Details of the Drug Combinations

General Information of This Drug (ID: DM1DP7T)

Drug Name

Levonorgestrel DM1DP7T

Synonyms

norgestrel; 797-63-7; D-Norgestrel; (-)-Norgestrel; Microval; Levonova; Postinor; Mirena; Ovrette; Neogest; Jadelle; Plan B; NORPLANT; Norplant 2; Microlution; Follistrel; Trivora; Monovar; Triciclor; Microgyn; Ovranette; Triagynon; Microlut; Nordet; Trigoa; 18-Methylnorethisterone; Levonorgestrelum; Microgynon CD; Microgest ED; Norplant II; Ovral-Lo; Logynon ED; Levlen ED; Trinordiol 28; Trinordiol 21; Microgynon 28; Microgynon 21; d(-)-Norgestrel; Neogynon 21; Monofeme 28; Nordette 28; Minivlar 30; Stediril 30; Nordette 21; Trifeme; Capronor; DNorgestrel; Levlen; Levonelle; Methylnorethindrone; Microluton; NorLevo; Norgeston; Norgestrel; Norgestrelum; Preven; Tetragynon; LD norgestrel [French]; Ld norgestrel; Levonorgestrel implants; Norgestrel [Progestins]; Norplant System in Plastic Container; Triquilar ED; Microgynon 30 ED; SH 70850; SH 850; Trifeme 28; Triphasil 21; Triphasil 28; Wy 3707; Alpha-Norgestrel; Component of Lo/ovral; Dl-Norgestrel; FH 122-A; LO/Ovral; Levonorgestrelum [INN-Latin]; Levora-21; Levora-28; Mirena (TN); Norgestrelum [INN-Latin]; Norplant (TN); Norplant-2; Ovoplex 30-150; Ovrette (TN); Postinor-2; Rigevidon 21+7; SOH-075; Tri-Levlen 21; Wy-3707; Wy-5104; E-Gen-C; Levonorgestrel [USAN:INN:BAN]; D(-)-Norgestrel; Levonorgestrel (JAN/USP/INN); Norgestrel (JP15/USP/INN); Norgestrel [USAN:BAN:INN:JAN]; Norgestrel [USAN:INN:BAN:JAN]; D-(-)-Norgestrel; Levonelle, D-Norgestrel, Levonova, Levonorgestrel; Norgestrel-(-)-D; Dl-13-beta-Ethyl-17-alpha-ethynyl-19-nortestosterone; 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE; 13-Ehyl-17alpha-ethynyl-17-hydroxygon-4-en-3-one; 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one; 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one; 13-Ethyl-17alpha-ethynylgon-4-en-17beta-ol-3-one; 13-beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one; 13beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one; 17-Ethynyl-18-methyl-19-nortestosterone; 17-alpha-Ethynyl-13-ethyl-19-nortestosterone; 17alpha-Ethynyl-13-ethyl-19-nortestosterone; 17alpha-Ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol; 17alpha-Ethynyl-17-hydroxy-18-methylestr-4-en-3-one; 17alpha-Ethynyl-18-homo-19-nor-testosterone; 17alpha-Ethynyl-18-homo-19-nortestosterone; 17alpha-ethynyl-17beta-hydroxy-18a-homoestr-4-en-3-one; 18,19-Dinor-4-pregnen-20-yn-3-one; 18-Methyl-17-alpha-ethynyl-19-nortestosterone; 72-HOURS

Indication

Disease Entry	ICD 11	Status	REF
Atypical endometrial hyperplasia	N.A.	Approved	[1]
Contraception	QA21	Approved	[2]
Hot flushes	GA30	Approved	[1]
Menorrhagia	GA20.50	Approved	[1]
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Therapeutic Class

Contraceptive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Levonorgestrel + Ethinyl estradiol	DC4WBB7	Ethinyl estradiol	Hepatitis C, Chronic	[3]
Levonorgestrel + Efavirenz	DCEU4AK	Efavirenz	HIV	[4]
Levonorgestrel + Mefenamic acid	DCF4Q9G	Mefenamic acid	Uterine Hemorrhage	[5]
Levonorgestrel + Estradiol	DCFICUL	Estradiol	Menopausal and Other Perimenopausal Disorders	[6]
Levonorgestrel + Tranexamic acid	DCLKQLV	Tranexamic acid	Uterine Hemorrhage	[5]
Levonorgestrel + Nevirapine	DCZO5AK	Nevirapine	HIV	[4]
Levonorgestrel + Meloxicam	DC1ES9G	Meloxicam	Pregnancy Prevention	[7]
Levonorgestrel + Piroxicam	DCB4DGT	Piroxicam	Emergency Contraception	[8]
Levonorgestrel + Semaglutide	DCBLT01	Semaglutide	Endometrial Cancer	[9]
Levonorgestrel + Mifepristone	DCQWR4T	Mifepristone	Missed Menstrual Period	[10]
Levonorgestrel + Ulipristal	DC0VE6B	Ulipristal	Contraception	[11]
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⏷ Show the Full List of 11 DrugCom(s)

References

1	Levonorgestrel FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2881).
3	ClinicalTrials.gov (NCT01570244) Drug-drug Interaction of BI 201335 and Microgynon
4	ClinicalTrials.gov (NCT01789879) A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral Therapy
5	ClinicalTrials.gov (NCT01295294) Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)
6	ClinicalTrials.gov (NCT01613131) Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression
7	ClinicalTrials.gov (NCT05695352) Oral Levonorgestrel Plus Meloxicam, IG-002 Delays Ovulation in Normal Menstruating Women by Seven Days
8	ClinicalTrials.gov (NCT03614494) Piroxicam and Levonorgestrel Co-treatment for Emergency Contraception
9	ClinicalTrials.gov (NCT06073184) Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
10	ClinicalTrials.gov (NCT04676776) Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills"
11	ClinicalTrials.gov (NCT02577601) Impact of Combined Hormonal Contraceptives on UPA