Details of the Drug Combination

General Information of Drug Combination (ID: DCMQMZU)

Drug Combination Name
Gonadorelin ARN-509
Indication
Disease Entry Status REF
Prostate Cancer Phase 3 [1]
Component Drugs Gonadorelin   DMAQ469 ARN-509   DMT81LZ
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Gonadorelin
Disease Entry ICD 11 Status REF
Amenorrhea GA20.0 Approved [2]
Hypothalamic hypogonadism 5A61.2 Approved [3]
Gonadorelin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Agonist [6]
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Gonadorelin Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Prolyl endopeptidase (PREP) DEVSCNZ PPCE_HUMAN Metabolism [7]
Thimet oligopeptidase (THOP1) DE95LJC THOP1_HUMAN Metabolism [8]
Metallo-endopeptidase-like 1 (MMEL1) DEYCUQ2 MMEL1_HUMAN Metabolism [9]
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Indication(s) of ARN-509
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Approved [4]
Prostate cancer 2C82.0 Phase 3 [5]
ARN-509 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Androgen receptor (AR) TTS64P2 ANDR_HUMAN Inhibitor [4]
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ARN-509 Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [10]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [10]
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References

1 ClinicalTrials.gov (NCT03009981) A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer
2 Gonadorelin FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4391).
4 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5 ClinicalTrials.gov (NCT01946204) A Study of ARN-509 in Men With Non-Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health.
6 Use of cognitive behavior therapy for functional hypothalamic amenorrhea. Ann N Y Acad Sci. 2006 Dec;1092:114-29.
7 Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase. Methods Mol Biol. 2011;681:215-28.
8 Sleep deprivation changes thimet oligopeptidase (THOP1) expression and activity in rat brain. Heliyon. 2019 Nov 26;5(11):e02896.
9 Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. Biochem J. 2002 May 1;363(Pt 3):697-705.
10 Apalutamide: first global approval. Drugs. 2018 Apr;78(6):699-705.