Details of the Drug Combination

General Information of Drug Combination (ID: DCW8R42)

• Drug Combination Name: Aprepitant + Dexamethasone
• Indication: Chemotherapy-induced Nausea and Vomiting; Status: Phase 2 [1]
• Component Drugs:
  Aprepitant (DM053KT): Small molecular drug
  Dexamethasone (DMMWZET): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Aprepitant

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Approved	[2]
Nausea	MD90	Approved	[3]
Vomiting	MD90	Approved	[4]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[5]

Aprepitant Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Substance-P receptor (TACR1)	TTZPO1L	NK1R_HUMAN	Antagonist	[9]

Aprepitant Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[10]

Aprepitant Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[11]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[12]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[12]

Aprepitant Interacts with 6 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Decreases Phosphorylation	[13]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[13]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[13]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[13]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[13]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Increases Expression	[13]

Indication(s) of Dexamethasone

Disease Entry	ICD 11	Status	REF
Acute adrenal insufficiency	N.A.	Approved	[6]
Acute asthma	CA23	Approved	[6]
Addison disease	5A74.0	Approved	[6]
Allergic otitis media	N.A.	Approved	[6]
Allergic rhinitis	CA08.0	Approved	[6]
Angioedema	4A00.15	Approved	[6]
Articular cartilage disorder	FA34.Y	Approved	[6]
Autoimmune haemolytic anaemia	3A20	Approved	[6]
Blepharoconjunctivitis	N.A.	Approved	[6]
Burkitt lymphoma	N.A.	Approved	[6]
Bursitis	N.A.	Approved	[6]
Central retinal vein occlusion with macular edema	N.A.	Approved	[6]
Cerebral edema	8D60.1	Approved	[6]
Congenital adrenal hyperplasia	5A71.01	Approved	[6]
Corneal abrasion	NA06.4	Approved	[6]
Corneal ulcer	9A76	Approved	[6]
Crohn disease	DD70	Approved	[6]
Dermatitis herpetiformis	EB44	Approved	[6]
Diamond-Blackfan anemia	N.A.	Approved	[6]
Disorder of orbital region	N.A.	Approved	[6]
Epicondylitis	N.A.	Approved	[6]
Erythema multiforme	N.A.	Approved	[6]
Exanthem	N.A.	Approved	[6]
Granuloma annulare	N.A.	Approved	[6]
Inflammatory bowel disease	DD72	Approved	[6]
Keratitis	N.A.	Approved	[6]
Liver cirrhosis	DB93.1	Approved	[6]
Lung cancer	2C25.0	Approved	[6]
Malignant otitis externa caused by Pseudomonas aeruginosa	N.A.	Approved	[6]
Miliary tuberculosis	N.A.	Approved	[6]
Multiple sclerosis	8A40	Approved	[6]
Mycosis fungoides	2B01	Approved	[6]
Nausea	MD90	Approved	[6]
Plasma cell myeloma	2A83.1	Approved	[6]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[6]
Psoriasis	EA90	Approved	[6]
Psoriatic arthritis	FA21	Approved	[6]
Rheumatic heart disease	N.A.	Approved	[6]
Rheumatoid arthritis	FA20	Approved	[7]
Rosacea	ED90.0	Approved	[6]
Sarcoidosis	4B20.5	Approved	[6]
Serum sickness	N.A.	Approved	[6]
Skin disease	EA00-EM0Z	Approved	[6]
Systemic lupus erythematosus	4A40.0	Approved	[6]
Vomiting	MD90	Approved	[6]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3	[8]
Acquired thrombocytopenia	N.A.	Investigative	[6]
Asthma	CA23	Investigative	[6]
B-cell neoplasm	N.A.	Investigative	[6]
Beta-thalassemia major	N.A.	Investigative	[6]
Classic Hodgkin lymphoma	N.A.	Investigative	[6]
Follicular lymphoma	2A80	Investigative	[6]
Iridocyclitis	N.A.	Investigative	[6]
Keloid	EE60	Investigative	[6]
Trichinellosis	N.A.	Investigative	[6]
Uveitis	9A96.Z	Investigative	[6]

Dexamethasone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Agonist	[23]

Dexamethasone Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[24]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[25]

Dexamethasone Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[26]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[27]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[28]
Carboxylesterase 2 (CES2)	DETHCPD	EST2_HUMAN	Metabolism	[29]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DEDH7FP	DHI2_HUMAN	Metabolism	[30]

Dexamethasone Interacts with 979 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[31]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Increases Expression	[32]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Increases Expression	[33]
Cytochrome P450 3A7 (CYP3A7)	OTTCDHHM	CP3A7_HUMAN	Increases Expression	[34]
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Expression	[35]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[36]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[16]
Haptoglobin (HP)	OTGUGAF9	HPT_HUMAN	Increases Expression	[16]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[16]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Decreases Expression	[17]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[37]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)	OTJZG0LD	GLUT4_HUMAN	Affects Expression	[38]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Decreases Phosphorylation	[39]
TSC22 domain family protein 3 (TSC22D3)	OT03UM03	T22D3_HUMAN	Increases Expression	[40]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases ADR	[41]
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1)	OTDAWAUZ	JIP1_HUMAN	Increases ADR	[41]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Response To Substance	[42]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Decreases Expression	[43]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Decreases Expression	[43]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[14]
Gasdermin-E (GSDME)	OT1ZWY32	GSDME_HUMAN	Increases Expression	[14]
Protein arginine N-methyltransferase 3 (PRMT3)	OTH2KILE	ANM3_HUMAN	Decreases Expression	[14]
GRB2-related adapter protein 2 (GRAP2)	OTS5NIZ3	GRAP2_HUMAN	Increases Expression	[14]
AP-1 complex subunit gamma-like 2 (AP1G2)	OTTJ7NXL	AP1G2_HUMAN	Increases Expression	[14]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Decreases Expression	[14]
Endonuclease domain-containing 1 protein (ENDOD1)	OTME0ZW5	ENDD1_HUMAN	Decreases Expression	[14]
Rho-related BTB domain-containing protein 3 (RHOBTB3)	OT1BFKPH	RHBT3_HUMAN	Increases Expression	[14]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[14]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Increases Expression	[14]
Integrin alpha-4 (ITGA4)	OTSCAL0V	ITA4_HUMAN	Decreases Expression	[14]
V(D)J recombination-activating protein 1 (RAG1)	OTV131E4	RAG1_HUMAN	Decreases Expression	[14]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)	OTEGNEHW	PP2BB_HUMAN	Decreases Expression	[14]
Interleukin-7 receptor subunit alpha (IL7R)	OTBMFLQQ	IL7RA_HUMAN	Increases Expression	[14]
Leukocyte surface antigen CD53 (CD53)	OT9U5OXJ	CD53_HUMAN	Increases Expression	[14]
Receptor-type tyrosine-protein phosphatase mu (PTPRM)	OTCEL6PN	PTPRM_HUMAN	Increases Expression	[14]
Inositol polyphosphate 1-phosphatase (INPP1)	OTHSJCRQ	INPP_HUMAN	Increases Expression	[14]
C-C chemokine receptor type 4 (CCR4)	OT68KZ9B	CCR4_HUMAN	Increases Expression	[14]
Calcipressin-1 (RCAN1)	OT1MVXC7	RCAN1_HUMAN	Increases Expression	[14]
Protein BTG1 (BTG1)	OTVJ2CDM	BTG1_HUMAN	Increases Expression	[14]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[14]
Microtubule-associated protein 1A (MAP1A)	OTHO8K43	MAP1A_HUMAN	Increases Expression	[14]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Decreases Expression	[14]
Transducin-like enhancer protein 4 (TLE4)	OT4QEH6T	TLE4_HUMAN	Decreases Expression	[14]
Synaptic vesicular amine transporter (SLC18A2)	OTUOMMM6	VMAT2_HUMAN	Increases Expression	[14]
Amidophosphoribosyltransferase (PPAT)	OTXK12ZB	PUR1_HUMAN	Decreases Expression	[14]
Lymphotoxin-beta (LTB)	OTUFS8CF	TNFC_HUMAN	Decreases Expression	[14]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Increases Expression	[14]
Src-like-adapter (SLA)	OTV17DY2	SLAP1_HUMAN	Increases Expression	[14]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[14]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Increases Expression	[14]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Increases Expression	[14]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Decreases Expression	[14]
Nuclear factor interleukin-3-regulated protein (NFIL3)	OTQH9HM3	NFIL3_HUMAN	Increases Expression	[14]
Pre-rRNA-processing protein TSR1 homolog (TSR1)	OTCVZFL9	TSR1_HUMAN	Decreases Expression	[14]
Neurobeachin-like protein 2 (NBEAL2)	OTMCAXWR	NBEL2_HUMAN	Increases Expression	[14]
Protein FAM216A (FAM216A)	OTL6I6AI	F216A_HUMAN	Decreases Expression	[14]
Junctional adhesion molecule C (JAM3)	OTX0F9QL	JAM3_HUMAN	Increases Expression	[14]
Coiled-coil domain-containing protein 86 (CCDC86)	OT5YQ0R0	CCD86_HUMAN	Decreases Expression	[14]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Increases Expression	[14]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)	OT8P6QNJ	CELR3_HUMAN	Decreases Expression	[14]
PALM2-AKAP2 fusion protein (PALM2AKAP2)	OTI618VF	PLAK2_HUMAN	Increases Expression	[14]
Nucleolar protein 16 (NOP16)	OT2829ZC	NOP16_HUMAN	Decreases Expression	[14]
Nucleolar complex protein 2 homolog (NOC2L)	OTNT7R33	NOC2L_HUMAN	Decreases Expression	[14]
Plexin-D1 (PLXND1)	OTNK9ALK	PLXD1_HUMAN	Increases Expression	[14]
Rho family-interacting cell polarization regulator 2 (RIPOR2)	OTXB6LIR	RIPR2_HUMAN	Increases Expression	[14]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Increases Expression	[14]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[44]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[32]
Period circadian protein homolog 1 (PER1)	OTVQF3WX	PER1_HUMAN	Increases Expression	[32]
Macrophage colony-stimulating factor 1 receptor (CSF1R)	OTDYTB9C	CSF1R_HUMAN	Increases Expression	[32]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Increases Expression	[32]
Olfactomedin-4 (OLFM4)	OTELHN9L	OLFM4_HUMAN	Increases Expression	[32]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Expression	[45]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Increases Expression	[45]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Increases Expression	[46]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Increases Expression	[47]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[48]
Pulmonary surfactant-associated protein B (SFTPB)	OTOHS07E	PSPB_HUMAN	Increases Expression	[49]
Pulmonary surfactant-associated protein A1 (SFTPA1)	OT87XL1U	SFTA1_HUMAN	Decreases Expression	[49]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[50]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Increases Expression	[51]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Increases Expression	[51]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Increases Expression	[52]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[53]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[53]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Decreases Activity	[53]
Mineralocorticoid receptor (NR3C2)	OT0F2V2Z	MCR_HUMAN	Increases Expression	[53]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Increases Expression	[53]
COUP transcription factor 1 (NR2F1)	OTGWZWYL	COT1_HUMAN	Increases Expression	[53]
Tyrosine aminotransferase (TAT)	OT2CJ91O	ATTY_HUMAN	Increases Expression	[53]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Increases Expression	[53]
Nuclear receptor ROR-alpha (RORA)	OTGQT12P	RORA_HUMAN	Increases Expression	[53]
Nuclear receptor subfamily 2 group C member 2 (NR2C2)	OTDZWVOJ	NR2C2_HUMAN	Increases Expression	[53]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Increases Expression	[53]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Increases Expression	[53]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Increases Expression	[53]
Nuclear receptor subfamily 6 group A member 1 (NR6A1)	OTFZOOQ9	NR6A1_HUMAN	Increases Expression	[53]
Nuclear receptor coactivator 2 (NCOA2)	OTMQFPBB	NCOA2_HUMAN	Increases Expression	[53]
Nuclear receptor coactivator 1 (NCOA1)	OTLIUJQD	NCOA1_HUMAN	Increases Expression	[53]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Increases Expression	[53]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Increases Expression	[53]
Organic solute transporter subunit alpha (SLC51A)	OTDJRZ0P	OSTA_HUMAN	Affects Expression	[54]
Organic solute transporter subunit beta (SLC51B)	OT4WYPSR	OSTB_HUMAN	Increases Expression	[54]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Increases Expression	[16]
Aquaporin-7 (AQP7)	OTSOSZEE	AQP7_HUMAN	Increases Expression	[16]
Lipid transferase CIDEA (CIDEA)	OTDUTSOV	CIDEA_HUMAN	Increases Expression	[16]
Renin receptor (ATP6AP2)	OT0IABVV	RENR_HUMAN	Decreases Expression	[16]
Complement factor D (CFD)	OTLNRXB6	CFAD_HUMAN	Increases Expression	[16]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Increases Expression	[16]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Decreases Expression	[16]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[16]
Retinol-binding protein 4 (RBP4)	OTL9RBH5	RET4_HUMAN	Increases Expression	[16]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[16]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[16]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[16]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[16]
Fatty acid-binding protein, adipocyte (FABP4)	OT3DKFOU	FABP4_HUMAN	Increases Expression	[16]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[16]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Increases Expression	[16]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Decreases Expression	[16]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[16]
Zinc-alpha-2-glycoprotein (AZGP1)	OTPD9TDR	ZA2G_HUMAN	Increases Expression	[16]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Increases Expression	[16]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Increases Expression	[16]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Increases Expression	[16]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[16]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Expression	[16]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[16]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Increases Expression	[16]
Lipid transferase CIDEC (CIDEC)	OTMDZ56K	CIDEC_HUMAN	Increases Expression	[16]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Increases Expression	[16]
Histone-lysine N-methyltransferase PRDM16 (PRDM16)	OT0BGA27	PRD16_HUMAN	Decreases Expression	[16]
Apelin (APLN)	OTSWJD7B	APEL_HUMAN	Decreases Expression	[16]
Hepatic sodium/bile acid cotransporter (SLC10A1)	OTUJVMCL	NTCP_HUMAN	Increases Expression	[55]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Increases Expression	[56]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[56]
Cytochrome P450 2S1 (CYP2S1)	OTKHX4RF	CP2S1_HUMAN	Decreases Expression	[57]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Increases Expression	[58]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[59]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Expression	[60]
Glucoside xylosyltransferase 2 (GXYLT2)	OTMLQQKP	GXLT2_HUMAN	Decreases Expression	[17]
Tetraspanin-11 (TSPAN11)	OT3GJF1N	TSN11_HUMAN	Decreases Expression	[17]
Glutamate-rich protein 2 (ERICH2)	OT0QA5Z1	ERIC2_HUMAN	Decreases Expression	[17]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3)	OTF6I8RV	PKHG3_HUMAN	Increases Expression	[17]
Coiled-coil domain-containing protein 69 (CCDC69)	OT43MI0R	CCD69_HUMAN	Increases Expression	[17]
Very-long-chain (HACD1)	OTEC7EP7	HACD1_HUMAN	Increases Expression	[17]
Isthmin-1 (ISM1)	OTZTK2TV	ISM1_HUMAN	Increases Expression	[17]
Transmembrane protein 233 (TMEM233)	OT9J7BRF	TM233_HUMAN	Decreases Expression	[17]
PDZ and LIM domain protein 1 (PDLIM1)	OT4EGCPG	PDLI1_HUMAN	Increases Expression	[17]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Decreases Expression	[17]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Decreases Expression	[17]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)	OTY2PROB	P3C2B_HUMAN	Increases Expression	[17]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Increases Expression	[17]
Dihydropyrimidinase-related protein 4 (DPYSL4)	OT3SBS2S	DPYL4_HUMAN	Decreases Expression	[17]
Cdc42 effector protein 2 (CDC42EP2)	OTX3YDPN	BORG1_HUMAN	Increases Expression	[17]
Glutathione S-transferase 3, mitochondrial (MGST3)	OTYK80JA	MGST3_HUMAN	Increases Expression	[17]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Decreases Expression	[17]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)	OT3LOE2J	MAST4_HUMAN	Increases Expression	[17]
Synaptojanin-2 (SYNJ2)	OTLRHXP1	SYNJ2_HUMAN	Decreases Expression	[17]
Serine/threonine-protein kinase DCLK1 (DCLK1)	OTVSPS98	DCLK1_HUMAN	Increases Expression	[17]
Mothers against decapentaplegic homolog 7 (SMAD7)	OTSLHWF4	SMAD7_HUMAN	Decreases Expression	[17]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Increases Expression	[17]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)	OTQUX50Z	LRAD4_HUMAN	Decreases Expression	[17]
Membrane-associated progesterone receptor component 2 (PGRMC2)	OTH6G1CV	PGRC2_HUMAN	Increases Expression	[17]
Protein SLC31A2 (SLC31A2)	OTQC136Q	COPT2_HUMAN	Decreases Expression	[17]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Decreases Expression	[17]
Glycogenin-2 (GYG2)	OTAJ7YEW	GLYG2_HUMAN	Increases Expression	[17]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Increases Expression	[17]
D-3-phosphoglycerate dehydrogenase (PHGDH)	OT1LMRTG	SERA_HUMAN	Decreases Expression	[17]
Rho GTPase-activating protein 6 (ARHGAP6)	OTNVXXFX	RHG06_HUMAN	Increases Expression	[17]
Cytohesin-3 (CYTH3)	OTBXAT3Z	CYH3_HUMAN	Increases Expression	[17]
Perilipin-1 (PLIN1)	OT3OAAZ4	PLIN1_HUMAN	Increases Expression	[17]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Increases Expression	[17]
Protein-tyrosine sulfotransferase 1 (TPST1)	OTDPQKEA	TPST1_HUMAN	Decreases Expression	[17]
DNA polymerase zeta catalytic subunit (REV3L)	OT0OP8EJ	REV3L_HUMAN	Increases Expression	[17]
Sushi repeat-containing protein SRPX2 (SRPX2)	OT6A63TX	SRPX2_HUMAN	Increases Expression	[17]
Thiamine transporter 1 (SLC19A2)	OTH5SB0M	S19A2_HUMAN	Increases Expression	[17]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Increases Expression	[17]
Slit homolog 3 protein (SLIT3)	OTU8MKEU	SLIT3_HUMAN	Decreases Expression	[17]
Multiple epidermal growth factor-like domains protein 6 (MEGF6)	OTEUYTP1	MEGF6_HUMAN	Decreases Expression	[17]
Rho-associated protein kinase 2 (ROCK2)	OTVYN14T	ROCK2_HUMAN	Increases Expression	[17]
Cartilage intermediate layer protein 1 (CILP)	OTKEY2NJ	CILP1_HUMAN	Increases Expression	[17]
Citrate synthase, mitochondrial (CS)	OTYLYXMO	CISY_HUMAN	Increases Expression	[17]
Sperm-associated antigen 7 (SPAG7)	OTSDFA2D	SPAG7_HUMAN	Decreases Expression	[17]
Claudin-11 (CLDN11)	OTNN6UTL	CLD11_HUMAN	Increases Expression	[17]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)	OTHODA1F	MYCB2_HUMAN	Increases Expression	[17]
Protein phosphatase 1B (PPM1B)	OTZMH6V3	PPM1B_HUMAN	Increases Expression	[17]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1)	OT15HOJX	AL1L1_HUMAN	Increases Expression	[17]
Diacylglycerol O-acyltransferase 1 (DGAT1)	OTL104WL	DGAT1_HUMAN	Increases Expression	[17]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)	OT1U2GWG	DDAH1_HUMAN	Increases Expression	[17]
Serine/threonine-protein kinase 17B (STK17B)	OT4NYNO8	ST17B_HUMAN	Increases Expression	[17]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Decreases Expression	[17]
Indolethylamine N-methyltransferase (INMT)	OT5NWOZH	INMT_HUMAN	Increases Expression	[17]
Neurexophilin-4 (NXPH4)	OTV057AG	NXPH4_HUMAN	Decreases Expression	[17]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)	OT4217NK	PDE8B_HUMAN	Increases Expression	[17]
CUGBP Elav-like family member 2 (CELF2)	OTLJJ4VT	CELF2_HUMAN	Increases Expression	[17]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)	OT1G9297	TFIP8_HUMAN	Increases Expression	[17]
Angiopoietin-related protein 1 (ANGPTL1)	OTXIN6V5	ANGL1_HUMAN	Increases Expression	[17]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Decreases Expression	[17]
Cholesterol 25-hydroxylase (CH25H)	OT9S2BSW	CH25H_HUMAN	Decreases Expression	[17]
Cytochrome b5 (CYB5A)	OT6SN4RM	CYB5_HUMAN	Increases Expression	[17]
All-trans-retinol dehydrogenase ADH1B (ADH1B)	OTV3TB81	ADH1B_HUMAN	Increases Expression	[17]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Increases Expression	[17]
Haptoglobin-related protein (HPR)	OTXSC9UB	HPTR_HUMAN	Increases Expression	[17]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[17]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Decreases Expression	[17]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Increases Expression	[17]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Increases Expression	[17]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[17]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[17]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Expression	[17]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Increases Expression	[17]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Increases Expression	[17]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Increases Expression	[17]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Decreases Expression	[17]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[17]
HLA class I histocompatibility antigen, A alpha chain (HLA-A)	OTAH14LU	HLAA_HUMAN	Decreases Expression	[17]
Metallothionein-1A (MT1A)	OTKBH52X	MT1A_HUMAN	Increases Expression	[17]
Fatty acid-binding protein, heart (FABP3)	OT562DA1	FABPH_HUMAN	Increases Expression	[17]
Tetranectin (CLEC3B)	OTFD29NF	TETN_HUMAN	Increases Expression	[17]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Expression	[17]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Increases Expression	[17]
Glycogen phosphorylase, liver form (PYGL)	OTS1YFGR	PYGL_HUMAN	Increases Expression	[17]
Lipoprotein lipase (LPL)	OTTW0267	LIPL_HUMAN	Increases Expression	[17]
Glia-derived nexin (SERPINE2)	OTYF5340	GDN_HUMAN	Decreases Expression	[17]
Acyl-CoA-binding protein (DBI)	OT884QY9	ACBP_HUMAN	Increases Expression	[17]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Increases Expression	[17]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[17]
Alcohol dehydrogenase 1A (ADH1A)	OTTS983E	ADH1A_HUMAN	Increases Expression	[17]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Decreases Expression	[17]
Metallothionein-1B (MT1B)	OTUA4FFH	MT1B_HUMAN	Increases Expression	[17]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Increases Expression	[17]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[17]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Decreases Expression	[17]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Increases Expression	[17]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Decreases Expression	[17]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[17]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Expression	[17]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Decreases Expression	[17]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)	OTGEU8IK	ODPA_HUMAN	Increases Expression	[17]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[17]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Decreases Expression	[17]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Increases Expression	[17]
Inhibin beta B chain (INHBB)	OT2QLD11	INHBB_HUMAN	Increases Expression	[17]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[17]
Protein ELFN1 (ELFN1)	OTM7M52U	ELFN1_HUMAN	Decreases Expression	[17]
Serum amyloid A-1 protein (SAA1)	OTO2D8S0	SAA1_HUMAN	Increases Expression	[17]
Zinc finger protein GLI2 (GLI2)	OTIRV97L	GLI2_HUMAN	Decreases Expression	[17]
HLA class I histocompatibility antigen, C alpha chain (HLA-C)	OTV38BUJ	HLAC_HUMAN	Decreases Expression	[17]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)	OT9LBJVN	ODP2_HUMAN	Increases Expression	[17]
Microsomal glutathione S-transferase 1 (MGST1)	OTGN1KVZ	MGST1_HUMAN	Increases Expression	[17]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Increases Expression	[17]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Expression	[17]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Decreases Expression	[17]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Expression	[17]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Decreases Expression	[17]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[17]
Nidogen-1 (NID1)	OTKLBLS6	NID1_HUMAN	Increases Expression	[17]
Phospholipase A2, membrane associated (PLA2G2A)	OT1NY7BF	PA2GA_HUMAN	Increases Expression	[17]
Myosin light chain 6B (MYL6B)	OTWTRGT7	MYL6B_HUMAN	Decreases Expression	[17]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Decreases Expression	[17]
Leukemia inhibitory factor (LIF)	OTO46S5S	LIF_HUMAN	Decreases Expression	[17]
Glutamine synthetase (GLUL)	OTYGTCGF	GLNA_HUMAN	Increases Expression	[17]
Beta-1,4-galactosyltransferase 1 (B4GALT1)	OTBCXEK7	B4GT1_HUMAN	Decreases Expression	[17]
Atrial natriuretic peptide receptor 1 (NPR1)	OTRWART5	ANPRA_HUMAN	Increases Expression	[17]
Platelet glycoprotein 4 (CD36)	OT5CZWKY	CD36_HUMAN	Increases Expression	[17]
Rho-related GTP-binding protein RhoQ (RHOQ)	OTUBTU57	RHOQ_HUMAN	Increases Expression	[17]
Endoglin (ENG)	OTL2LSMI	EGLN_HUMAN	Decreases Expression	[17]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[17]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Increases Expression	[17]
Alpha-2C adrenergic receptor (ADRA2C)	OT5B9RKP	ADA2C_HUMAN	Increases Expression	[17]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Decreases Expression	[17]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Decreases Expression	[17]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Decreases Expression	[17]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Increases Expression	[17]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Decreases Expression	[17]
Interleukin-11 (IL11)	OTXHN86R	IL11_HUMAN	Decreases Expression	[17]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Decreases Expression	[17]
Cytoplasmic aconitate hydratase (ACO1)	OT2VUR7L	ACOHC_HUMAN	Increases Expression	[17]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[17]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)	OTQW7TMB	GPDA_HUMAN	Increases Expression	[17]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Decreases Expression	[17]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Decreases Expression	[17]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Expression	[17]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Increases Expression	[17]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Increases Expression	[17]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Decreases Expression	[17]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4)	OTMWFDAC	AT2B4_HUMAN	Increases Expression	[17]
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1)	OTHV25GG	CX7A1_HUMAN	Increases Expression	[17]
Interleukin-4 receptor subunit alpha (IL4R)	OTTXOTCW	IL4RA_HUMAN	Decreases Expression	[17]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[17]
ATP synthase subunit alpha, mitochondrial (ATP5F1A)	OT3FZDLX	ATPA_HUMAN	Increases Expression	[17]
Metallothionein-3 (MT3)	OTVCZ7HI	MT3_HUMAN	Increases Expression	[17]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Increases Expression	[17]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Increases Expression	[17]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Increases Expression	[17]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Increases Expression	[17]
Leiomodin-1 (LMOD1)	OTZ2MEMG	LMOD1_HUMAN	Increases Expression	[17]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Decreases Expression	[17]
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)	OT25Z6XH	AL4A1_HUMAN	Increases Expression	[17]
Peroxiredoxin-6 (PRDX6)	OTS8KC8A	PRDX6_HUMAN	Increases Expression	[17]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)	OTZEXEFH	KAP3_HUMAN	Increases Expression	[17]
Transcription factor HIVEP2 (HIVEP2)	OTVOMCW4	ZEP2_HUMAN	Decreases Expression	[17]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)	OTQHB52T	P5CR1_HUMAN	Decreases Expression	[17]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Expression	[17]
Lymphocyte-specific protein 1 (LSP1)	OTSPSIFO	LSP1_HUMAN	Decreases Expression	[17]
Serine hydroxymethyltransferase, mitochondrial (SHMT2)	OT5NCAZN	GLYM_HUMAN	Decreases Expression	[17]
G protein-coupled receptor kinase 5 (GRK5)	OTJK79EK	GRK5_HUMAN	Increases Expression	[17]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Decreases Expression	[17]
Fibrillin-2 (FBN2)	OT3KYJQL	FBN2_HUMAN	Increases Expression	[17]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Increases Expression	[17]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Decreases Expression	[17]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Increases Expression	[17]
Serine/threonine-protein kinase receptor R3 (ACVRL1)	OT1HQR88	ACVL1_HUMAN	Increases Expression	[17]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)	OTIOLNHE	LICH_HUMAN	Increases Expression	[17]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Decreases Expression	[17]
Malate dehydrogenase, cytoplasmic (MDH1)	OTJEO4E8	MDHC_HUMAN	Increases Expression	[17]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Decreases Expression	[17]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)	OTOZTA1F	M3K8_HUMAN	Increases Expression	[17]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[17]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Increases Expression	[17]
Excitatory amino acid transporter 1 (SLC1A3)	OTILR60R	EAA1_HUMAN	Decreases Expression	[17]
Prostaglandin F2-alpha receptor (PTGFR)	OTUI456H	PF2R_HUMAN	Decreases Expression	[17]
Prostaglandin E2 receptor EP3 subtype (PTGER3)	OTQODQUN	PE2R3_HUMAN	Increases Expression	[17]
Cathepsin K (CTSK)	OTT3YX5O	CATK_HUMAN	Increases Expression	[17]
Nicotinamide phosphoribosyltransferase (NAMPT)	OTVJR3GL	NAMPT_HUMAN	Decreases Expression	[17]
Aspartoacylase (ASPA)	OTR2MWS4	ACY2_HUMAN	Increases Expression	[17]
Large proline-rich protein BAG6 (BAG6)	OT4Z0S2U	BAG6_HUMAN	Decreases Expression	[17]
B1 bradykinin receptor (BDKRB1)	OT1DHSVQ	BKRB1_HUMAN	Decreases Expression	[17]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Decreases Expression	[17]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Increases Expression	[17]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)	OTHRUON2	SC6A9_HUMAN	Decreases Expression	[17]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Decreases Expression	[17]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Increases Expression	[17]
Amphiphysin (AMPH)	OTWPGWZX	AMPH_HUMAN	Increases Expression	[17]
Thrombospondin-3 (THBS3)	OTDKMUBD	TSP3_HUMAN	Decreases Expression	[17]
Placenta growth factor (PGF)	OT5MF5DJ	PLGF_HUMAN	Decreases Expression	[17]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Decreases Expression	[17]
Selenoprotein P (SELENOP)	OT02B8IR	SEPP1_HUMAN	Increases Expression	[17]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Decreases Expression	[17]
RNA-binding protein Nova-1 (NOVA1)	OT6A9KHY	NOVA1_HUMAN	Increases Expression	[17]
Caveolin-2 (CAV2)	OT1FGRQX	CAV2_HUMAN	Increases Expression	[17]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Expression	[17]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Expression	[17]
Tricarboxylate transport protein, mitochondrial (SLC25A1)	OTIDXQ9F	TXTP_HUMAN	Increases Expression	[17]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[17]
Sodium/myo-inositol cotransporter (SLC5A3)	OT6FY2KA	SC5A3_HUMAN	Decreases Expression	[17]
Phospholipase A and acyltransferase 3 (PLAAT3)	OTVXXJ5K	PLAT3_HUMAN	Increases Expression	[17]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Increases Expression	[17]
Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)	OTOFL24U	AT1B3_HUMAN	Increases Expression	[17]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[17]
Microfibrillar-associated protein 2 (MFAP2)	OTMHVBTV	MFAP2_HUMAN	Decreases Expression	[17]
GTP-binding protein GEM (GEM)	OT6SK8ZV	GEM_HUMAN	Decreases Expression	[17]
Growth/differentiation factor 10 (GDF10)	OTEVXGJ7	GDF10_HUMAN	Decreases Expression	[17]
Laminin subunit beta-2 (LAMB2)	OT71OI2Y	LAMB2_HUMAN	Decreases Expression	[17]
GDNF family receptor alpha-1 (GFRA1)	OT3WBVYB	GFRA1_HUMAN	Increases Expression	[17]
Homeobox protein DLX-5 (DLX5)	OTEEFBEU	DLX5_HUMAN	Decreases Expression	[17]
Junctional adhesion molecule B (JAM2)	OTHVJJRJ	JAM2_HUMAN	Decreases Expression	[17]
Lysyl oxidase homolog 3 (LOXL3)	OTLLY1QI	LOXL3_HUMAN	Decreases Expression	[17]
Protein eva-1 homolog C (EVA1C)	OT18YR25	EVA1C_HUMAN	Increases Expression	[17]
Reactive oxygen species modulator 1 (ROMO1)	OTIEYVBW	ROMO1_HUMAN	Increases Expression	[17]
Ras-related protein Rab-2A (RAB2A)	OT6SK83U	RAB2A_HUMAN	Increases Expression	[17]
Somatostatin (SST)	OTY75GQH	SMS_HUMAN	Decreases Expression	[17]
Ras-related protein R-Ras2 (RRAS2)	OT83NCEB	RRAS2_HUMAN	Increases Expression	[17]
Thymosin beta-4 (TMSB4X)	OT9HPLP3	TYB4_HUMAN	Increases Expression	[17]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[17]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)	OTSSOMUP	RPAB5_HUMAN	Increases Expression	[17]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE)	OTXF5ICU	GBRE_HUMAN	Decreases Expression	[17]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Increases Expression	[17]
C-X-C motif chemokine 6 (CXCL6)	OTFTCQ4O	CXCL6_HUMAN	Decreases Expression	[17]
Metallothionein-1H (MT1H)	OT0MVBM6	MT1H_HUMAN	Increases Expression	[17]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Increases Expression	[17]
Nucleobindin-2 (NUCB2)	OTHO6JWN	NUCB2_HUMAN	Decreases Expression	[17]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Increases Expression	[17]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[17]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)	OTOVM4D4	SPTB2_HUMAN	Increases Expression	[17]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Increases Expression	[17]
Fatty acid-binding protein 5 (FABP5)	OTNM186C	FABP5_HUMAN	Increases Expression	[17]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Decreases Expression	[17]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Expression	[17]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)	OT62RL5P	BDH_HUMAN	Increases Expression	[17]
Collagen alpha-1(VII) chain (COL7A1)	OT3MIRZJ	CO7A1_HUMAN	Decreases Expression	[17]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Decreases Expression	[17]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)	OTF6OC66	GCNT1_HUMAN	Increases Expression	[17]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[17]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Increases Expression	[17]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Decreases Expression	[17]
Mevalonate kinase (MVK)	OTHJCUKT	KIME_HUMAN	Increases Expression	[17]
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Increases Expression	[17]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[17]
Hormone-sensitive lipase (LIPE)	OTMMVJ8A	LIPS_HUMAN	Increases Expression	[17]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Decreases Expression	[17]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Increases Expression	[17]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Decreases Expression	[17]
Nexilin (NEXN)	OTKB0B0H	NEXN_HUMAN	Increases Expression	[17]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Increases Expression	[17]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Decreases Expression	[17]
Trophinin (TRO)	OTRZQMU8	TROP_HUMAN	Decreases Expression	[17]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Increases Expression	[17]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Decreases Expression	[17]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Decreases Expression	[17]
Methanethiol oxidase (SELENBP1)	OT3NZNTR	SBP1_HUMAN	Increases Expression	[17]
Beta-2-syntrophin (SNTB2)	OTIVMQ2S	SNTB2_HUMAN	Increases Expression	[17]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A)	OTGTAGCV	PPR1A_HUMAN	Increases Expression	[17]
Cullin-4B (CUL4B)	OT2QX4DO	CUL4B_HUMAN	Increases Expression	[17]
Integrin alpha-7 (ITGA7)	OTTBTAYW	ITA7_HUMAN	Increases Expression	[17]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Increases Expression	[17]
Runt-related transcription factor 2 (RUNX2)	OT97RQQM	RUNX2_HUMAN	Decreases Expression	[17]
Protein Tob2 (TOB2)	OTEEHL60	TOB2_HUMAN	Increases Expression	[17]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Decreases Expression	[17]
Dihydropyrimidinase-related protein 3 (DPYSL3)	OTINJV20	DPYL3_HUMAN	Decreases Expression	[17]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Decreases Expression	[17]
Transforming growth factor beta activator LRRC32 (LRRC32)	OTG7EDZL	LRC32_HUMAN	Decreases Expression	[17]
Squalene monooxygenase (SQLE)	OT0GGRDO	ERG1_HUMAN	Increases Expression	[17]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1)	OT2E7A6W	KANK1_HUMAN	Increases Expression	[17]
Neutral alpha-glucosidase AB (GANAB)	OTYLXY4M	GANAB_HUMAN	Decreases Expression	[17]
Potassium voltage-gated channel subfamily B member 1 (KCNB1)	OTLCU4FR	KCNB1_HUMAN	Increases Expression	[17]
Delta(14)-sterol reductase LBR (LBR)	OT1HG3HG	LBR_HUMAN	Increases Expression	[17]
Latent-transforming growth factor beta-binding protein 2 (LTBP2)	OTS88GSD	LTBP2_HUMAN	Decreases Expression	[17]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Expression	[17]
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3)	OT6A9JT8	PA1B3_HUMAN	Decreases Expression	[17]
Inorganic pyrophosphatase (PPA1)	OTHZK1QB	IPYR_HUMAN	Increases Expression	[17]
Platelet-derived growth factor receptor-like protein (PDGFRL)	OTJPRECT	PGFRL_HUMAN	Decreases Expression	[17]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Increases Expression	[17]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Expression	[17]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Increases Expression	[17]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)	OTK3EJFD	NSDHL_HUMAN	Increases Expression	[17]
NGFI-A-binding protein 2 (NAB2)	OTG4BDF3	NAB2_HUMAN	Decreases Expression	[17]
Ovarian cancer G-protein coupled receptor 1 (GPR68)	OT1NXSMN	OGR1_HUMAN	Decreases Expression	[17]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[17]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Increases Expression	[17]
Neuronatin (NNAT)	OTNRLO7G	NNAT_HUMAN	Increases Expression	[17]
Neuronal regeneration-related protein (NREP)	OT2AZPKK	NREP_HUMAN	Decreases Expression	[17]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Increases Expression	[17]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[17]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Increases Expression	[17]
NADP-dependent malic enzyme, mitochondrial (ME3)	OT3XMLYG	MAON_HUMAN	Increases Expression	[17]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Increases Expression	[17]
Amine oxidase 3 (AOC3)	OT30YKV0	AOC3_HUMAN	Increases Expression	[17]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Decreases Expression	[17]
Cysteine dioxygenase type 1 (CDO1)	OTLG1P77	CDO1_HUMAN	Increases Expression	[17]
Transmembrane protein 132A (TMEM132A)	OTNUI7O1	T132A_HUMAN	Decreases Expression	[17]
Kinesin-like protein KIF26B (KIF26B)	OTVHWIKR	KI26B_HUMAN	Decreases Expression	[17]
Transmembrane protein 44 (TMEM44)	OTRUF467	TMM44_HUMAN	Decreases Expression	[17]
PWWP domain-containing DNA repair factor 3A (PWWP3A)	OTXQVL4U	PWP3A_HUMAN	Decreases Expression	[17]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Increases Expression	[17]
Fibronectin type III domain-containing protein 1 (FNDC1)	OTU2BA12	FNDC1_HUMAN	Decreases Expression	[17]
BolA-like protein 3 (BOLA3)	OTDEDY0S	BOLA3_HUMAN	Increases Expression	[17]
Cordon-bleu protein-like 1 (COBLL1)	OTQFN1TC	COBL1_HUMAN	Increases Expression	[17]
Mesoderm-specific transcript homolog protein (MEST)	OT8Q4U8Y	MEST_HUMAN	Increases Expression	[17]
Proline-rich transmembrane protein 3 (PRRT3)	OT231D18	PRRT3_HUMAN	Increases Expression	[17]
SH3 domain-containing protein 19 (SH3D19)	OTVU3VS2	SH319_HUMAN	Increases Expression	[17]
Dedicator of cytokinesis protein 11 (DOCK11)	OTFSTN6A	DOC11_HUMAN	Increases Expression	[17]
Long-chain fatty acid transport protein 3 (SLC27A3)	OTXB60L7	S27A3_HUMAN	Increases Expression	[17]
Transcription factor HIVEP3 (HIVEP3)	OTM3QT3L	ZEP3_HUMAN	Increases Expression	[17]
Transmembrane protein 170B (TMEM170B)	OT4AS8RJ	T170B_HUMAN	Increases Expression	[17]
Immediate early response gene 5-like protein (IER5L)	OT6IG629	IER5L_HUMAN	Decreases Expression	[17]
E3 ubiquitin-protein ligase RNF187 (RNF187)	OTXTN1HP	RN187_HUMAN	Decreases Expression	[17]
Collagen alpha-1(XIII) chain (COL13A1)	OTM9IM6J	CODA1_HUMAN	Decreases Expression	[17]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Increases Expression	[17]
Synaptophysin-like protein 2 (SYPL2)	OT6CV0CA	SYPL2_HUMAN	Increases Expression	[17]
Phospholipid phosphatase 4 (PLPP4)	OTH5EXZC	PLPP4_HUMAN	Decreases Expression	[17]
Pikachurin (EGFLAM)	OTACZZJ0	EGFLA_HUMAN	Increases Expression	[17]
Tensin-2 (TNS2)	OTP72P0F	TENS2_HUMAN	Increases Expression	[17]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Decreases Expression	[17]
La-related protein 1B (LARP1B)	OT9JZ7K5	LAR1B_HUMAN	Increases Expression	[17]
Protein sel-1 homolog 3 (SEL1L3)	OT10N6Z2	SE1L3_HUMAN	Decreases Expression	[17]
Scavenger receptor class A member 3 (SCARA3)	OT46I38Y	SCAR3_HUMAN	Decreases Expression	[17]
Dermokine (DMKN)	OTRIGZMK	DMKN_HUMAN	Increases Expression	[17]
Protein Jade-1 (JADE1)	OTBPJIRI	JADE1_HUMAN	Increases Expression	[17]
All-trans-retinol 13,14-reductase (RETSAT)	OTC3AOPX	RETST_HUMAN	Increases Expression	[17]
Caveolae-associated protein 1 (CAVIN1)	OTFO915U	CAVN1_HUMAN	Increases Expression	[17]
Lysophospholipid acyltransferase 5 (LPCAT3)	OTWI96P4	MBOA5_HUMAN	Increases Expression	[17]
F-box only protein 42 (FBXO42)	OTHPN53C	FBX42_HUMAN	Decreases Expression	[17]
Connector enhancer of kinase suppressor of ras 3 (CNKSR3)	OTXP4QH8	CNKR3_HUMAN	Increases Expression	[17]
Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2)	OTKH0NVX	DR4L2_HUMAN	Increases Expression	[17]
Ras-like protein family member 11A (RASL11A)	OTDO6CMY	RSLBA_HUMAN	Increases Expression	[17]
Kelch-like protein 17 (KLHL17)	OTUWIJIQ	KLH17_HUMAN	Decreases Expression	[17]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Increases Expression	[17]
Sushi domain-containing protein 1 (SUSD1)	OTR3UGLY	SUSD1_HUMAN	Increases Expression	[17]
Suprabasin (SBSN)	OT89RKJH	SBSN_HUMAN	Increases Expression	[17]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Decreases Expression	[17]
Inactive serine protease PAMR1 (PAMR1)	OT83ZH5U	PAMR1_HUMAN	Decreases Expression	[17]
Interleukin-20 receptor subunit beta (IL20RB)	OTHFXK95	I20RB_HUMAN	Decreases Expression	[17]
Very-long-chain (HACD2)	OTAZO9F6	HACD2_HUMAN	Increases Expression	[17]
Transmembrane protein 64 (TMEM64)	OTO9IDFD	TMM64_HUMAN	Increases Expression	[17]
Scavenger receptor class A member 5 (SCARA5)	OTOVA96E	SCAR5_HUMAN	Increases Expression	[17]
SPOC domain-containing protein 1 (SPOCD1)	OTF4K46N	SPOC1_HUMAN	Increases Expression	[17]
Nesprin-3 (SYNE3)	OTEOJBYB	SYNE3_HUMAN	Increases Expression	[17]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Decreases Expression	[17]
DNA-binding protein RFX8 (RFX8)	OT27SFGQ	RFX8_HUMAN	Decreases Expression	[17]
TOM1-like protein 2 (TOM1L2)	OTUXXUH8	TM1L2_HUMAN	Increases Expression	[17]
Protein phosphatase Slingshot homolog 2 (SSH2)	OT8NCK82	SSH2_HUMAN	Increases Expression	[17]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1)	OTTOGO05	EEPD1_HUMAN	Increases Expression	[17]
Peroxiredoxin-like 2C (PRXL2C)	OTI8ZAK8	PXL2C_HUMAN	Increases Expression	[17]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)	OTZ4BG4B	PARPT_HUMAN	Increases Expression	[17]
LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2)	OTZ7IIPM	LIMS2_HUMAN	Increases Expression	[17]
L-xylulose reductase (DCXR)	OTYVXRXB	DCXR_HUMAN	Increases Expression	[17]
Rho GTPase-activating protein 22 (ARHGAP22)	OTXUQEFL	RHG22_HUMAN	Decreases Expression	[17]
PX domain-containing protein kinase-like protein (PXK)	OTSP1WLK	PXK_HUMAN	Decreases Expression	[17]
Disheveled-associated activator of morphogenesis 2 (DAAM2)	OTC1WVZT	DAAM2_HUMAN	Increases Expression	[17]
Acyl-coenzyme A thioesterase 1 (ACOT1)	OTXFL7WM	ACOT1_HUMAN	Increases Expression	[17]
Regulating synaptic membrane exocytosis protein 1 (RIMS1)	OT10T7CK	RIMS1_HUMAN	Increases Expression	[17]
Metalloprotease TIKI1 (TRABD2A)	OTVMA26J	TIKI1_HUMAN	Increases Expression	[17]
Liprin-beta-1 (PPFIBP1)	OTRA2S7B	LIPB1_HUMAN	Decreases Expression	[17]
Chondroitin sulfate synthase 1 (CHSY1)	OTB1XSSF	CHSS1_HUMAN	Decreases Expression	[17]
Extracellular matrix organizing protein FRAS1 (FRAS1)	OTLPESF3	FRAS1_HUMAN	Increases Expression	[17]
Beta-klotho (KLB)	OTTKKFS8	KLOTB_HUMAN	Increases Expression	[17]
Protein O-mannosyl-transferase TMTC1 (TMTC1)	OTZ7NW96	TMTC1_HUMAN	Increases Expression	[17]
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Decreases Expression	[17]
Sodium/hydrogen exchanger 9 (SLC9A9)	OT00PCW3	SL9A9_HUMAN	Increases Expression	[17]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Increases Expression	[17]
Prolyl 3-hydroxylase 2 (P3H2)	OTY84H6U	P3H2_HUMAN	Decreases Expression	[17]
DCN1-like protein 3 (DCUN1D3)	OTG20VWE	DCNL3_HUMAN	Increases Expression	[17]
Cullin-9 (CUL9)	OTPUCLZT	CUL9_HUMAN	Decreases Expression	[17]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Decreases Expression	[17]
CD302 antigen (CD302)	OTX580VU	CD302_HUMAN	Increases Expression	[17]
Trafficking regulator of GLUT4 1 (TRARG1)	OTQ1R3JD	TARG1_HUMAN	Increases Expression	[17]
Polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12)	OTVIBUST	GLT12_HUMAN	Decreases Expression	[17]
Solute carrier family 22 member 15 (SLC22A15)	OT60WAAI	S22AF_HUMAN	Decreases Expression	[17]
Protein APCDD1 (APCDD1)	OTV9AD0L	APCD1_HUMAN	Increases Expression	[17]
Cell cycle exit and neuronal differentiation protein 1 (CEND1)	OTPHOC22	CEND_HUMAN	Increases Expression	[17]
ATP-binding cassette sub-family A member 6 (ABCA6)	OTJJELUF	ABCA6_HUMAN	Increases Expression	[17]
Glypican-2 (GPC2)	OT3WSQE1	GPC2_HUMAN	Decreases Expression	[17]
Protein odd-skipped-related 2 (OSR2)	OTYG371T	OSR2_HUMAN	Increases Expression	[17]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[17]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)	OTVLWW9T	GPD1L_HUMAN	Increases Expression	[17]
Metallothionein-1M (MT1M)	OTVT8PLU	MT1M_HUMAN	Increases Expression	[17]
Maturin (MTURN)	OTEBJNVG	MTURN_HUMAN	Increases Expression	[17]
GTP-binding protein 8 (GTPBP8)	OTI8X03A	GTPB8_HUMAN	Increases Expression	[17]
Tetratricopeptide repeat protein 39C (TTC39C)	OTKKI81C	TT39C_HUMAN	Increases Expression	[17]
Refilin-B (RFLNB)	OTI7ZM75	RFLB_HUMAN	Decreases Expression	[17]
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2)	OT2SH7HJ	CGAT2_HUMAN	Decreases Expression	[17]
Uncharacterized protein FAM241A (FAM241A)	OTC12ETA	F241A_HUMAN	Increases Expression	[17]
Interleukin-17 receptor C (IL17RC)	OTEFOBSS	I17RC_HUMAN	Increases Expression	[17]
Protein APCDD1-like (APCDD1L)	OTP7CAV5	APCDL_HUMAN	Decreases Expression	[17]
LRRN4 C-terminal-like protein (LRRN4CL)	OTJFDTVR	LRN4L_HUMAN	Increases Expression	[17]
Phospholipid phosphatase 5 (PLPP5)	OTHT51D6	PLPP5_HUMAN	Decreases Expression	[17]
Activin receptor type-1C (ACVR1C)	OTOTYERF	ACV1C_HUMAN	Increases Expression	[17]
Neuron navigator 1 (NAV1)	OT667KTL	NAV1_HUMAN	Decreases Expression	[17]
Nesprin-1 (SYNE1)	OTSBSLUH	SYNE1_HUMAN	Decreases Expression	[17]
Interleukin-17 receptor E (IL17RE)	OTMFTNLS	I17RE_HUMAN	Increases Expression	[17]
Neuroligin-2 (NLGN2)	OTHDYL3H	NLGN2_HUMAN	Decreases Expression	[17]
Tetraspanin-14 (TSPAN14)	OT29167O	TSN14_HUMAN	Increases Expression	[17]
LIM domain only protein 3 (LMO3)	OTR7AJHN	LMO3_HUMAN	Increases Expression	[17]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[17]
Protein cornichon homolog 3 (CNIH3)	OTNLZ2QS	CNIH3_HUMAN	Decreases Expression	[17]
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1)	OT4WOLA8	ENOX1_HUMAN	Decreases Expression	[17]
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2)	OTN3D4ZM	PHOP2_HUMAN	Increases Expression	[17]
Melanocortin-2 receptor accessory protein (MRAP)	OTLBWM7X	MRAP_HUMAN	Increases Expression	[17]
Pleckstrin homology domain-containing family O member 2 (PLEKHO2)	OT2FTK68	PKHO2_HUMAN	Increases Expression	[17]
G-protein coupled bile acid receptor 1 (GPBAR1)	OT4BKEJ9	GPBAR_HUMAN	Increases Expression	[17]
Actin filament-associated protein 1-like 1 (AFAP1L1)	OTWNTNDB	AF1L1_HUMAN	Increases Expression	[17]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)	OTY829Z3	ABHD5_HUMAN	Increases Expression	[17]
Cell migration-inducing and hyaluronan-binding protein (CEMIP)	OTK80FYN	CEMIP_HUMAN	Decreases Expression	[17]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5)	OTX4Q83J	S38A5_HUMAN	Decreases Expression	[17]
Protein prune homolog 2 (PRUNE2)	OTGW2974	PRUN2_HUMAN	Increases Expression	[17]
Coiled-coil domain-containing protein 107 (CCDC107)	OTF1H2TM	CC107_HUMAN	Increases Expression	[17]
RING finger protein 141 (RNF141)	OT07ANSG	RN141_HUMAN	Increases Expression	[17]
Palladin (PALLD)	OTZ2MUJZ	PALLD_HUMAN	Increases Expression	[17]
Gem-associated protein 6 (GEMIN6)	OTE262KF	GEMI6_HUMAN	Increases Expression	[17]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Increases Expression	[17]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10)	OTCDHAM6	CHC10_HUMAN	Increases Expression	[17]
SHC-transforming protein 3 (SHC3)	OT305NPA	SHC3_HUMAN	Increases Expression	[17]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Increases Expression	[17]
Receptor-type tyrosine-protein phosphatase U (PTPRU)	OTHDO0QG	PTPRU_HUMAN	Decreases Expression	[17]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Increases Expression	[17]
Retinol dehydrogenase 5 (RDH5)	OTYBZHCC	RDH5_HUMAN	Increases Expression	[17]
NEDD4-binding protein 2-like 2 (N4BP2L2)	OTV2F04G	N42L2_HUMAN	Decreases Expression	[17]
Neuronal cell adhesion molecule (NRCAM)	OT80HHQ2	NRCAM_HUMAN	Increases Expression	[17]
Protein tyrosine phosphatase type IVA 1 (PTP4A1)	OTK0NFXJ	TP4A1_HUMAN	Decreases Expression	[17]
Ribonuclease P/MRP protein subunit POP5 (POP5)	OTCZTDJC	POP5_HUMAN	Increases Expression	[17]
Protein TMEPAI (PMEPA1)	OTY8Z9UF	PMEPA_HUMAN	Decreases Expression	[17]
Protein lifeguard 3 (TMBIM1)	OTE47B57	LFG3_HUMAN	Increases Expression	[17]
Antizyme inhibitor 2 (AZIN2)	OT8OB7CG	AZIN2_HUMAN	Decreases Expression	[17]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Increases Expression	[17]
Patatin-like phospholipase domain-containing protein 2 (PNPLA2)	OTR3ERMR	PLPL2_HUMAN	Increases Expression	[17]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[17]
Mas-related G-protein coupled receptor member F (MRGPRF)	OT74OZ2Z	MRGRF_HUMAN	Increases Expression	[17]
Dapper homolog 3 (DACT3)	OTSNQ55G	DACT3_HUMAN	Decreases Expression	[17]
Inactive rhomboid protein 1 (RHBDF1)	OTCQ7UDS	RHDF1_HUMAN	Decreases Expression	[17]
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)	OTBB799S	ACSF2_HUMAN	Increases Expression	[17]
Isochorismatase domain-containing protein 1 (ISOC1)	OTAO7Z87	ISOC1_HUMAN	Increases Expression	[17]
Galectin-12 (LGALS12)	OTNTQULB	LEG12_HUMAN	Increases Expression	[17]
Transcription elongation factor A protein-like 4 (TCEAL4)	OTX24CQI	TCAL4_HUMAN	Increases Expression	[17]
C1GALT1-specific chaperone 1 (C1GALT1C1)	OTRTZUF5	C1GLC_HUMAN	Increases Expression	[17]
Small integral membrane protein 12 (SMIM12)	OTMOQSL4	SIM12_HUMAN	Increases Expression	[17]
Intraflagellar transport protein 43 homolog (IFT43)	OTKWYQ5C	IFT43_HUMAN	Decreases Expression	[17]
Kelch domain-containing protein 7B (KLHDC7B)	OT2H5BNX	KLD7B_HUMAN	Decreases Expression	[17]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Decreases Expression	[17]
Receptor expression-enhancing protein 6 (REEP6)	OTY4FPO8	REEP6_HUMAN	Increases Expression	[17]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLG2)	OT0KHLY2	SUCB2_HUMAN	Increases Expression	[17]
Calmin (CLMN)	OT7U5J3T	CLMN_HUMAN	Increases Expression	[17]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Decreases Expression	[17]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)	OTYXJQCW	FGD4_HUMAN	Increases Expression	[17]
RIPOR family member 3 (RIPOR3)	OTHZ4RKK	RIPR3_HUMAN	Increases Expression	[17]
Pseudokinase FAM20A (FAM20A)	OT5Z5IW8	FA20A_HUMAN	Decreases Expression	[17]
Prickle-like protein 1 (PRICKLE1)	OT9HHEM9	PRIC1_HUMAN	Decreases Expression	[17]
Sterile alpha motif domain-containing protein 11 (SAMD11)	OT6WRQOX	SAM11_HUMAN	Decreases Expression	[17]
Diacylglycerol O-acyltransferase 2 (DGAT2)	OTE5PDD0	DGAT2_HUMAN	Increases Expression	[17]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Decreases Expression	[17]
Coiled-coil domain-containing protein 85A (CCDC85A)	OT2GLF5Z	CC85A_HUMAN	Increases Expression	[17]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[17]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Decreases Expression	[17]
Ethanolamine-phosphate cytidylyltransferase (PCYT2)	OTT8TAEA	PCY2_HUMAN	Increases Expression	[17]
Sphingosine 1-phosphate receptor 3 (S1PR3)	OTXBIYO8	S1PR3_HUMAN	Increases Expression	[17]
Sortilin (SORT1)	OTFCQ4B1	SORT_HUMAN	Increases Expression	[17]
Perilipin-2 (PLIN2)	OTRXJ9UN	PLIN2_HUMAN	Increases Expression	[17]
Monoglyceride lipase (MGLL)	OT5ES4IE	MGLL_HUMAN	Increases Expression	[17]
Collagen alpha-1(XII) chain (COL12A1)	OTHLTV53	COCA1_HUMAN	Decreases Expression	[17]
Metalloproteinase inhibitor 4 (TIMP4)	OT8A68SW	TIMP4_HUMAN	Increases Expression	[17]
MyoD family inhibitor (MDFI)	OTIA6YUG	MDFI_HUMAN	Decreases Expression	[17]
Paired mesoderm homeobox protein 2 (PRRX2)	OT8UR4AU	PRRX2_HUMAN	Decreases Expression	[17]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[17]
Histone H2A type 1-J (H2AC14)	OT5Y4MMC	H2A1J_HUMAN	Increases Expression	[17]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Decreases Expression	[17]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Decreases Expression	[17]
FYVE and coiled-coil domain-containing protein 1 (FYCO1)	OTKZHTZ5	FYCO1_HUMAN	Increases Expression	[17]
Calsyntenin-3 (CLSTN3)	OTPUFK4C	CSTN3_HUMAN	Decreases Expression	[17]
Ferroptosis suppressor protein 1 (AIFM2)	OT57XWXO	FSP1_HUMAN	Increases Expression	[17]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Decreases Expression	[17]
Peroxiredoxin-like 2A (PRXL2A)	OTR4X7UH	PXL2A_HUMAN	Increases Expression	[17]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Decreases Expression	[17]
Transmembrane protein 204 (TMEM204)	OT7X11D9	TM204_HUMAN	Decreases Expression	[17]
Histone H2A.J (H2AJ)	OTVA4XTW	H2AJ_HUMAN	Increases Expression	[17]
Chordin-like protein 1 (CHRDL1)	OTGMWVVA	CRDL1_HUMAN	Increases Expression	[17]
Protein ABHD14A (ABHD14A)	OT94GKE1	ABHEA_HUMAN	Increases Expression	[17]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (CHCHD7)	OTHHROAQ	CHCH7_HUMAN	Increases Expression	[17]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Decreases Expression	[17]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Increases Expression	[17]
Sorbin and SH3 domain-containing protein 1 (SORBS1)	OTWH8762	SRBS1_HUMAN	Increases Expression	[17]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Decreases Expression	[17]
EMILIN-2 (EMILIN2)	OTOYK5A8	EMIL2_HUMAN	Increases Expression	[17]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1)	OTOOXC7B	HOIL1_HUMAN	Decreases Expression	[17]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Decreases Expression	[17]
Forkhead box protein Q1 (FOXQ1)	OT6S3EB0	FOXQ1_HUMAN	Decreases Expression	[17]
Carbohydrate sulfotransferase 6 (CHST6)	OTXD2IWK	CHST6_HUMAN	Decreases Expression	[17]
N-alpha-acetyltransferase 50 (NAA50)	OTFJ8S47	NAA50_HUMAN	Increases Expression	[17]
Serine/threonine-protein kinase SIK2 (SIK2)	OTODY7XG	SIK2_HUMAN	Increases Expression	[17]
Uncharacterized protein C1orf21 (C1ORF21)	OTMD7O88	CA021_HUMAN	Increases Expression	[17]
Solute carrier family 25 member 32 (SLC25A32)	OTPP3NWG	S2532_HUMAN	Increases Expression	[17]
Ras association domain-containing protein 4 (RASSF4)	OT7YLOFH	RASF4_HUMAN	Increases Expression	[17]
Forkhead box protein P1 (FOXP1)	OTSG6XGF	FOXP1_HUMAN	Decreases Expression	[17]
SPARC-related modular calcium-binding protein 2 (SMOC2)	OTK1EQ49	SMOC2_HUMAN	Increases Expression	[17]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Decreases Expression	[17]
Regulator of cell cycle RGCC (RGCC)	OTYJMLWM	RGCC_HUMAN	Increases Expression	[17]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Increases Expression	[17]
IGF-like family receptor 1 (IGFLR1)	OTPUCWQR	IGFR1_HUMAN	Increases Expression	[17]
Reticulophagy regulator 1 (RETREG1)	OTYOSLZX	RETR1_HUMAN	Increases Expression	[17]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Decreases Expression	[17]
Gremlin-2 (GREM2)	OTE91EWT	GREM2_HUMAN	Decreases Expression	[17]
Protein eva-1 homolog A (EVA1A)	OTCY3Q2M	EVA1A_HUMAN	Decreases Expression	[17]
RING finger protein 122 (RNF122)	OT8RE3IM	RN122_HUMAN	Decreases Expression	[17]
Interleukin-21 receptor (IL21R)	OTDIOB63	IL21R_HUMAN	Decreases Expression	[17]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Increases Expression	[17]
Mitochondrial thiamine pyrophosphate carrier (SLC25A19)	OT157TY3	TPC_HUMAN	Increases Expression	[17]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)	OTR1XD9B	GPAT1_HUMAN	Increases Expression	[17]
Plexin-A4 (PLXNA4)	OT5XKB3Q	PLXA4_HUMAN	Increases Expression	[17]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[17]
Carbohydrate-responsive element-binding protein (MLXIPL)	OTR9MLLW	MLXPL_HUMAN	Increases Expression	[17]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Decreases Expression	[17]
G-protein coupled receptor family C group 5 member C (GPRC5C)	OT45AJT3	GPC5C_HUMAN	Decreases Expression	[17]
Omega-amidase NIT2 (NIT2)	OTC1RAH3	NIT2_HUMAN	Increases Expression	[17]
PDZ and LIM domain protein 7 (PDLIM7)	OTAZVODU	PDLI7_HUMAN	Decreases Expression	[17]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Increases Expression	[17]
Sialin (SLC17A5)	OTM5EC0O	S17A5_HUMAN	Increases Expression	[17]
Teashirt homolog 2 (TSHZ2)	OTZWBXXY	TSH2_HUMAN	Decreases Expression	[17]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)	OTK0PG7R	NUA4L_HUMAN	Decreases Expression	[17]
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)	OT5CTQKO	PLCD_HUMAN	Decreases Expression	[17]
Semaphorin-3G (SEMA3G)	OTBLVF8V	SEM3G_HUMAN	Increases Expression	[17]
Protein C19orf12 (C19ORF12)	OTVSJ1AR	CS012_HUMAN	Increases Expression	[17]
Teneurin-2 (TENM2)	OTPLUYEF	TEN2_HUMAN	Decreases Expression	[17]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[17]
Copper homeostasis protein cutC homolog (CUTC)	OTOVHLU9	CUTC_HUMAN	Increases Expression	[17]
PI-PLC X domain-containing protein 1 (PLCXD1)	OTU7KCQL	PLCX1_HUMAN	Increases Expression	[17]
Fas apoptotic inhibitory molecule 1 (FAIM)	OTR67PGU	FAIM1_HUMAN	Increases Expression	[17]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Decreases Expression	[17]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Decreases Expression	[17]
Myotubularin-related protein 10 (MTMR10)	OTF6DB4O	MTMRA_HUMAN	Increases Expression	[17]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Decreases Expression	[17]
Very long chain fatty acid elongase 5 (ELOVL5)	OT375W1Z	ELOV5_HUMAN	Increases Expression	[17]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Decreases Expression	[17]
Potassium voltage-gated channel subfamily D member 2 (KCND2)	OTIFUVV7	KCND2_HUMAN	Decreases Expression	[17]
Ankycorbin (RAI14)	OT6USGBK	RAI14_HUMAN	Decreases Expression	[17]
Neurotrimin (NTM)	OTHF0UQU	NTRI_HUMAN	Decreases Expression	[17]
Rho GTPase-activating protein 20 (ARHGAP20)	OTG1STV8	RHG20_HUMAN	Increases Expression	[17]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)	OT8NJE5D	SI1L2_HUMAN	Decreases Expression	[17]
]-phosphatase 2, mitochondrial (PDP2)	OTADNMGK	PDP2_HUMAN	Increases Expression	[17]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Increases Expression	[17]
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)	OTSB4XO0	DPM3_HUMAN	Increases Expression	[17]
SUMO-activating enzyme subunit 1 (SAE1)	OT18HFX5	SAE1_HUMAN	Decreases Expression	[17]
C-type mannose receptor 2 (MRC2)	OTLWQAX1	MRC2_HUMAN	Decreases Expression	[17]
ATP-binding cassette sub-family D member 2 (ABCD2)	OT8RGNH8	ABCD2_HUMAN	Increases Expression	[17]
Copine-7 (CPNE7)	OTR0FJ8A	CPNE7_HUMAN	Increases Expression	[17]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Decreases Expression	[17]
Heat shock protein beta-7 (HSPB7)	OTLATAOV	HSPB7_HUMAN	Increases Expression	[17]
Tight junction protein ZO-2 (TJP2)	OTQUY6BV	ZO2_HUMAN	Increases Expression	[17]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Increases Expression	[17]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)	OTHTAM54	AAKG2_HUMAN	Increases Expression	[17]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)	OTVUZCLG	GTR6_HUMAN	Increases Expression	[17]
Sushi domain-containing protein 2 (SUSD2)	OTSJTAZP	SUSD2_HUMAN	Increases Expression	[17]
Zinc finger transcription factor Trps1 (TRPS1)	OT7XPPEL	TRPS1_HUMAN	Decreases Expression	[17]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Increases Expression	[17]
Potassium voltage-gated channel subfamily G member 1 (KCNG1)	OTZ9ZRG8	KCNG1_HUMAN	Decreases Expression	[17]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Increases Expression	[17]
A-kinase anchor protein 11 (AKAP11)	OT7E2FVD	AKA11_HUMAN	Decreases Expression	[17]
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)	OTSZE6L4	ATS6_HUMAN	Decreases Expression	[17]
Integrin alpha-11 (ITGA11)	OTBWSRA1	ITA11_HUMAN	Decreases Expression	[17]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5)	OT3L9XO3	ACSL5_HUMAN	Increases Expression	[17]
Frizzled-4 (FZD4)	OTGLZIE0	FZD4_HUMAN	Increases Expression	[17]
RING finger protein 112 (RNF112)	OT0Q9OUQ	RN112_HUMAN	Decreases Expression	[17]
Synaptopodin-2 (SYNPO2)	OTC3U0YH	SYNP2_HUMAN	Increases Expression	[17]
Protein NDRG2 (NDRG2)	OT5L6KD7	NDRG2_HUMAN	Increases Expression	[17]
Endothelial protein C receptor (PROCR)	OTRHED17	EPCR_HUMAN	Increases Expression	[17]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Decreases Expression	[17]
HIG1 domain family member 1A, mitochondrial (HIGD1A)	OTS351DV	HIG1A_HUMAN	Increases Expression	[17]
Dexamethasone-induced Ras-related protein 1 (RASD1)	OT2BAJHK	RASD1_HUMAN	Increases Expression	[17]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)	OT03QCLM	ATF5_HUMAN	Decreases Expression	[17]
Kelch-like protein 20 (KLHL20)	OTC0SFS9	KLH20_HUMAN	Increases Expression	[17]
Calcium-regulated heat-stable protein 1 (CARHSP1)	OTAUG6Y9	CHSP1_HUMAN	Decreases Expression	[17]
Deoxyribose-phosphate aldolase (DERA)	OT8SMO3N	DEOC_HUMAN	Increases Expression	[17]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)	OTBCIBC7	SAMH1_HUMAN	Increases Expression	[17]
C2 domain-containing protein 2 (C2CD2)	OTL1K0OB	C2CD2_HUMAN	Increases Expression	[17]
Lysyl oxidase homolog 2 (LOXL2)	OTRT46B5	LOXL2_HUMAN	Decreases Expression	[17]
ADP-ribose glycohydrolase OARD1 (OARD1)	OTNNWATS	OARD1_HUMAN	Decreases Expression	[17]
Ankyrin repeat and SOCS box protein 1 (ASB1)	OT0NZGEI	ASB1_HUMAN	Decreases Expression	[17]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B)	OTGZO1MT	TIM8B_HUMAN	Increases Expression	[17]
Retinoic acid-induced protein 2 (RAI2)	OTR8LX4J	RAI2_HUMAN	Increases Expression	[17]
Mitochondrial pyruvate carrier 1 (MPC1)	OT6DYFUO	MPC1_HUMAN	Increases Expression	[17]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Decreases Expression	[17]
Cysteine sulfinic acid decarboxylase (CSAD)	OT3I2G0A	CSAD_HUMAN	Increases Expression	[17]
Glypican-6 (GPC6)	OTNJBESF	GPC6_HUMAN	Decreases Expression	[17]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)	OTMRW5U5	IRAG1_HUMAN	Increases Expression	[17]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR)	OTTLD0KB	SQOR_HUMAN	Increases Expression	[17]
SET-binding protein (SETBP1)	OTKGCOSR	SETBP_HUMAN	Decreases Expression	[17]
Tryptophan 2,3-dioxygenase (TDO2)	OTV5HKJ4	T23O_HUMAN	Increases Expression	[61]
Serum paraoxonase/arylesterase 1 (PON1)	OTD0Z2XO	PON1_HUMAN	Increases Expression	[62]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Decreases Expression	[63]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Increases Expression	[63]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Decreases Expression	[63]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Decreases Expression	[63]
Collagen alpha-1(X) chain (COL10A1)	OTC4G2YC	COAA1_HUMAN	Increases Expression	[63]
Indian hedgehog protein (IHH)	OT1DWGXC	IHH_HUMAN	Increases Expression	[63]
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Increases Expression	[64]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[65]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1)	OTMI12L2	BMAL1_HUMAN	Affects Expression	[66]
Syntenin-1 (SDCBP)	OTS3NCC5	SDCB1_HUMAN	Increases Expression	[21]
Transcription factor SOX-1 (SOX1)	OTVI1RAR	SOX1_HUMAN	Increases Expression	[67]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[68]
Calsequestrin-2 (CASQ2)	OT09MNQ8	CASQ2_HUMAN	Affects Expression	[67]
Period circadian protein homolog 2 (PER2)	OTU2B1DJ	PER2_HUMAN	Affects Expression	[66]
Solute carrier family 22 member 1 (SLC22A1)	OT7817I4	S22A1_HUMAN	Increases Expression	[69]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Affects Expression	[70]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Increases Expression	[71]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[72]
Toll-like receptor 3 (TLR3)	OT8QPYXZ	TLR3_HUMAN	Decreases Expression	[73]
Circadian locomoter output cycles protein kaput (CLOCK)	OTNEOJY7	CLOCK_HUMAN	Affects Expression	[66]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Increases Expression	[73]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)	OT9ZS72C	SRGP3_HUMAN	Increases Expression	[74]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Increases Expression	[22]
Neuronal migration protein doublecortin (DCX)	OTISR7K3	DCX_HUMAN	Increases Expression	[67]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4)	OTLCYA32	G6PT1_HUMAN	Increases Expression	[75]
Left-right determination factor 1 (LEFTY1)	OT51HVC4	LFTY1_HUMAN	Increases Expression	[22]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Increases Expression	[76]
Sciellin (SCEL)	OT46SDNQ	SCEL_HUMAN	Increases Expression	[21]
Homeobox protein SIX3 (SIX3)	OTP5E3VU	SIX3_HUMAN	Increases Expression	[67]
Transforming acidic coiled-coil-containing protein 2 (TACC2)	OTW4M7HI	TACC2_HUMAN	Increases Expression	[77]
Eyes absent homolog 4 (EYA4)	OTINGR3Z	EYA4_HUMAN	Affects Expression	[67]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Decreases Expression	[78]
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Increases Expression	[18]
Eomesodermin homolog (EOMES)	OTB9VQFA	EOMES_HUMAN	Increases Expression	[67]
T-box transcription factor TBX6 (TBX6)	OTW1Q8RM	TBX6_HUMAN	Affects Expression	[67]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Affects Expression	[67]
Renin (REN)	OT52GZR2	RENI_HUMAN	Increases Activity	[79]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Decreases Expression	[80]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Decreases Expression	[81]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Decreases Expression	[82]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Expression	[83]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Decreases Expression	[79]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[84]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Decreases Response To Substance	[85]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[86]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[37]
Interleukin-2 receptor subunit alpha (IL2RA)	OT0MWCHG	IL2RA_HUMAN	Decreases Expression	[87]
T-cell surface glycoprotein CD4 (CD4)	OT7Z5LNF	CD4_HUMAN	Decreases Expression	[88]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)	OT7KZMP2	DRA_HUMAN	Increases Expression	[73]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)	OTC6GISG	DQA1_HUMAN	Increases Expression	[73]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Decreases Expression	[89]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)	OTVVI3UI	DQB1_HUMAN	Affects Expression	[73]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Increases Expression	[90]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Decreases Expression	[81]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Increases Expression	[91]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[37]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)	OTW8JHU2	DPB1_HUMAN	Increases Expression	[73]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[92]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[21]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[93]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Increases Expression	[94]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Expression	[37]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Increases Expression	[95]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Affects Expression	[67]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[20]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Phosphorylation	[96]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[74]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[94]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Increases Expression	[97]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Increases Expression	[90]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Affects Expression	[73]
Beta-microseminoprotein (MSMB)	OTYORAJC	MSMB_HUMAN	Increases Expression	[22]
Corticosteroid-binding globulin (SERPINA6)	OTOIBEW7	CBG_HUMAN	Increases Expression	[98]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Decreases Expression	[18]
Monocyte differentiation antigen CD14 (CD14)	OT83GJ47	CD14_HUMAN	Increases Expression	[99]
Receptor-type tyrosine-protein phosphatase C (PTPRC)	OT6KOR77	PTPRC_HUMAN	Affects Expression	[67]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Decreases Expression	[37]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[100]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[101]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Increases Expression	[21]
Transmembrane protein 191B (TMEM191B)	OTDKHB0K	T191B_HUMAN	Decreases Expression	[22]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[102]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases Expression	[21]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[93]
Transforming growth factor beta-3 proprotein (TGFB3)	OT2LOUQ1	TGFB3_HUMAN	Increases Expression	[21]
Phenylethanolamine N-methyltransferase (PNMT)	OTGLCPE8	PNMT_HUMAN	Increases Expression	[22]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Increases Expression	[74]
Pulmonary surfactant-associated protein C (SFTPC)	OTIZJD09	PSPC_HUMAN	Increases Expression	[103]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[104]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[105]
Myosin-7 (MYH7)	OT4Z9T8N	MYH7_HUMAN	Increases Expression	[67]
Myosin-6 (MYH6)	OT3YNCH1	MYH6_HUMAN	Affects Expression	[67]
Metallothionein-1G (MT1G)	OTAV1OCR	MT1G_HUMAN	Increases Expression	[21]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[106]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases Expression	[76]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Decreases Expression	[107]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[74]
Interleukin-2 receptor subunit beta (IL2RB)	OT6M0F70	IL2RB_HUMAN	Decreases Expression	[87]
Protein C-ets-2 (ETS2)	OTPVHOZ7	ETS2_HUMAN	Increases Expression	[73]
Mucin-1 (MUC1)	OTHQI7IY	MUC1_HUMAN	Increases Expression	[108]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Increases Phosphorylation	[109]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Increases Expression	[110]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Affects Expression	[73]
Syndecan-1 (SDC1)	OTWKRVZC	SDC1_HUMAN	Decreases Expression	[111]
Transcobalamin-2 (TCN2)	OT41D0L3	TCO2_HUMAN	Decreases Expression	[73]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Increases Expression	[74]
Nuclear receptor subfamily 1 group D member 1 (NR1D1)	OTJ38PTB	NR1D1_HUMAN	Decreases Expression	[112]
fMet-Leu-Phe receptor (FPR1)	OTFF9I6W	FPR1_HUMAN	Increases Expression	[92]
C-type natriuretic peptide (NPPC)	OTYJ0LMA	ANFC_HUMAN	Increases Expression	[22]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Affects Expression	[67]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[76]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[113]
Alpha-1D adrenergic receptor (ADRA1D)	OTW2CD1O	ADA1D_HUMAN	Increases Expression	[114]
Proteinase-activated receptor 1 (F2R)	OT4WVWBO	PAR1_HUMAN	Increases Expression	[115]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[116]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[73]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Increases Expression	[67]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[117]
Interleukin-1 receptor type 2 (IL1R2)	OT0G7E35	IL1R2_HUMAN	Increases Expression	[89]
Proteasome subunit beta type-9 (PSMB9)	OTFV57T8	PSB9_HUMAN	Decreases Expression	[80]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Decreases Expression	[118]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Activity	[117]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[21]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[119]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[120]
Macrosialin (CD68)	OTOYEY3J	CD68_HUMAN	Increases Expression	[99]
Alpha-1B adrenergic receptor (ADRA1B)	OTSAYAFD	ADA1B_HUMAN	Increases Expression	[114]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Expression	[78]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1)	OTJ6FM9F	G6PC1_HUMAN	Decreases Expression	[98]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Decreases Expression	[121]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Affects Expression	[67]
GMP reductase 1 (GMPR)	OTERWHYM	GMPR1_HUMAN	Increases Expression	[22]
TGF-beta receptor type-2 (TGFBR2)	OT3P7GZP	TGFR2_HUMAN	Increases Expression	[73]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Expression	[122]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[84]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Increases Expression	[21]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Increases Expression	[123]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Affects Activity	[124]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Affects Expression	[38]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Activity	[125]
Interleukin-12 receptor subunit beta-1 (IL12RB1)	OTM1IJO2	I12R1_HUMAN	Decreases Expression	[126]
Nuclear receptor subfamily 4 group A member 2 (NR4A2)	OT3F9IR2	NR4A2_HUMAN	Increases Expression	[67]
Transcription factor GATA-4 (GATA4)	OTQHWAZG	GATA4_HUMAN	Increases Expression	[67]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Affects Expression	[38]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[76]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Decreases Activity	[127]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Expression	[128]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Increases Expression	[129]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Decreases Expression	[130]
G protein-activated inward rectifier potassium channel 4 (KCNJ5)	OTA2MBIE	KCNJ5_HUMAN	Affects Expression	[67]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Increases Expression	[67]
Sodium/hydrogen exchanger 3 (SLC9A3)	OTZ7PFVT	SL9A3_HUMAN	Increases Expression	[131]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[132]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[133]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Increases Expression	[84]
Amiloride-sensitive sodium channel subunit beta (SCNN1B)	OT61QQTL	SCNNB_HUMAN	Increases Expression	[134]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G)	OTSJYQVQ	SCNNG_HUMAN	Increases Expression	[134]
C-C chemokine receptor type 3 (CCR3)	OT6GBUFA	CCR3_HUMAN	Decreases Expression	[135]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Increases Activity	[124]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	OTDAC6Z0	PRKX_HUMAN	Increases Expression	[21]
Thyroxine 5-deiodinase (DIO3)	OTNTITOT	IOD3_HUMAN	Decreases Activity	[136]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[137]
Transcription factor SOX-10 (SOX10)	OTF25ULQ	SOX10_HUMAN	Increases Expression	[67]
Forkhead box protein L2 (FOXL2)	OTFRQUYL	FOXL2_HUMAN	Decreases Expression	[128]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[138]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Increases Expression	[139]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Decreases Expression	[140]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Decreases Expression	[83]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Increases Expression	[74]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[141]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU)	OTLQN1E2	HNRPU_HUMAN	Affects Localization	[142]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Decreases Expression	[76]
Paired box protein Pax-5 (PAX5)	OTYBJJWX	PAX5_HUMAN	Affects Expression	[67]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Decreases Expression	[73]
Elongation factor 1-alpha 2 (EEF1A2)	OT9Z23K5	EF1A2_HUMAN	Increases Expression	[21]
Homeobox protein engrailed-1 (EN1)	OT2DKIDK	HME1_HUMAN	Increases Expression	[67]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Increases Expression	[143]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Expression	[21]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Decreases Expression	[132]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Increases Expression	[73]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[104]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Increases Cleavage	[120]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[74]
Receptor tyrosine-protein kinase erbB-4 (ERBB4)	OT9L6C41	ERBB4_HUMAN	Increases Expression	[21]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Increases Activity	[144]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[119]
Leukotriene C4 synthase (LTC4S)	OT3XNFJZ	LTC4S_HUMAN	Increases Expression	[145]
Protein Largen (PRR16)	OTG4TEGR	LARGN_HUMAN	Increases Expression	[22]
Zinc finger protein PLAG1 (PLAG1)	OTT9AJQY	PLAG1_HUMAN	Increases Expression	[21]
Beclin 1-associated autophagy-related key regulator (ATG14)	OTPZDKI0	BAKOR_HUMAN	Increases Expression	[104]
Histone H3.2 (H3C13)	OT97FS6C	H32_HUMAN	Increases Expression	[74]
Cytochrome P450 4Z1 (CYP4Z1)	OTKRGJBG	CP4Z1_HUMAN	Increases Expression	[146]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[21]
ATP-dependent RNA helicase TDRD9 (TDRD9)	OTS4UBI8	TDRD9_HUMAN	Increases Expression	[22]
Microprocessor complex subunit DGCR8 (DGCR8)	OT62LXE4	DGCR8_HUMAN	Increases Expression	[82]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Increases Expression	[147]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Expression	[78]
Ras-responsive element-binding protein 1 (RREB1)	OT62460U	RREB1_HUMAN	Increases Expression	[21]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[148]
Neurogenin-1 (NEUROG1)	OTMJZP9G	NGN1_HUMAN	Decreases Expression	[22]
Paired mesoderm homeobox protein 2B (PHOX2B)	OT3SFR2O	PHX2B_HUMAN	Affects Expression	[67]
Interleukin-12 receptor subunit beta-2 (IL12RB2)	OTDLV8H8	I12R2_HUMAN	Decreases Expression	[126]
Cbp/p300-interacting transactivator 1 (CITED1)	OTUJQ3VL	CITE1_HUMAN	Decreases Expression	[67]
Myocilin (MYOC)	OT6DAHNF	MYOC_HUMAN	Increases Expression	[90]
Mesoderm posterior protein 1 (MESP1)	OTY5QDBN	MESP1_HUMAN	Decreases Expression	[67]
Chitinase domain-containing protein 1 (CHID1)	OT4DIUKC	CHID1_HUMAN	Increases Expression	[121]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Decreases Expression	[71]
Negative elongation factor A (NELFA)	OT7O6E84	NELFA_HUMAN	Increases Expression	[21]
Rho-related GTP-binding protein RhoJ (RHOJ)	OTWI65OA	RHOJ_HUMAN	Increases Expression	[74]
Glucose-6-phosphatase 2 (G6PC2)	OTET1IKU	G6PC2_HUMAN	Increases Expression	[75]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[149]
Fibroblast growth factor 21 (FGF21)	OT3RXVRD	FGF21_HUMAN	Increases Expression	[150]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Increases Expression	[74]
FERM domain-containing protein 4A (FRMD4A)	OTJDTIK2	FRM4A_HUMAN	Decreases Expression	[22]
Vesicular glutamate transporter 2 (SLC17A6)	OTP1MJGP	VGLU2_HUMAN	Increases Expression	[67]
ETS-related transcription factor Elf-5 (ELF5)	OTLRU8YF	ELF5_HUMAN	Decreases Expression	[22]
Endoribonuclease Dicer (DICER1)	OTTVSEY0	DICER_HUMAN	Increases Expression	[82]
Histone deacetylase 5 (HDAC5)	OTWG387P	HDAC5_HUMAN	Increases Expression	[132]
Hepatocyte nuclear factor 3-beta (FOXA2)	OTJOCVOY	FOXA2_HUMAN	Decreases Expression	[67]
Potassium voltage-gated channel subfamily E member 2 (KCNE2)	OTUO214Y	KCNE2_HUMAN	Affects Expression	[67]
Mitogen-activated protein kinase 11 (MAPK11)	OT0AS010	MK11_HUMAN	Increases ADR	[41]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Increases ADR	[41]
Islet amyloid polypeptide (IAPP)	OT5Z8ERW	IAPP_HUMAN	Increases ADR	[41]
Programmed cell death protein 5 (PDCD5)	OT6T2DDL	PDCD5_HUMAN	Increases Response To Substance	[151]
Cadherin-4 (CDH4)	OT8LH3HN	CADH4_HUMAN	Increases ADR	[41]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Response To Substance	[152]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Response To Substance	[153]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Response To Substance	[154]
Gastrin (GAST)	OTD0IP9N	GAST_HUMAN	Increases ADR	[41]
Cadherin-12 (CDH12)	OTF2HCGA	CAD12_HUMAN	Increases ADR	[41]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Response To Substance	[149]
Poly polymerase 1 (PARP1)	OTIESHK4	PARP1_ARATH	Increases ADR	[41]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Increases ADR	[41]
Histidine decarboxylase (hdc)	OTM3771T	DCHS_RAOOR	Increases ADR	[41]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Increases ADR	[41]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Decreases Response To Substance	[155]
Interferon alpha-7 (IFNA7)	OTSQ6R46	IFNA7_HUMAN	Increases ADR	[41]
Polymerase delta-interacting protein 3 (POLDIP3)	OTTB5SV7	PDIP3_HUMAN	Increases Response To Substance	[42]
Alpha-2-HS-glycoprotein (AHSG)	OTUG0LEA	FETUA_HUMAN	Increases Response To Substance	[42]
Progranulin (GRN)	OTXXSJ53	GRN_HUMAN	Decreases Response To Substance	[156]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Decreases Response To Substance	[157]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Increases ADR	[41]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Postoperative Nausea and Vomiting (PONV)	DCIQIMI	N. A.	Phase 4	[158]
Chemotherapy-induced Nausea and Vomiting	DC44ZMX	N. A.	Phase 3	[159]
Chemotherapy-induced Nausea and Vomiting	DC562VS	N. A.	Phase 3	[160]
Chemotherapy-induced Nausea and Vomiting (CINV)	DC91BX6	N. A.	Phase 3	[161]
Chemotherapy-Induced Nausea and Vomiting (CINV)	DCIZP75	N. A.	Phase 3	[162]
Chemotherapy-induced Nausea and Vomiting	DCSH5XJ	N. A.	Phase 3	[159]
Myeloma, Plasma-Cell	DCLDEDP	N. A.	Phase 2	[163]
Cancer	DC5Z165	N. A.	Phase 1	[164]
Nausea	DCX0H9M	N. A.	Phase 1	[165]
Nausea	DCYX8UN	N. A.	Phase 1	[166]

References

• [1] ClinicalTrials.gov (NCT03237611) Low Dose Aprepitant for Patients Receiving Carboplatin
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3490).
• [4] Aprepitant FDA Label
• [5] ClinicalTrials.gov (NCT00571168) Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy. U.S. National Institutes of Health.
• [6] Dexamethasone FDA Label
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3447).
• [8] Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020 Jul 17. doi: 10.1056/NEJMoa2021436.
• [9] Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists. J Med Chem. 2009 May 14;52(9):3039-46.
• [10] Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109.
• [11] Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients. Cancer Chemother Pharmacol. 2005 Jun;55(6):609-16.
• [12] Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92.
• [13] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [14] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [15] Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol. 2005 Mar;67(3):845-55.
• [16] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [17] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
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