Details of the Drug Combination

General Information of Drug Combination (ID: DCQDAKR)

Drug Combination Name
Eflornithine Nifurtimox
Indication
Disease Entry Status REF
Human African Trypanosomiasis (HAT) Phase 1 [1]
Component Drugs Eflornithine   DMJOQM3 Nifurtimox   DMSQLZJ
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Eflornithine
Disease Entry ICD 11 Status REF
African trypanosomiasis 1F51 Approved [2]
Trypanosomiasis 1D51-1F53 Phase 2 [3]
Colon cancer 2B90.Z Investigative [4]
Familial adenomatous polyposis 2B90.Y Investigative [4]
Eflornithine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ornithine decarboxylase (ODC1) TTUMGNO DCOR_HUMAN Inhibitor [7]
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Indication(s) of Nifurtimox
Disease Entry ICD 11 Status REF
Chagas disease IF53 Approved [5]
Trypanosomiasis 1D51-1F53 Phase 4 [6]
Nifurtimox Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [8]
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References

1 ClinicalTrials.gov (NCT01685827) Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5176).
3 ClinicalTrials.gov (NCT01636128) Urinary Biomarker Study With Sulindac and Difluoromethylornithine. U.S. National Institutes of Health.
4 Eflornithine FDA Label
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
6 ClinicalTrials.gov (NCT00906880) Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense HumanAfrican Trypanosomiasis (HAT) in the Meningo-encephalitic Phase. U.S. National Institutes of Health.
7 Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
8 The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Brain Res. 2012 Feb 3;1436:111-21.