Details of the Drug Combination

General Information of Drug Combination (ID: DCMWC39)

Drug Combination Name
Varenicline Acetylcysteine
Indication
Disease Entry Status REF
Nicotine Dependence, Cigarettes Phase 2 [1]
Component Drugs Varenicline   DMMUOLJ Acetylcysteine   DMWSXI4
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Varenicline
Disease Entry ICD 11 Status REF
Drug dependence N.A. Approved [2]
Smoking dependence 6C4A.2 Approved [3]
Varenicline Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) TTL1ATN ACHA4_HUMAN; ACHB2_HUMAN Modulator [6]
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Varenicline Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [7]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [8]
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Indication(s) of Acetylcysteine
Disease Entry ICD 11 Status REF
Amyloidosis 5D00 Approved [4]
Bronchiectasis CA24 Approved [4]
Bronchitis CA20 Approved [4]
Bulimia nervosa 6B81 Approved [4]
Ischemia-reperfusion injury DB98.B Approved [4]
Liver disease DB90-BD99 Approved [5]
Paracetamol poisoning N.A. Approved [4]

References

1 ClinicalTrials.gov (NCT02723162) Translational Neuropsychopharmacology Research of Nicotine Addiction
2 Varenicline FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5459).
4 Acetylcysteine FDA Label
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
7 Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro-in vivo study. Clin Pharmacol Ther. 2008 Apr;83(4):567-76.
8 Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42.