [27]
Nicotinate dehydrogenase (nicA) DE4AMLP NICA_PSEPK Metabolism [28]
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⏷ Show the Full List of 13 DME(s)
Nicotine Interacts with 458 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Decreases Activity [29]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [30]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Oxidation [31]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [32]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [33]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Increases Phosphorylation [34]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Decreases Activity [35]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [10]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [10]
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Increases Expression [10]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [10]
Regulatory factor X-associated protein (RFXAP) OTX46DKQ RFXAP_HUMAN Decreases Expression [11]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [11]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA) OTZA82J1 PTPRA_HUMAN Decreases Expression [11]
Ras-related protein Rab-6A (RAB6A) OTLS86J5 RAB6A_HUMAN Decreases Expression [11]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Decreases Expression [11]
Contactin-1 (CNTN1) OT7RNPEY CNTN1_HUMAN Decreases Expression [11]
Rho guanine nucleotide exchange factor 7 (ARHGEF7) OT9BPJCL ARHG7_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase RBBP6 (RBBP6) OTTVG4HU RBBP6_HUMAN Decreases Expression [11]
Histone-lysine N-methyltransferase 2C (KMT2C) OTC59BCO KMT2C_HUMAN Decreases Expression [11]
Fasciculation and elongation protein zeta-1 (FEZ1) OTWCXPRE FEZ1_HUMAN Decreases Expression [11]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Decreases Expression [11]
Echinoderm microtubule-associated protein-like 4 (EML4) OTJC45TA EMAL4_HUMAN Decreases Expression [11]
Copper chaperone for superoxide dismutase (CCS) OTXHT3QO CCS_HUMAN Increases Expression [36]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Expression [36]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [36]
Syntaxin-binding protein 3 (STXBP3) OTTTYMAQ STXB3_HUMAN Increases Expression [12]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Decreases Expression [12]
Segment polarity protein dishevelled homolog DVL-2 (DVL2) OTMNYNCM DVL2_HUMAN Decreases Expression [12]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [12]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Increases Expression [12]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [12]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2) OTR7WJES DC1L2_HUMAN Increases Expression [12]
E3 ubiquitin-protein ligase parkin (PRKN) OTJBN41W PRKN_HUMAN Decreases Expression [12]
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) OT45AHMB JIP4_HUMAN Increases Expression [12]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Increases Expression [12]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [12]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Decreases Expression [12]
Serine protease 1 (PRSS1) OTA425AX TRY1_HUMAN Decreases Expression [12]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [12]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [12]
Complement component C7 (C7) OTZ27VJN CO7_HUMAN Increases Expression [12]
Nucleoprotein TPR (TPR) OTUBBA4W TPR_HUMAN Increases Expression [12]
Acylamino-acid-releasing enzyme (APEH) OTX258QE ACPH_HUMAN Decreases Expression [12]
Glucosidase 2 subunit beta (PRKCSH) OTJCQYUU GLU2B_HUMAN Decreases Expression [12]
Membrane cofactor protein (CD46) OTQ8NWJD MCP_HUMAN Increases Expression [12]
High mobility group protein HMG-I/HMG-Y (HMGA1) OTQUSHPX HMGA1_HUMAN Decreases Expression [12]
Creatine kinase S-type, mitochondrial (CKMT2) OT1KNPI1 KCRS_HUMAN Decreases Expression [12]
S-adenosylmethionine decarboxylase proenzyme (AMD1) OTKAGZY3 DCAM_HUMAN Increases Expression [12]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) OT8DXMS3 E2AK2_HUMAN Increases Expression [12]
Thymidylate kinase (DTYMK) OTJXYQYK KTHY_HUMAN Decreases Expression [12]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Increases Expression [12]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Decreases Expression [12]
GTP cyclohydrolase 1 (GCH1) OTOZ6NSL GCH1_HUMAN Increases Expression [12]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [12]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Increases Expression [12]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [12]
Patatin-like phospholipase domain-containing protein 4 (PNPLA4) OT5CVDJM PLPL4_HUMAN Decreases Expression [12]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Increases Expression [12]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [12]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Increases Expression [12]
Translation initiation factor IF-2, mitochondrial (MTIF2) OTAIOZ0J IF2M_HUMAN Increases Expression [12]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Increases Expression [12]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Increases Expression [12]
Deoxyhypusine synthase (DHPS) OTQIG7BL DHYS_HUMAN Decreases Expression [12]
RNA-binding protein 25 (RBM25) OTVOUOAG RBM25_HUMAN Increases Expression [12]
DNA ligase 4 (LIG4) OT40DNXU DNLI4_HUMAN Increases Expression [12]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10) OTLMZGBE GBG10_HUMAN Increases Expression [12]
Serpin H1 (SERPINH1) OTKGI7BS SERPH_HUMAN Decreases Expression [12]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Increases Expression [12]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [12]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Expression [12]
Protein transport protein Sec61 subunit gamma (SEC61G) OT7MJRXY SC61G_HUMAN Increases Expression [12]
Myosin light polypeptide 6 (MYL6) OT84YKPM MYL6_HUMAN Decreases Expression [12]
CMP-sialic acid transporter (SLC35A1) OTPWOOVA S35A1_HUMAN Increases Expression [12]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Increases Expression [12]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Increases Expression [12]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A) OTSK5GFC P2R3A_HUMAN Increases Expression [12]
Phosphatidylinositol-glycan biosynthesis class F protein (PIGF) OTJKE6VW PIGF_HUMAN Increases Expression [12]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Increases Expression [12]
Zinc finger protein Rlf (RLF) OTCSPZVK RLF_HUMAN Increases Expression [12]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Increases Expression [12]
Origin recognition complex subunit 2 (ORC2) OTLIYP8M ORC2_HUMAN Increases Expression [12]
Zinc transporter ZIP6 (SLC39A6) OTCYF466 S39A6_HUMAN Increases Expression [12]
Golgin subfamily A member 4 (GOLGA4) OTCMEHNJ GOGA4_HUMAN Increases Expression [12]
Serine incorporator 3 (SERINC3) OTQ1LAJ1 SERC3_HUMAN Increases Expression [12]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Increases Expression [12]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [12]
Cyclin-dependent kinase 13 (CDK13) OT3P7JF1 CDK13_HUMAN Increases Expression [12]
UDP-glucose 4-epimerase (GALE) OTVFS16E GALE_HUMAN Decreases Expression [12]
Protocadherin Fat 1 (FAT1) OTF174DH FAT1_HUMAN Increases Expression [12]
Serum paraoxonase/arylesterase 2 (PON2) OT55NCTD PON2_HUMAN Increases Expression [12]
Thyroid receptor-interacting protein 11 (TRIP11) OT4FJEAR TRIPB_HUMAN Increases Expression [12]
Serine/threonine-protein kinase N2 (PKN2) OTW0SOID PKN2_HUMAN Increases Expression [12]
DNA damage-binding protein 1 (DDB1) OTTR2L3Z DDB1_HUMAN Decreases Expression [12]
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) OTR848KZ NDUA5_HUMAN Increases Expression [12]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Increases Expression [12]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Increases Expression [12]
Heterochromatin protein 1-binding protein 3 (HP1BP3) OTTJ5LX2 HP1B3_HUMAN Increases Expression [12]
Pre-mRNA-splicing factor 38B (PRPF38B) OTQLH551 PR38B_HUMAN Increases Expression [12]
Lysine-specific demethylase 7A (KDM7A) OT1VGYCX KDM7A_HUMAN Increases Expression [12]
Serine/threonine-protein kinase TAO1 (TAOK1) OTFFLV6Q TAOK1_HUMAN Increases Expression [12]
Ninein (NIN) OTVH3M4Z NIN_HUMAN Increases Expression [12]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [12]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Increases Expression [12]
PHD finger protein 3 (PHF3) OTNOYLG9 PHF3_HUMAN Increases Expression [12]
Probable ATP-dependent RNA helicase DDX17 (DDX17) OTXRMMBP DDX17_HUMAN Increases Expression [12]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Increases Expression [12]
snRNA-activating protein complex subunit 3 (SNAPC3) OTSGZZCJ SNPC3_HUMAN Increases Expression [12]
PHD finger protein 21A (PHF21A) OTU3FFG4 PF21A_HUMAN Increases Expression [12]
THO complex subunit 1 (THOC1) OTVABJ4Z THOC1_HUMAN Increases Expression [12]
Chloride channel CLIC-like protein 1 (CLCC1) OTTXCXVT CLCC1_HUMAN Increases Expression [12]
Protein SCAF11 (SCAF11) OTX59D0X SCAFB_HUMAN Increases Expression [12]
Mediator of RNA polymerase II transcription subunit 28 (MED28) OTEDM1L5 MED28_HUMAN Increases Expression [12]
Pantothenate kinase 3 (PANK3) OT77CFJ6 PANK3_HUMAN Increases Expression [12]
Arginine and glutamate-rich protein 1 (ARGLU1) OTRVRZ4Z ARGL1_HUMAN Increases Expression [12]
DDB1- and CUL4-associated factor 16 (DCAF16) OT60PR7J DCA16_HUMAN Increases Expression [12]
Polypyrimidine tract-binding protein 2 (PTBP2) OTF4S7NE PTBP2_HUMAN Increases Expression [12]
Splicing factor 3B subunit 6 (SF3B6) OTPRKS6S SF3B6_HUMAN Increases Expression [12]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Increases Expression [12]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [37]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Affects Localization [37]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [37]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [38]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Increases Expression [38]
Deoxyribonuclease-2-alpha (DNASE2) OT6RC1BL DNS2A_HUMAN Decreases Expression [13]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Decreases Expression [13]
Serine/threonine-protein kinase 25 (STK25) OT4YPNTF STK25_HUMAN Increases Expression [13]
Krueppel-like factor 11 (KLF11) OTKVQDJD KLF11_HUMAN Decreases Expression [13]
Phospholipase D2 (PLD2) OT86I3WH PLD2_HUMAN Increases Expression [13]
Mothers against decapentaplegic homolog 9 (SMAD9) OTK4M1H8 SMAD9_HUMAN Increases Expression [13]
C-C motif chemokine 16 (CCL16) OTOOQI1F CCL16_HUMAN Decreases Expression [13]
Death effector domain-containing protein (DEDD) OTIL349E DEDD_HUMAN Decreases Expression [13]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Decreases Expression [13]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Increases Expression [13]
T-cell surface glycoprotein CD4 (CD4) OT7Z5LNF CD4_HUMAN Decreases Expression [13]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Decreases Expression [13]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [13]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [13]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [13]
Retinoic acid receptor gamma (RARG) OT8LHMDH RARG_HUMAN Decreases Expression [13]
CD59 glycoprotein (CD59) OTSUMQDH CD59_HUMAN Increases Expression [13]
POU domain, class 2, transcription factor 1 (POU2F1) OTK7ELJ0 PO2F1_HUMAN Increases Expression [13]
Interleukin-9 (IL9) OTK4XO6Q IL9_HUMAN Decreases Expression [13]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Increases Expression [13]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Decreases Expression [13]
Thyrotropin receptor (TSHR) OT0BC8LB TSHR_HUMAN Increases Expression [13]
Interferon alpha/beta receptor 1 (IFNAR1) OTD4OOFK INAR1_HUMAN Decreases Expression [13]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Decreases Expression [13]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Decreases Expression [13]
Transcription factor BTF3 (BTF3) OT5ZZFJL BTF3_HUMAN Decreases Expression [13]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [13]
C5a anaphylatoxin chemotactic receptor 1 (C5AR1) OT58QDI9 C5AR1_HUMAN Decreases Expression [13]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Expression [13]
E3 ubiquitin-protein ligase CBL (CBL) OTTKELCU CBL_HUMAN Increases Expression [13]
C-X-C chemokine receptor type 2 (CXCR2) OTISGW7L CXCR2_HUMAN Decreases Expression [13]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Decreases Expression [13]
Platelet-activating factor receptor (PTAFR) OT2133DF PTAFR_HUMAN Decreases Expression [13]
Nuclear transcription factor Y subunit beta (NFYB) OTXSE7KW NFYB_HUMAN Decreases Expression [13]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [13]
Hepatocyte growth factor-like protein (MST1) OTOC4UNG HGFL_HUMAN Decreases Expression [13]
Interleukin-3 receptor subunit alpha (IL3RA) OTDC3Y8O IL3RA_HUMAN Decreases Expression [13]
Embryonic growth/differentiation factor 1 (GDF1) OTZ1VRBH GDF1_HUMAN Increases Expression [13]
Proteasome subunit beta type-6 (PSMB6) OT9VXPNW PSB6_HUMAN Decreases Expression [13]
Ephrin type-A receptor 3 (EPHA3) OTZJF3ML EPHA3_HUMAN Decreases Expression [13]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Increases Expression [13]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [13]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Expression [13]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Decreases Expression [13]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [13]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [13]
Kappa-type opioid receptor (OPRK1) OTXCZF4L OPRK_HUMAN Decreases Expression [13]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [13]
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Increases Expression [13]
C-C chemokine receptor type 6 (CCR6) OT61JMYX CCR6_HUMAN Decreases Expression [13]
Signal transducer and activator of transcription 2 (STAT2) OTO9G2RZ STAT2_HUMAN Decreases Expression [13]
Ephrin type-B receptor 3 (EPHB3) OT4XD8O3 EPHB3_HUMAN Decreases Expression [13]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Decreases Expression [13]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [13]
Large ribosomal subunit protein eL8 (RPL7A) OT6E6UKF RL7A_HUMAN Decreases Expression [13]
Small ribosomal subunit protein eS25 (RPS25) OTKLWED2 RS25_HUMAN Increases Expression [13]
Transcription elongation factor SPT4 (SUPT4H1) OTB3UCTB SPT4H_HUMAN Decreases Expression [13]
Tyrosine-protein kinase BTK (BTK) OTG3CDVK BTK_HUMAN Decreases Expression [13]
Protein CBFA2T1 (RUNX1T1) OT30DED5 MTG8_HUMAN Decreases Expression [13]
Lymphotoxin-beta (LTB) OTUFS8CF TNFC_HUMAN Decreases Expression [13]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Increases Expression [13]
Nucleoside diphosphate kinase 3 (NME3) OT0CA0GF NDK3_HUMAN Decreases Expression [13]
Phospholipase D1 (PLD1) OTMVUKW6 PLD1_HUMAN Decreases Expression [13]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [13]
Helicase-like transcription factor (HLTF) OTRX2OSF HLTF_HUMAN Decreases Expression [13]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) OTRHB9SR NHRF2_HUMAN Decreases Expression [13]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [13]
Cocaine- and amphetamine-regulated transcript protein (CARTPT) OTTE4V9S CART_HUMAN Decreases Expression [13]
POU domain class 2-associating factor 1 (POU2AF1) OTOO6WHL OBF1_HUMAN Decreases Expression [13]
Anti-Muellerian hormone type-2 receptor (AMHR2) OT95APPM AMHR2_HUMAN Decreases Expression [13]
Serine/threonine-protein kinase LMTK1 (AATK) OTVHAX5N LMTK1_HUMAN Increases Expression [13]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Decreases Expression [13]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [13]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Expression [39]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [39]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [39]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [39]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [39]
Signal transducer and activator of transcription 6 (STAT6) OTCKMP49 STAT6_HUMAN Increases Expression [39]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [39]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Increases Expression [39]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Affects Expression [40]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Affects Expression [40]
Metalloproteinase inhibitor 4 (TIMP4) OT8A68SW TIMP4_HUMAN Affects Expression [40]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [41]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [41]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Increases Expression [41]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [41]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [41]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Increases Expression [41]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [41]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Increases Expression [41]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [41]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [32]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [32]
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Decreases Expression [42]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Decreases Expression [43]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [43]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [14]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Increases Expression [14]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Increases Activity [14]
Polycomb complex protein BMI-1 (BMI1) OTROVLJ0 BMI1_HUMAN Increases Expression [14]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [14]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [14]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [44]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [44]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [44]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Increases Expression [44]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [44]
Ankyrin repeat and BTB/POZ domain-containing protein 3 (ABTB3) OT3PLG38 ABTB3_HUMAN Increases Expression [15]
Envoplakin-like protein (EVPLL) OT1BCQEW EVPLL_HUMAN Increases Expression [15]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [15]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Increases Expression [15]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Increases Expression [15]
Ephrin-A2 (EFNA2) OTEAUKRX EFNA2_HUMAN Increases Expression [15]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Increases Expression [15]
Kinesin-like protein KIF21B (KIF21B) OTFXFIU3 KI21B_HUMAN Increases Expression [15]
Immunoglobulin superfamily member 3 (IGSF3) OT6GWBAF IGSF3_HUMAN Increases Expression [15]
Gamma-glutamylcyclotransferase (GGCT) OTKAICP5 GGCT_HUMAN Increases Splicing [15]
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3) OTDA431Y ENTP3_HUMAN Increases Expression [15]
Mediator of RNA polymerase II transcription subunit 24 (MED24) OTU4SJQ1 MED24_HUMAN Increases Expression [15]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [15]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Increases Expression [15]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Increases Expression [15]
Glycoprotein hormones alpha chain (CGA) OT00U3Y3 GLHA_HUMAN Increases Expression [15]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Decreases Expression [15]
Keratin, type II cytoskeletal 6B (KRT6B) OTBXJYHY K2C6B_HUMAN Increases Expression [15]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [15]
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) OTTLGRGH GNAI2_HUMAN Increases Splicing [15]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Increases Expression [15]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Increases Expression [15]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [15]
Coiled-coil domain-containing protein 159 (CCDC159) OTFKSPMZ CC159_HUMAN Increases Expression [15]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Increases Expression [15]
Fumarylacetoacetase (FAH) OTGZA1YR FAAA_HUMAN Increases Expression [15]
Homeobox protein Hox-B9 (HOXB9) OTMVHQOU HXB9_HUMAN Increases Expression [15]
Ganglioside GM2 activator (GM2A) OTIRWZC0 SAP3_HUMAN Increases Expression [15]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Increases Expression [15]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [15]
Small proline-rich protein 2D (SPRR2D) OT47THNK SPR2D_HUMAN Increases Expression [15]
Protein S100-A2 (S100A2) OTTGHJ1H S10A2_HUMAN Increases Expression [15]
Neurotensin receptor type 1 (NTSR1) OTTJUTE3 NTR1_HUMAN Increases Expression [15]
Caspase-14 (CASP14) OTKY93H9 CASPE_HUMAN Increases Expression [15]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Splicing [15]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Increases Expression [15]
Cathelicidin antimicrobial peptide (CAMP) OT3Y8011 CAMP_HUMAN Increases Expression [15]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [15]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E) OTMPLAIS ATP5E_HUMAN Increases Splicing [15]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Increases Splicing [15]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Increases Splicing [15]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Splicing [15]
Small ribosomal subunit protein eS24 (RPS24) OTSNKIL5 RS24_HUMAN Increases Splicing [15]
Keratin, type II cuticular Hb5 (KRT85) OT67IP7F KRT85_HUMAN Increases Expression [15]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [15]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Splicing [15]
Paired box protein Pax-8 (PAX8) OTRPD9MI PAX8_HUMAN Increases Expression [15]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Increases Expression [15]
Transcription intermediary factor 1-beta (TRIM28) OTE38OBF TIF1B_HUMAN Increases Splicing [15]
Melatonin-related receptor (GPR50) OT0EJBM4 MTR1L_HUMAN Increases Expression [15]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Splicing [15]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Increases Expression [15]
C3a anaphylatoxin chemotactic receptor (C3AR1) OT8J0TF8 C3AR_HUMAN Increases Expression [15]
Protein Aster-B (GRAMD1B) OTCG1GX2 ASTRB_HUMAN Increases Expression [15]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Increases Expression [15]
SH3 domain-containing protein 19 (SH3D19) OTVU3VS2 SH319_HUMAN Increases Splicing [15]
Late cornified envelope protein 1B (LCE1B) OT7BLO6L LCE1B_HUMAN Increases Expression [15]
Terminal nucleotidyltransferase 4A (TENT4A) OT0G3KR0 PAPD7_HUMAN Increases Splicing [15]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [15]
TMF-regulated nuclear protein 1 (TRNP1) OTYYV8LN TRNP1_HUMAN Increases Expression [15]
Olfactomedin-4 (OLFM4) OTELHN9L OLFM4_HUMAN Decreases Expression [15]
Solute carrier family 25 member 48 (SLC25A48) OTAMLAGE S2548_HUMAN Decreases Expression [15]
Activity-regulated cytoskeleton-associated protein (ARC) OTN2QQPG ARC_HUMAN Increases Expression [15]
5'-deoxynucleotidase HDDC2 (HDDC2) OTSO0JP4 HDDC2_HUMAN Increases Expression [15]
Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3) OTYAKC55 LRAD3_HUMAN Increases Splicing [15]
Neuronal PAS domain-containing protein 3 (NPAS3) OT8D1ILB NPAS3_HUMAN Decreases Expression [15]
Prominin-2 (PROM2) OTT8IVS7 PROM2_HUMAN Increases Expression [15]
Synaptopodin (SYNPO) OTICDJAB SYNPO_HUMAN Increases Expression [15]
Cilia- and flagella-associated protein 43 (CFAP43) OT6R8UGG CFA43_HUMAN Decreases Expression [15]
Protein FAM83F (FAM83F) OTGGJRO7 FA83F_HUMAN Increases Expression [15]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Increases Expression [15]
Retinoic acid early transcript 1E (RAET1E) OTLR3CEC RAE1E_HUMAN Increases Expression [15]
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2) OTH77FBE G6PT3_HUMAN Increases Expression [15]
Prospero homeobox protein 1 (PROX1) OT68R6IO PROX1_HUMAN Increases Expression [15]
Phosphatidate cytidylyltransferase 1 (CDS1) OT2F591M CDS1_HUMAN Increases Splicing [15]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Increases Expression [15]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) OTIUA60B SH3K1_HUMAN Increases Expression [15]
Androgen-dependent TFPI-regulating protein (ADTRP) OTFI2BQX ADTRP_HUMAN Increases Expression [15]
Gasdermin-A (GSDMA) OT912R2E GSDMA_HUMAN Increases Expression [15]
SH3 and cysteine-rich domain-containing protein (STAC) OTRVBSLR STAC_HUMAN Increases Expression [15]
Cell growth regulator with EF hand domain protein 1 (CGREF1) OTBZQX97 CGRE1_HUMAN Increases Expression [15]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Increases Expression [15]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Increases Expression [15]
Tubulointerstitial nephritis antigen-like (TINAGL1) OTZZO56M TINAL_HUMAN Increases Expression [15]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Increases Expression [15]
Transmembrane protein 222 (TMEM222) OTWFLPK2 TM222_HUMAN Increases Splicing [15]
Beta-defensin 129 (DEFB129) OT1R2LZM DB129_HUMAN Decreases Expression [15]
CXADR-like membrane protein (CLMP) OTU7C3GQ CLMP_HUMAN Increases Expression [15]
Protein S100-A14 (S100A14) OTVFJJ91 S10AE_HUMAN Increases Expression [15]
SH2 domain-containing protein 2A (SH2D2A) OTQSKW7U SH22A_HUMAN Increases Expression [15]
Triggering receptor expressed on myeloid cells 1 (TREM1) OTCVFEE6 TREM1_HUMAN Increases Expression [15]
Serine palmitoyltransferase 3 (SPTLC3) OTZDX6PT SPTC3_HUMAN Increases Expression [15]
G patch domain-containing protein 2 (GPATCH2) OT09TY4W GPTC2_HUMAN Increases Splicing [15]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [15]
Protocadherin Fat 2 (FAT2) OTRGT3E8 FAT2_HUMAN Increases Expression [15]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Increases Splicing [15]
Coiled-coil domain-containing protein 167 (CCDC167) OTUIAUE7 CC167_HUMAN Increases Expression [15]
Cysteine-rich C-terminal protein 1 (CRCT1) OTPYME8V CRCT1_HUMAN Increases Expression [15]
STEAP1 protein (STEAP1) OTJMW5R9 STEA1_HUMAN Increases Expression [15]
Protein mono-ADP-ribosyltransferase PARP4 (PARP4) OTXBK59G PARP4_HUMAN Increases Splicing [15]
Hippocalcin-like protein 4 (HPCAL4) OT793RNP HPCL4_HUMAN Increases Expression [15]
Angiopoietin-4 (ANGPT4) OT881M3K ANGP4_HUMAN Increases Expression [15]
Kallikrein-5 (KLK5) OT2TQXS7 KLK5_HUMAN Increases Expression [15]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Increases Expression [15]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Increases Expression [15]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Decreases Expression [45]
Steroidogenic factor 1 (NR5A1) OTOULYR4 STF1_HUMAN Decreases Expression [45]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Increases Expression [45]
Histone deacetylase 7 (HDAC7) OTQ3P0XA HDAC7_HUMAN Increases Expression [45]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Expression [45]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [46]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Increases Phosphorylation [46]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Increases Expression [46]
Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) OTR94VKQ ACHA9_HUMAN Increases Expression [46]
RNA binding protein fox-1 homolog 3 (RBFOX3) OTL0F3D6 RFOX3_HUMAN Increases Expression [47]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [19]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [48]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [49]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Increases Secretion [50]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Phosphorylation [51]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [52]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Activity [53]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Increases Expression [54]
Beta-nerve growth factor (NGF) OTOLABJT NGF_HUMAN Increases Expression [55]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Increases Secretion [56]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Secretion [56]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Degradation [17]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Secretion [57]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Decreases Expression [58]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [59]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [52]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Increases Activity [53]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Increases Secretion [60]
High affinity nerve growth factor receptor (NTRK1) OTJORQAU NTRK1_HUMAN Increases Expression [55]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Decreases Expression [61]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [50]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [62]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [63]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Expression [59]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [64]
Tyrosine 3-monooxygenase (TH) OT6ZORKP TY3H_HUMAN Increases Expression [65]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Increases Expression [47]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Decreases Expression [63]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [66]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [55]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Increases Expression [52]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [52]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Decreases Expression [61]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Secretion [67]
Dopamine beta-hydroxylase (DBH) OTC6I2SP DOPO_HUMAN Increases Expression [65]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [54]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Increases Expression [55]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [68]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [69]
Phenylethanolamine N-methyltransferase (PNMT) OTGLCPE8 PNMT_HUMAN Increases Expression [65]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [70]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [71]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [72]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases Phosphorylation [51]
Lysosome-associated membrane glycoprotein 2 (LAMP2) OTLUGEJC LAMP2_HUMAN Decreases Expression [73]
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Increases Expression [19]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Decreases Expression [70]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) OT6EBDHM DHB1_HUMAN Decreases Expression [70]
Neutrophil cytosol factor 1 (NCF1) OTMHT3G6 NCF1_HUMAN Increases Expression [74]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [75]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Increases Expression [76]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Increases Activity [77]
Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) OTNAT2M5 ACHB2_HUMAN Increases Expression [47]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [78]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [79]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Increases Expression [72]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Phosphorylation [80]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Secretion [81]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Increases Expression [82]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [83]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Phosphorylation [74]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Decreases Activity [84]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [75]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Activity [77]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [71]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) OTCZQY1U ACHA3_HUMAN Decreases Expression [85]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [74]
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) OTBUSUTE ACHA7_HUMAN Decreases Expression [85]
Pigment epithelium-derived factor (SERPINF1) OTWZH98J PEDF_HUMAN Decreases Expression [16]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Activity [72]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Decreases Expression [76]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) OT1H0ZXC ACHA4_HUMAN Increases Expression [86]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [52]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Decreases Expression [49]
C-X-C chemokine receptor type 3 (CXCR3) OTIGS220 CXCR3_HUMAN Increases Expression [47]
Adenosine 5'-monophosphoramidase HINT1 (HINT1) OTQIR8LF HINT1_HUMAN Increases Expression [87]
Oxysterols receptor LXR-beta (NR1H2) OT4APA60 NR1H2_HUMAN Decreases Expression [49]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [64]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Response To Substance [71]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Increases Expression [47]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Decreases Expression [88]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Increases Expression [64]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [64]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Decreases Secretion [89]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [74]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Increases Activity [90]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Decreases Expression [91]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Phosphorylation [92]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Decreases Expression [49]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [73]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Increases Secretion [57]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Expression [64]
Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6) OTT6W86V ACHA6_HUMAN Decreases Expression [85]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Increases Expression [81]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [93]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Decreases Expression [49]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Increases Expression [57]
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Increases Metabolism [94]
Regulatory-associated protein of mTOR (RPTOR) OT4TQZ9F RPTOR_HUMAN Affects Response To Substance [95]
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) OTA7IBLE LYSM3_HUMAN Affects Response To Substance [95]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Increases Response To Substance [96]
Pleckstrin homology domain-containing family G member 1 (PLEKHG1) OTDVYW2F PKHG1_HUMAN Affects Response To Substance [95]
Choline O-acetyltransferase (CHAT) OTEJWQ45 CLAT_HUMAN Increases ADR [97]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Affects Response To Substance [98]
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) OTGIL2YD ACHA5_HUMAN Increases Response To Substance [99]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases ADR [97]
Plastin-2 (LCP1) OTK61F2A PLSL_HUMAN Affects Response To Substance [95]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Increases ADR [97]
Neuronal acetylcholine receptor subunit alpha-2 (CHRNA2) OTVQQSMK ACHA2_HUMAN Affects Response To Substance [100]
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⏷ Show the Full List of 458 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Smoking Cessation DC65DT3 N. A. Phase 2 [101]
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References

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4 Nicotine FDA Label
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101 ClinicalTrials.gov (NCT05413122) Evaluating Smoking Cessation Interventions for PWH in South Africa