Details of the Drug Combination

General Information of Drug Combination (ID: DCAWEAQ)

• Drug Combination Name: Citalopram + Amphotericin B
• Indication: Major Depressive Disorder; Status: Phase 4 [1]
• Component Drugs:
  Citalopram (DM2G9AE): Small molecular drug
  Amphotericin B (DMTAJQE): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Citalopram

Disease Entry	ICD 11	Status	REF
Acute coronary syndrome	BA41	Approved	[2]
Anxiety	N.A.	Approved	[2]
Depression	6A70-6A7Z	Approved	[3]
Insomnia	7A00-7A0Z	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Major depressive disorder	6A70.3	Approved	[2]
Colon cancer	2B90.Z	Investigative	[2]
Gastric cancer	2B72	Investigative	[2]

Citalopram Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Modulator	[7]

Citalopram Interacts with 3 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[8]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[9]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[10]

Citalopram Interacts with 4 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[11]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[12]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[13]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[14]

Citalopram Interacts with 29 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Methylation	[15]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Decreases Methylation	[15]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Decreases Methylation	[16]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Response	[17]
Glutamate receptor 3 (GRIA3)	OT34CNBR	GRIA3_HUMAN	Affects Response To Substance	[18]
Glutamate receptor ionotropic, kainate 2 (GRIK2)	OTQ41U3D	GRIK2_HUMAN	Affects Response To Substance	[18]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Decreases Expression	[19]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[20]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Increases Expression	[20]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Increases Expression	[20]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Decreases Expression	[20]
Inhibin beta E chain (INHBE)	OTOI2NYG	INHBE_HUMAN	Increases Expression	[20]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Decreases Expression	[20]
Lysophospholipase D GDPD3 (GDPD3)	OTOHM9QM	GDPD3_HUMAN	Increases Expression	[20]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Affects Binding	[21]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Activity	[22]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[23]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Increases Expression	[24]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[25]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[26]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[27]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Expression	[23]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[28]
Sodium-dependent dopamine transporter (SLC6A3)	OT39XG28	SC6A3_HUMAN	Affects Response To Substance	[29]
Sodium-dependent serotonin transporter (SLC6A4)	OT6FGDLW	SC6A4_HUMAN	Affects Response To Substance	[30]
Glutamate receptor 1 (GRIA1)	OT85LOCJ	GRIA1_HUMAN	Affects Response To Substance	[18]
Glutamate receptor ionotropic, kainate 4 (GRIK4)	OTL5EIPA	GRIK4_HUMAN	Increases Response	[31]
Glutamate receptor ionotropic, NMDA 3A (GRIN3A)	OTQS9GYY	NMD3A_HUMAN	Affects Response To Substance	[18]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Increases Response	[32]

Indication(s) of Amphotericin B

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[4]
Actinomycosis	N.A.	Approved	[4]
Acute gonococcal cervicitis	N.A.	Approved	[4]
Aspergillosis	1F20	Approved	[4]
Blastomycosis	1F22	Approved	[4]
Bronchitis	CA20	Approved	[4]
Brucellosis	N.A.	Approved	[4]
Candidiasis	1F23	Approved	[4]
Coccidioidomycosis	1F25	Approved	[4]
Cryptococcal meningitis	N.A.	Approved	[4]
Cryptococcosis	N.A.	Approved	[4]
Cutaneous candidiasis	1F23.14	Approved	[4]
Disseminated sporotrichosis	N.A.	Approved	[4]
Fungal infection	1F29-1F2F	Approved	[5]
Histoplasmosis	N.A.	Approved	[4]
Invasive candidiasis	1F23	Approved	[4]
Leishmaniasis	1F54	Approved	[4]
Lymphogranuloma venereum	N.A.	Approved	[4]
Mycotic endocarditis	N.A.	Approved	[4]
Oral candidiasis	1F23.0	Approved	[4]
Ornithosis	N.A.	Approved	[4]
Pneumonia	CA40	Approved	[4]
Q fever	N.A.	Approved	[4]
Relapsing fever	N.A.	Approved	[4]
Rickettsialpox	N.A.	Approved	[4]
Rocky mountain spotted fever	N.A.	Approved	[4]
Syphilis	N.A.	Approved	[4]
Trachoma	N.A.	Approved	[4]
Typhus	N.A.	Approved	[4]
Urinary tract infection	GC08	Approved	[4]
Yaws	N.A.	Approved	[4]
Candidemia	1F23.3Y	Investigative	[4]
Esophageal candidiasis	N.A.	Investigative	[4]
Mycoses	1F2Z	Investigative	[6]
Pelvic inflammatory disease	GA05	Investigative	[4]
Sinusitis	CA0A.Z	Investigative	[4]

Amphotericin B Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Fungal Cell membrane ergosterol (Fung CME)	TTQKWA4	NOUNIPROTAC	Modulator	[35]

Amphotericin B Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[36]

Amphotericin B Interacts with 296 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[37]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Increases Expression	[33]
RNA-binding protein 47 (RBM47)	OT6W67VM	RBM47_HUMAN	Decreases Expression	[33]
Neural cell adhesion molecule L1-like protein (CHL1)	OT6E6E8P	NCHL1_HUMAN	Decreases Expression	[33]
Disks large-associated protein 1 (DLGAP1)	OTF2PUUI	DLGP1_HUMAN	Decreases Expression	[33]
Receptor-type tyrosine-protein phosphatase T (PTPRT)	OTV5TXNN	PTPRT_HUMAN	Increases Expression	[33]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[33]
Transcription factor EC (TFEC)	OTUST8MR	TFEC_HUMAN	Decreases Expression	[33]
Calsequestrin-2 (CASQ2)	OT09MNQ8	CASQ2_HUMAN	Increases Expression	[33]
Long-chain fatty acid transport protein 2 (SLC27A2)	OT7JEG5F	S27A2_HUMAN	Decreases Expression	[33]
Serine/threonine-protein kinase DCLK1 (DCLK1)	OTVSPS98	DCLK1_HUMAN	Decreases Expression	[33]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)	OTQUX50Z	LRAD4_HUMAN	Increases Expression	[33]
Kynurenine 3-monooxygenase (KMO)	OT3MRMM9	KMO_HUMAN	Decreases Expression	[33]
Metabotropic glutamate receptor 6 (GRM6)	OTH95T77	GRM6_HUMAN	Increases Expression	[33]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Increases Expression	[38]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Increases Expression	[33]
TOX high mobility group box family member 3 (TOX3)	OTC9NR4W	TOX3_HUMAN	Decreases Expression	[33]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[33]
Glutamate receptor ionotropic, delta-2 (GRID2)	OTJ3R10R	GRID2_HUMAN	Increases Expression	[33]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Decreases Expression	[33]
Protein sprouty homolog 1 (SPRY1)	OT764FXI	SPY1_HUMAN	Decreases Expression	[33]
Germinal-center associated nuclear protein (MCM3AP)	OT895FEC	GANP_HUMAN	Increases Expression	[33]
Periplakin (PPL)	OTTM4WDO	PEPL_HUMAN	Decreases Expression	[33]
GDNF family receptor alpha-3 (GFRA3)	OT07XAZF	GFRA3_HUMAN	Increases Expression	[33]
Galanin receptor type 3 (GALR3)	OTXU6PKO	GALR3_HUMAN	Increases Expression	[33]
Receptor activity-modifying protein 3 (RAMP3)	OTX6XLLM	RAMP3_HUMAN	Increases Expression	[33]
Nucleolar protein 3 (NOL3)	OT1K0L0D	NOL3_HUMAN	Decreases Expression	[33]
Slit homolog 1 protein (SLIT1)	OT35RBNT	SLIT1_HUMAN	Decreases Expression	[34]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Decreases Expression	[33]
Histone deacetylase complex subunit SAP30 (SAP30)	OT73OLML	SAP30_HUMAN	Increases Expression	[33]
Carboxypeptidase D (CPD)	OT2CS64Y	CBPD_HUMAN	Decreases Expression	[33]
Ribosomal L1 domain-containing protein 1 (RSL1D1)	OT3CL4R3	RL1D1_HUMAN	Decreases Expression	[33]
Annexin A9 (ANXA9)	OTKNYMU2	ANXA9_HUMAN	Decreases Expression	[33]
Cyclin-dependent kinase-like 5 (CDKL5)	OTGL5HRV	CDKL5_HUMAN	Increases Expression	[33]
Contactin-5 (CNTN5)	OTWU5FLZ	CNTN5_HUMAN	Increases Expression	[33]
Phospholipid-transporting ATPase VB (ATP10B)	OTSOUTE1	AT10B_HUMAN	Increases Expression	[33]
Transmembrane and coiled-coil domains protein 1 (TMCC1)	OTRXDL86	TMCC1_HUMAN	Decreases Expression	[33]
D-glucuronyl C5-epimerase (GLCE)	OTPRSHX5	GLCE_HUMAN	Decreases Expression	[33]
Glutaminase kidney isoform, mitochondrial (GLS)	OTGOZG2M	GLSK_HUMAN	Increases Expression	[33]
Protein FAM13A (FAM13A)	OTZ6GN0Q	FA13A_HUMAN	Decreases Expression	[33]
Fibrinogen silencer-binding protein (RAD54B)	OTMWB2P2	FSBP_HUMAN	Decreases Expression	[33]
Chondroitin sulfate proteoglycan 5 (CSPG5)	OTXFEBWR	CSPG5_HUMAN	Decreases Expression	[33]
RAS guanyl-releasing protein 1 (RASGRP1)	OTX9WN2E	GRP1_HUMAN	Decreases Expression	[33]
BAG family molecular chaperone regulator 4 (BAG4)	OTUPX3M2	BAG4_HUMAN	Decreases Expression	[33]
Olfactory receptor 2H2 (OR2H2)	OTOSTYE2	OR2H2_HUMAN	Increases Expression	[33]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[33]
Alpha-lactalbumin (LALBA)	OTA6ZLP4	LALBA_HUMAN	Increases Expression	[33]
Glycoprotein hormones alpha chain (CGA)	OT00U3Y3	GLHA_HUMAN	Increases Expression	[33]
Interferon alpha-21 (IFNA21)	OTUA0R1F	IFN21_HUMAN	Increases Expression	[33]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[39]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Decreases Expression	[40]
Apolipoprotein C-II (APOC2)	OTLINYIQ	APOC2_HUMAN	Increases Expression	[33]
Fibrinogen beta chain (FGB)	OT6RKLI9	FIBB_HUMAN	Decreases Expression	[33]
Hemopexin (HPX)	OT14T7Q1	HEMO_HUMAN	Increases Expression	[33]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Increases Expression	[33]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[33]
Plasma serine protease inhibitor (SERPINA5)	OTTZXPGD	IPSP_HUMAN	Decreases Expression	[33]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[33]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Increases Expression	[33]
T-cell surface antigen CD2 (CD2)	OTLYO0DB	CD2_HUMAN	Increases Expression	[33]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Decreases Expression	[33]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Decreases Expression	[33]
Platelet glycoprotein Ib alpha chain (GP1BA)	OT62PSOB	GP1BA_HUMAN	Increases Expression	[33]
T-cell surface glycoprotein CD3 epsilon chain (CD3E)	OT13LE5J	CD3E_HUMAN	Increases Expression	[33]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Increases Expression	[33]
Monocyte differentiation antigen CD14 (CD14)	OT83GJ47	CD14_HUMAN	Decreases Expression	[33]
Fibroblast growth factor 4 (FGF4)	OTNVV3ZG	FGF4_HUMAN	Increases Expression	[33]
Alpha-2A adrenergic receptor (ADRA2A)	OTZFGOTP	ADA2A_HUMAN	Decreases Expression	[33]
Homeobox protein Hox-D4 (HOXD4)	OTQR4WCG	HXD4_HUMAN	Decreases Expression	[33]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[33]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[33]
Tumor-associated calcium signal transducer 2 (TACSTD2)	OTLSZR00	TACD2_HUMAN	Decreases Expression	[33]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	OT7FOIK2	LOX5_HUMAN	Decreases Expression	[33]
Adenosine receptor A3 (ADORA3)	OTHO1BLK	AA3R_HUMAN	Increases Expression	[33]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Decreases Expression	[33]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[33]
COUP transcription factor 1 (NR2F1)	OTGWZWYL	COT1_HUMAN	Decreases Expression	[33]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Expression	[33]
High affinity immunoglobulin gamma Fc receptor I (FCGR1A)	OTOBCS2O	FCGR1_HUMAN	Increases Expression	[33]
Bone morphogenetic protein 2 (BMP2)	OT23T37S	BMP2_HUMAN	Decreases Expression	[33]
Cytochrome P450 4B1 (CYP4B1)	OTJP46CB	CP4B1_HUMAN	Decreases Expression	[33]
Sodium/glucose cotransporter 1 (SLC5A1)	OT0T78JI	SC5A1_HUMAN	Increases Expression	[33]
Phospholipase A2, membrane associated (PLA2G2A)	OT1NY7BF	PA2GA_HUMAN	Increases Expression	[33]
Glutamine synthetase (GLUL)	OTYGTCGF	GLNA_HUMAN	Decreases Expression	[33]
Interferon gamma receptor 1 (IFNGR1)	OTCTQBWW	INGR1_HUMAN	Increases Expression	[41]
Antigen-presenting glycoprotein CD1d (CD1D)	OT3ROU4J	CD1D_HUMAN	Decreases Expression	[33]
Platelet endothelial cell adhesion molecule (PECAM1)	OTXOM4D9	PECA1_HUMAN	Increases Expression	[33]
T-cell acute lymphocytic leukemia protein 1 (TAL1)	OTX4K6QZ	TAL1_HUMAN	Increases Expression	[33]
Bone morphogenetic protein 7 (BMP7)	OTYATP2K	BMP7_HUMAN	Increases Expression	[33]
Erythropoietin receptor (EPOR)	OTUIOEU3	EPOR_HUMAN	Increases Expression	[33]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Increases Expression	[33]
Transcobalamin-1 (TCN1)	OTW6A49Y	TCO1_HUMAN	Decreases Expression	[33]
Kallikrein-2 (KLK2)	OT9RE37R	KLK2_HUMAN	Increases Expression	[33]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Increases Expression	[33]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Increases Expression	[33]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Decreases Expression	[33]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[33]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Increases Expression	[33]
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)	OTZNYEKF	GTR5_HUMAN	Decreases Expression	[33]
Carbonic anhydrase 4 (CA4)	OT3K93LZ	CAH4_HUMAN	Decreases Expression	[33]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[33]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4)	OTOCBX7P	TNFL4_HUMAN	Decreases Expression	[33]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[34]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[34]
Acrosomal protein SP-10 (ACRV1)	OTUTG7PL	ASPX_HUMAN	Increases Expression	[33]
Interleukin-1 receptor type 2 (IL1R2)	OT0G7E35	IL1R2_HUMAN	Decreases Expression	[33]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Decreases Expression	[33]
T-cell surface glycoprotein CD1c (CD1C)	OT4XINUJ	CD1C_HUMAN	Increases Expression	[33]
HLA class I histocompatibility antigen, alpha chain F (HLA-F)	OT76CM19	HLAF_HUMAN	Increases Expression	[34]
Pyruvate kinase PKLR (PKLR)	OTTTM1QI	KPYR_HUMAN	Increases Expression	[33]
Olfactory receptor 10J1 (OR10J1)	OTS7B2ZB	O10J1_HUMAN	Increases Expression	[33]
Homeobox protein Hox-D3 (HOXD3)	OTBUZ35T	HXD3_HUMAN	Decreases Expression	[33]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Decreases Expression	[33]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Increases Expression	[33]
Ribonuclease 4 (RNASE4)	OTA5SZLC	RNAS4_HUMAN	Decreases Expression	[33]
Cannabinoid receptor 2 (CNR2)	OTYP9P43	CNR2_HUMAN	Increases Expression	[33]
Merlin (NF2)	OT6E5ACG	MERL_HUMAN	Decreases Expression	[33]
Nuclear receptor ROR-alpha (RORA)	OTGQT12P	RORA_HUMAN	Decreases Expression	[33]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[33]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Decreases Expression	[33]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Decreases Expression	[33]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Decreases Expression	[33]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Decreases Expression	[33]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[33]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Decreases Expression	[33]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Increases Expression	[33]
DNA-binding protein inhibitor ID-4 (ID4)	OTPMJ39I	ID4_HUMAN	Decreases Expression	[33]
Serpin B4 (SERPINB4)	OT88LHZ8	SPB4_HUMAN	Decreases Expression	[33]
Beta-arrestin-1 (ARRB1)	OT2NJS37	ARRB1_HUMAN	Increases Expression	[33]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Decreases Expression	[33]
Cytosolic purine 5'-nucleotidase (NT5C2)	OTJMF66Z	5NTC_HUMAN	Increases Expression	[34]
RNA-binding protein FXR1 (FXR1)	OTEMQ1SR	FXR1_HUMAN	Decreases Expression	[33]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Expression	[33]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[33]
LIM domain kinase 1 (LIMK1)	OTFZ8MZ0	LIMK1_HUMAN	Increases Expression	[33]
Beta-crystallin B1 (CRYBB1)	OTDI4W3V	CRBB1_HUMAN	Increases Expression	[33]
DNA polymerase subunit gamma-1 (POLG)	OTDUCT04	DPOG1_HUMAN	Increases Expression	[33]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Decreases Expression	[33]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)	OTU7J3F7	PDE1A_HUMAN	Decreases Expression	[33]
GTP-binding protein RAD (RRAD)	OTW2O4GD	RAD_HUMAN	Decreases Expression	[33]
Aquaporin-5 (AQP5)	OT77GBY8	AQP5_HUMAN	Increases Expression	[33]
Galectin-4 (LGALS4)	OTKQCG0H	LEG4_HUMAN	Increases Expression	[33]
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)	OT29B58J	KCNQ4_HUMAN	Decreases Expression	[34]
Serine/threonine-protein kinase SIK1 (SIK1)	OT6FCHME	SIK1_HUMAN	Increases Expression	[33]
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)	OTG7HEA2	ATS12_HUMAN	Increases Expression	[33]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Decreases Expression	[33]
Rho-related GTP-binding protein RhoE (RND3)	OTXMXPIH	RND3_HUMAN	Increases Expression	[33]
Small ribosomal subunit protein eS8 (RPS8)	OTEBS4HZ	RS8_HUMAN	Increases Expression	[33]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Decreases Expression	[33]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Decreases Expression	[33]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Increases Expression	[33]
Neutrophil gelatinase-associated lipocalin (LCN2)	OTSB42BR	NGAL_HUMAN	Decreases Expression	[33]
Zinc finger protein basonuclin-1 (BNC1)	OTGJ5WUF	BNC1_HUMAN	Increases Expression	[33]
Blood group Rh(D) polypeptide (RHD)	OTUPKABF	RHD_HUMAN	Increases Expression	[33]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Decreases Expression	[33]
Mucin-2 (MUC2)	OT3X4QVX	MUC2_HUMAN	Increases Expression	[33]
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Increases Expression	[33]
Homeobox protein EMX2 (EMX2)	OT0V8OYK	EMX2_HUMAN	Decreases Expression	[33]
Proto-oncogene c-Rel (REL)	OTTCKMAC	REL_HUMAN	Decreases Expression	[33]
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3)	OTE5XENW	ACHB3_HUMAN	Increases Expression	[33]
Myocyte-specific enhancer factor 2C (MEF2C)	OTZGF1Y5	MEF2C_HUMAN	Decreases Expression	[33]
Adenylate cyclase type 2 (ADCY2)	OTYCBR8I	ADCY2_HUMAN	Increases Expression	[33]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Decreases Expression	[33]
Killer cell lectin-like receptor subfamily B member 1 (KLRB1)	OTQ2959Y	KLRB1_HUMAN	Increases Expression	[33]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Decreases Expression	[33]
Heat shock protein beta-3 (HSPB3)	OTE67YM5	HSPB3_HUMAN	Increases Expression	[33]
AP-3 complex subunit beta-2 (AP3B2)	OT7BFBLP	AP3B2_HUMAN	Increases Expression	[33]
Unconventional myosin-VIIa (MYO7A)	OTBZSPEL	MYO7A_HUMAN	Increases Expression	[33]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Decreases Expression	[33]
Mucosal addressin cell adhesion molecule 1 (MADCAM1)	OTHIPW4U	MADCA_HUMAN	Increases Expression	[33]
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)	OTHD9KJG	KCC2G_HUMAN	Increases Expression	[33]
Interferon regulatory factor 5 (IRF5)	OT8SIIAP	IRF5_HUMAN	Increases Expression	[33]
Runt-related transcription factor 3 (RUNX3)	OTITK1XD	RUNX3_HUMAN	Decreases Expression	[34]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[33]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)	OTTUU92F	ENPP2_HUMAN	Decreases Expression	[33]
Plakophilin-1 (PKP1)	OT9HSQ8F	PKP1_HUMAN	Increases Expression	[33]
Krueppel-like factor 9 (KLF9)	OTBFEJRQ	KLF9_HUMAN	Decreases Expression	[33]
Transcription factor Dp-2 (TFDP2)	OTKQFX5H	TFDP2_HUMAN	Decreases Expression	[33]
Calcipressin-2 (RCAN2)	OTGGWTWS	RCAN2_HUMAN	Decreases Expression	[33]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Increases Expression	[33]
Enhancer of filamentation 1 (NEDD9)	OTGCFN4M	CASL_HUMAN	Decreases Expression	[33]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Increases Expression	[33]
Potassium voltage-gated channel subfamily B member 1 (KCNB1)	OTLCU4FR	KCNB1_HUMAN	Decreases Expression	[33]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[33]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Decreases Expression	[33]
Corneodesmosin (CDSN)	OTQW4HV6	CDSN_HUMAN	Increases Expression	[33]
Transcription initiation factor TFIID subunit 13 (TAF13)	OT1XMYAD	TAF13_HUMAN	Decreases Expression	[33]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Decreases Expression	[33]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Activity	[42]
Carbonic anhydrase 9 (CA9)	OTNA51XT	CAH9_HUMAN	Decreases Expression	[33]
Reticulon-1 (RTN1)	OTCX1SMK	RTN1_HUMAN	Decreases Expression	[33]
Carcinoembryonic antigen-related cell adhesion molecule 21 (CEACAM21)	OTHVCMIP	CEA21_HUMAN	Increases Expression	[33]
Transmembrane protein 176B (TMEM176B)	OTEGF2BV	T176B_HUMAN	Decreases Expression	[33]
Mitogen-activated protein kinase kinase kinase 19 (MAP3K19)	OTBE2OCY	M3K19_HUMAN	Increases Expression	[33]
Transmembrane protein 255A (TMEM255A)	OTVIYMEZ	T255A_HUMAN	Decreases Expression	[33]
Protein THEMIS2 (THEMIS2)	OTI1OBLN	THMS2_HUMAN	Decreases Expression	[33]
Myomegalin (PDE4DIP)	OTS15WNF	MYOME_HUMAN	Decreases Expression	[33]
Kazrin (KAZN)	OTPM7BYM	KAZRN_HUMAN	Increases Expression	[33]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[33]
Kelch-like protein 24 (KLHL24)	OTWZSX5C	KLH24_HUMAN	Decreases Expression	[33]
BEN domain-containing protein 5 (BEND5)	OT6J6LY3	BEND5_HUMAN	Decreases Expression	[33]
Glucosylceramide transporter ABCA12 (ABCA12)	OTKH9YQZ	ABCAC_HUMAN	Decreases Expression	[33]
E3 ubiquitin-protein ligase DZIP3 (DZIP3)	OTOFK9KG	DZIP3_HUMAN	Decreases Expression	[33]
Homeodomain-interacting protein kinase 1 (HIPK1)	OTSEA8RS	HIPK1_HUMAN	Decreases Expression	[33]
Transmembrane protein 151B (TMEM151B)	OTTEDBUJ	T151B_HUMAN	Increases Expression	[33]
Calcium-responsive transcription factor (CARF)	OTWE0T6Q	CARTF_HUMAN	Decreases Expression	[33]
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2)	OT2SH7HJ	CGAT2_HUMAN	Increases Expression	[33]
RalBP1-associated Eps domain-containing protein 2 (REPS2)	OTSE3TRP	REPS2_HUMAN	Decreases Expression	[33]
Centrosomal protein of 76 kDa (CEP76)	OTL2SJX0	CEP76_HUMAN	Decreases Expression	[33]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Decreases Expression	[33]
Dynein axonemal heavy chain 3 (DNAH3)	OTD2JOKM	DYH3_HUMAN	Increases Expression	[33]
Partitioning defective 3 homolog (PARD3)	OTH5BPLO	PARD3_HUMAN	Decreases Expression	[34]
GATOR1 complex protein NPRL2 (NPRL2)	OTOB10MO	NPRL2_HUMAN	Decreases Expression	[34]
DnaJ homolog subfamily A member 4 (DNAJA4)	OTT7YCD2	DNJA4_HUMAN	Increases Expression	[33]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Decreases Expression	[33]
Zinc transporter SLC39A7 (SLC39A7)	OTYMA1VB	S39A7_HUMAN	Decreases Expression	[33]
Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B)	OTDNRW37	CPT1B_HUMAN	Decreases Expression	[33]
Sortilin-related receptor (SORL1)	OTQ8FFNS	SORL_HUMAN	Decreases Expression	[33]
Amyloid beta precursor protein binding family B member 2 (APBB2)	OT1VD51B	APBB2_HUMAN	Increases Expression	[33]
Far upstream element-binding protein 1 (FUBP1)	OT77SC9N	FUBP1_HUMAN	Decreases Expression	[33]
Serine/threonine-protein kinase Sgk3 (SGK3)	OTQ6QO99	SGK3_HUMAN	Decreases Expression	[33]
Rho guanine nucleotide exchange factor 26 (ARHGEF26)	OTX0U8PX	ARHGQ_HUMAN	Increases Expression	[34]
ATP-dependent DNA helicase DDX11 (DDX11)	OT1WR3MD	DDX11_HUMAN	Increases Expression	[33]
Unconventional myosin-XVB (MYO15B)	OTA3ZP22	MY15B_HUMAN	Increases Expression	[33]
Testis-specific serine/threonine-protein kinase 2 (TSSK2)	OTPZB4XJ	TSSK2_HUMAN	Increases Expression	[33]
M-phase phosphoprotein 8 (MPHOSPH8)	OTYI2WNS	MPP8_HUMAN	Decreases Expression	[33]
Calcineurin B homologous protein 1 (CHP1)	OTHTXN1A	CHP1_HUMAN	Decreases Expression	[33]
G-protein coupled receptor 20 (GPR20)	OTPCR8F7	GPR20_HUMAN	Increases Expression	[34]
Pituitary homeobox 2 (PITX2)	OTWMXAOY	PITX2_HUMAN	Decreases Expression	[33]
Lysosomal-trafficking regulator (LYST)	OTIUB1B3	LYST_HUMAN	Increases Expression	[33]
Sperm-associated antigen 8 (SPAG8)	OTZC5XP9	SPAG8_HUMAN	Decreases Expression	[33]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[33]
Galactosylceramide sulfotransferase (GAL3ST1)	OTSFFZRD	G3ST1_HUMAN	Decreases Expression	[33]
Transcription factor Ovo-like 2 (OVOL2)	OTFM1GKF	OVOL2_HUMAN	Increases Expression	[33]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[33]
Sorbin and SH3 domain-containing protein 1 (SORBS1)	OTWH8762	SRBS1_HUMAN	Decreases Expression	[33]
Transient receptor potential cation channel subfamily M member 6 (TRPM6)	OTW7SPUV	TRPM6_HUMAN	Increases Expression	[33]
Partitioning defective 6 homolog beta (PARD6B)	OTLBAVQD	PAR6B_HUMAN	Increases Expression	[33]
Sialoadhesin (SIGLEC1)	OTNWSQA9	SN_HUMAN	Increases Expression	[33]
INO80 complex subunit B (INO80B)	OTSHV8JF	IN80B_HUMAN	Decreases Expression	[33]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4)	OTRKV2N8	B3GN4_HUMAN	Increases Expression	[33]
GDNF family receptor alpha-4 (GFRA4)	OTOLGKQM	GFRA4_HUMAN	Increases Expression	[33]
Polyadenylate-binding protein-interacting protein 1 (PAIP1)	OTL2F5T5	PAIP1_HUMAN	Decreases Expression	[34]
Large subunit GTPase 1 homolog (LSG1)	OTDAXJ9L	LSG1_HUMAN	Decreases Expression	[34]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Increases Expression	[33]
Stathmin-4 (STMN4)	OT7ZUKW6	STMN4_HUMAN	Increases Expression	[33]
Matrix metalloproteinase-28 (MMP28)	OTHQZXM1	MMP28_HUMAN	Decreases Expression	[33]
Dendritic cell-specific transmembrane protein (DCSTAMP)	OTFKRP2H	DCSTP_HUMAN	Increases Expression	[33]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Decreases Expression	[33]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Increases Expression	[33]
Prolyl hydroxylase EGLN3 (EGLN3)	OTXV3RYX	EGLN3_HUMAN	Decreases Expression	[33]
E3 ubiquitin-protein transferase RMND5A (RMND5A)	OTXJ7HNB	RMD5A_HUMAN	Decreases Expression	[33]
Glyoxalase domain-containing protein 4 (GLOD4)	OTBJKFXA	GLOD4_HUMAN	Decreases Expression	[34]
Transient receptor potential cation channel subfamily M member 3 (TRPM3)	OTE4CDOQ	TRPM3_HUMAN	Decreases Expression	[33]
X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2)	OTP7IOJO	IRPL2_HUMAN	Increases Expression	[33]
DNA-directed DNA/RNA polymerase mu (POLM)	OT0SRIP4	DPOLM_HUMAN	Increases Expression	[34]
Triggering receptor expressed on myeloid cells 1 (TREM1)	OTCVFEE6	TREM1_HUMAN	Decreases Expression	[33]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Increases Expression	[33]
PDZ and LIM domain protein 7 (PDLIM7)	OTAZVODU	PDLI7_HUMAN	Decreases Expression	[33]
Spectrin beta chain, non-erythrocytic 5 (SPTBN5)	OT8MUQDU	SPTN5_HUMAN	Increases Expression	[33]
Dual oxidase 2 (DUOX2)	OTU14HCN	DUOX2_HUMAN	Increases Expression	[33]
Ubiquitin-like-conjugating enzyme ATG3 (ATG3)	OT28VBVK	ATG3_HUMAN	Decreases Expression	[34]
Transmembrane protein 140 (TMEM140)	OTQCEGEO	TM140_HUMAN	Decreases Expression	[33]
Transmembrane protein 45A (TMEM45A)	OT54KJG6	TM45A_HUMAN	Decreases Expression	[33]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)	OT3XMZU3	FLRT3_HUMAN	Decreases Expression	[33]
Dickkopf-related protein 4 (DKK4)	OTWCCVF6	DKK4_HUMAN	Increases Expression	[33]
Transcription factor 20 (TCF20)	OT8LQAOV	TCF20_HUMAN	Increases Expression	[33]
N-acetyltransferase 8 (NAT8)	OTU9OWOW	NAT8_HUMAN	Decreases Expression	[33]
Tachykinin-3 (TAC3)	OTOJGM38	TKNK_HUMAN	Increases Expression	[33]
Zinc finger transcription factor Trps1 (TRPS1)	OT7XPPEL	TRPS1_HUMAN	Decreases Expression	[33]
Alpha-methylacyl-CoA racemase (AMACR)	OTUU22PK	AMACR_HUMAN	Decreases Expression	[33]
Cytohesin-4 (CYTH4)	OTOR82ID	CYH4_HUMAN	Increases Expression	[33]
SLAM family member 5 (CD84)	OTAY5B0F	SLAF5_HUMAN	Increases Expression	[33]
Protein Hook homolog 1 (HOOK1)	OTTTKV7V	HOOK1_HUMAN	Decreases Expression	[33]
Teneurin-1 (TENM1)	OTSKSU4V	TEN1_HUMAN	Decreases Expression	[33]
Carbonic anhydrase 14 (CA14)	OT1TRKFN	CAH14_HUMAN	Increases Expression	[33]
ALK tyrosine kinase receptor (ALK)	OTV3P4V8	ALK_HUMAN	Increases Expression	[33]
Endoribonuclease Dicer (DICER1)	OTTVSEY0	DICER_HUMAN	Decreases Expression	[33]
Pregnancy-specific beta-1-glycoprotein 11 (PSG11)	OTLZJVLL	PSG11_HUMAN	Increases Expression	[33]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Decreases Expression	[33]
Solute carrier family 22 member 14 (SLC22A14)	OTHRY1XS	S22AE_HUMAN	Increases Expression	[33]
E3 ubiquitin-protein ligase DTX4 (DTX4)	OTGX30AO	DTX4_HUMAN	Decreases Expression	[33]
Protein EFR3 homolog B (EFR3B)	OTVKWU2L	EFR3B_HUMAN	Increases Expression	[33]
FERM domain-containing protein 4B (FRMD4B)	OTVI6YFP	FRM4B_HUMAN	Decreases Expression	[33]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22)	OTDCNTC3	PTN22_HUMAN	Decreases Expression	[33]
Dehydrogenase/reductase SDR family member 7 (DHRS7)	OTV729DT	DHRS7_HUMAN	Decreases Expression	[33]
Nuclear receptor subfamily 2 group E member 1 (NR2E1)	OTW47GKM	NR2E1_HUMAN	Increases Expression	[33]
Metal-response element-binding transcription factor 2 (MTF2)	OTNL1O2O	MTF2_HUMAN	Decreases Expression	[33]
Krueppel-like factor 12 (KLF12)	OTVH4KD4	KLF12_HUMAN	Increases Expression	[33]
Hypoxia-inducible lipid droplet-associated protein (HILPDA)	OTEID3ZM	HLPDA_HUMAN	Decreases Expression	[33]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Decreases Expression	[33]
Calpain-6 (CAPN6)	OT8K5PR5	CAN6_HUMAN	Decreases Expression	[33]
D-dopachrome decarboxylase (DDT)	OTF5HTYL	DOPD_HUMAN	Increases ADR	[43]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases ADR	[43]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Increases ADR	[43]
Macrophage migration inhibitory factor (MIF)	OTUCMVCX	MIF_HUMAN	Increases ADR	[43]

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