DOT Name |
DOT ID |
UniProt ID |
Mode of Action |
REF |
Multidrug resistance-associated protein 1 (ABCC1)
|
OTGUN89S
|
MRP1_HUMAN
|
Decreases Response To Substance
|
[12] |
ATP-dependent translocase ABCB1 (ABCB1)
|
OTEJROBO
|
MDR1_HUMAN
|
Decreases Response To Substance
|
[13] |
Urokinase-type plasminogen activator (PLAU)
|
OTX0QGKK
|
UROK_HUMAN
|
Increases Expression
|
[5] |
Dihydropyrimidinase-related protein 4 (DPYSL4)
|
OT3SBS2S
|
DPYL4_HUMAN
|
Increases Expression
|
[5] |
Integral membrane protein GPR137B (GPR137B)
|
OT1CINQQ
|
G137B_HUMAN
|
Increases Expression
|
[5] |
Integrin alpha-IIb (ITGA2B)
|
OT4Y17PY
|
ITA2B_HUMAN
|
Increases Expression
|
[5] |
Ras-related protein R-Ras (RRAS)
|
OTBBF28C
|
RRAS_HUMAN
|
Increases Expression
|
[5] |
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
|
OTDRV63V
|
GA45A_HUMAN
|
Increases Expression
|
[5] |
Stomatin (STOM)
|
OTC8R6EH
|
STOM_HUMAN
|
Increases Expression
|
[5] |
Cellular retinoic acid-binding protein 2 (CRABP2)
|
OTY01V9G
|
RABP2_HUMAN
|
Increases Expression
|
[5] |
Tyrosine-protein kinase receptor UFO (AXL)
|
OTKA2SUX
|
UFO_HUMAN
|
Increases Expression
|
[5] |
14-3-3 protein sigma (SFN)
|
OTLJCZ1U
|
1433S_HUMAN
|
Increases Expression
|
[5] |
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)
|
OTV9L89D
|
TNFL9_HUMAN
|
Increases Expression
|
[5] |
Galectin-7 (LGALS7)
|
OTMSVI7R
|
LEG7_HUMAN
|
Increases Expression
|
[5] |
Large ribosomal subunit protein eL34 (RPL34)
|
OT0U9VMQ
|
RL34_HUMAN
|
Increases Expression
|
[5] |
Rho GDP-dissociation inhibitor 2 (ARHGDIB)
|
OT9PD6CS
|
GDIR2_HUMAN
|
Increases Expression
|
[5] |
Epithelial membrane protein 1 (EMP1)
|
OTSZHUHQ
|
EMP1_HUMAN
|
Increases Expression
|
[5] |
Epithelial membrane protein 3 (EMP3)
|
OTODMJ1D
|
EMP3_HUMAN
|
Increases Expression
|
[5] |
Protein ripply3 (RIPPLY3)
|
OT1HK35I
|
DSCR6_HUMAN
|
Increases Expression
|
[5] |
Endonuclease III-like protein 1 (NTHL1)
|
OTPQXPT1
|
NTH_HUMAN
|
Decreases Expression
|
[5] |
Antigen peptide transporter 1 (TAP1)
|
OTJL27PW
|
TAP1_HUMAN
|
Increases Expression
|
[5] |
Apoptosis regulator BAX (BAX)
|
OTAW0V4V
|
BAX_HUMAN
|
Increases Expression
|
[5] |
Kinesin-like protein KIF1A (KIF1A)
|
OT3JVEGV
|
KIF1A_HUMAN
|
Increases Expression
|
[5] |
Protein AF1q (MLLT11)
|
OTG5RVHC
|
AF1Q_HUMAN
|
Increases Expression
|
[5] |
Laminin subunit gamma-2 (LAMC2)
|
OTJMTM72
|
LAMC2_HUMAN
|
Increases Expression
|
[5] |
Filamin-C (FLNC)
|
OT3F8J6Y
|
FLNC_HUMAN
|
Increases Expression
|
[5] |
Immediate early response gene 5 protein (IER5)
|
OTJPTXMD
|
IER5_HUMAN
|
Increases Expression
|
[5] |
Keratin, type II cytoskeletal 80 (KRT80)
|
OTAU54U3
|
K2C80_HUMAN
|
Increases Expression
|
[5] |
All-trans-retinol 13,14-reductase (RETSAT)
|
OTC3AOPX
|
RETST_HUMAN
|
Increases Expression
|
[5] |
Interleukin-27 receptor subunit alpha (IL27RA)
|
OTSQBAKI
|
I27RA_HUMAN
|
Increases Expression
|
[5] |
Neuropilin and tolloid-like protein 2 (NETO2)
|
OT0YAMC0
|
NETO2_HUMAN
|
Increases Expression
|
[5] |
Mitochondria-eating protein (SPATA18)
|
OTOEHTHU
|
MIEAP_HUMAN
|
Increases Expression
|
[5] |
Phospholipase ABHD3 (ABHD3)
|
OTH8P977
|
ABHD3_HUMAN
|
Increases Expression
|
[5] |
Homer protein homolog 3 (HOMER3)
|
OTQ6D9X1
|
HOME3_HUMAN
|
Increases Expression
|
[5] |
BSD domain-containing protein 1 (BSDC1)
|
OT853CP9
|
BSDC1_HUMAN
|
Increases Expression
|
[5] |
Stathmin-3 (STMN3)
|
OT20F289
|
STMN3_HUMAN
|
Increases Expression
|
[5] |
Endothelial protein C receptor (PROCR)
|
OTRHED17
|
EPCR_HUMAN
|
Increases Expression
|
[5] |
Fatty acid desaturase 3 (FADS3)
|
OT9RVXGE
|
FADS3_HUMAN
|
Increases Expression
|
[5] |
Protein O-mannosyl-transferase 1 (POMT1)
|
OTGQSHL5
|
POMT1_HUMAN
|
Increases Expression
|
[5] |
Tissue factor (F3)
|
OT3MSU3B
|
TF_HUMAN
|
Decreases Expression
|
[14] |
Tumor protein p53-inducible protein 11 (TP53I11)
|
OTFPDYZU
|
P5I11_HUMAN
|
Decreases Expression
|
[15] |
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
|
OTA1CPBV
|
TR10B_HUMAN
|
Decreases Expression
|
[16] |
CASP8 and FADD-like apoptosis regulator (CFLAR)
|
OTX14BAS
|
CFLAR_HUMAN
|
Decreases Expression
|
[17] |
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
|
OTUXEASC
|
M3K7_HUMAN
|
Decreases Expression
|
[18] |
Prominin-1 (PROM1)
|
OTBHV8NX
|
PROM1_HUMAN
|
Decreases Expression
|
[19] |
Myc proto-oncogene protein (MYC)
|
OTPV5LUK
|
MYC_HUMAN
|
Decreases Expression
|
[18] |
Low-density lipoprotein receptor (LDLR)
|
OTH559LU
|
LDLR_HUMAN
|
Decreases Expression
|
[20] |
Tumor necrosis factor (TNF)
|
OT4IE164
|
TNFA_HUMAN
|
Increases Response To Substance
|
[21] |
Collagen alpha-1(I) chain (COL1A1)
|
OTI31178
|
CO1A1_HUMAN
|
Decreases Expression
|
[22] |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
|
OTBPMIMW
|
G3P_HUMAN
|
Increases Expression
|
[18] |
Cellular tumor antigen p53 (TP53)
|
OTIE1VH3
|
P53_HUMAN
|
Increases Activity
|
[23] |
Cytochrome P450 1A1 (CYP1A1)
|
OTE4EFH8
|
CP1A1_HUMAN
|
Decreases Expression
|
[24] |
Interleukin-6 (IL6)
|
OTUOSCCU
|
IL6_HUMAN
|
Decreases Secretion
|
[22] |
Proto-oncogene tyrosine-protein kinase ROS (ROS1)
|
OTDSKUGE
|
ROS1_HUMAN
|
Increases Expression
|
[18] |
Fibroblast growth factor 2 (FGF2)
|
OT7YUJ9F
|
FGF2_HUMAN
|
Decreases Expression
|
[25] |
Heme oxygenase 1 (HMOX1)
|
OTC1W6UX
|
HMOX1_HUMAN
|
Decreases Expression
|
[26] |
Interleukin-8 (CXCL8)
|
OTS7T5VH
|
IL8_HUMAN
|
Increases Expression
|
[27] |
Apoptosis regulator Bcl-2 (BCL2)
|
OT9DVHC0
|
BCL2_HUMAN
|
Decreases Expression
|
[28] |
Endoplasmic reticulum chaperone BiP (HSPA5)
|
OTFUIRAO
|
BIP_HUMAN
|
Decreases Expression
|
[29] |
Matrix metalloproteinase-9 (MMP9)
|
OTB2QDAV
|
MMP9_HUMAN
|
Decreases Expression
|
[30] |
Histone H2AX (H2AX)
|
OT18UX57
|
H2AX_HUMAN
|
Increases Expression
|
[19] |
CCAAT/enhancer-binding protein beta (CEBPB)
|
OTM9MQIA
|
CEBPB_HUMAN
|
Decreases Expression
|
[18] |
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
|
OTNRRD8I
|
NFKB1_HUMAN
|
Decreases Expression
|
[18] |
Lamin-B1 (LMNB1)
|
OT100T3P
|
LMNB1_HUMAN
|
Decreases Expression
|
[18] |
rRNA 2'-O-methyltransferase fibrillarin (FBL)
|
OTRODIE5
|
FBRL_HUMAN
|
Affects Localization
|
[31] |
DNA-directed RNA polymerase II subunit RPB1 (POLR2A)
|
OTHJQ1DZ
|
RPB1_HUMAN
|
Decreases Phosphorylation
|
[32] |
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
|
OTQWHCZE
|
CDN1A_HUMAN
|
Decreases Expression
|
[33] |
Signal transducer and activator of transcription 1-alpha/beta (STAT1)
|
OTLMBUZ6
|
STAT1_HUMAN
|
Increases Expression
|
[18] |
Caspase-3 (CASP3)
|
OTIJRBE7
|
CASP3_HUMAN
|
Decreases Expression
|
[18] |
Caspase-2 (CASP2)
|
OTUDYSPP
|
CASP2_HUMAN
|
Increases Cleavage
|
[34] |
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
|
OTZPZX11
|
MP2K4_HUMAN
|
Decreases Expression
|
[18] |
Caspase-7 (CASP7)
|
OTAPJ040
|
CASP7_HUMAN
|
Decreases Expression
|
[18] |
DNA repair protein RAD51 homolog 1 (RAD51)
|
OTNVWGC1
|
RAD51_HUMAN
|
Decreases Expression
|
[35] |
Bcl-2-like protein 1 (BCL2L1)
|
OTRC5K9O
|
B2CL1_HUMAN
|
Decreases Expression
|
[36] |
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
|
OT2YYI1A
|
MCL1_HUMAN
|
Decreases Expression
|
[37] |
Son of sevenless homolog 1 (SOS1)
|
OTTCWXC3
|
SOS1_HUMAN
|
Decreases Expression
|
[18] |
FAS-associated death domain protein (FADD)
|
OTV7GFHH
|
FADD_HUMAN
|
Decreases Expression
|
[18] |
Growth arrest-specific protein 6 (GAS6)
|
OTPOPUUE
|
GAS6_HUMAN
|
Increases Degradation
|
[38] |
Caspase-8 (CASP8)
|
OTA8TVI8
|
CASP8_HUMAN
|
Decreases Expression
|
[18] |
Bcl-2-binding component 3, isoforms 3/4 (BBC3)
|
OTUAXDAY
|
BBC3B_HUMAN
|
Increases Expression
|
[28] |
Proheparin-binding EGF-like growth factor (HBEGF)
|
OTLU00JS
|
HBEGF_HUMAN
|
Decreases Expression
|
[25] |
Transcription factor SOX-17 (SOX17)
|
OT9H4WWE
|
SOX17_HUMAN
|
Decreases Localization
|
[39] |
Cystine/glutamate transporter (SLC7A11)
|
OTKJ6PXW
|
XCT_HUMAN
|
Decreases Expression
|
[19] |
Hyaluronidase-1 (HYAL1)
|
OT2SJN0X
|
HYAL1_HUMAN
|
Increases ADR
|
[40] |
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)
|
OTPYQX3K
|
C1QBP_HUMAN
|
Decreases Response To Substance
|
[41] |
------------------------------------------------------------------------------------ |
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