Details of the Drug Combinations

General Information of This Drug (ID: DM053KT)

Drug Name

Aprepitant DM053KT

Synonyms

Aprepitant [USAN]; L 754030; MK 0869; Emend (TN); L-754030; MK-0869; ONO-7436; Aprepitant (JAN/USAN/INN); MK-869, L-754030, Emend, Aprepitant; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-Delta(2)-1,2,4-triazolin-5-one; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(sup 2)-1,2,4-triazolin-5-one; 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Approved	[1]
Nausea	MD90	Approved	[2]
Vomiting	MD90	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
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Therapeutic Class

Antiemetics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

93 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aliskiren + Aprepitant	DCE00KL	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Amodiaquine + Aprepitant	DCFGXQ7	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Anamorelin + Aprepitant	DC8HP6G	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Kanamycin	DCS6NP9	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Citalopram	DCPQ2RY	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Tindamax	DCQYWU1	Tindamax	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Dihydroergotamine	DCB2BMM	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Miglustat	DCI6RFE	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Fomepizole	DCJ59L3	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Everolimus	DC4MCYT	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Pepstatin	DC3KG1W	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Metyrosine	DC8SDVJ	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Testosterone cypionate	DCZFRQF	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + ETHISTERONE	DC1BL8I	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Aminosalicylic acid	DC9BLWY	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Etonogestrel	DCOOOLQ	Etonogestrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + GINKGOLIDE A	DCXTX8N	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Fenoprofen	DCIB91I	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Idarubicin	DC3ZQN2	Idarubicin	Glioblastoma? (Cell Line: T98G)	[5]
Aprepitant + BRL-15572	DC45U9Y	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Probenecid	DCLO32N	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Darunavir	DCHH953	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Linagliptin	DC2SDHB	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Acamprosate	DCQYMLN	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Topotecan	DCKZVEY	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Trimethobenzamide	DCDBENO	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Oxyphenbutazone	DCILR52	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Novobiocin	DCF886S	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Cisatracurium	DCAICUT	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Zileuton	DCOKQ3F	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Olmesartan medoxomil	DC2TWQL	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Auranofin	DC5VV3J	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Estramustine	DC55GK6	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Raltegravir	DC0GG2V	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aprepitant + Cilostazol	DCZT6GP	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Artemisinin + Aprepitant	DCMRXTC	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
AS-1949490 + Aprepitant	DCDAL3O	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Asenapine + Aprepitant	DCADRQL	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Azatadine + Aprepitant	DCRZHZ2	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Baclofen + Aprepitant	DC16T3Y	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Benserazide + Aprepitant	DC14UFI	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
BIO-300 + Aprepitant	DCGP7KO	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bortezomib + Aprepitant	DCMNO4G	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Brincidofovir + Aprepitant	DC66O5L	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bumetanide + Aprepitant	DCXD7AF	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cefmenoxime + Aprepitant	DC07ZLP	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chlorambucil + Aprepitant	DC256RW	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chlormezanone + Aprepitant	DC0AFQ4	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cilastatin + Aprepitant	DCWZEW0	Cilastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Daidzin + Aprepitant	DCREOQC	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Diethylcarbamazine + Aprepitant	DCCYUMX	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Doxorubicin + Aprepitant	DCVFHMR	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Enalaprilat + Aprepitant	DCCJ69R	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Endoxifen + Aprepitant	DCGOIR0	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Epinephrine + Aprepitant	DC8JRP8	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Fibrates + Aprepitant	DCVU7IQ	Fibrates	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Galantamine + Aprepitant	DCCHHGD	Galantamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Gefitinib + Aprepitant	DCJMO95	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
GSK2194069 + Aprepitant	DCNX1YX	GSK2194069	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Hydroxychloroquine + Aprepitant	DCJ81NL	Hydroxychloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Imatinib + Aprepitant	DCBVQP7	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
K-134 + Aprepitant	DCTV8G1	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Aprepitant	DCCEV8J	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Maprotiline + Aprepitant	DCFCJOV	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mebendazole + Aprepitant	DCQR284	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mebutamate + Aprepitant	DC1L73R	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mefloquine + Aprepitant	DCEAOY5	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Metaxalone + Aprepitant	DCC9XPP	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Nitisinone + Aprepitant	DC2CB1U	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Oseltamivir + Aprepitant	DCPJQT0	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pazopanib + Aprepitant	DC589T8	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
PF-02545920 + Aprepitant	DCNTHD3	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Phenprocoumon + Aprepitant	DCA1DL1	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Phensuximide + Aprepitant	DCZ2OPN	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Picoplatin + Aprepitant	DCM71OI	Picoplatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pinacidil + Aprepitant	DCYQ7BJ	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pizotyline + Aprepitant	DCFT33A	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pomalidomide + Aprepitant	DCB0SI1	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Rifampin + Aprepitant	DCQ7IFP	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
SCH 727965 + Aprepitant	DCLVVJ2	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Spironolactone + Aprepitant	DCDOO5M	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tacrine + Aprepitant	DCJF0RF	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tamoxifen + Aprepitant	DCRZ7K3	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Terameprocol + Aprepitant	DC424FF	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tetracycline + Aprepitant	DCP3HOI	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tiagabine + Aprepitant	DCK4T6M	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tolvaptan + Aprepitant	DCBI9QL	Tolvaptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tranexamic acid + Aprepitant	DC25KG4	Tranexamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Triapine + Aprepitant	DC0TOD9	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Triflupromazine + Aprepitant	DCVDP0T	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trimethobenzamide + Aprepitant	DC6CWSZ	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
WAY-100635 + Aprepitant	DC7RCAD	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Zaleplon + Aprepitant	DC3CHIK	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
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⏷ Show the Full List of 93 DrugCom(s)

19 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aprepitant + Dexamethasone	DC5Z165	Dexamethasone	Cancer	[7]
Aprepitant + Desloratadine	DC9H6TV	Desloratadine	Pruritus	[8]
Aprepitant + Oxycodone	DCJ12PH	Oxycodone	Narcotic Abuse	[9]
Aprepitant + Dexamethasone	DCX0H9M	Dexamethasone	Nausea	[10]
Aprepitant + Ondansetron	DC3WL60	Ondansetron	Nausea	[11]
Aprepitant + Ondansetron	DC8N8TH	Ondansetron	Hematologic Diseases	[12]
Aprepitant + Palonosetron	DCMQ9DD	Palonosetron	Leukemia	[13]
Aprepitant + Palonosetron	DCP2LMK	Palonosetron	Postoperative Nausea and Vomiting	[14]
Aprepitant + Ramosetron	DCPF48D	Ramosetron	Postoperative Nausea and Vomiting	[14]
Aprepitant + Dexamethasone	DCYX8UN	Dexamethasone	Nausea	[15]
Aprepitant + Dexamethasone	DCLDEDP	Dexamethasone	Myeloma, Plasma-Cell	[16]
Aprepitant + Dexamethasone	DCW8R42	Dexamethasone	Chemotherapy-induced Nausea and Vomiting	[17]
Aprepitant + Olanzapine	DCKOO1K	Olanzapine	Chemotherapy Induced Nausea and Vomiting	[18]
Aprepitant + Dexamethasone	DC44ZMX	Dexamethasone	Chemotherapy-induced Nausea and Vomiting	[19]
Aprepitant + Dexamethasone	DC562VS	Dexamethasone	Chemotherapy-induced Nausea and Vomiting	[20]
Aprepitant + Dexamethasone	DC91BX6	Dexamethasone	Chemotherapy-induced Nausea and Vomiting (CINV)	[21]
Aprepitant + Dexamethasone	DCIZP75	Dexamethasone	Chemotherapy-Induced Nausea and Vomiting (CINV)	[22]
Aprepitant + Dexamethasone	DCSH5XJ	Dexamethasone	Chemotherapy-induced Nausea and Vomiting	[19]
Aprepitant + Dexamethasone	DCIQIMI	Dexamethasone	Postoperative Nausea and Vomiting (PONV)	[23]
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⏷ Show the Full List of 19 DrugCom(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3490).
3	Aprepitant FDA Label
4	ClinicalTrials.gov (NCT00571168) Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy. U.S. National Institutes of Health.
5	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
7	ClinicalTrials.gov (NCT00248547) Aprepitant in Preventing Nausea and Vomiting in Patients Who Are Undergoing a Stem Cell Transplant
8	ClinicalTrials.gov (NCT04399148) Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
9	ClinicalTrials.gov (NCT00999544) Aprepitant Effects on Oxycodone Response
10	ClinicalTrials.gov (NCT00314743) Efficacy & Safety of the Oral Neurokinin-1 Antagonist, Aprepitant, in Combo With Ondansetron & Dexamethasone in Patients Undergoing Auto Peripheral Blood Stem Cell Transplantation
11	ClinicalTrials.gov (NCT01450826) Emend and Ondansetron Compared to Ondansetron Alone to Prevent CINV in Glioma Patients Receiving Temozolomide
12	ClinicalTrials.gov (NCT00954941) Ondansetron Versus Aprepitant Plus Ondansetron for Emesis
13	ClinicalTrials.gov (NCT00415103) AMENO-2: Aprepitant Plus Palonosetron Versus Granisetron in the Prevention of Nausea and the Emesis Induced by Chemotherapy in Patients Treated With Haematopoietic Progenitors
14	ClinicalTrials.gov (NCT02597907) Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant
15	ClinicalTrials.gov (NCT00835965) Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries
16	ClinicalTrials.gov (NCT00600353) Multi-day Doses in Prevention of Nausea and Emesis
17	ClinicalTrials.gov (NCT03237611) Low Dose Aprepitant for Patients Receiving Carboplatin
18	ClinicalTrials.gov (NCT02097823) Pilot Study of Olanzapine and Aprepitant to Prevent Nausea and Vomiting in Children Receiving Chemotherapy
19	ClinicalTrials.gov (NCT02484911) Aprepitant ,Olanzapine,Palonosetron and Dexamethasone for the Prevention of Chemotherapy-induced Nausea and Vomiting
20	ClinicalTrials.gov (NCT03219710) "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)"
21	ClinicalTrials.gov (NCT04912271) Granisetron Transdermal Patch for Prophylaxis of Delayed CINV
22	ClinicalTrials.gov (NCT00619359) Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)
23	ClinicalTrials.gov (NCT01474915) Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting