Details of the Drug Combinations

General Information of This Drug (ID: DM2G9AE)

Drug Name

Citalopram DM2G9AE

Synonyms

Akarin; Celapram; Celexa; Celius; Ciazil; Cilift; Cipram; Ciprapine; Citabax; Citadur; Citalec; Citalopramum; Citopam; Cytalopram; Dalsan; Humorup; Nitalapram; Oropram; Pramcit; Recital; Seropram; Talam; Talohexal; Temperax; Vodelax; Zentius; Zetalo; Citalopram [Celexa]; [3H]Citalopram; Akarin (TN); Celapram (TN); Celexa (TN); Celius (TN); Ciazil (TN); Cilift (TN); Cipram (TN); Cipramil (TN); Ciprapine (TN); Citabax (TN); Citadur (TN); Citalec (TN); Citalopram [INN:BAN]; Citalopramum [INN-Latin]; Citaxin (TN); Citol (TN); Citopam (TN); Citox (TN); Citrol (TN); Dalsan (TN); Lu 10-171; Recital (TN); Seropram (TN); Talam (TN); Zentius (TN); Zetalo (TN); AE-641/00603021; Citalopram (USP/INN); Lu-10-171; 1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile; 1,3-dihydro[3,4]benzofuran-5-carbonitrile; 1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile

Indication

Disease Entry	ICD 11	Status	REF
Acute coronary syndrome	BA41	Approved	[1]
Anxiety	N.A.	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Insomnia	7A00-7A0Z	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Major depressive disorder	6A70.3	Approved	[1]
Colon cancer	2B90.Z	Investigative	[1]
Gastric cancer	2B72	Investigative	[1]
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⏷ Show the Full List of Indication(s)

Therapeutic Class

Antidepressants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

107 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetohydroxamic Acid + Citalopram	DCWPZPC	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acitretin + Citalopram	DCLM1XD	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Citalopram	DCYNVCI	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Citalopram	DC1BEO5	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Anamorelin + Citalopram	DCTFMCB	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aprepitant + Citalopram	DCPQ2RY	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
AS-1949490 + Citalopram	DCKKIK6	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Atovaquone + Citalopram	DC444WL	Atovaquone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Auranofin + Citalopram	DCLC3EE	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Baclofen + Citalopram	DCSHADA	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Citalopram	DC93DPK	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Citalopram	DCGK7KX	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Ribavirin-TP	DCE47NQ	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Mebutamate	DC2G9WF	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Gefitinib	DCO7VGO	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Diethylcarbamazine	DC2Z8OK	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Kanamycin	DCCSWJK	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Imipramine	DCCZMVQ	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Epinephrine	DC7FRR8	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Furazolidone	DCQ2X39	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Chlorphenesin	DCPJVXQ	Chlorphenesin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Dihydroergotamine	DCAW8F3	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Triapine	DCZGBO5	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + IT-141	DCNFCY5	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Isosorbide dinitrate	DC3E66H	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Testosterone cypionate	DC4N0O8	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Cinacalcet	DCCFHYZ	Cinacalcet	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Chlorzoxazone	DCEWT1B	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Memantine	DCT32ZB	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Docetaxel	DC7M25U	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Pazopanib	DC7HGLS	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + WAY-100635	DC6TGK3	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Tolazoline	DC8V35Q	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Sulfapyridine	DC93H0L	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Arfolitixorin	DCWY12V	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + BIO-300	DC6D15F	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Tiagabine	DCENO5H	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Oseltamivir	DC9ZUAB	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Diazoxide	DCRJ06G	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Fenoprofen	DC9J74I	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Probenecid	DC0LU47	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Methylene blue	DC6H7RL	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Trimethobenzamide	DCZ7RA8	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Maprotiline	DCUTVVN	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Acetohexamide	DCOA7T4	Acetohexamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Leflunomide	DC6W8RZ	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Acarbose	DC3LOA3	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Sorafenib	DCX0DOR	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Hyodeoxycholic acid	DC447YX	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Spironolactone	DCSA8ES	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Mycophenolic acid	DCA1V0J	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Mefloquine	DCW315W	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Zileuton	DCKMI5B	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Testolactone	DCJG099	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Olmesartan medoxomil	DC2E0F9	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Rufinamide	DC2WO5E	Rufinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Vorinostat	DC33ED5	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Cevimeline	DCELXU3	Cevimeline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Estramustine	DCX3UU2	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Cerivastatin	DCOF54A	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Hydroxychloroquine	DCP9CR6	Hydroxychloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Atovaquone	DCK5JB5	Atovaquone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Acetohydroxamic Acid	DCTA0JC	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Albendazole	DC0DD1A	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Cytarabine	DC6E7UN	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dactinomycin + Citalopram	DCYOOOM	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dantrolene + Citalopram	DCOKUY2	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Citalopram	DC0S950	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Citalopram	DCRBERM	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Citalopram	DCKS4N4	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diphenidol + Citalopram	DCSWONQ	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Citalopram	DCY0WF5	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Citalopram	DC2H7SY	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Citalopram	DC5BK3M	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + Citalopram	DCTPF1S	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Citalopram	DCDGGFL	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Etonogestrel + Citalopram	DCHUMQF	Etonogestrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fenoprofen + Citalopram	DCTQZCK	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Citalopram	DC3MEXZ	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Citalopram	DCK6FH3	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Citalopram	DCX74MH	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Citalopram	DCMTI29	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
LY03004 + Citalopram	DCIKM4M	LY03004	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mephenytoin + Citalopram	DC1UNIU	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metaxalone + Citalopram	DC5W673	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Citalopram	DCXMC2C	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Citalopram	DCR4JAC	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Citalopram	DCF7WR7	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oxyphenbutazone + Citalopram	DCHJFJZ	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Palonosetron + Citalopram	DCIWAYE	Palonosetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pepstatin + Citalopram	DC8WXPN	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Citalopram	DCX01KO	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pramipexole + Citalopram	DCDM54V	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Citalopram	DCXX5LO	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Quinine + Citalopram	DCGIX91	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ribavirin-TP + Citalopram	DCC4RJO	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
SCH 727965 + Citalopram	DC02FFI	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sorafenib + Citalopram	DC5BJI2	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Citalopram	DCRFYQT	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terameprocol + Citalopram	DC3VFZF	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tetracycline + Citalopram	DC1F4E8	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tiagabine + Citalopram	DCUNJTM	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolazoline + Citalopram	DC99CMP	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Topotecan + Citalopram	DCXSNH6	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triapine + Citalopram	DCQUTM9	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trifluoperazine + Citalopram	DCKACTS	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trioxsalen + Citalopram	DCGJJN7	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 107 DrugCom(s)

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cannabidiol + Citalopram	DC8XFJS	Cannabidiol	Cannabidiol	[5]
Citalopram + Fingolimod	DC9UVNM	Fingolimod	Depression	[6]
Citalopram + Fluoxetine	DCBOEH6	Fluoxetine	Depression	[7]
Citalopram + Risperidone	DCN9DPZ	Risperidone	Schizophrenia	[8]
Citalopram + Raltegravir	DC6PTSC	Raltegravir	HIV	[9]
Citalopram + Acetylcysteine	DCFZF3Y	Acetylcysteine	Major Depressive Disorder	[10]
Reboxetine + Citalopram	DCCFI2K	Reboxetine	Schizophrenia	[11]
Citalopram + Pregabalin	DCWOFP5	Pregabalin	Burning Mouth Syndrome	[12]
Citalopram + Amphotericin B	DCAWEAQ	Amphotericin B	Major Depressive Disorder	[13]
Citalopram + Bupropion	DCZ31IN	Bupropion	Depressive Illness	[14]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	Citalopram FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7547).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT06192589) Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
6	ClinicalTrials.gov (NCT01436643) Combination of Antidepressants and Fingolimod Relapsing-remitting Multiple Sclerosis (RRMS) Patients With Depression
7	ClinicalTrials.gov (NCT00018902) Treatment of SSRI-Resistant Depression In Adolescents (TORDIA)
8	ClinicalTrials.gov (NCT00893256) Effect of Add-on Citalopram to Risperidone on Negative Symptoms in Schizophrenia
9	ClinicalTrials.gov (NCT01978782) Pharmacokinetic Drug-drug Interaction Study Between RaltEgravir and CITALopram in Healthy Subjects (RECITAL).
10	ClinicalTrials.gov (NCT02269540) A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)
11	ClinicalTrials.gov (NCT01300364) Reboxetine and Citalopram as an Adjunct Treatment to Second Generation Antipsychotics in the Treatment of Negative Symptoms of Schizophrenia
12	ClinicalTrials.gov (NCT06025474) Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome
13	ClinicalTrials.gov (NCT04975724) Safety of Liposom With Citalopram in Elderly Patients With Major Depressive Disorder
14	ClinicalTrials.gov (NCT03278938) Add-on to Cognitive, Event-Related Potentials (ERP) and Electroencephalogram (EEG) Asymmetry in Affective Disorders