General Information of This Drug (ID: DM0WX6I)

Drug Name
Primidone   DM0WX6I
Synonyms
Cyral; Desoxyphenobarbital; Desoxyphenobarbitone; Hexadiona; Lepimidin; Lepsiral; Liskantin; Majsolin; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; Neurosyn; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidona; Primidonum; Primoline; Prysoline; Resimatil; Sertan; Apotex Brand of Primidone; Astra Brand of Primidone; AstraZeneca Brand of Primidone; Desitin Brand of Primidone; Draxis Brand of Primidone; Holsten Brand of Primidone; Pms Primidone; Primidon Holsten; Primidone Methanol Solution; Xcel Brand of Primidone; Zeneca Brand of Primidone; P 7295; Roe 101; Apo-Primidone; Hexamidine (the antispasmodic); Hexamidine(the antispasmodic); Liskantin (TN); Medi-Pets; Mylepsinum (TN); Mysoline (TN); Primidona [INN-Spanish]; Primidone (primaclone); Primidonum [INN-Latin]; Prysoline (TN); Pyrimidone Medi-pets; Resimatil (TN); Sanofi-Synthelabo Brand of Primidone; Sertan (TN); Apo-Primidone (TN); Pyrimidone (Medi-pets); Primidone (JP15/USP/INN); Primidone [USAN:INN:BAN:JAN]; 2-Deoxyphenobarbital; 2-Desoxyphenobarbital; 4,4'-(Hexamethylenedioxy)dibenzamidine; 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion; 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion [German]; 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione; 5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione; 5-Ethylhexahydro-4,6-dioxo-5-phenylpyrimidine; 5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione; 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6); 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6) [German]; 5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione; 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione; 5-ethylhe xahydro-4,6-dioxo-5-phenylpyrimidine
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Epilepsy with generalized tonic-clonic seizures N.A. Approved [2]
Focal epilepsy N.A. Approved [2]
Therapeutic Class
Anticonvulsants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Brincidofovir + Primidone DCBIXNV Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Carglumic acid + Primidone DCHV97O Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Primidone DCQGYYF Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Primidone DC58U4X Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cycloguanil + Primidone DCU3DLE Cycloguanil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dantrolene + Primidone DC05UEB Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Darunavir + Primidone DCWJN1Z Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diethylcarbamazine + Primidone DCODB1D Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Primidone DCZN8DC Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Endoxifen + Primidone DCFXRB2 Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethambutol + Primidone DCWDV5Y Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Flavonoid derivative 1 + Primidone DC0JUMW Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Primidone DC1AHGI Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Primidone DC6QSHV Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Furazolidone + Primidone DCAAKLZ Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Primidone DC5HPSP Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Primidone DCLOAIE IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Leflunomide + Primidone DC0WZRR Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Primidone DC3X2XA Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Primidone DC9RL0L Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Primidone DCFY6RU Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Norcisapride + Primidone DC59HZV Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PHA-739358 + Primidone DCNPV6I PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Primidone DC4ZDP4 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Ribavirin-TP DCPV8CH Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Kanamycin DC6FHTA Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + PMID28460551-Compound-2 DC77J0O PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Palonosetron DCM1Q48 Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Terameprocol DC4H2X5 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Fluspirilene DC9J7EJ Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + BIO-300 DC6QCDD BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Oseltamivir DCK5H32 Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + GINKGOLIDE A DCJ9A8M GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Idarubicin DCS7HL6 Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Primidone + Imatinib DC91S2F Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Bortezomib DCN56US Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Amantadine DCP7GTX Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Doxorubicin DCCCFC9 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Cerivastatin DC16KV1 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Metaxalone DCE8GNU Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Primidone + Acetohydroxamic Acid DCWOP9E Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Probenecid + Primidone DC26VNY Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pyrazinamide + Primidone DC71TD6 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tiagabine + Primidone DCRRG65 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolvaptan + Primidone DC1K4YQ Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + Primidone DCWCVV5 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trimethobenzamide + Primidone DCJH5XX Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
WAY-100635 + Primidone DCGX0RA WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 48 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5338).
2 Primidone FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.